1. Quantitative measurement of ultrasound attenuation and Hepato-Renal Index in Non-Alcoholic Fatty Liver Disease
- Author
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Terese Haaland, John Willy Haukeland, Roald Flesland Havre, Trygve Hausken, Else Marit Løberg, Odd Helge Gilja, Heike Immervoll, and Hilde Løland von Volkmann
- Subjects
Adult ,Male ,medicine.medical_specialty ,Acoustics and Ultrasonics ,Ultrasound attenuation ,Kidney ,Sensitivity and Specificity ,Gastroenterology ,Non-alcoholic Fatty Liver Disease ,Fibrosis ,Internal medicine ,Image Interpretation, Computer-Assisted ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Ultrasonography ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Fatty liver ,Ultrasound ,Reproducibility of Results ,Middle Aged ,Image Enhancement ,medicine.disease ,Fatty Liver ,medicine.anatomical_structure ,Liver ,Liver biopsy ,Female ,Steatosis ,business ,Transient elastography ,Algorithms - Abstract
Objective: The aim of this study was to non-invasively explore new methods of ultrasound attenuation measurements in livers of patients with Non-Alcoholic-Fatty-Liver-Disease (NAFLD) and to measure the liver tissue elasticity. Material and method: Sixteen patients with NAFLD, twelve patients with liver fibrosis and fifteen healthy subjects were included. Echo Levels (ELs) in dB were measured at 2 and 7cm depths in the right liver to calculate the attenuation. ELs were measured in liver and right kidney tissue to calculate the Hepato-Renal Index (HRI). This index was calculated both as a difference, HRIdiff; (EL Liver –EL Kidney) and HRI-ratio; (EL Liver / EL Kidney) using built-in software of the ultrasound scanner. Liver tissue elasticity was measured using transient elastography (TE, Fibroscan®). NAFLD and liver fibrosis were confirmed by liver biopsy. Results: We found that HRI- diff was significantly higher in the NAFLD group compared with healthy subjects, 6.2 dB (0.8-11.4) vs.1. 9 dB (0.0-6.1), p=0.012. HRI- ratio was significantly lower between the same two groups, 0.9 dB (0.81.02) vs.1.01 dB (0.9-1.12), and p
- Published
- 2013
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