1. Ultra-high-field 7-T MRI in multiple sclerosis and other demyelinating diseases: from pathology to clinical practice
- Author
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Matilde Inglese, Nicolò Bruschi, and Giacomo Boffa
- Subjects
lcsh:Medical physics. Medical radiology. Nuclear medicine ,Pathology ,medicine.medical_specialty ,Susac Syndrome ,lcsh:R895-920 ,Disease ,Sensitivity and Specificity ,Ultra-high-field magnetic resonance imaging ,030218 nuclear medicine & medical imaging ,Multiple sclerosis ,03 medical and health sciences ,0302 clinical medicine ,Ultra high field ,medicine ,Humans ,Lupus Erythematosus, Systemic ,Radiology, Nuclear Medicine and imaging ,Neuroradiology ,Lesion detection ,medicine.diagnostic_test ,business.industry ,Metabolic imaging ,Neuromyelitis Optica ,Magnetic resonance imaging ,medicine.disease ,Magnetic Resonance Imaging ,Clinical Practice ,Demyelinating diseases ,Early Diagnosis ,Systemic autoimmune diseases ,Neuromyelitis optica spectrum disorders ,Narrative Review ,business ,030217 neurology & neurosurgery - Abstract
Magnetic resonance imaging (MRI) is essential for the early diagnosis of multiple sclerosis (MS), for investigating the disease pathophysiology, and for discriminating MS from other neurological diseases. Ultra-high-field strength (7-T) MRI provides a new tool for studying MS and other demyelinating diseases both in research and in clinical settings. We present an overview of 7-T MRI application in MS focusing on increased sensitivity and specificity for lesion detection and characterisation in the brain and spinal cord, central vein sign identification, and leptomeningeal enhancement detection. We also discuss the role of 7-T MRI in improving our understanding of MS pathophysiology with the aid of metabolic imaging. In addition, we present 7-T MRI applications in other demyelinating diseases. 7-T MRI allows better detection of the anatomical, pathological, and functional features of MS, thus improving our understanding of MS pathology in vivo. 7-T MRI also represents a potential tool for earlier and more accurate diagnosis.
- Published
- 2020