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16 results on '"Brown, Matthew P."'

4. Spectrum of ankylosing spondylitis in Portugal. Development of BASDAI, BASFI, BASMI and mSASSS reference centile charts

Author

Pimentel-Santos, Fernando M., Mourão, Ana Filipa, Ribeiro, Célia, Costa, José, Santos, Helena, Barcelos, Anabela, Pinto, Patricia, Godinho, Fátima, Cruz, Margarida, Vieira-Sousa, Elsa, Santos, Rui André, Rabiais, Sara, Félix, Jorge, Fonseca, João Eurico, Guedes-Pinto, Henrique, Brown, Matthew A, Branco, Jaime C., and CORPOREA Study Group

Published
2012
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16. Intradialytic cycling does not exacerbate microparticles or circulating markers of systemic inflammation in haemodialysis patients.

Author

Highton PJ, March DS, Churchward DR, Grantham CE, Young HML, Graham-Brown MPM, Estruel S, Martin N, Brunskill NJ, Smith AC, Burton JO, and Bishop NC

Subjects
Humans, Kidney Failure, Chronic therapy, Male, Middle Aged, Phenotype, Renal Dialysis, Biomarkers blood, Cell-Derived Microparticles metabolism, Exercise Therapy methods, Inflammation blood, Kidney Failure, Chronic blood, Kidney Failure, Chronic rehabilitation
Abstract

Purpose: Patients receiving haemodialysis (HD) display elevated circulating microparticle (MP) concentration, tissue factor (TF) expression and markers of systemic inflammation, though regular intradialytic cycling (IDC) may have a therapeutic effect. This study investigated the impact of regular, moderate-intensity IDC on circulating MPs and inflammatory markers in unit-based HD patients., Methods: Patients were cluster-randomised to intervention (n = 20, age: 51.4 ± 18.1 years, body mass: 77.6 ± 18.3 kg, mean ± SD) or no-exercise control (n = 20, 56.8 ± 14.0 years, 80.5 ± 26.5 kg). Intervention participants completed 30 min of moderate intensity (rating of perceived exertion [RPE] of 12-14) IDC, thrice weekly for 6 months. Pre-dialysis venous blood samples were obtained at 0, 3 and 6 months. Circulating MP phenotypes, cytokines, chemokine and MP TF expression were quantified using flow cytometry and cytometric bead array assays., Results: Despite high exercise compliance (82%), no IDC-dependent effects were observed for any MP, cytokine or chemokine measure (p ≥ 0.051, η ρ  ≤ 0.399) other than TNF-α (p = 0.001, η 2  ≤ 0.399) other than TNF-α (p = 0.001, η ρ 2  = 0.186), though no significance was revealed upon post hoc analysis., Conclusion: Six months of regular, moderate-intensity IDC had no effect on MPs, cytokines or chemokines. This suggests that the exercise did not exacerbate thrombotic or inflammatory status, though further functional assays are required to confirm this., Trial Registration: ISRCTN1129707, prospectively registered on 05/03/2015., (© 2021. The Author(s).)

Published
2022
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