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The role of prognostics and health management is ever more prevalent with advanced techniques of estimation methods. However, data processing and remaining useful life prediction algorithms are often very different. Some difficulties in accurate prediction can be tackled by redefining raw data parameters into more meaningful and comprehensive health level indicators that will then provide performance information. Proper data processing has a significant importance on remaining useful life predictions, for example, to deal with data limitations or/and multi-regime operating conditions. The framework proposed in this paper considers a similarity-based prognostic algorithm that is fed by the use of data normalisation and filtering methods for operational trajectories of complex systems. This is combined with a data-driven prognostic technique based on feed-forward neural networks with multi-regime normalisation. In particular, the paper takes a close look at how pre-processing methods affect algorithm performance. The work presented herein shows a conceptual prognostic framework that overcomes challenges presented by short-term test datasets and that increases the prediction performance with regards to prognostic metrics. Validerad;2019;Nivå 2;2019-04-12 (johcin)