1. Which is the most suitable lymph node predictor for overall survival after primary surgery of head and neck cancer: pN, the number or the ratio of positive lymph nodes, or log odds?
- Author
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Yildiz MM, Petersen I, Eigendorff E, Schlattmann P, and Guntinas-Lichius O
- Subjects
- Adult, Aged, Chemoradiotherapy, Adjuvant, Chemotherapy, Adjuvant, Female, Germany epidemiology, Head and Neck Neoplasms pathology, Head and Neck Neoplasms therapy, Humans, Kaplan-Meier Estimate, Lymphatic Metastasis, Male, Middle Aged, Neoplasm Staging, Predictive Value of Tests, Prognosis, Radiotherapy, Adjuvant, Registries, Head and Neck Neoplasms mortality, Head and Neck Neoplasms surgery, Lymph Nodes pathology
- Abstract
Purpose: To investigate the best lymph node (LN) metastasis predictor for overall survival (OS) in head neck cancer (HNC): pN classification, number of positive lymph nodes (PNOD), lymph node ratio (LNR), or log odds of positive lymph nodes (LODDS)., Methods: In total, 225 surgically treated HNC patients were evaluated for the different LN classifications and OS., Results: Five-year OS was 71.8 %. Mean number of yielded LN and PNOD was 25.3 ± 16.7 and 2.7 ± 5.9, respectively. 64.8 % had a LNR > 0.10 and 64.4 % a LODDS > 10. In univariable analysis, multimodal therapy (p = 0.039), advanced pT (p < 0.0001), advanced UICC stage (p = 0.029), LNR > 0.10 (p = 0.049), and LODDS > -1.0 (p = 0.021) were associated with lower OS. In multivariable analysis, advanced pT [hazard ratio (HR) 2.194; 95 % confidence interval (CI) 1.294-3.722; p = 0.004] and LODDS > -1.0 (HR 1.634; 95 % CI 1.002-2.665; p = 0.059) remained independent predictors for lower OS., Conclusions: It seems useful to analyze the prognostic significance of LODDS in other samples of HNC.
- Published
- 2016
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