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SystemsX. ch has the objective of supporting and promoting the paradigm shift in life sciences research, moving from qualitative to quantitative and predictive biology. The Swiss government has invested CHF 220 million in around 250 interdisciplinary projects involving more than 400 research groups since 2008. Almost half of the projects are designed for PhD students and postdocs to train the next generation of systems biologists. The initiative will conclude in 2018; different measures will ensure its sustainable impact.