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4 results on '"Sedlák K"'

3. Reverse-zoonotic transmission of SARS-CoV-2 lineage alpha (B.1.1.7) to great apes and exotic felids in a zoo in the Czech Republic.

Author

Nagy A, Stará M, Vodička R, Černíková L, Jiřincová H, Křivda V, and Sedlák K

Subjects
Animals, Czech Republic epidemiology, Humans, Phylogeny, SARS-CoV-2 genetics, COVID-19, Felidae, Hominidae
Abstract

We report an outbreak of SARS-CoV-2 lineage alpha in gorillas and felid species in a zoo in Prague, Czech Republic. The course of illness and clinical signs are described, as are the results of characterization of these particular SARS-CoV-2 variants by next-generation sequencing and phylogenetic analysis. The putative transmission routes are also discussed., (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)

Published
2022
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4. Microevolution and independent incursions as main forces shaping H5 Hemagglutinin diversity during a H5N8/H5N5 highly pathogenic avian influenza outbreak in Czech Republic in 2017.

Author

Nagy A, Dán Á, Černíková L, Vitásková E, Křivda V, Horníčková J, Masopust R, and Sedlák K

Subjects
Animals, Birds classification, Birds virology, Czech Republic epidemiology, Disease Outbreaks, Genetic Variation, Influenza A Virus, H5N8 Subtype classification, Influenza A Virus, H5N8 Subtype isolation & purification, Influenza A Virus, H5N8 Subtype pathogenicity, Influenza A virus classification, Influenza A virus isolation & purification, Influenza A virus pathogenicity, Influenza in Birds epidemiology, Phylogeny, Virulence, Evolution, Molecular, Hemagglutinin Glycoproteins, Influenza Virus genetics, Influenza A Virus, H5N8 Subtype genetics, Influenza A virus genetics, Influenza in Birds virology
Abstract

Here, we present a comprehensive analysis of the H5N8/H5N5 highly pathogenic avian influenza (HPAI) virus strains detected in the Czech Republic during an outbreak in 2017. Network analysis of the H5 Hemagglutinin (HA) from 99% of the outbreak localities suggested that the diversity of the Czech H5N8/H5N5 viruses was influenced by two basic forces: local microevolution and independent incursions. The geographical occurrence of the central node H5 HA sequences revealed three eco-regions, which apparently played an important role in the origin and further spread of the local H5N8/HPAI variants across the country. A plausible explanation for the observed pattern of diversity is also provided.

Published
2018
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