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55 results on '"Schwarz, E"'

49. TRP channels in lymphocytes.

Author

Schwarz EC, Wolfs MJ, Tonner S, Wenning AS, Quintana A, Griesemer D, and Hoth M

Subjects
Animals, Biotransformation drug effects, Humans, Ion Channels physiology, Lymphocyte Activation physiology, Lymphocytes metabolism, Transient Receptor Potential Channels agonists, Transient Receptor Potential Channels antagonists & inhibitors, Transient Receptor Potential Channels biosynthesis, Lymphocytes physiology, Transient Receptor Potential Channels physiology
Abstract

TRP proteins form ion channels that are activated following receptor stimulation. Several members of the TRP family are likely to be expressed in lymphocytes. However, in many studies, messenger RNA (mRNA) but not protein expression was analyzed and cell lines but not primary human or murine lymphocytes were used. Among the expressed TRP mRNAs are TRPC1, TRPC3, TRPM2, TRPM4, TRPM7, TRPV1, and TRPV2. Regulation of Ca2+ entry is a key process for lymphocyte activation, and TRP channels may both increase Ca2+ influx (such as TRPC3) or decrease Ca2+ influx through membrane depolarization (such as TRPM4). In the future, linking endogenous Ca2+/cation channels in lymphocytes with TRP proteins should lead to a better molecular understanding of lymphocyte activation.

Published
2007
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50. [Kidney calculus episode in a supernumerary 3rd kidney].

Author

Eberle J, Schwarz E, and Abbrederis K

Subjects
Humans, Hydronephrosis diagnostic imaging, Kidney diagnostic imaging, Male, Middle Aged, Remission, Spontaneous, Urography, Kidney abnormalities, Kidney Calculi diagnostic imaging, Tomography, X-Ray Computed
Abstract

Supernumerary kidney is a rare renal anomaly. As a distinct encapsulated parenchymatous mass, this free accessory organ has a separate blood supply and excretory duct system. We report on a patient who presented with an acute episode of abdominopelvic pain, secondary to hydronephrosis of a third kidney, situated in the pelvis behind the bladder. Modern diagnostic methods assisted in the conservative management of this well functioning third kidney.

Published
2002
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