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Start Over Descriptor "Pamidronate" Publisher springer-verlag
86 results on '"Pamidronate"'

33. Immediate implant placement following 1-year treatment with oral versus intravenous bisphosphonates: a histomorphometric canine study on peri-implant bone.

Author

Khojasteh A, Dehghan MM, and Nazeman P

Subjects
Animals, Dogs, Female, Alendronate pharmacology, Bone Density Conservation Agents pharmacology, Dental Implantation, Endosseous, Dental Implants, Osseointegration, Pamidronate pharmacology
Abstract

Objectives: Bisphosphonates (BPs) are anti-resorptive medications with inhibitory effects on osteoclasts which decrease bone turnover. The present study aimed to assess the early effects of BPs on peri-implant bone., Materials and Methods: Twelve female mongrel dogs were assigned to one control and two experimental groups as follows: 12 months of oral alendronate (ALN, 3.5 mg/kg/week) or intravenous (IV) pamidronate (PAM, 1 mg/kg/week) for experimental groups. Following 8 weeks after implant insertion, the specimens were sacrificed, histological evaluation was performed, and C-terminal telopeptide of collagen I (CTx) analysis was performed on serums., Results: PAM demonstrated the greatest marginal bone level (MBL), 2.64 ± 0.48, followed by ALN and control, 2.5 ± 0.4 and 0.66 ± 0.5 respectively. The least bone-implant contact was observed in PAM group (%39 ± 0.03) while it was significantly greater in the control group (p < 0.05). PAM and ALN demonstrated < 10 CTx levels versus > 300 in controls., Conclusion: It is assumed that long-term oral or IV BP therapy decreases marginal bone resorption and osseointegration. These changes were more accentuated in IV BP administration. CTx does not seem to be a precise predictor for bisphosphonate-related osteonecrosis of the jaw., Clinical Relevance: BPs impair peri-implant bone remodeling and this phenomena may be effective for reducing resorption at esthetic zone implants; however, decrease in osseointegration may be a concern for implant treatment in patients receiving BPs.

Published
2019
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50. Vertical jump performance after 90 days bed rest with and without flywheel resistive exercise, including a 180 days follow-up

Author

Jörn Rittweger, Dieter Felsenberg, Constantinos N. Maganaris, and José Luis Ferretti

Subjects
Adult, Male, Time Factors, Physiology, medicine.medical_treatment, Pamidronate, Physical exercise, Motor Activity, medicine.disease_cause, Bed rest, Flywheel, Head-Down Tilt, Vertical jump, Jumping, Animal science, Physiology (medical), medicine, Humans, Orthopedics and Sports Medicine, Muscle Strength, Ground reaction force, Muscle, Skeletal, Exercise, Bone Density Conservation Agents, Diphosphonates, Resistive exercise, business.industry, Public Health, Environmental and Occupational Health, Recovery of Function, General Medicine, Baseline data, Combined Modality Therapy, Exercise Therapy, Muscular Atrophy, business, Bed Rest
Abstract

Muscle atrophy and neuromuscular de-conditioning occur in response to space flight and bed-rest. In this study, we investigated the efficacy of flywheel training to conserve jumping power and height during 90 days bed rest. Twenty-four young healthy men underwent strict bed-rest (-6 degrees head down tilt) for 90 days. Eight participants were assigned to a flywheel group (FW) and 16 to a control group (Ctrl). The ground reaction force was measured during vertical jump tests twice during baseline data collection, and on day 4, 7, 14, 90 and 180 of recovery. In half of the participants, jump tests were also performed within minutes after re-ambulation and on four more occasions during the first 2 days of recovery. Jump height was reduced from 40.6 cm (SD 6.1 cm) during the first baseline measurement to 27.6 cm (SD 5.6 cm) on day 4 of recovery in Ctrl, but only from 38.6 cm (SD 3.9 cm) to 34.4 cm (SD 6.5 cm) in FW (P0.001). At the same time, peak power was reduced from 47.4 W/kg (SD 8.0 W/kg) to 34.5 W/kg in Ctrl, but only from 46.2 W/kg (6.0 W/kg) to 42.2 W/kg SD 4.6 W/kg) in FW (P0.001). Jump height and peak power were completely recovered after 163 and 140 days in Ctrl, respectively, and after 72 and 18 days in FW (regression analysis). In conclusion, flywheel exercise could effectively offset neuromuscular de-conditioning during bed-rest, and led to full recovery at an earlier stage. These findings nourish the hope that adequate training paradigms can fully sustain neuromuscular function under microgravity conditions.

Published
2007

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