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1. The C terminus of the Saccharomyces cerevisiae alpha-factor receptor contributes to the formation of preactivation complexes with its cognate G protein.

2. Identification of a polar region in transmembrane domain 6 that regulates the function of the G protein-coupled alpha-factor receptor.

3. Dominant-negative mutations in the G-protein-coupled alpha-factor receptor map to the extracellular ends of the transmembrane segments.

4. Regulation of the G-protein-coupled alpha-factor pheromone receptor by phosphorylation.

5. AFR1 promotes polarized apical morphogenesis in Saccharomyces cerevisiae.

6. AFR1 acts in conjunction with the alpha-factor receptor to promote morphogenesis and adaptation.

7. Activation of the c-abl oncogene by viral transduction or chromosomal translocation generates altered c-abl proteins with similar in vitro kinase properties.

8. Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products.

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