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15 results on '"Martignoni E"'

6. A multicenter Italian randomised study on early treatment of Parkinson disease: comparison of 1-dopa, 1-deprenyl and dopaminoagonists. Study design and short term results

Author

Caraceni T., Musicco M., Gasparini M., Beghi E., Scigliano G., Carella F., Cossutta E., Chiaro C., Lovicu G., Giminiani G., Currado I., Solari, A., Nicolosi A., Agnoli A., Nappi G., Giuliani G., Angeleri A., Moro G., Franciosi A., De Mari M., Lamberti P., Huber R., Coppola G., Trianni G., Onofri M., Curatola L., Paolino E., Casetta I., Scaglioni P., Caffarra P., Marini P., Vanni P., Genitrini S., Sterzi R., Ferrarini M., Bassi P., Contri P., Comi G. C., Comola M., Campanella G., De Michele G., Pacchetti C., Martignoni E., Piccirilli M., Finali G., Massetani R., Galli R., Albanese A., Bentivoglio A., Scoppetta C., Peppe A., Stanzione P., Semprini R., Rossi F., Castellano A., Marconi R., Fincati E., Tomelleri G., Nardelli E., Nordera G., Iemolo F., D'Asta G., Lorizio A., Salsa F., Freschi R., Meregalli S., Bandinelli S., Gangemi S., Capus L., Piola P., Bino G., Achille P., Pederzoli M., Lenzi G. L., and The Italian Parkinson Study Group

Published
1992
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13. Autonomic disorders in Parkinson's disease.

Author

Martignoni E, Pacchetti C, Godi L, Micieli G, and Nappi G

Subjects
Autonomic Nervous System Diseases epidemiology, Basal Ganglia Diseases epidemiology, Basal Ganglia Diseases etiology, Cardiovascular Diseases epidemiology, Cardiovascular Diseases etiology, Disease Progression, Gastrointestinal Diseases epidemiology, Gastrointestinal Diseases etiology, Humans, Incidence, Urologic Diseases epidemiology, Urologic Diseases etiology, Autonomic Nervous System Diseases etiology, Parkinson Disease complications
Abstract

Patients with idiopathic Parkinson's disease (IPD) often show signs and symptoms of autonomic involvement, related to the disease itself or to its progression. The more frequently disturbances reported are connected with loss of extrapyramidal motor control, i.e. dysphagia, gastric emptying and the most common constipation. They concern about 73% of the patients. A high frequency of urinary symptoms, ranging from 37% to 71%, is also reported in IPD, in particular detrusor hyperreflexia causing urgency, frequency of micturing or urgency incontinence. Another autonomic groups of symptoms are related to the failure of cardiopressor adaptability which involve 15% of the subjects and are more typical of late onset cases or forms bordering with the Multiple System Atrophy, finally resulting in orthostatic hypotension (OH).

Published
1995

14. (-)Deprenyl in Parkinson's disease: a two-year study in the different evolutive stages.

Author

Giovannini P, Martignoni E, Piccolo I, Pacchetti C, Grassi MP, Nappi G, and Caraceni T

Subjects
Adult, Aged, Carboxy-Lyases antagonists & inhibitors, Drug Therapy, Combination, Female, Humans, Levodopa therapeutic use, Male, Middle Aged, Parkinson Disease physiopathology, Selegiline adverse effects, Parkinson Disease drug therapy, Phenethylamines therapeutic use, Selegiline therapeutic use
Abstract

Seventy-nine patients with idiopathic Parkinson's disease in various phases of evolution of the clinical picture were studied. All the patients, already under treatment with L-dopa + PDI, were treated with (-)deprenyl at the dose of 10 mg/day orally in two daily administrations. The mean follow-up was 8.7 months (range, 1-29). Overall, 47.6% of the patients improved, 27.4% showed a marked improvement, 38.1% showed evident modifications, and 27.4% worsened. Sixteen patients were excluded from the study for various reasons. In 53.2% of the cases it was possible to reduce the daily L-dopa dose by a mean of 30%. Overall, (-)deprenyl was effective in the treatment of our parkinsonian patients in the various conditions evaluated, and thus constitutes a new therapeutic strategy for Parkinson's disease.

Published
1986

15. Autonomic disorders in idiopathic parkinsonism.

Author

Martignoni E, Micieli G, Cavallini A, Pacchetti C, Magri M, and Nappi G

Subjects
Antiparkinson Agents adverse effects, Body Temperature Regulation, Dopamine physiology, Humans, Hypotension etiology, Pupil physiology, Urination Disorders etiology, Autonomic Nervous System Diseases physiopathology, Parkinson Disease physiopathology
Abstract

Clinical evidences and experimental data on various signs and symptoms of autonomic dysfunction in idiopathic parkinsonism are reported and their characteristics related to the effects of the drugs usually administered for the therapy of the extrapyramidal symptoms. The use of instrumental diagnostic criteria may sometimes help to detect alterations of autonomic functions (micturition disturbances, disorders of pupil reactivity, orthostatic and postprandial hypotension, temperature dysregulation), otherwise not easily identifiable. The existence of a large involvement of autonomic structures both at central and peripheral levels underlines the concept of Parkinson's disease being part of a wide spectrum of degenerative disorders where multiple nervous structures are at risk.

Published
1986

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