18 results on '"Burckhardt, G"'
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2. Nachruf auf Prof. Dr. med. Dr. h.c. mult. Karl Julius Ullrich: 18.11.1925−02.08.2010
- Author
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Burckhardt, G.
- Published
- 2010
- Full Text
- View/download PDF
3. Characterization of the chloride conductance in porcine renal brush-border membrane vesicles
- Author
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Krick, Wolfgang, Dölle, Astrid, Hagos, Yohannes, and Burckhardt, G.
- Published
- 1998
- Full Text
- View/download PDF
4. Absence of vacuolar H+-ATPases from rat small intestine brush-border membranes
- Author
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Sabolic, Ivan, Herak-Kramberger, Carol M., Schweickhardt, Christa, and Burckhardt, G.
- Published
- 1997
- Full Text
- View/download PDF
5. Evidence for a cytosolic inhibitor of epithelial chloride channels
- Author
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Krick, W., Disser, J., Hazama, A., Burckhardt, G., and Frömter, E.
- Published
- 1991
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6. Abstract of the 68th Meeting (Spring Meeting) 6–9 March 1990, Heidelberg
- Author
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Sakmann, B., Schrader, J., Brenner, B., Murer, H., Boeckh, J., Handwerker, H. O., HonerjÄger, P., Dugas, M., Wang, G., DeLuca, A., Brinkmeier, H., Fakler, B., Pröbstle, T., Rüdel, R., Pohl, J. -A., Meves, H., Kroll, B., Bremer, S., Tümmler, B., Frömter, E., Schwegler, J. S., Steigner, W., Silbernagl, S., Pusch, Michael, Niemann, P., Schmidtmayer, J., Ulbricht, W., Hansen, G., Lönnendonker, U., Neumcke, B., Eickhorn, R., Hornung, D., Antoni, H., Penner, R., Neher, E., Takeshima, H., Nishimura, S., Numa, S., Melzer, W., Feldmeyer, D., Pohl, B., Zöllner, P., Müller, T. H., Swandulla, D., Misgeld, U, Ganitkevich, V. Ya., Isenberg, G., Cavalié, A., Allen, T. J. A., Trautwein, W., Pelzer, Siegried, Shuba, Yaroslav M., Asai, Tatsuya, Trautwein, Wolfgang, Brown, Arthur M., Birnbauner, Lutz, McDonald, Terence F., Pelzer, Dieter, Eckert, R., Hescheler, J., Rosenthal, W., Offermann, S., Krautwurst, D., Schultz, G., Kettenmahn, Helmut, Trotter, J., Verkhratsky, Alexe J N., Savtchenko, Alexej N., Verkhratsky, Alexej N., Schiefer, A., Klöckner, U., Partridge, L. D., SchÄfer, S., Jonas, P., Koh, D. S., Kampe, K., Hermsteiner, M., Vogel, W., Bauer, C. K., Schwarz, J. R., Fink, R. H. A., Wettwer, E., Weik, R., Schlatter, E., Bleich, M., Granitzer, M., Leal, T., Nagel, W., Crabbé, J., Lang, F., Kahn, E., Friedrich, F., Paulmichl, M., Hammerer, M., Maly, K., Grunicke, H., Böhm, T., Nilius, B., Gögelein, H., Dahlem, D., Weiss, H., Waldegger, S., Woell, E., Paulmichl, R., Ruppersberg, J. P., Schröter, K. H., Stocker, M., Pongs, O., Wittka, R., Boheim, G., Lichtinghagen, R, Augustine, C. K., Stühmer, W., Hoppe, Dorothe, Hoppe, D., Zittlau, K. E., Walther, C., Hatt, H., Franke, C., Quasthoff, S., Wischmeyer, E., Jockusch, H., Friedrich, M., Benndorf, K., Bollmann, G., Hirche, Hj., Hollunder-Reese, F., Mohrmann, M., Greger, R., Weber-Schürholz, S., Schürholz, T., Akabas, M., Landry, D., Al-Awqati, Q., Guse, A. H., Gercken, G., Meyerhof, W., Westphale, H. -J., Kerstins, U., Oberleithner, H., Tilmann, M., Kunzelmann, K., Klitsch, T., Siemen, D., Draguhn, A., Verdoorn, T. A., Pritchett, D. B., Seeburg, P. H., Malherbe, P., Möhler, H., Sakmann, B., Hatt H., Dudel, J., Stern, P., Zufall, F., Rosenheimer, J., Smith, D. O., Dörner, R., Ballanyi, K., Schlue, W. -R., Kalthof, B., Pott, L., Busch, C., Konno, T., Stenql, M., Reinhardt, Ch., Kaiser, H., Baumann, R., Wilimzig, M., Eichenlaub, R., Neumann, E., Lessmann, V., Gottmann, K., Dietzel, I. D., Keller, B. U., Yaari, Y., Konnerth, A., Backus, K. H., Giller, T., Knoflach, F., Pflimlin, P., Trübe, G., von Blankenfeld, G., Ymer, S., Sontheimer, H., Ewert, M., Seeburg, P. H., Kettenmann, H., Schneggenburger, R., Paschke, D., Hülser, D. F., Ubl, J., Kolb, H. A., Ströttchen, J., Boheim, S., Wehner, F., Guth, D., Kinne, R. K. H., Hülser, D. F., Polder, H. R., Bödeker, D., Hoppe, Susanne, Höller, H., Hampe, W., Ruf, H., Schulz, I., Dehlinger-Kremer, M., Ozawa, T., Vasilets, L., Schmalzing, G., MÄdefessel, K., Biel, H., Schwarz, W., Burckhardt, B. C., Stallmach, N., MairbÄurl, H., Hoffman, J. F., Schömig, E., Heuner, A., Göbel, B. O., Siffert, W., Butke, A., Hoffmann, G., zu Brickwedde, M. -K. Meyer, Vetter, H., Düsing, R., Rosskopf, D., Osswald, U., Steffgen, J., Koepsell, H., Martens, H., Rübbelke, M., GÄbel, G., Arens, J., Stabel, J., Fischer, Y., Thomas, J., Rose, H., Kammermeier, H., Munsch, Thomas, Deitmer, Joachim W., Engelmann, B., Duhm, J., Deitmer, Joachim W., Gunzel, D., Galler, S., Fischer, H., Clauss, W., Van Driessche, W., Köckerling, A, Schulzke, JD, Sorgenfrei, D, Fromm, M, Simon, B., Ganapathy, V., Leibach, F. H., Burckhardt, G., Krattenmacher, R., Voigt, Rosita, Dietrich, S., Leyssens, A., Zhang, S. L., Weltens, R., Steels, P., Hoffmann, B., Heinz, M., Habura, B., Dörge, A., Rechkemmer, G., von Engelhardt, W., StrauB, O., Wiederholt, M., Margineanu, D. -G., Van Driessche, W., Kreusel, K. M., Fromm, M., Lempart, U., Sorgenfrei, D., Hegel, U., Augustin, A. J., . Goldstein, R., Purucker, E., Lutz, J., Illek, B., Thiele, K -P., Schwealer, JS., Dittmer J., Bauer C., Eckardt, K. -U., Dittmer, J., Neumann, R., Bauer, C., Kurtz, A., Fromm, H., Schulzke, J. D., Clausen, P., Krohn, A., Lüderitz, S., Hierholzer, K., Kersting, U., Woinowski, L., Gro\mann, R., Bin, X. U., Ellendorff, F., Nitschke, R., Fröbe, U., Scholz, H., della Bruna, R., Ehmke, H., Persson, P. B., Seyfarth, M., Kirchheim, H. R., Dietrich, M. S., Parekh, N., Steinhausen, M., Bührle, C. P., Nobiling, R., Ullrich, K. J., Rumrich, G., Klöss, S., Papavassiliou, F., Hoyer, J., Schmitt, C., Jungwirth, A., Ritter, M., Westphale, H. J., Bevan, C., Theiss, C., Denek, Liliana, Schwegler, Johann S., SchÄfer, Roland, Augustin, Albert J., Heidland, August, Nafz, B., Just, A., Steidl, M., Pinggera, G., Gerstberger, R., Schütz, H., Simon, E., Lohrmann, E., Masereel, B., Delarge, J., Lang, H. J., Englert, H. C., Caliebe, D., Mályusz, M., Wrigge, P., Gronow, G., Klause N., Mályusz, M., Zinnert, H., Fagel, H., Jelkmann, W., Weiss, Ch., Augustin, A. J., Keil, R., Schmidt, W., Kröger, C., Brabant, E. G., Hilgendorf, A., Strauch, S., Lane, F., Prick, A., Golenhofen, N., Mildenberger, S., Schwegler, J. S., Flemming, B., Roloff, D., Wronski, T., Drews, G., Debuyser, A., Henquin, J. C., Jackson, M. B., DeRiemer, S. A., Schmid, A., Schnefel, S., Pröfrock, A., Hinsch, K. -D., Milz, J., Lamprecht, G., Seidler, U., Silen, W., Aziz, O., Reschke, W., Fischer, G., De Decker, N., Hayes, T., Coast, G., Van Kerkhove, E., von zur Mühlen, F., Eckstein, F., Hegel, U, Bentzel, CJ, Riecken, EO, Siemer, C., Rothenpieler, P., Smith, E., Lutnicki, K. R., Wróbel, J. T., Ledwożyw, A., PietraŚ, E., Sender, S., Jürgens, Klaus D., Kleinschmidt, T., Werkmeister, F., Kiwull-Schöne, H., Kiwull, P., Vahle, J., Ott, M., Zimmermann, R. E., Elsing, J. G., Million, D., Zillner, P., Thiel, M., Bardenheuer, H., Peter, K., Fandrey, J., Siegers, C. P., Rupp, H., Elimban, V., Dhalla, N. S., Morano, I., Agostini, B., Mühleisen, M., Mommaerts, W. F. H. M., Ono, K., Wussling, M., Schenk, W., Boldt, W., Lipp, P., Schüttler, K., Szymanski, G., Wendt-Gallitelli, M. F., Herzig, J. W., Depersin, H., Grupp, G., Grupp, I., Glitsch, H. G., Pusch, H., Zylka, Ch., Brāndle, M., Jacob, R., Stein, T., Isselhard, W., Sturz, J., Minor, T., Wingenfeld, P., Siegmund, B., Klietz, T., Schwartz, P., Piper, H. M., Linder, Christa, SchÄfer, Stefan, Heusch, Gerd, Becker, B. F., Reinholz, N., Raschke, P., Leipert, B., Gerlach, E., Dierberger, B., Gülch, R. W., Leverkus, M., Mitsuiye, T., Pohl, U., Wang, S. Y., Meyer, R., Haas, H. G., Christmann, H. Ph, Dörner, Th, Hock, D., Hertel, R., Gagelmann, M., Forssmann, W. G., Leijendekker, W. J., Kissling, G., Michel, H., Goetz, A., Freya, M., Fleckenstein-Grün, G., Schipke, Jochen D., Harasawa, Yasuhiko, Sugiura, Seiryo, Alexander, Joe, Burkhoff, Daniel, Kling, L., Müller-Beckmann, B., Schroth, M., Sponer, G., Böhm, E., Strein, K., Dorszewski, A., Arnold, G., Pike, G. K., Bryant, D. J., Roberts, M. L., Fink, R. H., Ross, Ch., Skyschally, A., Schulz, R., Linder, C., Heusch, G., Schipke, J. D., Burkhoff, D., Alexander, J., Gollnick, F., Peter, Kh., Franken-Weyers, R., Borst, M. M., Deussen, A., Pöpping, S., Hose, H., Strotmann, K. H., Lukascek, B., Karnath, T., Güttier, K., Klaus, W., Haverkampf, K., Guhlmann, M., Schmidt-Ott, S., Heuschen, U., Mall, G., Pfitzer, G., Rösch, J., Arner, A., Rüegg, J. C., Kröger, K., Schipke, J. D., ThÄmer, V., Ehring, Thomas, ThÄmer, Volker, Guth, B. D., Schnabel, Ph A., Schmiedl, A., Gebhard, M. M., Richter, J., Bretschneider, H. J., Guth, B. D., Oudiz, R. J., Schnabel, Ph., Richter, J ., Watanabe, H., Spahr, R., Piper, H. M., Obst, O., Mertens, H., Mülsch, A., Busse, R., Lamontagne, D., Herlan, K., Huang, A., Bassenae, E., Mackert, J. R. L., Schilling, L., Parsons, A. A., Wahl, M., Hock, D., Christmann, M. Ph., Thimm, F., Frey, M., Fleckenstein, a. A., Theilen, H., Göbel, U., Kuschinsky, W., Elbert, Th., Tafil-Klawe, M., Rau, H., Lutzenberger, W., Fleckenstein, A., Forst, H., Haller, M., Santjohanser, C., Lauterjung, L., Smieško, Y., Lang, D. J., Johnson, P. C., Schröck, H., Rau H., Elbert T., Geiger B, Lutzenberger W., Koch, G., Koralewski, H. E., Perschel, F. H., Wagner, K., Krüger, U., Albrecht, M., Hohlbach, G., Maassen, N., Foerster, M., Mühling, J., Bari, F., Pleschka, K., Schmidt, H. D., Gro\, H., Loock, W., Stick, C., Diefenbacher, U., Gronewold, D., Tobinsky, M., Walther-Behrends, A., Witzleb, E., Brummermann, M., Reinertsen, R. E., Rogausch, H., Rohn, W. M., Acker, H., Delpiano, M., Dufau, E., Hentschel, J., Heller, H., Schuster, K. -D., Siekmeier, R., Kronenberger, H., Lintl, H., Schiller-Scotland, Ch. F., Gebhart, J., Heyder, J., Meier-Sydow, J., Stahlhofen, W., Mottaghy, K., Geisen, C., Richter, W., Beckman, J., Marek, W., Ulmer, W. T., Thiele, A. E., Raschke, F., Peter, J. H., Hildebrandt, G., Kullmer, T., Kozianka-Burghof, G., Thiele, A. E., Schlaefke, M. E., Gnuschke, H., Schaefer, T., Schaefer, D., Schaefer, C., Bradley, Ronald J., Sterz, Raimund, Peper, Klaus, Benterbusch, R., Kraft, Th., Yu, L. C., Kuhn, H. J., Blankenbach, K., Asmussen, G., Kunze, I., Pieper, K. -S., Steinmetz, J., Schmidt, H., Krippeit-Drews, P., Hübschen, U., Nacimiento, A. C., Günzel, D., Rathmayer, W., Gaunitz, U., Költgen, D., Zachar, E., Soltau, B., De Martino, L., Hasselbach, W., Kössler, F., Lange, P., Küchler, G., Zeugner, C., Van Eyk, J., Hodges, R. S., Lorkovic, H., Clemens, N., Scheid, P., Noack, Th., Deitmer, P., Golenhofen, K., Lammel, E., Welling, Andrea, Felbel, Jochen, Hofmann, Franz, Katoch, S., Watanabe, T., Mandrek, K., Milenov, K., Hammer, K., Rössler, W., Sann, H., Pierau, Fr -K., Nguyen-Duong, H., Schneider, P., Stahl, F., Lepple-Wienhues, A., Korbmacher, C., Haller, H., Gebauer, M., Willner, U., Bialojan, C., Lengsfeld, M., Kyrtatas, V., Dartsch, Peter C., Boels, P. J., Fischer, W., Lenz, T., Thei\, U., Kreye, V. A. W., Ohkubo, T., Kupp, H., Vonderlage, M., Schreiner, V., Dorlöchter, M., Brinkers, M., Irintchev, A., Wernig, A., Langenfeld, B., Finger, W., Wolburg, H., Beer, A., Schwejda, Ch., Scheller, D., Heister, U., Tegtmeier, F., Knöpfel, Thomas, Spuler, Andreas, Grafe, Peter, GÄhwiler, Beat, Bijak, M., Misgeld, U., Müller, W., Rausche, G., Leweke, F M., Bingmann, D., Moraidis, I., Speckmann, E. -J., Madeja, M., Mu\hoff, U., Lehmenkühler, A, Kuhlmann, D., Hans, M., Lux, H. D., StrÄub, H., Waiden, J., Baker, R. E., Grantyn, R., Perouansky, M., Kraszewski, K, Lehmenkühler, Chr, Dodt, H. U., ZieglgÄnsberger, W., Pawelzik, H., ZieglgÄngsberger, W., Mann, K., Wiethölter, H., Albrecht, D., Dreier, J., Ficker, E., Beck, H., Corrette, B J., Dreyer, F., Repp, H., Dreessen, J., Augustine, G. J., Lehmenkühler, A., Büsselberg, D., Heimrich, B., Haas, H. L., Birnstiel, S., Haas, H. L., Schönrock, B., Altrup, U., Reith, H., Speckmann, E. -J., Alzheimer, C., Bruagencate, G. ten, Fruhstorfer, B., Mignot, E., Nishino, S., Dement, W. C., Guilleminault, C., Simon-Oppermann, Christa, Günther, Olaf, Stehle, J., Reuss, S., Seidel, A., Riemann, R., Vollrath, L., Reimer, Susanne, HölIt, Volker, Sonnhof, U., Krupp, J., Claus, H, Hinckel, P., Dick, H. B. H., Hiemke, C., Jussofie, A., Dorn, T., Uhlig, S., Witte, O. W., Bother B., Eiselt M., Witte H., Zwiener ö, Rother M, Eiseit H., Taghavy, A., KrÄtzer, A., Clusmann, H., Heinemann, U., Block, F., Sonatg, K. -H., Falkeristein, M., Hohnsbein, J., Hoormann, J., Frieling, A., Tarkka, I. M., Kullmann, W., Bromm, B., Hirsch, M. Chr, Wissing, H., Braun, H. A., Igelmund, P., Klu\mann, F. W., Ehrenstein, W. H., Yakimoff, N., Mateeff, S., Zeise, M. L., Arriagada, J., Teschemacher, A., ZieglgÄnsberger, W., Pöppelmann, T., Köhling, R., Boerrigter, P., Reith, H., Anders, K., Ohndorf, W., Dermietzel, R., Richter, D. W., Tölle, T. R., Castro-Lopes, J. M., Neuropharmakologie, Klinische, Sandkühler, J., Leah, J. D., Herdegen, T., Zimmermann, M., Vaitl, D., Gnippe, H., Herbert, M. K., Mengel, M. K. C., Kniffki, K. -D., Linke, R., Vahle-Hinz, C., Schenda, J., Matsumura, K., Herdegen, T., fu, Q. -G., Forster, C., Hutchison, W. D., Morton, C. R., Aschoff, J., Wilhelm, Z., Schwarzacher, S. W., Wasserschaff, M, Hörner, M., Kümmel, H., Windhorst, U., Feldman, J. L., Schmid, K., Foutz, A. S., Denavit-Saubié, M., Pak, M. A., Wehling, P., Evans, C., Bandara, G., Awiszus, F., Feistner, H., Heinze, H. -J., Illert, M., Wasserschaff, M., Kleinebeckel, D., Böhmer, G., Schauer, W., Abel, H. -H., Klü\endorf, D., Koepchen, H. P., Jarolimek, W, König, St, Czachurski, J., Seller, H., Meckler, R. L., McLachlan, E. M., Boczek-Funcke, A., HÄbler, H. -J., JÄnig, W., Michaelis, M., Dembowsky, K., Königr, S., Rau, Harald, HÄbler, H. -J., Unger, M., Merker, G., Roth, J., Zeisberger, E., Gao, H., Hunold, M., Kirchner, F., Takano, K., Schulze, K., Pokorski, M., Sakakibara, Y., Masuda, A., Morikawa, T., Ahn, B., Takaishi, S., Paulev, P. -E., Honda, Y., Flügge, G., Fuchs, E., König, S., Eysel, U. Th., Schmidt-Kastner, R., Skrandies, W., Geib, T., Baumann, C., Schmidt, K. -F., Knapp, A. G., Dowling, J. E., Kuba, M., Toyonaga, N., Kubová, Z., Ehrenstein, W. H., Jacobi, P., Schmidt, K. -F., Nöll, G. N., Baumann, Ch., Tabata, M., Martin, Ch., Meissl, H., Knottenberg, Th., Scheibner, H., Zenner, Hans P., Zimmennann, Ulrike, Gitter, Alfred H., Ding, D., Smolders, J. W. T., Klinke, R., Boekhoff, I., Raming, K., Krieger, J., Tareilus, E., Strotinann, J., Breer, H., Schild, D., DeSimone, J. A., Hellwig, S., Gitter, A. H., Plinkert, P. K., Zenner, H. P., Koltzenbwg, M., Pinter, E., SchÄfer, K., Braun, H. A., Necker, R., Hanesch, U., Heppelmann, B., Schmidt, R. F., Mense, S., Hoheisel, U., Steen, K. H., Anton, F., Reek, P. W., Handwerker, H. O., Lewin, G. R., McMahon, S. B., Heyer, G., Hornstein, O. P., Klement, W., Arndt, J. O., Maeerl, W., GrÄmer, G., Schepelmann, K., Me\linger, K., Schaible, H. -G., Treede, R. D., Meyer, R. A., Campbell, J. N., Claus, D., Neundörfer, B., Ernst, R., Tick-Waider, A. M., Bretschneider, F., Peters, R. C., Tennis, P. F. M., Teunis, P. F. M., Hoheisel, D., Scherotzke, R., Bub, A., Manzl, G., Forssmann, W. G., Jessen, C., Nuesslein, B., Schmidt, I., Wetzig, J., Reiser, M., Bregenzer, N., von Baumgarten, R. J., Mohr, E., Krzywanek, H., Warncke, G., Schuchmann, K. -L., Linow, H., Klu\mann, F. H., Redlin, U., Heldmaier, G., Bamler, A, Koller, A., Felber, S., Haid, C., Wicke, K., Raas, E., Xuemin, Wang, Kerning, Chen, Ying, Shi, Hanping, Shi, Warncke, Günther, Voisord, R., Dortsch, P. C., Betz, E., Karbach, U., Walenta, S., Gross, M. W., Mueller-Klieser, W., Vaupel, P., Okunieff, P., Mayer, W. -K., Stohrer, M., Krüger, W., Müller-Klieser, W., Strupp, M., Weial, P., Bostock, H., Piwernetz, K., Renner, R., Grafe, P., Lankers, J., Zangemeister, W., Kunze, K., Tries, S., Heinle, H., Beckerath, N. V., Maier-Rudolph, W., Mehrke, G., Günther, K., Goedel-Meinen, L., Daut, J., Piper, H. M., Kopp, A., Noll, T., Goellner, A., Gerlach, S., Teutsch, H. F., Schienger, K., Schwab, R., Höckel, M., Fotev, Z., Nienhaus, M., Kaczmarczyk, Gabriele, Richter, Dinah, Korte, Gabriele, Förther, J., Reinhardt, H. W., Schreiber, R., Rupp, J., Murphy, G., Fingerle, J., Kloiber, O., Miyazawa, T., Höhn-Berlage, M., Hossmann, K. -A., Schad, H., Heimisch, W., Blasini, R., Haas, F., Mendier, M., Spuler, A., Lehmann-Hom, F., Wolfram, U., Fenske, M., Sachser, N., Weis, Ch., Marktl, W., Kopta, B., Klammer, N., Rudas, B., Pohl, H., Nienartowicz, A., Moll, W., Klempt, M., Blum, S., Bühler, H., Lichtenstein, I., Novak, A., Siebe, H., Hierholzer, K., and Peper, K.
- Published
- 1990
- Full Text
- View/download PDF
7. Expression of rat renal Na+HCO3-cotransporter in Xenopus laevis oocytes
- Author
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Burckhardt, B. C., Thelen, P., and Burckhardt, G.
- Published
- 1994
- Full Text
- View/download PDF
8. Demonstration of sodium-dependent, electrogenic substrate transport in rat small intestinal brush border membrane vesicles by a cyanine dye
- Author
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Stieger, B., Burckhardt, G., and Murer, H.
- Published
- 1984
- Full Text
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9. Lack of intestinal transport of [3H]-demethylphalloin: Comparative studies with phallotoxins and bile acids on isolated small intestinal cells and ileal brush border membrane vesicles
- Author
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Petzinger, E., Burckhardt, G., Schwenk, M., and Faulstich, H.
- Published
- 1982
- Full Text
- View/download PDF
10. The influence of pH on phosphate transport into rat renal brush border membrane vesicles
- Author
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Burckhardt, G., Stern, H., and Murer, H.
- Published
- 1981
- Full Text
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11. Beobachtungen über die Temperaturen Geisteskranker: Psychiatrische Beiträge
- Author
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Burckhardt, G.
- Published
- 1878
- Full Text
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12. Weitere Mittheilungen über Gefässbewegungen. Theoretisches und Practisches
- Author
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Burckhardt, G.
- Published
- 1889
- Full Text
- View/download PDF
13. Das Epithelium der ableitenden Harnwege
- Author
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Burckhardt, G.
- Published
- 1859
- Full Text
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14. The influence of K+ diffusion potentials on the fluorescence of a cyanine dye in brush border membrane vesicles
- Author
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Burckhardt, G.
- Published
- 1980
- Full Text
- View/download PDF
15. Preface
- Author
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Greger, R. and Burckhardt, G.
- Published
- 1986
- Full Text
- View/download PDF
16. In vitro and in vivo evidence of the importance of organic anion transporters (OATs) in drug therapy.
- Author
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Burckhardt G and Burckhardt BC
- Subjects
- Age Factors, Animals, Biological Transport, Drug Interactions, Evidence-Based Medicine, Genotype, Humans, Kidney metabolism, Organic Anion Transporters drug effects, Organic Anion Transporters genetics, Pharmacogenetics, Phenotype, Polymorphism, Single Nucleotide, Sex Factors, Species Specificity, Organic Anion Transporters metabolism, Pharmaceutical Preparations metabolism
- Abstract
Organic anion transporters 1-10 (OAT1-10) and the urate transporter 1 (URAT1) belong to the SLC22A gene family and accept a huge variety of chemically unrelated endogenous and exogenous organic anions including many frequently described drugs. OAT1 and OAT3 are located in the basolateral membrane of renal proximal tubule cells and are responsible for drug uptake from the blood into the cells. OAT4 in the apical membrane of human proximal tubule cells is related to drug exit into the lumen and to uptake of estrone sulfate and urate from the lumen into the cell. URAT1 is the major urate-absorbing transporter in the apical membrane and is a target for uricosuric drugs. OAT10, also located in the luminal membrane, transports nicotinate with high affinity and interacts with drugs. Major extrarenal locations of OATs include the blood-brain barrier for OAT3, the placenta for OAT4, the nasal epithelium for OAT6, and the liver for OAT2 and OAT7. For all transporters we provide information on cloning, tissue distribution, factors influencing OAT abundance, interaction with endogenous compounds and different drug classes, drug/drug interactions and, if known, single nucleotide polymorphisms.
- Published
- 2011
- Full Text
- View/download PDF
17. Transport of organic anions across the basolateral membrane of proximal tubule cells.
- Author
-
Burckhardt BC and Burckhardt G
- Subjects
- Animals, Anion Transport Proteins metabolism, Humans, Mice, Models, Biological, Organic Anion Transport Protein 1 metabolism, Organic Anion Transporters, Sodium-Independent metabolism, Protein Transport, Rats, Substrate Specificity, Sulfate Transporters, Anions, Biological Transport, Intracellular Membranes metabolism, Kidney Tubules, Proximal cytology, Kidney Tubules, Proximal metabolism
- Abstract
Renal proximal tubules secrete diverse organic anions (OA) including widely prescribed anionic drugs. Here, we review the molecular properties of cloned transporters involved in uptake of OA from blood into proximal tubule cells and provide extensive lists of substrates handled by these transport systems. Where tested, transporters have been immunolocalized to the basolateral cell membrane. The sulfate anion transporter 1 (sat-1) cloned from human, rat and mouse, transported oxalate and sulfate. Drugs found earlier to interact with sulfate transport in vivo have not yet been tested with sat-1. The Na(+)-dicarboxylate cotransporter 3 (NaDC-3) was cloned from human, rat, mouse and flounder, and transported three Na(+) with one divalent di- or tricarboxylate, such as citric acid cycle intermediates and the heavy metal chelator 2,3-dimercaptosuccinate (succimer). The organic anion transporter 1 (OAT1) cloned from several species was shown to exchange extracellular OA against intracellular alpha-ketoglutarate. OAT1 translocated, e.g., anti-inflammatory drugs, antiviral drugs, beta-lactam antibiotics, loop diuretics, ochratoxin A, and p-aminohippurate. Several OA, including probenecid, inhibited OAT1. Human, rat and mouse OAT2 transported selected anti-inflammatory and antiviral drugs, methotrexate, ochratoxin A, and, with high affinities, prostaglandins E(2) and F(2alpha). OAT3 cloned from human, rat and mouse showed a substrate specificity overlapping with that of OAT1. In addition, OAT3 interacted with sulfated steroid hormones such as estrone-3-sulfate. The driving forces for OAT2 and OAT3, the relative contributions of all OA transporters to, and the impact of transporter regulation by protein kinases on renal drug excretion in vivo must be determined in future experiments.
- Published
- 2003
- Full Text
- View/download PDF
18. Membrane transport of anions across epithelia of mammalian small intestine and kidney proximal tubule.
- Author
-
Murer H and Burckhardt G
- Subjects
- Amino Acids metabolism, Animals, Bicarbonates metabolism, Bile Acids and Salts metabolism, Biological Transport, Biological Transport, Active, Carboxylic Acids metabolism, Chlorides metabolism, Diffusion, Epithelium metabolism, Humans, Microvilli metabolism, Phosphates metabolism, Protons, Sodium metabolism, Sulfates metabolism, Vitamins metabolism, Anions metabolism, Intestine, Small metabolism, Kidney Tubules, Proximal metabolism
- Published
- 1983
- Full Text
- View/download PDF
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