192 results on '"Wolff, H."'
Search Results
2. [Prurigo pigmentosa].
- Author
-
Schlager JG, Hayani KM, Betke M, and Wolff H
- Subjects
- Humans, Hyperpigmentation, Prurigo
- Published
- 2020
- Full Text
- View/download PDF
3. [Posttraumatic erosive pustular dermatosis on the scalp of a young woman].
- Author
-
Wolff H and Flaig MJ
- Subjects
- Female, Humans, Scalp, Connective Tissue Diseases, Scalp Dermatoses diagnosis, Scalp Dermatoses drug therapy, Skin Diseases, Vesiculobullous diagnosis, Skin Diseases, Vesiculobullous drug therapy, Skin Diseases, Vesiculobullous etiology
- Published
- 2020
- Full Text
- View/download PDF
4. [Acrokeratosis paraneoplastica in hemato-oncological disease].
- Author
-
Engels L, Kapp F, Ruzicka T, von Braunmühl T, and Wolff H
- Subjects
- Humans, Carcinoma, Basal Cell, Hypotrichosis, Paraneoplastic Syndromes, Skin Neoplasms
- Published
- 2018
- Full Text
- View/download PDF
5. [Alopecia areata universalis under immune checkpoint blockade for metastasized melanoma].
- Author
-
Niesert AC, Goldscheider I, Wolff H, and Berking C
- Subjects
- Alopecia, Humans, Alopecia Areata, Melanoma
- Published
- 2018
- Full Text
- View/download PDF
6. [Monolocular erythema elevatum diutinum on the back of the hand].
- Author
-
Kapp F, Flaig MJ, and Wolff H
- Subjects
- Erythema, Humans, Vasculitis, Leukocytoclastic, Cutaneous
- Published
- 2018
- Full Text
- View/download PDF
7. [Erratum to: Monolocular erythema elevatum diutinum on the back of the hand].
- Author
-
Kapp F, Flaig MJ, and Wolff H
- Published
- 2018
- Full Text
- View/download PDF
8. [Multicentric reticulohistiocytosis].
- Author
-
Kapp F, Flaig MJ, and Wolff H
- Subjects
- Humans, Skin, Histiocytosis, Non-Langerhans-Cell
- Published
- 2018
- Full Text
- View/download PDF
9. [Minoxidil : From side effects to therapy].
- Author
-
Wolff H
- Subjects
- Alopecia diagnosis, Evidence-Based Medicine, Humans, Hypertrichosis prevention & control, Treatment Outcome, Alopecia prevention & control, Dermatology trends, Hypertrichosis chemically induced, Minoxidil adverse effects, Minoxidil therapeutic use
- Published
- 2016
- Full Text
- View/download PDF
10. Dendritic polyglycerol sulfate attenuates murine graft-versus-host disease.
- Author
-
Budde H, Sorns MS, Welker P, Licha K, Wolff H, Riggert J, Wulf G, and Legler TJ
- Subjects
- Animals, Bone Marrow Transplantation adverse effects, Graft vs Host Disease etiology, Graft vs Host Disease pathology, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Dendrimers therapeutic use, Glycerol therapeutic use, Graft vs Host Disease prevention & control, Polymers therapeutic use, Sulfates therapeutic use
- Abstract
Graft-versus-host disease (GvHD) is a severe immune reaction commonly occurring after hematopoietic stem cell transplantation. The outcome of patients who do not respond to the currently used immunosuppressive drugs is poor, thus there is an urgent need for the evaluation of new therapies. Heparin has a well-known anti-inflammatory effect and heparin analogues with a low anticoagulant effect are interesting candidates as new anti-inflammatory drugs. We explored the therapeutic potential of dendritic polyglycerol sulfates (dPGS), a novel class of heparin derivatives, on murine acute GvHD in vivo. The therapeutic effect of dPGS on murine GvHD was more intense after intravenous application compared to subcutaneous injection. An increased survival rate and improved clinical scores were observed in mice treated with 5 mg/kg once a week. In these animals, there was a reduction in the percentage of CD4(+) and CD8(+) T cells, which are the main effectors of GvHD. In addition, dPGS treatment decreased the number of tumor necrosis factor alpha (TNFα)-producing T cells. Increasing the dose of dPGS reversed the positive effect on survival as well as the clinical score, which indicates a small therapeutic range. Here, we report for the first time that dPGS have a significant immunosuppressive in vivo effect in a mouse model of severe acute GvHD. Therefore, we propose to study dPGS as promising candidates for the development of potential new drugs in the treatment of steroid-refractory GvHD patients first in larger animals and later in humans.
- Published
- 2016
- Full Text
- View/download PDF
11. Driver Gene and Novel Mutations in Asbestos-Exposed Lung Adenocarcinoma and Malignant Mesothelioma Detected by Exome Sequencing.
- Author
-
Mäki-Nevala S, Sarhadi VK, Knuuttila A, Scheinin I, Ellonen P, Lagström S, Rönty M, Kettunen E, Husgafvel-Pursiainen K, Wolff H, and Knuutila S
- Subjects
- Asbestos adverse effects, Cell Adhesion Molecules genetics, Coatomer Protein genetics, DNA Mutational Analysis, ErbB Receptors genetics, Female, Humans, Male, Membrane Glycoproteins genetics, Mesothelioma, Malignant, Mitochondrial Proteins genetics, Peptide Synthases genetics, Phosphoric Monoester Hydrolases genetics, Polymorphism, Single Nucleotide, Proto-Oncogene Proteins B-raf genetics, Proto-Oncogene Proteins p21(ras) genetics, Receptors, Eph Family genetics, Ribosomal Proteins genetics, Semaphorins genetics, Tumor Suppressor Proteins genetics, Ubiquitin Thiolesterase genetics, Adenocarcinoma genetics, Exome genetics, Lung Neoplasms genetics, Mesothelioma genetics, Peritoneal Neoplasms genetics, Pleural Neoplasms genetics
- Abstract
Background: Asbestos is a carcinogen linked to malignant mesothelioma (MM) and lung cancer. Some gene aberrations related to asbestos exposure are recognized, but many associated mutations remain obscure. We performed exome sequencing to determine the association of previously known mutations (driver gene mutations) with asbestos and to identify novel mutations related to asbestos exposure in lung adenocarcinoma (LAC) and MM., Methods: Exome sequencing was performed on DNA from 47 tumor tissues of MM (21) and LAC (26) patients, 27 of whom had been asbestos-exposed (18 MM, 9 LAC). In addition, 9 normal lung/blood samples of LAC were sequenced. Novel mutations identified from exome data were validated by amplicon-based deep sequencing. Driver gene mutations in BRAF, EGFR, ERBB2, HRAS, KRAS, MET, NRAS, PIK3CA, STK11, and ephrin receptor genes (EPHA1-8, 10 and EPHB1-4, 6) were studied for both LAC and MM, and in BAP1, CUL1, CDKN2A, and NF2 for MM., Results: In asbestos-exposed MM patients, previously non-described NF2 frameshift mutation (one) and BAP1 mutations (four) were detected. Exome data mining revealed some genes potentially associated with asbestos exposure, such as MRPL1 and SDK1. BAP1 and COPG1 mutations were seen exclusively in MM. Pathogenic KRAS mutations were common in LAC patients (42 %), both in non-exposed (n = 5) and exposed patients (n = 6). Pathogenic BRAF mutations were found in two LACs., Conclusion: BAP1 mutations occurred in asbestos-exposed MM. MRPL1, SDK1, SEMA5B, and INPP4A could possibly serve as candidate genes for alterations associated with asbestos exposure. KRAS mutations in LAC were not associated with asbestos exposure.
- Published
- 2016
- Full Text
- View/download PDF
12. [Focus on the scalp].
- Author
-
Hamm H and Wolff H
- Subjects
- Head and Neck Neoplasms therapy, Humans, Head and Neck Neoplasms diagnosis, Scalp pathology, Scalp Dermatoses diagnosis, Scalp Dermatoses therapy, Skin Neoplasms diagnosis, Skin Neoplasms therapy
- Published
- 2014
- Full Text
- View/download PDF
13. Investigation of four novel male androgenetic alopecia susceptibility loci: no association with female pattern hair loss.
- Author
-
Nuwaihyd R, Redler S, Heilmann S, Drichel D, Wolf S, Birch P, Dobson K, Lutz G, Giehl KA, Kruse R, Tazi-Ahnini R, Hanneken S, Böhm M, Miesel A, Fischer T, Wolff H, Becker T, Garcia-Bartels N, Blume-Peytavi U, Nöthen MM, Messenger AG, and Betz RC
- Subjects
- Female, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Male, Polymorphism, Single Nucleotide, Wnt Signaling Pathway genetics, Alopecia genetics, Receptors, Androgen genetics, Wnt Proteins genetics, Xedar Receptor genetics
- Abstract
Female pattern hair loss (FPHL) is a common hair loss disorder in women and has a complex mode of inheritance. The etiopathogenesis of FPHL is largely unknown; however, it is hypothesized that FPHL and male pattern baldness [androgenetic alopecia (AGA)] share common genetic susceptibility alleles. Our recent findings indicate that the major AGA locus, an X-chromosome region containing the androgen receptor and the ectodysplasin A2 receptor (EDA2R) genes, may represent a common genetic factor underlying both early-onset FPHL and AGA. This gives further support for the widespread assumption of shared susceptibility loci for FPHL and AGA. However, we could not demonstrate association of further AGA risk loci, including 20p11, 1p36.22, 2q37.3, 7p21.1, 7q11.22, 17q21.31, and 18q21.1, with FPHL. Interestingly, a recent study identified four novel AGA risk loci in chromosomal regions 2q35, 3q25.1, 5q33.3, and 12p12.1. In particular, the 2q35 locus and its gene WNT10A point to an as-yet unknown involvement of the WNT signaling pathway in AGA. We hypothesized that the novel loci and thus also the WNT signaling may have a role in the etiopathogenesis of FPHL and therefore examined the role of these novel AGA risk loci in our FPHL samples comprising 440 German and 145 UK affected patients, 500 German unselected controls (blood donors), and 179 UK supercontrols. Patients and controls were genotyped for the top two single nucleotide polymorphisms at each of the four AGA loci. However, none of the genotyped variants displayed any significant association. In conclusion, the results of this study provide no support for the hypothesis that the novel AGA loci influence susceptibility to FPHL.
- Published
- 2014
- Full Text
- View/download PDF
14. [Diseases of hair].
- Author
-
Wolff H and Merk HF
- Subjects
- Humans, Dermatologic Agents therapeutic use, Hair pathology, Hair transplantation, Hair Diseases diagnosis, Hair Diseases therapy
- Published
- 2013
- Full Text
- View/download PDF
15. Selected variants of the melanocortin 4 receptor gene (MC4R) do not confer susceptibility to female pattern hair loss.
- Author
-
Mahmoudi H, Redler S, Birch P, Drichel D, Dobson K, Tazi-Ahnini R, Teßmann P, Giehl KA, Kruse R, Lutz G, Hanneken S, Wolff H, Blume-Peytavi U, Becker T, Nöthen MM, Messenger AG, Böhm M, and Betz RC
- Subjects
- Case-Control Studies, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genetic Variation, Genotype, Humans, Obesity genetics, Polymorphism, Single Nucleotide, Hypotrichosis genetics, Receptor, Melanocortin, Type 4 genetics
- Abstract
Female pattern hair loss (FPHL) is a common hair loss disorder in women with a complex mode of inheritance. Its etiopathogenesis is poorly understood. Widespread assumptions of overlapping susceptibility variants between FPHL and male pattern baldness (androgenetic alopecia) and a crucial role of androgens or distinct sexual steroid hormones in the development of FPHL could neither be clearly demonstrated nor completely excluded at the molecular level up to date. Interestingly, recent studies suggested an association of metabolic syndrome-including obesity, hyperlipidaemia, hypertension and diabetes mellitus type 2 or abnormally high fasting blood glucose-with FPHL. Of note, mutations in the melanocortin 4 receptor gene (MC4R) have been identified in patients with morbid obesity. Interestingly, this neuropeptide receptor has been detected amongst others in the dermal papilla of the hair follicle. As almost half of our FPHL patients of German origin present with adipositas and/or obesity, we hypothesized as to whether FPHL could be associated with variants of the MC4R gene. Thus, we genotyped a total of six variants from MC4R in our case-control sample comprising 245 UK patients of German and UK origin. However, based on our present study none of the genotyped MC4R variants displayed any significant association, neither in the overall UK and German samples nor in any subgroup analyses. In summary, these results do not point to an involvement of MC4R in FPHL.
- Published
- 2013
- Full Text
- View/download PDF
16. [History of the textbook].
- Author
-
Plewig G and Wolff HH
- Subjects
- Germany, History, 20th Century, History, 21st Century, Dermatology history, Textbooks as Topic history, Venereology history
- Abstract
The textbook "Dermatologie und Venerologie" originated with the 1st (1961) and 2nd (1969) German editions by Keining and Braun-Falco from the Departments of Dermatology at the Universities of Mainz and Marburg. The 3rd German edition was written by Braun-Falco, Plewig and Wolff (1984). The three authors became editors with the 4th German edition. Until now three English and several other foreign editions appeared. New editors are now Plewig, Burgdorf, Landthaler, Ruzicka and Hertl. Not only in German speaking countries but also in many other parts of the world the textbook is frequently used by students, residents, and dermatologists. With this retrospective view, the story of the revised editions of the book and its distribution is told.
- Published
- 2012
- Full Text
- View/download PDF
17. Hyperforin is a modulator of inducible nitric oxide synthase and phagocytosis in microglia and macrophages.
- Author
-
Kraus B, Wolff H, Elstner EF, and Heilmann J
- Subjects
- Animals, Bridged Bicyclo Compounds administration & dosage, Bridged Bicyclo Compounds isolation & purification, Bridged Bicyclo Compounds pharmacology, Cell Line, Dose-Response Relationship, Drug, Flow Cytometry, Macrophages drug effects, Macrophages metabolism, Mice, Microglia drug effects, Microglia metabolism, Microscopy, Fluorescence, Nitric Oxide metabolism, Nitric Oxide Synthase Type II metabolism, Phloroglucinol administration & dosage, Phloroglucinol isolation & purification, Phloroglucinol pharmacology, Plant Extracts administration & dosage, Plant Extracts pharmacology, Terpenes administration & dosage, Terpenes isolation & purification, Hypericum chemistry, Nitric Oxide Synthase Type II drug effects, Phagocytosis drug effects, Phloroglucinol analogs & derivatives, Terpenes pharmacology
- Abstract
Upon activation, microglia, the immunocompetent cells in the brain, get highly phagocytic and release pro-inflammatory mediators like nitric oxide (NO). Excessive NO production is pivotal in neurodegenerative disorders, and there is evidence that abnormalities in NO production and inflammatory responses may at least support a range of neuropsychiatric disorders, including depression. Although extracts of St. John's wort (Hypericum perforatum L.) have been used for centuries in traditional medicine, notably for the treatment of depression, there is still considerable lack in scientific knowledge about the impact on microglia. We used N11 and BV2 mouse microglia, as well as RAW 264.7 macrophages to investigate the effects of St. John's wort extract and constituents thereof on NO production Moreover, flow cytometry and fluorescence microscopy were employed to analyze the influence on phagocytosis, transcription factor activation states, and cell motility. We found that extracts of St. John's wort efficiently suppress lipopolysaccharide-induced NO release and identified hyperforin as the responsible compound, being effective at concentrations between 0.25 and 0.75 microM. The reduced NO production was mediated by diminished inducible nitric oxide synthase expression on the mRNA and protein level. In addition, at similar concentrations, hyperforin reduced zymosan phygocytosis to 20-40% and putatively acted by downregulating the CD206 macrophage mannose receptor and modulation of cell motility. We found that the observed effects correlate with a suppression of the activated state of Nf-kappaB and phospho-CREB, while c-JUN, STAT1, and HIF-1alpha activity and cyclooxygenase-2 expression remained unaffected by hyperforin. These results reveal that hyperforin influences pro-inflammatory and immunological responses of microglia that are involved in the progression of neuropathologic disorders.
- Published
- 2010
- Full Text
- View/download PDF
18. [Radiotherapy : an option for refractory salivary fistulas].
- Author
-
Christiansen H, Wolff HA, Knauth J, Hille A, Vorwerk H, Engelke C, Rödel R, and Laskawi R
- Subjects
- Adenolymphoma diagnostic imaging, Combined Modality Therapy, Cutaneous Fistula diagnostic imaging, Humans, Injections, Male, Microsurgery, Middle Aged, Neoplasm, Residual diagnostic imaging, Neoplasm, Residual radiotherapy, Parotid Diseases diagnostic imaging, Parotid Neoplasms diagnostic imaging, Postoperative Complications diagnostic imaging, Recurrence, Reoperation, Salivary Gland Fistula diagnostic imaging, Tomography, X-Ray Computed, Ultrasonography, Interventional, Adenolymphoma surgery, Botulinum Toxins, Type A administration & dosage, Cutaneous Fistula radiotherapy, Parotid Diseases radiotherapy, Parotid Gland surgery, Parotid Neoplasms surgery, Postoperative Complications radiotherapy, Salivary Gland Fistula radiotherapy
- Abstract
A 45-year-old patient presented with refractory salivary fistula, attributed to multiple surgery and Botulinum toxin, following lateral parotidectomy. He underwent fractionated radiotherapy of the remaining parotid gland including the fistula opening (total dose of 30 Gy) at our clinic. In time, fistula secretion could be inhibited completely. Although the indication for radiotherapy for such fistulas is rare since Botulinum toxin has been in use, it should still be considered in refractory disease courses.
- Published
- 2009
- Full Text
- View/download PDF
19. [Guidelines for varicocele management].
- Author
-
Haidl G, Köhn FM, Ochsendorf FR, Schill WB, Glander HJ, and Wolff H
- Subjects
- Adolescent, Adult, Child, Germany, Humans, Infertility, Male etiology, Infertility, Male physiopathology, Male, Practice Guidelines as Topic, Risk Factors, Spermatogenesis physiology, Varicocele diagnosis, Varicocele therapy
- Published
- 2002
- Full Text
- View/download PDF
20. [Kossard frontal fibrosing alopecia in a man].
- Author
-
Stockmeier M, Kunte C, Sander CA, and Wolff H
- Subjects
- Aged, Alopecia pathology, Biopsy, Fibrosis, Hair Follicle pathology, Humans, Lichen Planus pathology, Male, Scalp pathology, Sex Factors, Alopecia diagnosis, Lichen Planus diagnosis
- Abstract
In 1994 Steven Kossard described a new and peculiar type of hair loss that he named postmenopausal frontal fibrosing alopecia. In 6 elderly women he observed a symmetric regression of the frontal hair line. Often the eyebrows were also affected. Histology showed lichen planopilaris. There were no clinical signs of lichen planus on the rest of the body. Since the original description by Kossard, several cases of frontal fibrosing alopecia have been described--almost all of them in elderly women. We report a man with frontal fibrosing alopecia of the Kossard type.
- Published
- 2002
- Full Text
- View/download PDF
21. [Recent therapeutic progress in alopecia and hypertrichosis].
- Author
-
Feldmann KA, Kunte C, and Wolff H
- Subjects
- Alopecia etiology, Female, Hirsutism etiology, Hirsutism therapy, Humans, Hypertrichosis etiology, Male, Alopecia therapy, Hypertrichosis therapy
- Published
- 2002
- Full Text
- View/download PDF
22. [Current treatment of hypertrichosis].
- Author
-
Kunte C and Wolff H
- Subjects
- Eflornithine therapeutic use, Electrolysis, Enzyme Inhibitors therapeutic use, Female, Hair Removal, Hirsutism drug therapy, Humans, Hypertrichosis drug therapy, Male, Ornithine Decarboxylase Inhibitors, Quality of Life, Surveys and Questionnaires, Hirsutism therapy, Hypertrichosis therapy
- Abstract
Facial hypertrichosis and hirsutism may cause severe cosmetic and psychologic problems. In the following, new developments in the treatment of hypertrichosis will be presented. Permanent depilation by photothermolysis is currently the most promising treatment. A new topical treatment of hypertrichosis is eflornithine cream. It inhibits the enzyme ornithine decarboxylase which is essential for the rapidly dividing cells of the hair follicle. Furthermore, other methods of hair removal such as plucking, waxing, chemical depilation by thioglycolates, electrolysis, thermolysis and systemic therapies of hirsutism will be discussed.
- Published
- 2001
- Full Text
- View/download PDF
23. [Bleomycin prick in therapy-resistant verruca vulgaris].
- Author
-
Werfel S and Wolff H
- Subjects
- Adult, Female, Follow-Up Studies, Humans, Injections, Intralesional, Mixed Connective Tissue Disease complications, Time Factors, Anti-Bacterial Agents administration & dosage, Bleomycin administration & dosage, Foot Dermatoses drug therapy, Hand Dermatoses drug therapy, Warts drug therapy
- Abstract
Common warts can be highly resistant to conventional treatments such as cryotherapy, laser surgery, salicylic acid and mechanical removal. Intralesional bleomycin has been described as an effective treatment for common warts since 1970. We treated a 27-year-old woman with Sharp's syndrome who was on immunosuppressive drugs and had suffered for nine years from therapy-resistant warts on palms and soles. A bleomycin-prick technique using a bifurcated needle to introduce bleomycin sulfate (1 mg/ml sterile saline solution) into the warts resulted in almost complete remission after 16 treatment sessions.
- Published
- 2001
- Full Text
- View/download PDF
24. [Addendum to the contribution by Rupec, RA, et al.: Erythema palmare hereditarium].
- Author
-
Wolff H and Rupec R
- Subjects
- Adult, Female, Humans, Middle Aged, Erythema genetics, Hand Dermatoses genetics
- Published
- 2001
- Full Text
- View/download PDF
25. [Cutaneous paraneoplastic syndromes].
- Author
-
Wolff H
- Subjects
- Acanthosis Nigricans diagnosis, Acanthosis Nigricans etiology, Acanthosis Nigricans pathology, Acanthosis Nigricans therapy, Aged, Dermatomyositis diagnosis, Dermatomyositis etiology, Dermatomyositis pathology, Dermatomyositis therapy, Diagnosis, Differential, Erythema diagnosis, Erythema etiology, Erythema pathology, Erythema therapy, Female, Hand Dermatoses diagnosis, Hand Dermatoses etiology, Hand Dermatoses pathology, Hand Dermatoses therapy, Humans, Hypertrichosis diagnosis, Hypertrichosis etiology, Hypertrichosis pathology, Hypertrichosis therapy, Keratosis diagnosis, Keratosis etiology, Keratosis pathology, Keratosis therapy, Male, Pemphigoid, Bullous diagnosis, Pemphigoid, Bullous etiology, Pemphigoid, Bullous pathology, Pemphigoid, Bullous therapy, Pemphigus diagnosis, Pemphigus etiology, Pemphigus pathology, Pemphigus therapy, Pyoderma Gangrenosum diagnosis, Pyoderma Gangrenosum etiology, Pyoderma Gangrenosum pathology, Pyoderma Gangrenosum therapy, Skin pathology, Skin Diseases diagnosis, Skin Diseases pathology, Skin Diseases therapy, Sweet Syndrome diagnosis, Sweet Syndrome etiology, Sweet Syndrome pathology, Sweet Syndrome therapy, Paraneoplastic Syndromes classification, Paraneoplastic Syndromes diagnosis, Paraneoplastic Syndromes pathology, Skin Diseases etiology
- Published
- 2001
- Full Text
- View/download PDF
26. [Morphological changes in melanocytic nevi induced by exogenous factors].
- Author
-
Tronnier M, Alexander M, Neitmann M, Brinckmann J, and Wolff HH
- Subjects
- Adult, Antigens, Neoplasm immunology, Biomarkers, Tumor, Cells, Cultured immunology, Cells, Cultured pathology, Diagnosis, Differential, Humans, Integrins immunology, Keratinocytes immunology, Keratinocytes pathology, Melanocytes immunology, Melanocytes pathology, Melanoma diagnosis, Melanoma immunology, Nevus, Pigmented diagnosis, Nevus, Pigmented immunology, Skin immunology, Skin pathology, Skin Neoplasms diagnosis, Skin Neoplasms immunology, Melanoma pathology, Nevus, Pigmented pathology, Skin Neoplasms pathology, Ultraviolet Rays adverse effects
- Abstract
Malignant melanoma is the most important differential diagnosis in both clinical and histologic examination of melanocytic nevi. UV exposure with an erythemogenic dose and mechanical irritation of melanocytic nevi are able to induce reversible morphologic changes which simulate malignant melanoma. These changes are associated with an increased expression of HMB-45 antigen. In addition, an increased proliferation and repair activity is observed after UV exposure. The increased number of melanocytes located in suprabasal layers of the epidermis is accompanied by a change in keratinocyte adhesion molecule expression. The UV light is also able to influence the adhesive properties of melanocytes in vitro. Therefore, both keratinocyte-derived factors and direct influence of UV on the melanocyte system are probably responsible for the morphologic changes. While these exogenously evoked changes are reversible, the potential biologic relevance--especially a possible role in the initiation of the carcinogenesis cascade--requires clarification.
- Published
- 2000
- Full Text
- View/download PDF
27. [Erythema palmare hereditarium ("red palms")].
- Author
-
Rupec RA, Wolff H, Lindner A, and Kind P
- Subjects
- Adult, Chromosome Aberrations genetics, Chromosome Disorders, Female, Genes, Recessive genetics, Humans, Pedigree, Erythema genetics, Hand Dermatoses genetics
- Abstract
We report a woman with erythema palmare hereditarium, an anomaly not documented so far in the German literature. It is characterized by a bright erythema of the palms, usually persistent since birth. It is transmitted in an autosomal-recessive mode and has a benign course. In our patient it was possible to trace the palmar erythema over three generations.
- Published
- 2000
- Full Text
- View/download PDF
28. Accelerated phase in partial albinism with immunodeficiency (Griscelli syndrome): genetics and stem cell transplantation in a 2-month-old girl.
- Author
-
Baumeister FA, Stachel D, Schuster F, Schmid I, Schaller M, Wolff H, Weiss M, and Belohradsky BH
- Subjects
- Chromosomes, Human, Pair 15, Female, Hair Color, Humans, Immunologic Deficiency Syndromes genetics, Immunologic Deficiency Syndromes pathology, Immunologic Deficiency Syndromes therapy, Infant, Melanosomes ultrastructure, Pedigree, Piebaldism genetics, Piebaldism immunology, Piebaldism pathology, Hematopoietic Stem Cell Transplantation, Immunologic Deficiency Syndromes physiopathology, Piebaldism physiopathology
- Abstract
Unlabelled: A 2-month-old girl presented with fever, hepatosplenomegaly, pancytopenia, hypertriglyceridaemia and silvery-greyish hair, suggesting the diagnosis of Griscelli syndrome (partial albinism with immunodeficiency). This diagnosis was confirmed by the characteristic agglomeration of melanin in the hair shaft and accumulation of melanosomes in melanocytes of the skin. The patient was homozygous for polymorphic markers around the myosin-Va gene on chromosome 15q21, which co-localize to the Griscelli disease locus. Natural-killer cells were in the lower range. The stimulation of lymphocytes with antigen and mitogen was normal. The patient's accelerated phase, characterized by haemophagocytosis was treated with prednisolone, rabbit anti-thymocyte globulins, and intrathecal methotrexate. Remission was maintained with cyclosporin A until HLA-compatible peripheral blood stem cell transplantation from her mother., Conclusion: The silvery-greyish hair associated with fever, pancytopenia and hypertriglyceridaemia is the clue to early diagnosis of Griscelli syndrome and important to prevent death before stem cell transplantation.
- Published
- 2000
- Full Text
- View/download PDF
29. [Finasteride: also effective in acne vulgaris?].
- Author
-
Wolff H
- Subjects
- Humans, Treatment Outcome, Acne Vulgaris drug therapy, Enzyme Inhibitors therapeutic use, Finasteride therapeutic use
- Published
- 1999
- Full Text
- View/download PDF
30. [Ethical questions--once and now].
- Author
-
Wolff H
- Subjects
- Cost Control trends, Forecasting, Germany, Humans, National Health Programs economics, Ethics, Medical, Health Expenditures trends, National Health Programs trends
- Published
- 1999
31. [Calciphylaxis of the skin as a sequela of terminal kidney failure. Report and discussion of 3 cases].
- Author
-
Hiss U, Tronnier M, Rob PM, Gutsche HU, and Wolff HH
- Subjects
- Aged, Calciphylaxis pathology, Calciphylaxis therapy, Diabetes Mellitus, Type 1 complications, Diabetes Mellitus, Type 1 pathology, Diabetes Mellitus, Type 1 therapy, Diabetic Nephropathies pathology, Diabetic Nephropathies therapy, Female, Humans, Kidney Failure, Chronic pathology, Kidney Failure, Chronic therapy, Leg Ulcer pathology, Leg Ulcer therapy, Male, Middle Aged, Muscle, Smooth, Vascular pathology, Necrosis, Skin blood supply, Skin pathology, Skin Diseases pathology, Skin Diseases therapy, Calciphylaxis etiology, Diabetic Nephropathies complications, Kidney Failure, Chronic complications, Leg Ulcer etiology, Skin Diseases etiology
- Abstract
Calciphylaxis is a rare syndrome mostly affecting patients with secondary hyperparathyroidism and in some cases with functional protein C or protein S deficiency. Skin lesions begin as superficial painful patches that progress to deep necrotic lesions. The findings are often misdiagnosed as livedo vasculitis and the prognosis is poor. Histopathologically, calcification in the media of small arteries and arterioles with intimal hyperplasia is seen. It is unclear if this morphologic hallmark is pathogenetic. Therapeutically, the calcium-phosphate product should be lowered pharmacologically by an intensified and modified dialysis treatment and parathyroidectomy.
- Published
- 1999
- Full Text
- View/download PDF
32. [Ehlers-Danlos syndrome].
- Author
-
Brinckmann J, Behrens P, Brenner R, Bätge B, Tronnier M, and Wolff HH
- Subjects
- Humans, Ehlers-Danlos Syndrome classification, Ehlers-Danlos Syndrome diagnosis, Ehlers-Danlos Syndrome etiology, Ehlers-Danlos Syndrome pathology
- Abstract
The Ehlers-Danlos syndrome (EDS) comprises a heterogenous group of nine hereditary connective tissue disorders, characterized by hyperelasticity of skin and hypermobility of joints to differing extents. The skin is easily injured and wound healing is delayed. The majority of EDS patients belong to EDS-types I-III. The pathogenesis in these cases is not known, although recent data suggest a role for collagen V. In contrast, the etiology of EDS-types IV, VI and VII has been found. While EDS IV is caused by a mutation in the collagen III gene, in EDS VI a mutation in the lysyl hydroxylase gene is present. In EDS VII, the underlying defect is a mutation in the collagen I gene. The EDS-types V, VII and X are very rare; their symptoms resemble those of EDS-type II.
- Published
- 1999
- Full Text
- View/download PDF
33. [Treatment of androgenetic alopecia in the man using systemic 5 alpha-reductase inhibition].
- Author
-
Wolff H and Kunte C
- Subjects
- Dose-Response Relationship, Drug, Finasteride adverse effects, Humans, Male, Randomized Controlled Trials as Topic, Treatment Outcome, 5-alpha Reductase Inhibitors, Alopecia drug therapy, Finasteride therapeutic use
- Published
- 1998
- Full Text
- View/download PDF
34. SLS-irritated human skin shows no correlation between degree of proliferation and TEWL increase.
- Author
-
Welzel J, Metker C, Wolff HH, and Wilhelm KP
- Subjects
- Adult, Cell Division drug effects, Female, Humans, Male, Middle Aged, Skin pathology, Irritants adverse effects, Skin drug effects, Sodium Dodecyl Sulfate adverse effects, Surface-Active Agents adverse effects, Water Loss, Insensible drug effects
- Abstract
It is well known that cutaneous irritants influence epidermal proliferation but the pathogenesis is poorly understood. Recent investigations have shown that the skin barrier integrity influences the proliferation of the basal keratinocytes. Our question was whether the proliferating activity of keratinocytes is indeed regulated by the degree of skin barrier damage or by a direct toxic action of the irritant on the keratinocytes. Therefore various degrees of skin irritation were induced by the application of 0.1%, 0.5% and 2% sodium lauryl sulphate (SLS) solution to the forearm skin of six healthy volunteers. This experiment was performed to evaluate the relationship between SLS concentration and epidermal proliferation. In a second experiment another 14 volunteers were treated with a single SLS concentration (0.5%) to look for interindividual differences in the patterns of skin reaction and susceptibility to the irritant. Skin barrier function was evaluated by measurements of transepidermal water loss (TEWL) before and after irritation. Punch biopsies were taken after 96 h from exposed areas and from unexposed normal skin. Dividing keratinocytes were identified immunocytochemically using three different monoclonal antibodies: PCNA, MIB 1 and KiS1. Exposure to SLS resulted in concentration-dependent increases in both TEWL and epidermal proliferation. However, no significant correlation could be found between the degree of hyperproliferation and the TEWL changes. The results suggest that epidermal proliferation is modulated by a direct interaction of the surfactant with the keratinocytes and/or by release of mediators rather than the consequence of a barrier disturbance.
- Published
- 1998
- Full Text
- View/download PDF
35. [Problems, responsibility and goals in dermatopathology].
- Author
-
Kerl H, Burg G, Sterry W, and Wolff HH
- Subjects
- Diagnosis, Differential, Europe, Forecasting, Humans, Quality Assurance, Health Care trends, Skin pathology, Specialization trends, Skin Diseases pathology, Skin Neoplasms pathology
- Published
- 1998
- Full Text
- View/download PDF
36. Inhibition of interleukin-4 and interleukin-13 release from immunologically activated human basophils due to the actions of anti-allergic drugs.
- Author
-
Gibbs BF, Vollrath IB, Albrecht C, Amon U, and Wolff HH
- Subjects
- Adrenergic beta-Agonists pharmacology, Albuterol pharmacology, Basophils immunology, Histamine H1 Antagonists pharmacology, Humans, Phosphodiesterase Inhibitors pharmacology, Theophylline pharmacology, Anti-Allergic Agents pharmacology, Basophils metabolism, Interleukin-13 metabolism, Interleukin-4 metabolism
- Abstract
Human basophils have recently been shown to rapidly produce and release interleukin (IL-)4 and IL-13 as well as histamine and eicosanoids. Since both IL-4 and IL-13 can initiate and maintain late phase allergic reactions we addressed whether some widely used anti-allergic drugs can inhibit the anti-IgE induced release of these cytokines from enriched human basophils. Basophils were enriched (47-92% purity) by Ficoll density centrifugation followed by elutriation and negative selection of contaminating cells using immunomagnetic beads. Basophils were stimulated with sub-optimal dilutions of anti-IgE in the presence or absence of various drugs and the release of histamine and cytokines were measured after 30 min and 4 h, respectively. The beta-2 agonist salmeterol, the H1-receptor antagonist terfenadine and the phosphodiesterase inhibitor theophylline inhibited the release of IL-4 and IL-13 by more than 50% following 4 h of basophil stimulation with anti-IgE. These drugs also inhibited the release of histamine following 30 min stimulation, although with less efficacy than for IL-4 and IL-13. Short preincubation of basophils with salmeterol or terfenadine before stimulation gave rise to significantly greater inhibition of histamine release but had less effect on the inhibition of cytokine release. The effects of theophylline, however, were not significantly affected by preincubation of the cells with the drug. In contrast to the aforementioned drugs, salbutamol and cetirizine were ineffective at inhibiting both histamine and cytokine release from basophils. These results suggest that a number of anti-allergic drugs may mediate their effects, in part, in reducing late phase allergic responses due to their actions on IL-4 and IL-13 secretion from basophils.
- Published
- 1998
- Full Text
- View/download PDF
37. [Aseptic femur head necrosis--sequelae of systemic corticosteroid therapy?].
- Author
-
Volkmar C and Wolff H
- Subjects
- Administration, Oral, Adrenal Cortex Hormones administration & dosage, Dose-Response Relationship, Drug, Drug Administration Schedule, Humans, Risk Factors, Adrenal Cortex Hormones adverse effects, Femur Head Necrosis chemically induced
- Published
- 1998
- Full Text
- View/download PDF
38. [Symposium: Recent developments in pathogenesis and therapy of hair diseases 9 July 1997 in Munich].
- Author
-
Kunte C and Wolff H
- Subjects
- Alopecia therapy, Germany, Hair Diseases therapy, Humans, Alopecia etiology, Hair Diseases etiology
- Published
- 1998
- Full Text
- View/download PDF
39. [HiVision video technique in international presentations--close to the skin even in the last row of the auditorium].
- Author
-
Plewig G, Wolff H, and Bilek P
- Subjects
- Education, Medical, Continuing, Equipment Design, Humans, Image Processing, Computer-Assisted instrumentation, Audiovisual Aids, Dermatology education, Image Enhancement instrumentation, Video Recording instrumentation
- Published
- 1998
- Full Text
- View/download PDF
40. [Dorfman-Chanarin syndrome--a neutral lipid storage disease].
- Author
-
Wollenberg A, Schaller M, Röschinger W, Schirren CG, and Wolff H
- Subjects
- Adolescent, Biopsy, Diagnosis, Differential, Humans, Ichthyosiform Erythroderma, Congenital diagnosis, Ichthyosiform Erythroderma, Congenital pathology, Lipid Metabolism, Lipid Metabolism, Inborn Errors diagnosis, Lipid Metabolism, Inborn Errors pathology, Male, Neutrophils pathology, Pedigree, Skin pathology, Syndrome, Vacuoles pathology, Ichthyosiform Erythroderma, Congenital genetics, Lipid Metabolism, Inborn Errors genetics
- Abstract
Dorfman-Chanarin syndrome is a rare, autosomal recessive inherited lipid storage disease with skin manifestations in form of congenital ichthyotic erythroderma. Demonstration of lipid vacuoles in neutrophils from peripherals blood smears in patients with ichthyotic erythroderma leads to the diagnosis. Other organ systems, such as CNS, liver, muscle, ears and eyes, are frequently involved. Since Dorfman-Chanarin syndrome may present with just skin findings, it should be included in the differential diagnosis of the congenital ichthyoses. Microscopic examination of peripheral blood smears is recommended in all patients with ichthyosis. We summarize the current data on the pathogenesis, diagnosis, differential diagnosis, and therapeutic options in Dorfman-Chanarin syndrome, give an overview of the clinical manifestations of the 23 patients affected with this rare disease.
- Published
- 1997
- Full Text
- View/download PDF
41. [Standards in histopathologic diagnosis of malignant melanomas. Recommendations of the Working Group of the Central Malignant Melanoma Registry of the German Dermatologic Society].
- Author
-
Tronnier M, Garbe C, Bröcker EB, Stadler R, Steinkraus V, Soyer HP, and Wolff HH
- Subjects
- Biomarkers, Tumor analysis, Biopsy, Diagnosis, Differential, Humans, Neoplasm Invasiveness, Neoplasm Staging, Reproducibility of Results, Melanoma pathology, Quality Assurance, Health Care, Skin Neoplasms pathology
- Abstract
The evaluation of melanocytic tumors represents one of the most intriguing and challenging aspects of the daily practice in dermatohistopathology. For the diagnosis of malignant melanoma and melanocytic nevi, standardized and reproducible criteria are required. In case of the diagnosis of melanoma, the histopathological report must include all important data relevant for the prognosis which may also influence the therapeutic procedure. The following paper summarizes the recommendations of the study group on malignant melanoma formed by the Deutsche Dermatologische Gesellschaft.
- Published
- 1997
- Full Text
- View/download PDF
42. [Combined naevus flammeus and naevus fuscocoeruleus: phacomatosis pigmentovascularis type IIa].
- Author
-
Achtelik W, Tronnier M, and Wolff HH
- Subjects
- Adult, Biopsy, Diagnosis, Differential, Dysplastic Nevus Syndrome diagnosis, Dysplastic Nevus Syndrome pathology, Female, Hamartoma Syndrome, Multiple diagnosis, Hamartoma Syndrome, Multiple pathology, Humans, Melanocytes pathology, Microscopy, Electron, Phagocytes pathology, Skin pathology, Skin Neoplasms diagnosis, Skin Neoplasms pathology, Dysplastic Nevus Syndrome genetics, Hamartoma Syndrome, Multiple genetics, Nevus of Ota genetics, Skin Neoplasms genetics
- Abstract
The association of nevus flammeus with mongolian spot, nevus fuscoceruleus, nevus spilus and, with variable frequency, with nevus anemicus has been termed phacomatosis pigmentovascularis, a genodermatosis first described by Ota and co-workers. Four different combinations have been specified. Most cases are reported from the Japanese literature. Phacomatosis pigmentovascularis may constitute an exclusively cutaneous disorder, but overlapping with other syndromes like Klippel-Trenaunay syndrome or Sturge-Weber syndrome is also possible. We report a 30-year-old woman with nevus flammeus on the back and right arm associated with nevus fuscoceruleus on the back.
- Published
- 1997
- Full Text
- View/download PDF
43. [The surgical school--a continuous contribution to quality assurance].
- Author
-
Wolff H
- Subjects
- Education, Medical, Continuing trends, Education, Medical, Graduate trends, Forecasting, Germany, Humans, General Surgery education, Quality Assurance, Health Care trends, Schools, Medical trends
- Published
- 1997
44. [Brazilian pemphigus foliaceus (fogo selvagem)].
- Author
-
Kunte C, Barbosa JM, Wolff H, and Meurer M
- Subjects
- Adolescent, Adult, Autoantibodies immunology, Autoimmune Diseases etiology, Autoimmune Diseases immunology, Autoimmune Diseases pathology, Brazil, Child, Cytoskeletal Proteins immunology, Desmoglein 1, Desmogleins, Desmoplakins, Desmosomes immunology, Desmosomes pathology, Fluorescent Antibody Technique, Indirect, Humans, Immunoglobulin G analysis, Pemphigus immunology, Pemphigus pathology, Skin immunology, Skin pathology, gamma Catenin, Pemphigus etiology
- Abstract
Most of the clinical, histological and immunohistological features of fogo selvagem resemble those of idiopathic pemphigus foliaceus (PF). Both diseases are clinically characterized by small flaccid bullae evolving into to scaly and crusted lesions, sometimes with pustules, mainly in seborrheic areas of the skin. Mucosal surfaces are mostly spared. The main histologic feature of endemic pemphigus foliaceus is a subcorneal acantholytic blister. Standard immunofluorescence studies demonstrate intercellular IgG deposits throughout the entire epidermis. These IgG antibodies are mainly of the IgG4-subclass. Almost all patients have circulating IgG-autoantibodies in their serum directed against stratified epithelial desmosomes. The fogo selvagem autoantibodies and the PF antibodies are directed against the 160 kD desmosomal glycoprotein desmoglein 1 which together with plakoglobin (85 kD) forms a complex of adhesion proteins with desmosomes of stratified epithelia. Fogo selvagem occurs in endemic foci in some areas of Brazil and possibly in neighbouring South American countries, very often in children, adolescents and young adults. The etiology of fogo selvagem is still unknown. The frequent association with insect bites has lead to the concept of fogo selvagem being a transmissible disease with acquired immunity in adulthood. However, the infectious agent and possible vectors have not yet been identified.
- Published
- 1997
- Full Text
- View/download PDF
45. Development of T-tube tracts in piglets: effect of insertion method and material of T-tubes.
- Author
-
Koivusalo A, Eskelinen M, Wolff H, Talva M, and Mäkisalo H
- Subjects
- Adult, Anastomosis, Surgical methods, Animals, Bile metabolism, Female, Gallstones surgery, Humans, Latex, Liver Transplantation methods, Male, Materials Testing, Middle Aged, Silicones, Swine, Common Bile Duct surgery, Stents adverse effects
- Abstract
T-tube-related bile leakage is a considerable problem in liver transplantation but rather rare in surgery of biliary lithiasis. To investigate the effect of T-tube insertion method and material on the intraperitoneal T-tube tract, we performed a choledochotomy and insertion of T-tube (four of silicone, seven of latex, four of silicone with a latex sheath around the long arm) for 2 weeks on 15 piglets (choledochotomy group), and sutured a transected bile duct over a T-tube stent in nine piglets (five silicone, four latex), inserted similarly as in liver transplantations, for 6 weeks. Sixteen patients underwent cholectochotomy and T-tube drainage with a latex T-tube (n = 8) and latex-sheathed silicone T-tube (n = 8) for a median 9 (7-21) days. Histological examination of T-tube tracts in piglets was made, and complications after T-tube removal in the latex T-tube group were compared with those in the latex-sheathed silicone T-tube group. In piglets, latex T-tubes induced better tracts than silicone T-tubes (P < 0.05). Piglets in the choledochotomy group had tracts superior to those in the anastomotic stent group (P < 0.05). There was one bile leakage in the latex T-tube group, and none in the latex-sheathed silicone T-tube group. We conclude that T-tube tract development is affected by both the material and the insertion method of T-tubes. A silicone T-tube with a latex sheath around the long arm may also be a good choice for T-tube material in liver transplantation.
- Published
- 1997
- Full Text
- View/download PDF
46. [Activation of epidermal melanocytes is independent of epithelial proliferation and vascularization. Immunohistologic study using HMB-45 antibody with review of the literature].
- Author
-
Lommel K, Tronnier M, and Wolff HH
- Subjects
- Antigens, Neoplasm, Biomarkers, Tumor analysis, Biopsy, Diagnosis, Differential, Humans, Immunoenzyme Techniques, Melanoma pathology, Melanoma-Specific Antigens, Neovascularization, Pathologic pathology, Skin blood supply, Skin pathology, Skin Diseases pathology, Skin Neoplasms pathology, Cell Division physiology, Melanocytes pathology, Melanoma diagnosis, Neoplasm Proteins analysis, Neovascularization, Pathologic diagnosis, Skin Diseases diagnosis, Skin Neoplasms diagnosis
- Abstract
Antibodies against HMB-45 antigen are widely used in the immunohistochemical investigation of melanocytic tumours as a marker of activation. While malignant transformation is one explanation for HMB-45 expression, we searched for other factors by investigating 252 biopsies of non-melanocytic skin lesions with 21 different diagnoses for the presence of HMB-45, using both single and double staining techniques. Epidermal melanocytes in lesions with an increased epithelial proliferation-either neoplastic or reactive-and lesions with a prominent vasculature showed an enhanced expression of HMB-45. The results indicate that the presence of HMB-45 is not only influenced by primary melanocytic changes but also may be dependent on epithelial proliferation and vascular factors. These mechanisms should be considered when interpreting HMB-45 staining of melanocytic lesions.
- Published
- 1996
- Full Text
- View/download PDF
47. Effects of basophil-priming and stimulating cytokines on histamine release from isolated human skin mast cells.
- Author
-
Nitschke M, Sohn K, Dieckmann D, Gibbs BF, Wolff HH, and Amon U
- Subjects
- Chemokine CCL2 pharmacology, Chemokine CCL4, Chemokine CCL5 pharmacology, Evaluation Studies as Topic, Granulocyte-Macrophage Colony-Stimulating Factor pharmacology, Humans, In Vitro Techniques, Interleukin-3 pharmacology, Interleukin-5 pharmacology, Macrophage Inflammatory Proteins pharmacology, Mast Cells metabolism, Skin cytology, Skin metabolism, Stimulation, Chemical, Basophils physiology, Cytokines pharmacology, Histamine Release drug effects, Mast Cells drug effects, Skin drug effects
- Abstract
Cell priming and stimulation of different cytokines (which include chemokines and growth factors) are typical features of human basophils. Recently, it has been shown that the macrophage chemotactic protein-1 (MCP-1), RANTES and macrophage inflammatory protein-1 alpha (MIP-1 alpha) are potent direct secretagogues for human basophils and that interleukin-3 (IL-3), IL-5 and granulocyte/macrophage colony-stimulating factor (GM-CSF) are priming factors for subsequent potentiation of mediator release from basophils induced by different stimuli. This observation may be clinically important for the activation and recruitment of inflammatory cells in different immune responses of the skin (e.g. late-phase reactions). The aim of the present study was to investigate whether cytokines and chemokines are also capable of priming or stimulating isolated human skin mast cells (SMC). SMC were either stimulated directly with the cytokines alone or preincubated with these factors for 10 min before being activated with suboptimal concentrations of anti-IgE, A23187 or substance P. IL-3, IL-5, GM-CSF, platelet factor-4 (PF-4), IL-8, MCP-1 and MIP-1 alpha (each at concentrations of 1 ng/ml to 1 microgram/ml, log steps) did not significantly modulate histamine release from SMC induced by the three different secretagogues. RANTES exhibited a weak but significant potentiating effect on IgE-mediated activation. Stem cell factor (SCF) as a positive control was able to prime mast cell histamine release strongly. In addition, PF-4, MCP-1, RANTES and MIP-1 alpha were incapable of inducing direct histamine release from SMC. In experiments with isolated human peripheral basophils, however, we observed potent Fc epsilon RI-mediated priming effects evoked through IL-3, IL-5 and GM-CSF. We conclude that SMC derived from healthy donors are not targets of (immuno)modulatory factors that prime or stimulate basophils.
- Published
- 1996
- Full Text
- View/download PDF
48. [Eruptive vellus hair cysts].
- Author
-
Jansen T, Wolff H, Schirren H, and Plewig G
- Subjects
- Adult, Biopsy, Diagnosis, Differential, Facial Dermatoses genetics, Facial Dermatoses pathology, Humans, Male, Pilonidal Sinus genetics, Pilonidal Sinus pathology, Skin pathology, Facial Dermatoses diagnosis, Pilonidal Sinus diagnosis
- Abstract
Eruptive vellus hair cysts are rare epidermal cysts with vellus hairs, which appear in children or young adults. A 21-year-old patient is reported who developed asymptomatic comedo-like papules on his face, neck and chest. Histopathologically, epidermoid cysts with a fine stratum granulosum, laminated keratinous material and numerous vellus hairs were found in the mid-dermis. Evaluation of immediate family members revealed that the patient's father was similarly affected. Eruptive vellus hair cysts and steatocystoma multiplex are clinically similar, but have distinctive histopathological features and should be regarded as distinct entities.
- Published
- 1996
- Full Text
- View/download PDF
49. Biocompatibility of latex and silicone T tubes in the porcine common bile duct: an experimental study.
- Author
-
Koivusalo A, Makisalo H, Talja M, Cormio L, Ruutu M, Wolff H, and Hockerstedt K
- Subjects
- Animals, Common Bile Duct injuries, Common Bile Duct pathology, Drainage adverse effects, Epithelium injuries, Epithelium pathology, Female, Fibrosis, Humans, In Vitro Techniques, Inflammation etiology, Inflammation pathology, Materials Testing, Microscopy, Electron, Scanning, Swine, Biocompatible Materials toxicity, Common Bile Duct surgery, Drainage instrumentation, Latex toxicity, Silicones toxicity
- Abstract
Toxicity of materials used in indwelling drains or catheters has the potential to damage surrounding tissues. The biocompatibility of biliary T-tubes was investigated using in groups of piglets (total 30 animals). In group 1 (n=16) a choledochotomy was performed with insertion of a latex T-tube (n=6) or a silicone T-tube (n=8), or without a T-tube (n=2). In group 2 (n=14) the common bile duct (CBD) was 3/4-transected, and the lesion was sutured over a latex T-tube (n=4) or a silicone T-tube (n=5), or without a T-tube (n=5). The groups were reoperated upon after 2 and 6 weeks respectively, and the CBD was harvested for scanning electron microscopy and light microscopy. The T-tubes were examined for cell culture toxicity with a DNA synthesis inhibition test. According to the cell culture tests, latex T-tubes were toxic and silicone T-tubes nontoxic. T-tubes induced moderate to pronounced fibrosis and epithelial damage in the CBD wall, but did not induce excessive fibrosis or scarring at the site of CBD suture. In the 6-week study period, however, the grade of tissue reactions in the CBD did not correlate with the toxicity of the T-tube materials, but rather reflected a foreign body reaction and mechanical pressure. Although gross anatomical changes did not occur, neither material seemed to be completely harmless for porcine CBD wall.
- Published
- 1996
- Full Text
- View/download PDF
50. [Abdominal variant of benign symmetrical Launois-Bensaude lipomatosis].
- Author
-
Amon U, Yaguboglu R, Reinauer S, Ruzicka T, Schmolke B, Kreusch J, and Wolff HH
- Subjects
- Adipose Tissue pathology, Adult, Combined Modality Therapy, Diagnosis, Differential, Humans, Lipomatosis, Multiple Symmetrical genetics, Lipomatosis, Multiple Symmetrical therapy, Male, Skin pathology, Abdomen pathology, Lipomatosis, Multiple Symmetrical diagnosis
- Abstract
We report on a patient with an abdominal type of benign symmetrical Launois-Bensaude lipomatosis. New aspects of the pathogenesis of abnormal distribution of the fatty tissue are also discussed.
- Published
- 1995
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.