1. The immune injury effects and clinical significance of eosinophils in auto-immune-related hematocytopenia.
- Author
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Sun LF, Han B, Wu QQ, Wang GC, Hao HF, Du YH, and Zhang Y
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Autoimmune Diseases blood, Bone Marrow immunology, Cytokines blood, Cytokines immunology, Female, Hematologic Diseases blood, Humans, Male, Middle Aged, Phagocytosis, Young Adult, Autoimmune Diseases immunology, Eosinophils immunology, Hematologic Diseases immunology
- Abstract
Eosinophils (EOS) quantity, active state, peroxidase activity (POX), and HLA-DR expression in bone marrow of 176 Auto-Immune-Related Hematocytopenia (AIRH) patients were analyzed. Immunofluorescent staining (IF) is performed to observe the expression of immunizing molecules on EOS. In serum of AIRH patients the levels of IL-4, IL-5, IL-6, IL-12, IL-17, and IFN- γ were increased but there was no significance on IL-2 level. In marrow of AIRH, activated EOS expressed POX, and other molecules, it played various cell-mediated immunity injury roles to hemocyte. EOS might be possessed with multiple immunological fuctions, it playes an important immune effect in AIRH autoimmune pathological processes.
- Published
- 2015
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