1. Influence of phosphodiesterase inhibition on myocardial energetics in dilative cardiomyopathy
- Author
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Ch. Holubarsch, Tassilo Bonzel, T. Meinertz, Gerd Hasenfuss, H. Just, and W. H. Heiss
- Subjects
Myocardial energetics ,Left Ventricular Systolic Pressure ,medicine.medical_specialty ,Contraction (grammar) ,Chemistry ,Phosphodiesterase ,Hemodynamics ,Anesthesia ,Internal medicine ,Heart rate ,medicine ,Cardiology ,Enoximone ,Phosphodiesterase inhibitor ,medicine.drug - Abstract
The effects of inhibition of phosphodiesterase by enoximone on left ventricular haemodynamics and myocardial energetics were investigated in 10 patients with idiopathic dilative cardiomyopathy. After intravenous administration of enoximone, there was a significant reduction of left ventricular systolic pressure from 126±21 to 93±16 mm Hg, of left ventricular end-diastolic pressure from 16±8 to 5±3 mm Hg and of left ventricular end-diastolic volume from 287±54 to 215±69 ml. Left ventricular pressure-volume work decreased significantly from 12.1±3.6 to 7.6±2.8 mm Hg · 1. Heart rate was 87±17 before and 103±18 min−1 after administration of enoximone (p
- Published
- 1987