Search

Conducting polymers (CPs) are conductive materials composed of organic polymers. CPs have excellent properties such as easy synthesis and effortless fabrication, tunable electrical property, high environmental stability, high mechanical and optical properties. These unique properties have attracted researchers to discover a wide variety of uses, such as batteries, solar cells, sensors, supercapacitors, electrochromic devices, and biochemical applications. Although CPs have many limitations in their pristine form, hybridization with other materials overcomes these limitations. Here in this review article, we discuss different CPs based chemosensors for colorimetric and fluorimetric detection and determination of noble metal ions (Ag + , Pd 2+ , Pt 2+/4+ , and Au 3+ ) in different environmental, agricultural, and biological samples. Further, the sensing performances of these chemosensors have been compared and discussed. We hope this article will help the readers with the future design of CPs based optical sensor (colorimetric and fluorescent) for detecting noble metal cations.

Thiazol-based molecules have practically infinite biological implementation. Today, there are many medical applications for compounds containing the thiazole moiety owing to their presence in most clinically applied anticancer drugs, such as dasatinib, dabrafenib, ixabepilone, patellamide A and epothilone. In this study, the polycondensation, of a new group of thiazole-containing polyamides with the formulas PA 1-4 was carried out by the interaction of 2-aminothiazole diphenyl sulfide and variable diacid chlorides in dimethyl formamide in the presence of potassium carbonate anhydrous as a catalyst. Fourier transform-infrared spectroscopy (FTIR) was initially used to figure out the PA 1-4 structures, which were further characterized using solubility, gel permeation chromatography (GPC), X-ray diffraction analyses (XRD) and scanning electron microscopy (SEM). The solubility results revealed that the presence of heteroaromatic thiazole ring units and sulfur content in the polyamides main chain, made the solubility easier as it increases the chain packing distance. From the values of average molecular weight, it was clear that all synthesized polyamides have almost the same chain length which ranged from 37,561.80 to 39,827.66. Moreover, the thermogravimetric analysis (TGA) confirm that PA 1-4 were thermally stable even at high temperatures especially the polyamides which were synthesized from aromatic diacid chlorides. Furthermore, the newly synthesized polyamides were investigated for their antimicrobial properties against different species of Gram-positive and Gram-negative bacteria and also against different fungi. The results revealed that compound PA 2 showed the highest antibacterial activity. Also, their inhibitory activity against breast carcinoma cells (MCF-7 cell line) and colon carcinoma cells (HCT cell line) was evaluated. It was clear that there was an enhancement in the anticancer activity for the synthesized polyamides owing to the presence of the thiazole moiety as well as sulfur linkage. According to the results of the 50% inhibitory concentration (IC50), the synthesized polymers were found to be more active against the MCF-7 cell line than the HCT cell line., Competing Interests: No potential conflict of interest was reported by the authors., (© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.)