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Your search keyword '"Rapoport, S."' showing total 45 results
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45 results on '"Rapoport, S."'

14. Blut- und Harnbestandteile

Author

Luszczak, A., Grassberger, R., Hüfner, G., Loewy, A., Zuntz, N., Fischinger, O., May, J., Seydel, F., Oettel, H., Schmidt, O., Frederick, R. C., Kohn-Abrest, E., Froman, J., Leinzinger, Maria, Häusler, H., Rappaport, F., Gottdenker, F., Kanitz, H. R., Apitzsch, J., Hecht, G., Hayes, F. R., Mansfeld, G., Scheff-Pfeifer, Irene, Lugg, J. W. H., Robbins, B. H., Orcutt, F. S., Waters, R. M., Seevers, M. H., Gutschmidt, J., Hinsberg, K., Breutel, E., Friedemann, Theodore E., Klaas, Rosalind, Hallén-Paulsen, L., Gershenfeld, L., Pojurowski, S. D., Looney, J. M., Walsh, Anna I., Florkin, M., Gomez, J., Bing, J., Guyader, G., Campbell, W. R., Hanna, Marion I., Reifer, J., Schalm, L., Danielson, I. S., d'Alessio, Rosa C., Fromageot, Cl., Heitz, P., Jones, D. B., Moeller, O., Desnuelle, P., Sullivan, M. X., Hess, W. C., Popovici, N., Radulescu, A., Hunter, A., Pettigrew, J. B., Jansen, B. C. P., Dauphinee, J. A., Krebs, H. A., Henseleit, K., van Slyke, D. D., Rapoport, S., Eichinger, W., Voisenet, E., Rosenthal, H. G., Binet, L., Weller, G., Hartner, F., Sehleiß, E., Code, C. F., Eggerth, A. H., Littwin, R. J., Deutsch, Joyce V., Koessler, K. K., Hanke, M. T., Kahane, E., Levy, Jeanne, Claudatus, I., Botezatu, M., Kisch, B., Beattie, Florence, Yoshimatsu, S. I., Andes, J. E., Myers, V. C., Greenwald, I., Eucker, H., Böhm, F., Grüner, G., Ludwig, H., Salkowski, E., Euler, H. v., Raekallio, T., Cattelain, E., Chabrier, P., Tchitchibabine, A., Hoffmann, Ch., Schulemann, W., Schönhöfer, F., Wingler, A., Brundage, J. T., Gruber, Ch. M., Reimers, F., Marshall, Jr., E. K., Emerson, Jr., K., Cutting, W. C., Frehden, O., Huang, Chen-Hua, Nosaka, K., Genkin, A. M., Simonovits, S., Wierzuchowski, M., Dzisiów, F., Sysa, J., Borkowski, Z., Colutta, A., and Herbert, Freda Katharine

Published
1941
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15. Quantitative Analyse

Author

Wenger, P., Cimerman, Ch., Wyszewianska, M., Hecht, F., Reissner, R., Möller, M., Schlegel, G., Gaptschenko, M. W., Sumuleanu, C., Ghimieeseu, G., Wolf, L., Düsing, W., Martos, A., Stock, A., Friedrich, A., Rapoport, S., Hughes, J. S., and Withrow, J. R.

Published
1937
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17. Bestimmung organischer Blut-, Harn- und Pflanzenbestandteile

Author

Olson, C., Billimoria, M. C., Werr, F., Jendrassik, L., Polgar, A., Sharlit, H., Lee, M. H., Widdowson, E. M., Archer, B. H., Robb, G. P., Conway, E. J., Beattie, Florence, Diller, I. M., Bierbrajer, M. L., Kern, A., Stransky, E., Florkin, M., Dirr, K., Schade, H. L., Ilarden, A., Norris, R. V., Fujita, A., Okamoto, K., Hoffman, W. S., Sankaran, G., Rajagopal, K., Heck, Kathrin, Brown, W. H., Kirk, P. L., Lasausse, E., Kermarec, R., Frocrain, I., Joachimoglu, G., Panagopoulos, K., Parnas, J. K., Umschweif, B., Ferdmann, D., Lutwak-Mann, C., Lohmann, K., Schuster, Ph., Wagner-Jauregg, Th., Rapoport, S., Henry-Cornet, J., Henry, L., Gróf, P., and Weiß, M.

Published
1939
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21. Mikrochemie

Author

Rosenthaler, L., Kuhn, Richard, Roth, Hubert, Friedrich, A., and Rapoport, S.

Published
1935
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42. Is phosphoadenosine phosphate phosphatase a target of lithium's therapeutic effect?

Author

Shaltiel G, Deutsch J, Rapoport SI, Basselin M, Belmaker RH, and Agam G

Subjects
Adenine Nucleotides metabolism, Adenosine Diphosphate metabolism, Adenosine Triphosphate metabolism, Animals, Antimanic Agents pharmacology, Antimanic Agents therapeutic use, Bipolar Disorder physiopathology, Brain physiopathology, Brain Chemistry drug effects, Brain Chemistry physiology, Lithium Chloride pharmacology, Lithium Compounds therapeutic use, Male, Neuroprotective Agents pharmacology, Phosphoric Monoester Hydrolases genetics, RNA, Messenger metabolism, Rats, Rats, Inbred F344, Bipolar Disorder drug therapy, Bipolar Disorder enzymology, Brain drug effects, Brain enzymology, Lithium Compounds pharmacology, Phosphoric Monoester Hydrolases metabolism
Abstract

Lithium, which is approved for treating patients with bipolar disorder, is reported to inhibit 3'(2')-phosphoadenosine-5'-phosphate (PAP) phosphatase activity. In yeast, deletion of PAP phosphatase results in elevated PAP levels and in inhibition of sulfation and of growth. The effect of lithium on PAP phosphatase is remarkable for the low Ki (approximately 0.2 mM), suggesting that this system would be almost completely shut down in vivo with therapeutic levels of 1 mM lithium, thereby elevating PAP levels. To test the hypothesis that lithium inhibition of PAP phosphatase is pharmacologically relevant to bipolar disorder, we fed rats LiCl for 6 weeks, and assayed brain PAP levels after subjecting the brain to high-energy microwaving. We also measured PAP phosphatase mRNA and protein levels in frozen brain tissue of lithium-treated mice. Brain adenosine phosphates were extracted by trichloroacetic acid and assayed by HPLC with a gradient system of two phases. PAP phosphatase mRNA was measured by RT-PCR, and PAP phosphatase protein was measured by Western blotting. Brain PAP levels were below detection limit of 2 nmol/g wet weight, even following lithium treatment. Lithium treatment also did not significantly change brain PAP phosphatase mRNA or protein levels. These results question the relevance of PAP phosphatase to the therapeutic mechanism of lithium. A statistically significant 25% reduced brain ADP/ATP ratio was found following lithium treatment in line with lithium's suggested neuroprotective effects.

Published
2009
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43. Neocortical metabolic abnormalities precede nonmemory cognitive impairments in early dementia of the Alzheimer type: longitudinal confirmation.

Author

Haxby JV, Grady CL, Friedland RP, and Rapoport SI

Subjects
Frontal Lobe metabolism, Functional Laterality physiology, Humans, Language, Longitudinal Studies, Parietal Lobe metabolism, Psychomotor Performance physiology, Temporal Lobe metabolism, Wechsler Scales, Alzheimer Disease metabolism, Cerebral Cortex metabolism, Cognition physiology
Abstract

Patterns or regional cerebral metabolism and neuropsychological function were studied longitudinally in 10 mildly demented patients with dementia of the Alzheimer type (DAT) and compared to those of moderately demented patients and controls. As reported previously (Haxby et al., 1986), the mildly demented patients initially had significant neocortical metabolic abnormalities, namely parietal reductions and right-left asymmetries, but did not differ from controls on any test of neocortically-mediated visuospatial and language functions. Right-left metabolic asymmetries correlated with neuropsychological discrepancies between visuospatial and language function in moderately demented but not mildly demented patients. We now report that longitudinal studies of these mildly demented patients showed significant decline of nonmemory cognitive function. Moreover, correlations of metabolic asymmetries with neuropsychological discrepancies between visuospatial and language functions became significant. These longitudinal results confirm our previous conclusion that neocortical metabolic abnormalities precede neocortically-mediated neuropsychological impairments in early DAT.

Published
1987

44. [Studies on phage lysozyme. IV. The molecular cause of the cold-sensitive phenotype of the phage T4D mutant csebu56: the amino acid substitution tyrosine 88 leads to histidine].

Author

Liebscher DH, Dauberschmidt R, Rapoport SM, Heitmann P, and Rosenthal HA

Subjects
Cold Temperature, DNA Viruses metabolism, Electrophoresis, Genetics, Microbial, Indicators and Reagents, Molecular Biology, Mutation, Phenotype, Temperature, Tryptophan metabolism, Coliphages enzymology, Histidine metabolism, Muramidase metabolism, Tyrosine metabolism
Published
1974
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45. [On erythrocyte metabolism in phosphate diabetes].

Author

Syllm-Rapoport I, Jacobasch G, Grossmann P, and Rapoport S

Subjects
Adolescent, Child, Enzyme Repression, Female, Glycolysis, Humans, Hypophosphatemia, Familial metabolism, Male, Phosphates therapeutic use, Vitamin D therapeutic use, Chronic Kidney Disease-Mineral and Bone Disorder metabolism, Erythrocytes metabolism, Phosphates metabolism
Published
1966

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