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Burkholderia pseudomallei , an environmental saprophyte, causes an infection that results in melioidosis. A high case-fatality rate is linked to it. Melioidosis is becoming an increasingly global infection. It can present a wide spectrum of manifestations and can affect any part of the human being. The head-and-neck region is a major site of melioidosis infection. Melioidosis in the head-and-neck region is a potentially life-threatening infection. Careful clinical correlation and proper evaluation are needed to establish an early diagnosis of melioidosis. Early diagnosis and prompt treatment are very required. A high index of suspicion in susceptible patients should prompt assessment for melioidosis. The awareness of melioidosis and its clinical manifestations with early diagnosis are needed to avoid failure of treatment which may result in high morbidity and mortality. As melioidosis in the head-and-neck region is not so common, there is very less information available. Therefore, a review article on melioidosis in the head-and-neck region is written with consideration of epidemiology, aetiopathology, clinical manifestations, diagnosis, treatment and prognosis. [ABSTRACT FROM AUTHOR]