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Your search keyword '"Griffin, S. J."' showing total 11 results
Start Over Author "Griffin, S. J." Publisher springer-verlag
11 results on '"Griffin, S. J."'

11. Comparison of effects of desipramine and amitriptyline on EEG sleep of depressed patients.

Author

Shipley JE, Kupfer DJ, Griffin SJ, Dealy RS, Coble PA, McEachran AB, Grochocinski VJ, Ulrich R, and Perel JM

Subjects
Adult, Amitriptyline therapeutic use, Depression drug therapy, Depression psychology, Desipramine therapeutic use, Double-Blind Method, Female, Humans, Male, Middle Aged, Sleep, REM drug effects, Amitriptyline pharmacology, Depression physiopathology, Desipramine pharmacology, Electroencephalography, Sleep drug effects
Abstract

Despite their widespread use, there are few data concerning the effects of tricyclic antidepressants on EEG sleep in depression. The present study documented the effects of desipramine (DMI, n = 17) and amitriptyline (AT, n = 16) upon EEG sleep in hospitalized depressed patients as part of a double-blind protocol involving 28 days of active treatment. Compared to placebo, patients receiving DMI showed somewhat worsened sleep continuity, particularly after 1 week of administration when the dose was 150 mg/day. On the other hand, sleep architecture and REM measures showed a rapid suppression of REM sleep, and then partial tolerance for this effect was observed with continued administration of DMI for 3 weeks. DMI was a more potent suppressor of REM sleep, while AT was more sedative. Based on these differences in effects upon EEG sleep, a discriminant function was derived and resulted in a correct classification of 87.5% of AT cases and 76.5% of DMI cases. These results are discussed in terms of the differences in pharmacological profiles for uptake blockade and anticholinergic potency for these two compounds.

Published
1985
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