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Your search keyword '"Trube, G."' showing total 4 results
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4 results on '"Trube, G."'

1. Abstracts of the poster-session on the adult myocyte model

Author

Achenbach, C., Wiemer, J., Preisler, R., Borgers, M., Thoné, F., Callewaert, G., Carmeliet, E., Vereecke, J., van Echten, G., Eckel, J., Reinauer, H., Cheung, J. Y., Bonventre, J. V., Osterrieder, W., Brum, G., Jacobson, S. L., Schwartz, P., Piper, H. M., Spahr, R., Hütter, J. F., Spieckermann, P. G., Trube, G., Hescheler, J., Isenberg, G., Ravens, U., Koch, R., Piper, H. M., editor, and Spieckermann, P. G., editor

Published
1984
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4. Measurements of single-channel currents in the membrane of isolated cells: ATP-dependence of K+-channels.

Author

Trube G

Subjects
Animals, Cells, Cultured, Guinea Pigs, Heart Ventricles cytology, Sarcolemma physiology, Adenosine Triphosphate metabolism, Electrocardiography, Ion Channels physiology, Myocardium cytology, Potassium metabolism
Abstract

Single-channel currents in ventricular cells of guinea-pig hearts were recorded by the patch-clamp technique. An inwardly rectifying K+-current was found in cell-attached membrane patches. Patches could be isolated from the cell exposing the cytoplasmic face of the membrane directly to the bathing solution. After isolation, the same current as in cell-attached patches was seen if the bath contained 4 mM ATP. Without ATP, this current disappeared and another channel of larger conductance and different kinetics was activated. Currents through the latter channel were also seen in cell-attached patches after poisoning the cells by DNP. It is suggested that the ATP-dependence of the observed membrane channels mediates the increase of potassium conductance after metabolic inhibition.

Published
1985
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