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Routine use of micro HPLC will need the development of several important constituents; the reproducible preparation of high-performance columns, small-volume pumps and gradient systems, and improvement of an injection system. Subjects to be studied are the development of high-performance monolithic silica columns for a variety of separation modes, multidimensional micro LC systems, and optimization of an interface between LC and MS instruments. Large peak capacities realized by highly efficient micro HPLC systems or multidimensional HPLC will greatly contribute to metabolomics studies when coupled with MS instruments.