1. Safety considerations with the use of platelet inhibitors for elderly patients with non-ST- elevation acute coronary syndrome.
- Author
-
Gimbel ME and Ten Berg JM
- Subjects
- Acute Coronary Syndrome physiopathology, Age Factors, Aged, Cytochrome P-450 CYP2C19 genetics, Dual Anti-Platelet Therapy adverse effects, Genotype, Hemorrhage chemically induced, Humans, Platelet Aggregation Inhibitors adverse effects, Platelet Function Tests, Thrombosis prevention & control, Acute Coronary Syndrome drug therapy, Dual Anti-Platelet Therapy methods, Platelet Aggregation Inhibitors administration & dosage
- Abstract
Introduction : Dual antiplatelet therapy (DAPT) is standard treatment for patients with acute coronary syndrome (ACS). This includes lifelong aspirin combined with a P2Y
12 inhibitor for 1 year. The indication for one of the P2Y12 inhibitors (clopidogrel, prasugrel, ticagrelor) is dependent on the treatment strategy; whether patients undergo coronary angiography or are treated medically only. Tailoring antiplatelet therapy to the risk profile of the individual patient is of specific importance to the older patient. Areas covered : In this review, we discuss dual antiplatelet therapy in elderly patients with ACS. We present the options to tailor antiplatelet therapy based on platelet function testing, CYP2C19 genotyping and patients' thrombotic and bleeding risk. Finally, we discuss alternatives for dual antiplatelet therapy. Expert opinion : DAPT in elderly patients with ACS should consist of aspirin with clopidogrel or ticagrelor. Weighing patients' thrombotic and bleeding risk, based on clinical judgment or with use of specific risk scores, is probably the most convenient method to individualize antiplatelet therapy; however, CYP2C19 genotyping can also be used. In elderly patients with an increased bleeding risk, clopidogrel is a safe and effective alternative to ticagrelor. An alternative to 12 months DAPT could be ticagrelor monotherapy after a short period of DAPT.- Published
- 2021
- Full Text
- View/download PDF