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Intraocular pressure was evaluated in 414 eyes using Keeler Pulsair tonometry in comparison with values obtained by Goldmann tonometry. No statistically significant differences were found between the two techniques. Landis K statistical analysis was used to evaluate the measurements obtained by two operators in 125 eyes, with the results indicating good reproducibility. In 20 eyes, a statistically significant difference was found between values obtained with patients in the seated vs supine positions, whereas measurements made with subjects' heads in a supported or unsupported position yielded no statistically different values.

The Interzeag 701 Lens Opacity Meter was used to study the lenses of 122 cataract eyes and 73 healthy eyes with clear lenses. The readings taken separately in 67 eyes by two different operators did not significantly differ. Statistically significant differences were found between the readings taken by the same operator when the pupil size was different in all types of cataract and also in eyes with transparent lenses. Opacity Meter readings correlate well with the visual acuity of eyes with nuclear and mixed cataracts, but no correlation was found in eyes with cortical or posterior subcapsular cataracts. In healthy eyes with clear lens, a correlation was found between the instrument readings and age.

Topical treatment with 1% thymoxamine produces in rabbit and human eyes a small but real miotic and tension-lowering effect. The latter is more evident using two different models of experimental ocular hypertension in rabbits. In human open-angle glaucoma eyes, tonographic measurements indicate that the outflow facility is left unchanged by the drug.

Weekly subconjunctival injections of 4mg repository betamethasone, repeated over three weeks, produced a sustained increase of intraocular pressure (IOP) in 96% of the treated rabbits. Treatment was generally well tolerated and important systemic toxic effects were present only in a few animals. The ocular hypertension so obtained was constant, well reproducible and sensitive to antiglaucoma drugs. The authors believe they have developed an animal model which is very suitable for testing the pressure-lowering effect of drugs and for other studies on ocular hypertension and glaucoma.