11 results on '"Wilder RL"'
Search Results
2. A genetic linkage map of rat Chromosome 15 derived from five F2 crosses.
- Author
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Shepard JS, Remmers EF, Chen S, Chang L, Kawahito Y, Gulko PS, Joe B, Longman RE, Dracheva S, Ge L, Wang J, Reese VR, Cannon GW, Griffiths MM, and Wilder RL
- Subjects
- Animals, Chromosome Mapping, Female, Genetic Linkage, Male, Microsatellite Repeats, Polymorphism, Genetic, Rats, Rats, Inbred ACI, Rats, Inbred BN, Rats, Inbred F344, Rats, Inbred Lew, Rats, Inbred Strains, Chromosomes genetics, Crosses, Genetic
- Published
- 1999
- Full Text
- View/download PDF
3. Genomic cloning and genetic mapping of the rat Nramp1 (Bcg) gene on chromosome 9.
- Author
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Ge L, Remmers EF, Du Y, and Wilder RL
- Subjects
- Animals, Base Sequence, DNA Primers, Genetic Linkage, Mice, Molecular Sequence Data, Polymerase Chain Reaction, Rats, Species Specificity, Carrier Proteins genetics, Cation Transport Proteins, Chromosome Mapping, Membrane Proteins genetics, Rats, Inbred Strains genetics
- Published
- 1996
- Full Text
- View/download PDF
4. Genetic map of 16 polymorphic markers forming three linkage groups assigned to rat chromosome 4.
- Author
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Goldmuntz EA, Remmers EF, Du Y, Zha H, Mathern P, Crofford LJ, and Wilder RL
- Subjects
- Animals, Base Sequence, DNA genetics, Genotype, Molecular Sequence Data, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Rats, Inbred F344, Rats, Inbred Lew, Rats, Inbred Strains, Chromosome Mapping, Chromosomes, Genetic Linkage, Genetic Markers, Polymorphism, Genetic, Rats genetics
- Abstract
Sixteen polymorphic markers, including markers for eight new loci, forming three linkage groups, were assigned to rat Chromosome (Chr) 4 by linkage analysis of the progeny of an F2 intercross of Fischer (F344/N) and Lewis (LEW/N) inbred rats. One gene, Igk, was mapped by restriction fragment length polymorphism (RFLP) analysis. One marker for Tcrb was identified by the polymorphic insertion of a repetitive LINE element. The remaining 14 markers contained polymorphic simple sequence repeats (SSRs). Ten were identified in genes (Tgfa, Npy, Prss1, Prss2, Aldr1, Iapp, Prp, Eno2, Cacnl1a1, and Il6), one was identified in a sequence related to a gene (Egr4l1), and three were identified in anonymous DNA segments. The SSR markers were highly polymorphic in 16 inbred rat strains. These markers expand the genetic map of the rat and should be useful in future genetic studies of inbred rats.
- Published
- 1995
- Full Text
- View/download PDF
5. A genetic map of microsatellite markers on rat chromosome 7.
- Author
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Du Y, Remmers EF, Zha H, Goldmuntz EA, Szpirer J, Szpirer C, and Wilder RL
- Subjects
- Alleles, Animals, Base Sequence, Chromosome Mapping, DNA, Satellite, Heterozygote, Hybrid Cells, Mice, Molecular Sequence Data, Polymerase Chain Reaction, Rats, Rats, Inbred F344, Rats, Inbred Lew, Chromosomes, Genetic Linkage, Genetic Markers, Rats, Inbred Strains genetics
- Abstract
Nine microsatellite loci were mapped to rat Chromosome (Chr) 7 by genetic linkage and somatic cell hybrid analysis. These loci include the gene encoding a member of the IID sub-family of cytochrome P450 (Cyp2d), a gene with repetitive sequences expressed during myotube formation (D7Arb1e), four anonymous loci, D7Arb81, D7Arb208, D7Arb569, D7Arb609a, and three DNA loci defined by MapPair markers R245, R513, and R1071. The nine loci were all identified by PCR-based microsatellite polymorphism analysis and were characterized in 40 F2 intercross progeny of Fischer (F344/N) and Lewis (LEW/N) rats for segregation analysis. These markers formed a single linkage group spanning 76.8 cM with the following order and distances: D7Arb569-11.4 cM-D7Arb81-9.7 cM-R513-2.6 cM-Cyp2d-0.0 cM-R245-1.3 cM-D7Arb1e-10.4 cM-R1071-15.9 cM-D7Arb609a-15.4 cM-D7Arb208. Physical mapping of Cyp2d by somatic cell hybrid analysis allowed us to assign this linkage group to rat Chr 7. For each marker, two to six alleles were detected in a panel of 16 inbred rat strains (ACI/N, BN/SsN, BUF/N, DA/Bkl, F344/N, LER/N, LEW/N, LOU/MN, MNR/N, MR/N, SHR/N, SR/Jr, SS/Jr, WBB1/N, WBB2/N, WKY/N).
- Published
- 1995
- Full Text
- View/download PDF
6. The rat athymic nude (rnu) locus is closely linked to the inducible nitric oxide synthase gene (Nos2).
- Author
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Zha H, Remmers EF, Du Y, Cash JM, Goldmuntz EA, Crofford LJ, and Wilder RL
- Subjects
- Animals, Base Sequence, Crosses, Genetic, Genes, Molecular Sequence Data, Nitric Oxide Synthase, Rats, Rats, Inbred F344, Rats, Inbred Lew, Amino Acid Oxidoreductases genetics, Rats, Nude genetics
- Published
- 1995
- Full Text
- View/download PDF
7. A single linkage group comprising 11 polymorphic DNA markers on rat chromosome 3.
- Author
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Zha H, Remmers EF, Du Y, Goldmuntz EA, Mathern P, Zhang H, Cash JM, Crofford LJ, and Wilder RL
- Subjects
- Alleles, Animals, Base Sequence, Crosses, Genetic, DNA Primers, Genetic Markers, Genotype, Liver metabolism, Molecular Sequence Data, Random Allocation, Rats, Rats, Inbred Strains genetics, Chromosome Mapping, DNA genetics, Genetic Linkage, Polymorphism, Genetic, Rats, Inbred F344 genetics, Rats, Inbred Lew genetics
- Abstract
Eleven polymorphic DNA markers were mapped to rat Chromosome (Chr) 3 by linkage analysis of F2 progeny of F344/N and LEW/N rat strains. The markers, including seven genes and four anonymous loci, formed a single linkage group covering approximately 112 cM with the following order: Ptgs1 (prostaglandin G/H synthase I)-D3Arb178-Scn2a (sodium channel, type II, alpha-polypeptide)-D3Arb1-Cat (catalase)-Bdnf (brain-derived neurotropic factor)-D3Arb219-D3Arb2-Sus2 (seminal vesicle secretion II protein)-Sdc4 (ryudocan/syndecan4)-Stn1 (statin-like protein). Eight of these markers were analyzed for polymorphisms in 14 additional inbred rat strains. Three to five alleles were detected for each marker, suggesting that they are highly polymorphic and useful for genetic mapping studies with inbred rat strains. Chromosomal syntenic conservation among rats, mice and humans is also discussed.
- Published
- 1994
- Full Text
- View/download PDF
8. Genetic map of seven polymorphic markers comprising a single linkage group on rat chromosome 5.
- Author
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Goldmuntz EA, Remmers EF, Zha H, Mathern P, Du Y, Crofford LJ, and Wilder RL
- Subjects
- Animals, Base Sequence, Crosses, Genetic, DNA, Female, Humans, Male, Molecular Sequence Data, Rats, Rats, Inbred F344, Rats, Inbred Lew, Repetitive Sequences, Nucleic Acid, Chromosome Mapping, Genetic Linkage, Genetic Markers, Polymorphism, Restriction Fragment Length
- Abstract
Seven polymorphic markers comprising a single linkage group were assigned to rat Chromosome (Chr) 5 by linkage analysis of the progeny of an F2 intercross of Fischer (F344/N) and Lewis (LEW/N) inbred rats. Three genes, alpha-L-fucosidase 1 (FUCA1), mitochondrial superoxide dismutase (SOD2), and glucose transporter (GLUT1), were mapped by restriction fragment length polymorphism (RFLP) analysis. Two genes, glucose transporter (GTG3) and elastase II (ELAII), one pseudogene for alpha tubulin (TUBAPS), and one sequence related to the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene (PFKFBP1-related sequence) were mapped by simple sequence repeat (SSR) polymorphism analysis. The loci are in the following order: SOD2, GTG3/GLUT1, FUCA1, ELAII/PFKFBP1-related sequence, and TUBAPS. This linkage group covered 68.3 cM of rat Chr 5. The SSR markers were highly polymorphic in 13 inbred rat strains (SHR/N, WKY/N, MNR/N, MR/N, LOU/MN, BN/SsN, BUF/N, WBB1/N, WBB2/N, ACI/N, LER/N, F344/N, and LEW/N). These markers, located on rat Chr 5, will be useful in genetic studies of inbred rats.
- Published
- 1993
- Full Text
- View/download PDF
9. Genetic mapping of the athymic nude (RNU) locus in the rat to a region on chromosome 10.
- Author
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Cash JM, Remmers EF, Goldmuntz EA, Crofford LJ, Zha H, Hansen CT, and Wilder RL
- Subjects
- Animals, Base Sequence, Female, Genetic Linkage, Genotype, Male, Molecular Sequence Data, Oligonucleotide Probes, Phenotype, Rats, Rats, Inbred F344, Rats, Inbred Lew, Chromosome Mapping, Rats, Nude genetics
- Abstract
The nude trait in the rat is transmitted in an autosomal recessive manner and is associated with thymic aplasia, T-cell deficiency, and hairlessness. Congenic rats homozygous for the RNU (Rowett nude) locus are important models in the study of inflammatory disease, tumor growth, and transplant rejection. The RNU locus has not been previously mapped, and the nature of the gene product is unknown. To determine the map location of this gene, a single F344.rnu/rnu (athymic nude congenic Fischer rat) male congenic rat was bred with 3 LEW/N (NIH stock Lewis rat) female rats to produce F1 progeny. Twelve F1 brother-sister breeding pairs were established. Forty-nine phenotypically nude F2 offspring (198 total) were obtained. Linkage analysis done on F2 DNA revealed highly significant cosegregation between the nude phenotype and eight polymorphic markers located on Chromosome (Chr) 10. The tightest linkages were with: MYH3 (embryonic, skeletal myosin heavy chain) and SHBG (sex hormone-binding globulin), giving 2 point lod scores of 20.2, and 20.0, respectively. The map order and map distances, determined by multipoint linkage calculations, were: RR24-(16.1 cM)-MYH3-(3.5 cM)-SHBG-(4.7 cM)-RNU-(11.9 cM)-F16F2-(24.1 cM)-CLATP (citrate lyase ATPase)-(2.4 cM)-ACE (angiotensin converting enzyme)/PPY (pancreatic polypeptide)-(14.1 cM)-RR1023. The position of the RNU locus in the rat corresponds closely with that of the recently reported nu locus in the mouse. This finding suggests that the nude phenotype in the rat and the mouse arise from defects in homologous genes.
- Published
- 1993
- Full Text
- View/download PDF
10. Linkage map of seven polymorphic markers on rat chromosome 18.
- Author
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Remmers EF, Goldmuntz EA, Zha H, Crofford LJ, Cash JM, Mathern P, Du Y, and Wilder RL
- Subjects
- Alleles, Animals, Base Sequence, Chromosome Mapping, Crosses, Genetic, DNA genetics, Genetic Linkage, Molecular Sequence Data, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, Rats, Inbred F344, Rats, Inbred Lew, Rats, Inbred Strains, Genetic Markers, Rats genetics
- Abstract
A genetic linkage map of seven polymorphic markers was created with F2 intercross progeny of F344/N and LEW/N rats and assigned to rat Chromosome (Chr) 18. Five of the markers described were defined by simple sequence length polymorphisms (SSLPs) associated with five genes: transthyretin (TTR), trypsin inhibitor-like protein (TILP), beta 2 adrenergic receptor (ADRB2), olfactory neuron-specific G protein (OLF), and gap junction protein (GJA1). One marker was defined by a restriction fragment length polymorphism (RFLP) detected with a probe for the human colony stimulating factor 1 receptor (CSF1R) gene. The D18N1R locus was defined by an anonymous DNA fragment amplified by the randomly amplified polymorphic DNA (RAPD) technique with a single short primer. These seven DNA loci formed a single genetic linkage group 30.4 cM in length with the following order: TTR-6.8 cM-D18N1R-9.1 cM-TILP-4.3 cM-CSF1R-0 cM-ADRB2-10.2 cM-OLF-0 cM-GJA1. The five SSLP markers were highly polymorphic. In a total of 13 inbred rat strains analyzed (F344/N, LEW/N, LOU/MN, WBB1/N, WBB2/N, MR/N, MNR/N, ACI/N, SHR/N, WKY/N, BN/SsN, BUF/N, and LER/N), three to six alleles were detected for each marker. Remarkable linkage conservation was detected between the region of rat Chr 18 mapped and a region of mouse Chr 18. However, genes associated with these markers have been mapped to three different human chromosomes (Chrs 5, 6, and 18). The markers described here should be useful for genetic mapping studies and genetic monitoring of inbred rat strains.
- Published
- 1993
- Full Text
- View/download PDF
11. Map of seven polymorphic markers on rat chromosome 14: linkage conservation with human chromosome 4.
- Author
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Remmers EF, Goldmuntz EA, Cash JM, Zha H, Crofford LJ, Misiewicz-Poltorak B, Mathern P, and Wilder RL
- Subjects
- Animals, Base Sequence, Crosses, Genetic, DNA, Single-Stranded, Humans, Molecular Sequence Data, Rats, Rats, Inbred F344, Rats, Inbred Lew, Chromosome Mapping, Chromosomes, Human, Pair 4, Genetic Linkage, Genetic Markers, Polymorphism, Genetic
- Abstract
Seven polymorphic markers identified by polymerase chain reaction (PCR) amplification, including markers for six genes--DRD1L (dopamine receptor, D1-like-2), GLUKA (glucokinase), PF4 (platelet factor 4), ALB (albumin), AFP (alpha-fetoprotein), and BSP (bone sialoprotein)--and one anonymous locus (D14N52), were mapped to a single 67-cM linkage group with F2 intercross progeny of F344/N and LEW/N inbred rat strains. Two of these markers, ALB and AFP, have previously been assigned to rat Chromosome (Chr) 14, allowing assignment of this entire linkage group. Five of the markers--DRD1L, PF4, ALB, AFP, and BSP--have been physically mapped to a large region of human Chr 4 encompassing the p arm and the q arm to band q28. Homologs of two of the markers, ALB and AFP, have been mapped to Chr 5 in the mouse. Comparison of human Chr 4 with the homologous regions on Chr 14 of the rat and Chr 5 of the mouse indicated that linkage conservation with human Chr 4 extends over a greater region in the rat than in the mouse. The markers described here were found to be highly polymorphic in twelve inbred strains (F344/N, LEW/N, ACI/N, BUF/N, BN/SsN, LOU/MN, MNR/N, MR/N, SHR/N, WBB1/N, WBB2/N, and WKY/N). These polymorphic markers should be useful in genetic linkage studies of important phenotypes in rats.
- Published
- 1993
- Full Text
- View/download PDF
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