1. Survival and Fibre Outgrowth of Neuronal Cells Transplanted into Brain Areas Associated with Interstitial Oedema
- Author
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Koichi Ishikawa, Shuhei Miyazaki, Y. Katayama, Haruhiko Ogawa, Takashi Tsubokawa, and Morimichi Koshinaga
- Subjects
Transplantation ,Pathology ,medicine.medical_specialty ,Fetus ,Raphe ,business.industry ,medicine ,Interstitial oedema ,Immunohistochemistry ,Serotonin ,business ,Corpus callosum - Abstract
The influence of interstitial oedema on the survival of fetal raphe cells transplanted into serotonin (5-HT)-denervated rats and the fibre outgrowth from these cells was investigated. Fetal raphe cells were transplanted into the corpus callosum in which long-lasting interstitial oedema had been induced by intracisternal kaolin injection. The 5-HT and 5HIAA levels in the corpus callosum were restored to their maximum within 5–6 weeks post-transplantation regardless of whether interstitial oedema was induced or not. Furthermore, it was appeared that the presence of interstitial oedema even facilitated fibre growth as demonstrated by the 5-HT immunohistochemistry and the restoration of the 5-HT and 5-HIAA levels in brain areas distant from the transplantation sites. These results imply favourable effects of interstitial oedema on the survival of transplanted raphe cells and their fibre outgrowth.
- Published
- 1990
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