1. Impact of three variants of prolonged exposure therapy on comorbid diagnoses in patients with childhood abuse-related PTSD.
- Author
-
Hoeboer CM, Kullberg MJ, Oprel DAC, Schoorl M, van Minnen A, Antypa N, Mouthaan J, de Kleine RA, and van der Does W
- Subjects
- Humans, Female, Male, Adult, Middle Aged, Substance-Related Disorders therapy, Substance-Related Disorders complications, Adult Survivors of Child Abuse psychology, Anxiety Disorders therapy, Anxiety Disorders epidemiology, Child Abuse psychology, Depressive Disorder therapy, Depressive Disorder complications, Depressive Disorder epidemiology, Depressive Disorder psychology, Child, Treatment Outcome, Stress Disorders, Post-Traumatic therapy, Stress Disorders, Post-Traumatic epidemiology, Stress Disorders, Post-Traumatic psychology, Implosive Therapy, Comorbidity
- Abstract
Recent studies indicated that Prolonged Exposure (PE) is safe and effective for posttraumatic stress disorder (PTSD). It is unclear whether PE also leads to a reduction in comorbid diagnoses. Data from a large randomized controlled trial ( N = 149) on the effects of three variants of PE for PTSD were used. We examined the treatment effects on co-morbid diagnoses of depressive, anxiety, obsessive compulsive, substance abuse, psychotic, eating and personality disorders in a sample of patients with PTSD related to childhood abuse. Outcomes were assessed with clinical interviews at baseline, post-treatment and at 6- and 12-month follow-up. All variants of PE led to a decrease from baseline to post-treatment in diagnoses of depressive, anxiety, substance use and personality disorders. Improvements were sustained during follow-up. We found an additional decrease in the number of patients that fulfilled the diagnostic criteria of a depressive disorder between 6- and 12-month follow-up. No significant changes were observed for the presence of OCD, psychotic and eating disorders. Findings suggest that it is effective to treat PTSD related to childhood abuse with trauma-focused treatments since our 14-to-16 weeks PE for PTSD resulted in reductions in comorbid diagnoses of depressive, anxiety, substance use and personality disorders.
- Published
- 2024
- Full Text
- View/download PDF