54 results on '"Hemangioma therapy"'
Search Results
2. The Perfect Fit: Unraveling the Treatment Algorithms for Symptomatic Hepatic Hemangiomas.
- Author
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Young S and Golzarian J
- Subjects
- Humans, Embolization, Therapeutic methods, Liver Neoplasms therapy, Liver Neoplasms diagnostic imaging, Hemangioma diagnostic imaging, Hemangioma therapy, Algorithms
- Published
- 2024
- Full Text
- View/download PDF
3. Transcatheter Arterial Embolization with Bleomycin-Lipiodol of Hepatic Hemangiomas: Safety, Efficacy and Predictors of Response.
- Author
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Zhao D, Xie L, Makamure J, Liu Z, Zhang L, Li Q, Zhang X, Zhao Y, Zheng C, Shi L, and Liang B
- Subjects
- Humans, Male, Retrospective Studies, Female, Middle Aged, Adult, Treatment Outcome, Aged, Embolization, Therapeutic methods, Antibiotics, Antineoplastic therapeutic use, Antibiotics, Antineoplastic administration & dosage, Tumor Burden, Chemoembolization, Therapeutic methods, Gelatin Sponge, Absorbable therapeutic use, Ethiodized Oil administration & dosage, Ethiodized Oil therapeutic use, Liver Neoplasms therapy, Liver Neoplasms diagnostic imaging, Bleomycin therapeutic use, Hemangioma therapy, Hemangioma diagnostic imaging
- Abstract
Purpose: To evaluate the safety, efficacy and predictors of response of transcatheter arterial embolization (TAE) to treat hepatic hemangiomas (HHs)., Materials and Methods: A retrospective analysis was conducted of consecutive HH patients who received TAE with bleomycin-Lipiodol emulsion and gelatin sponge particles at three institutions from January 2014 to January 2021. TAE effectiveness was defined as more than 50% reduction of tumor volume. The effectiveness, safety, and CT changes of hemangiomas after TAE were assessed. Factors affecting TAE efficacy on tumor size were analyzed with logistic regression analysis., Results: A total of 102 patients with 109 HHs were included. After treatment, both the tumor diameter and volume were significantly reduced from 8.5 ± 3.9 to 5.9 ± 3.8 cm (P < 0.001) and 412.6 ± 742.3 cm
3 to 102.0 ± 232.7 cm3 (P < 0.001), respectively. TAE effectiveness was achieved in 80.7% (88/109) of hemangiomas, which was characterized by progressive reduction in tumor volume over time with Lipiodol retention. Atypical enhancement pattern (tiny enhancing dots in the hepatic arterial and portal venous phase) (p = 0.001) and central arterioportal shunt (APS) (p = 0.002) associated with the tumor were independent predictors of TAE ineffectiveness. Postembolization syndrome and transient increase in liver enzymes were common without severe complications and death., Conclusion: TAE was safe and effective in reducing HH size. Lesion enhancement pattern and APS type were associated with TAE efficacy on tumor shrinkage., Level of Evidence: Level 3, non-controlled retrospective cohort study., (© 2024. Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE).)- Published
- 2024
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4. Skin sequelae in patients with infantile hemangioma: a systematic review.
- Author
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Li W, Kang J, Bai S, Yuan L, Liu J, Bi Y, Sun J, and He Y
- Subjects
- Humans, Infant, Skin pathology, Disease Progression, Vascular Neoplasms, Skin Neoplasms complications, Skin Neoplasms therapy, Hemangioma complications, Hemangioma therapy
- Abstract
Infantile hemangioma (IH) is the most common vascular tumor in infancy. Although IHs can regress spontaneously, some problematic IHs still need treatment. However, either treated or untreated IHs may leave skin sequelae which can cause permanent disfigurement. Many studies evaluated the short-term efficacy of different kinds of treatment, but now, few studies are focusing on long-term skin sequelae. The objectives of our systemic review were to identify skin sequelae of IH thoroughly, determine specific factors associated with long-term IH sequelae, and learn how to improve these sequelae. We searched the following electronic databases: PubMed, EMBASE, Cochrane Library, and Clinicaltrials.gov. Three independent authors assessed the articles, and we reported this systemic review following PRISMA guidelines. Of 4448 articles initially identified, 62 underwent full-text review, and 17 met inclusion criteria. The overall rate of sequelae ranged from 5.3 to 93.5%. Factors associated with skin sequelae included patients' demographics, hemangioma characteristics, and treatment factors. What is Known: • Infantile hemangioma is the most common vascular tumor during infancy. • Infantile hemangiomas can regress spontaneously but either treated or untreated patients may leave permanent skin sequelae. What is New: • Skin sequelae in involuted Infantile hemangiomas are very common. • It is significant to prevent, recognize, and improve skin sequelae of infantile hemangiomas., (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Published
- 2023
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5. Multidisciplinary, articular surface-preserving treatment strategy for locally aggressive epithelioid hemangioma of the acetabulum employing serial bland transarterial embolization.
- Author
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Abboud S, Bhatt A, Pateva I, Saab S, Hameed M, Healey J, and Getty P
- Subjects
- Acetabulum diagnostic imaging, Acetabulum pathology, Acetabulum surgery, Bone Transplantation, Curettage methods, Humans, Bone Neoplasms diagnostic imaging, Bone Neoplasms pathology, Bone Neoplasms therapy, Hemangioma diagnostic imaging, Hemangioma therapy, Vascular Neoplasms pathology
- Abstract
Epithelioid hemangioma is a rare, histologically benign but locally aggressive primary vascular neoplasm that can rarely arise in bone. Mainstay treatment is surgical resection or curettage with bone grafting. We report a novel multidisciplinary, joint-sparing treatment approach for an epithelioid hemangioma of bone arising in the acetabulum causing severe thinning of the subchondral bone plate. After 4 sessions of transarterial bland particle and ethanol embolization, the resultant increased ossification of the tumor allowed preservation of the articular surface during surgical resection. Imaging follow-up 14 months after surgical resection showed no evidence of recurrence and continued ossification of the portions of the lesion treated only with embolization., (© 2022. ISS.)
- Published
- 2022
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6. [Interdisciplinary management of extracranial vascular anomalies].
- Author
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Geisthoff U, Mahnken AH, Knaus P, Schnittler HJ, Stuck BA, and Knöppel C
- Subjects
- Humans, Arteriovenous Malformations diagnosis, Arteriovenous Malformations therapy, Hemangioma diagnosis, Hemangioma therapy, Vascular Malformations diagnosis, Vascular Malformations therapy
- Abstract
Background: A multitude of vascular anomalies exist and can lead to severe complications. Treatment can be complex., Objective: This overview aims to provide important information for the management of vascular anomalies., Materials and Methods: In addition to current literature, experiences from the interdisciplinary Vascular Anomalies Center in Marburg were included in this review., Results: Hemangiomas at critical sites, arteriovenous malformations, and vascular anomalies of uncertain etiology require particular attention., Conclusion: Self-help and support groups, specialized interdisciplinary centers, scientific medical societies, and networks can provide help for the treatment of vascular anomalies., (© 2022. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2022
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7. Therapeutic Evaluation and Management Strategy of Transarterial Embolization for Giant Liver Hemangiomas Exceeding 10 cm in Diameter.
- Author
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Li X, Liu FY, Yuan HJ, Tian XM, Tang J, Ye T, and Ji K
- Subjects
- Humans, Embolization, Therapeutic, Hemangioma diagnostic imaging, Hemangioma therapy, Liver Neoplasms diagnostic imaging, Liver Neoplasms therapy
- Published
- 2021
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8. Effectiveness of Transarterial Embolization in Treatment of Symptomatic Hepatic Hemangiomas: Systematic Review and Meta-analysis.
- Author
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Torkian P, Li J, Kaufman JA, and Jahangiri Y
- Subjects
- Embolization, Therapeutic methods, Hemangioma diagnosis, Humans, Liver Neoplasms diagnosis, Tomography, X-Ray Computed, Treatment Outcome, Hemangioma therapy, Liver Neoplasms therapy
- Abstract
Purpose: To evaluate the current evidence for the effectiveness of transarterial embolization (TAE) in treatment of symptomatic hepatic hemangiomas., Materials and Methods: A systematic literature review was conducted in PubMed, CINAHL and Scopus databases to identify studies of hepatic hemangiomas treated with transarterial embolization. Main outcome was defined as the mean difference between pre- and post-TAE hemangioma diameters. Treatment agents were categorized as Lipiodol based [bleomycin (L + BE), pingyangmycin (L + PYG) or ethanol (L + ethanol)] and non-Lipiodol based (polyvinyl-alcohol-only). Conventional random-effect meta-analysis technique was applied to analyze data., Results: Of 3080 initially inspected publications, 21 studies were included in the meta-analysis comprising of 1450 patients with total of 1871 hemangiomas (36.2% male, mean age: 46.3 ± 3.6 years). One hundred and twenty-six, 1666, 41 and 38 lesions were treated with L + BE, L + PYG, L + ethanol and PVA, respectively. Median follow-up time after embolization was 12 months. Lipiodol-based treatments showed significant effect in reducing hemangioma size after TAE compared to PVA (P < 0.001). Pooled diameter reduction (cm) (95% confidence interval) was - 4.37( - 5.32, - 3.42), - 4.70( - 5.70, - 3.71), - 0.93( - 2.02, 0.16) for overall TAE treatment, Lipiodol-based and non-Lipiodol-based treatments, respectively. Main complications included post-embolization syndrome and transient liver enzyme elevation (pooled incidence for Lipiodol-based and non-Lipiodol-based techniques: 36% and 33%; and 37% and 0, respectively). No fatal complications were reported. Symptomatic improvement was reported in 63.3%-100% of the cases with majority of studies (15/21) reporting improvement in all cases (pooled response rate: 98%)., Conclusions: Transarterial embolization with bleomycin, pingyangmycin or ethanol in combination with Lipiodol is safe and associated with reduced size of hemangiomas resulting in symptoms alleviation.
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- 2021
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9. Infantile hepatic hemangioma: current state of the art, controversies, and perspectives.
- Author
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Zavras N, Dimopoulou A, Machairas N, Paspala A, and Vaos G
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- Child, Child Health, Child, Preschool, Combined Modality Therapy, Diagnosis, Differential, Global Health, Humans, Infant, Infant, Newborn, Prognosis, Hemangioma diagnosis, Hemangioma epidemiology, Hemangioma etiology, Hemangioma therapy, Liver Neoplasms diagnosis, Liver Neoplasms epidemiology, Liver Neoplasms etiology, Liver Neoplasms therapy
- Abstract
Infantile hepatic hemangioma (IHH) is a common vascular tumor, distinctive for its perinatal presentation, rapid growth during the first year of life, and subsequent involution. Although they generally follow a benign course, some tumors have been reported to undergo malignant transformation. The diagnosis of IHH is based on patient's medical history, physical examination, and imaging. Moreover, the management of this vascular tumor is based on clinical presentation and includes observational, medical, surgical, and radiological interventional treatment options. The present review presents the currently available data in the literature on the diverse aspects of the terminology, epidemiology, clinical presentation, pathogenesis, diagnosis, indications for surgery, malignant potential, and long-term outcomes of these tumors.Conclusion: No formal guidelines have yet been established for the treatment of these hepatic lesions, and the therapeutic strategies implemented vary widely from simple observation to medical, radiological, and surgical interventions in the prism of multidisciplinary teams.What is Known:• Infantile hepatic hemangioma is the most common benign tumor of the liver in infancy, but despite its benign nature, it can present with life-threatening complications.• The treatment strategies range from simple observation to a series of medical, surgical, and radiological interventions.What is New:• This review gives an overview of the developments and current status about the management of IHH.• The aim of this study is to clear up the confusion and controversy that exists about terminology, diagnosis, and treatment of IHH.
- Published
- 2020
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10. Transarterial (Chemo-)Embolization and Lipiodolization for Hepatic Haemangioma.
- Author
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Furumaya A, van Rosmalen BV, Takkenberg RB, van Delden OM, Dejong CHC, Verheij J, and van Gulik TM
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, Chemoembolization, Therapeutic methods, Hemangioma therapy, Liver Neoplasms therapy
- Abstract
Background: Transarterial (chemo-)embolization/lipiodolization (TAE/TAL) might be an attractive minimally invasive alternative to surgery in the treatment of symptomatic hepatic haemangioma. This review assesses the efficacy and safety of TAE/TAL as primary treatment for symptomatic hepatic haemangioma., Methods: A systematic search of the literature was performed by two reviewers following the PRISMA guidelines. Cohort studies and case reports were identified; outcomes of cohort studies were reported. The primary efficacy outcome was tumour size before and after TAE/TAL. Improvement of symptoms and quality of life (QoL) were secondary outcomes; the primary safety outcome was complications. The Downs and Black statement was used for quality assessment., Results: Eighteen cohort studies were identified, including 1284 patients. TAE/TAL led to a decrease in tumour size in 1100/1223 (89.9%) patients and to improvement or disappearance of symptoms in 1080/1096 (98.5%) patients. A significant decrease in tumour size from 9.79 ± 0.79 cm to 4.00 ± 1.36 cm (p < 0.001) was shown. Grade 3 complications occurred in 37/1284 (2.9%) patients. Surgical treatment was necessary in 35/1284 (2.7%) of patients., Conclusion: TAE/TAL appears to be a promising and safe treatment to decrease tumour size of hepatic haemangioma. The technique might also provide partial relief of symptoms, although no randomized clinical trials or prospective studies using validated QoL questionnaires are available. TAE/TAL may be considered as a viable alternative to resection.
- Published
- 2019
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11. Transarterial Bleomycin-Lipiodol Embolization (B/LE) for Symptomatic Giant Hepatic Hemangioma.
- Author
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Akhlaghpoor S, Torkian P, and Golzarian J
- Subjects
- Adult, Feasibility Studies, Female, Hemangioma diagnostic imaging, Humans, Liver Neoplasms diagnostic imaging, Male, Middle Aged, Retrospective Studies, Tomography, X-Ray Computed, Treatment Outcome, Antibiotics, Antineoplastic therapeutic use, Bleomycin therapeutic use, Chemoembolization, Therapeutic methods, Ethiodized Oil therapeutic use, Hemangioma therapy, Liver Neoplasms therapy
- Abstract
Background: Large hepatic hemangiomas can cause symptoms such as pain and bleeding. No consensus currently exists on the optimal management of large and symptomatic hemangiomas. The purpose of this study was to evaluate the role of transarterial bleomycin-lipiodol embolization (B/LE) in the treatment of symptomatic large hepatic hemangioma., Materials and Methods: We retrospectively reviewed 23 patients (29 hemangiomas) treated between July 2011 and August 2017. Transarterial B/LE was performed using 7-15 cc of Lipiodol mixed with 30-45 IU of bleomycin by standard three-way stopcocks. All patients were followed clinically and by imaging for an average of 7.5 months. Patterns of bleomycin-lipiodol distribution in the periphery of hemangiomas were categorized into four different grades. Technical success was defined as proper delivery of bleomycin-lipiodol into the hemangioma confirmed by post-embolization computed tomography. Clinical success was defined as more than 50% reduction of hemangioma volume and symptom improvement during follow-ups., Results: Technical success and clinical success were 100 and 73.9% (17 patients), respectively. Six patients (26.08%) experienced transient post-embolization syndrome. Significant size reduction was seen in patients with grade 4 hemangioma border coverage (P = 0.042)., Conclusion: Transarterial B/LE is a safe and efficient alternative for controlling symptoms related to large hemangiomas.
- Published
- 2018
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12. Multiple Enlarged Aneurysms in Primary Racemose Hemangioma of the Bronchial Artery: Successful Prophylactic Transcatheter Arterial Embolization Using N-butyl-2-cyanoacrylate and Coils.
- Author
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Saiga A, Sugiura T, Higashide T, Tsuchiya S, Nishiyama A, Kubota Y, Horikoshi T, and Uno T
- Subjects
- Aneurysm complications, Aneurysm diagnostic imaging, Bronchial Arteries diagnostic imaging, Bronchial Diseases complications, Bronchial Diseases diagnostic imaging, Computed Tomography Angiography methods, Diagnosis, Differential, Hemangioma complications, Hemangioma diagnostic imaging, Humans, Iodized Oil therapeutic use, Male, Middle Aged, Aneurysm therapy, Bronchial Diseases therapy, Embolization, Therapeutic methods, Enbucrilate therapeutic use, Hemangioma therapy
- Abstract
An asymptomatic 48-year-old man presented with multiple aneurysms in a primary racemose hemangioma of the right bronchial artery. Bronchial arteriography revealed a tortuous artery with four fusiform aneurysms of varying sizes and aneurysmal dilatation with marked thrombus formation in the long segment of the distal portion. Because the tip of catheter could not pass beyond the aneurysmal dilatation, we performed balloon-occluded embolization using a mixture of N-butyl-2-cyanoacrylate (NBCA) and iodized oil. For four other aneurysms, we performed embolization using a coil alone or with NBCA. After 6 months, right bronchial arteriography revealed no enhancement of the aneurysms. Despite the rarity of this procedure, embolization with NBCA is a good option for bronchial artery aneurysm embolization.
- Published
- 2018
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13. Tufted angiomas of the head and neck.
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Häußler SM, Uecker FC, Knopke S, Roßner F, Olze H, and Böttcher A
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- Adult, Child, Female, Humans, Male, Hemangioma diagnosis, Hemangioma therapy, Skin Neoplasms diagnosis, Skin Neoplasms therapy
- Abstract
Background: Tufted angiomas (TAs) are uncommon benign vascular tumors mostly located cutaneously or subcutaneously in the skin of the neck and upper trunk, which appear during childhood and grow slowly. TAs are a variant of lobular capillary hemangiomas. This is the first study to provide an overview of the current literature in combination with the authors' own clinical experience on this rare entity in the head and neck area with non-dermatological localization., Methods: A selective Medline and Google Scholar database search was performed. Additionally, we conducted an ICD-10-based database search on hemangiomas (D18.0) in the Charité SAP patient records., Results: We identified 13 reports in the literature consisting of 16 cases of TA of the head and neck. Males were predominantly affected by TAs (70.6%). The mean age of the patients at the time of surgery was 31.5 years; the mean maximum diameter of the tumors was 16.3 mm. Additionally, we report on one case of TA in our Department of Head and Neck Surgery. A male patient presented with swelling and redness of the left upper eyelid. Radiological examination with computed tomography showed a suprabulbar tumor with a diameter of 13 mm. The tumor was surgically removed via a transcutaneous blepharoplasty approach with the patient under general anesthesia., Discussion: There is only one other case report on the surgical excision of an intra-orbital TA described to date. Here, we present an epidemiological overview, therapeutic considerations, and differential diagnoses.
- Published
- 2018
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14. [Acute complications of vascular anomalies in childhood].
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Fließer M, Teichler A, and Höger PH
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- Child, Child, Preschool, Diagnosis, Differential, Hemangioendothelioma complications, Hemangioendothelioma diagnosis, Hemangioendothelioma therapy, Hemangioma complications, Hemangioma diagnosis, Hemangioma therapy, Humans, Infant, Infant, Newborn, Kasabach-Merritt Syndrome complications, Kasabach-Merritt Syndrome diagnosis, Kasabach-Merritt Syndrome therapy, Klippel-Trenaunay-Weber Syndrome complications, Klippel-Trenaunay-Weber Syndrome diagnosis, Klippel-Trenaunay-Weber Syndrome therapy, Sarcoma, Kaposi complications, Sarcoma, Kaposi diagnosis, Sarcoma, Kaposi therapy, Vascular Malformations diagnosis, Vascular Malformations therapy, Vascular Neoplasms diagnosis, Vascular Neoplasms therapy, Vascular Malformations complications
- Abstract
Congenital and acquired vascular anomalies are common in childhood. In addition to predominantly harmless vascular skin alterations there are others which must be immediately treated due to the potentially threatening complications. As examples three anomalies and the typical complications are presented. Hemangiomas in infancy can make urgent treatment necessary because they can be complicated by obstruction or painful ulceration. Kaposiform hemangioendothelioma can lead to a life-threatening consumption coagulopathy. Klippel-Trenaunay syndrome can be complicated by thrombosis, localized coagulopathy, and superinfections.
- Published
- 2017
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15. Treatment of infantile haemangiomas: recommendations of a European expert group.
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Hoeger PH, Harper JI, Baselga E, Bonnet D, Boon LM, Ciofi Degli Atti M, El Hachem M, Oranje AP, Rubin AT, Weibel L, and Léauté-Labrèze C
- Subjects
- Administration, Topical, Adrenergic beta-Antagonists therapeutic use, Aortic Coarctation complications, Cryotherapy, Diagnosis, Differential, Esthetics, Eye Abnormalities complications, Glucocorticoids therapeutic use, Hemangioma diagnosis, Humans, Immunosuppressive Agents therapeutic use, Infant, Laser Therapy, Neurocutaneous Syndromes complications, Phototherapy, Propranolol therapeutic use, Risk Factors, Sirolimus therapeutic use, Vascular Neoplasms diagnosis, Watchful Waiting, Hemangioma therapy
- Abstract
Unlabelled: With a prevalence of 2.6-4.5 %, infantile haemangiomas (IH) represent the most common tumour of infancy. While the majority of IH does not require therapy and regresses spontaneously, about 10 % of IH exhibit complications such as obstruction, ulceration or disfigurement. With the advent of oral propranolol, many conventional treatment options have become obsolete. This paper summarizes current recommendations for management of complicated IH. These recommendations have been written by an expert group after a consensus process including bibliographic review, several drafts of synthesis, meetings with quantitative voting system and redaction of an approved final manuscript., Conclusion: Oral propranolol is the first-line agent for the treatment of complicated IH., What Is Known: • Infantile haemangiomas (IH) are the most common tumours of infancy. Within a very short period after its discovery and long before the publication of randomized controlled trials, propranolol has become the number one agent for the treatment of complicated IH. What is New: • We report IH treatment recommendations of an international, interdisciplinary team of experts, based on an up-to-date review of the literature.
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- 2015
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16. Aggressive vertebral hemangioma treated with combination of vertebroplasty and sclerotherapy through transpedicular and direct approach.
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Kelekis A, Filippiadis DK, Martin JB, and Kelekis NL
- Subjects
- Bone Cements therapeutic use, Combined Modality Therapy, Contrast Media, Diagnosis, Differential, Fluoroscopy, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Pain Measurement, Polymethyl Methacrylate therapeutic use, Radiography, Interventional, Tomography, X-Ray Computed, Hemangioma diagnosis, Hemangioma therapy, Sclerotherapy, Spinal Neoplasms diagnosis, Spinal Neoplasms therapy, Vertebroplasty
- Published
- 2014
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17. Minimally invasive treatment of giant haemangiomas of the liver: embolisation with bleomycin.
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Bozkaya H, Cinar C, Besir FH, Parıldar M, and Oran I
- Subjects
- Adult, Aged, Antibiotics, Antineoplastic administration & dosage, Antineoplastic Agents administration & dosage, Bleomycin administration & dosage, Diagnostic Imaging, Ethiodized Oil administration & dosage, Female, Hemangioma diagnosis, Humans, Liver Neoplasms diagnosis, Male, Middle Aged, Treatment Outcome, Chemoembolization, Therapeutic methods, Hemangioma therapy, Liver Neoplasms therapy
- Abstract
Purpose: The management of patients with giant haemangioma of the liver remains controversial. Although the usual treatment method for symptomatic giant haemangioma is surgery, the classical paradigm of operative resection remains. In this study, we evaluated the symptomatic improvement and size-reduction effect of embolisation with bleomycin mixed with lipiodol for the treatment of symptomatic giant hepatic haemangioma., Methods: This study included 26 patients [21 female, five male; age 41-65 years (mean 49.83 ± 1.53)] with symptomatic giant haemangioma unfit for surgery and treated with selective embolisation by bleomycin mixed with lipiodol. The patients were followed-up (mean 7.4 ± 0.81 months) clinically and using imaging methods. Statistical analysis was performed using SPSS version 16.0, and p < 0.05 was considered to indicate statistical significance., Results: Embolisation of 32 lesions in 26 patients was performed. The mean volume of the haemangiomas was 446.28 ± 88 cm(3) (range 3.39-1559 cm(3)) before intervention and 244.43 ± 54.38 cm(3) (range 94-967 cm(3)) after intervention. No mortality or morbidity related to the treatment was identified. Symptomatic improvement was observed in all patients, and significant volume reduction was achieved (p = 0.001)., Conclusion: The morbidity of surgical treatment in patients with giant liver hemangioma were similar to those obtained in patients followed-up without treatment. Therefore, follow-up without treatment is preferred in most patients. Thus, minimally invasive embolisation is an alternative and effective treatment for giant symptomatic haemangioma of the liver.
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- 2014
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18. [Hemangioma and vascular malformations in the head and neck region as a prime example of interdisciplinarity].
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Werner JA
- Subjects
- Humans, Patient Care Team, Head and Neck Neoplasms diagnosis, Head and Neck Neoplasms therapy, Hemangioma diagnosis, Hemangioma therapy, Vascular Malformations diagnosis, Vascular Malformations therapy
- Published
- 2014
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19. Photodynamic therapy suppresses tumor growth in an in vivo model of human hemangioma.
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Choi J, Kim WJ, Park SW, Xu L, Kim SH, Min HS, Kwon GY, Cho CH, Kim S, and Choi TH
- Subjects
- Activating Transcription Factor 3 biosynthesis, Animals, Apoptosis, Child, Dihematoporphyrin Ether therapeutic use, Female, Glucose Transporter Type 1 biosynthesis, Humans, Male, Mice, Mice, Nude, Neoplasm Transplantation, Photosensitizing Agents therapeutic use, Platelet Endothelial Cell Adhesion Molecule-1 analysis, Transplantation, Heterologous, Hemangioma therapy, Photochemotherapy
- Abstract
The authors investigated the efficacy of photodynamic therapy against infantile hemangioma using a hemangioma animal model. Eighty-three hemangioma specimens from five children were implanted into nude mice. The gross and volume changes of the implants were evaluated for up to 13 weeks. The histological change of the implant was evaluated at 5 weeks after transplantation. Photodynamic therapy was performed between 6 and 10 weeks after transplantation. The photosensitizer uptake of the implant was evaluated at 24 h after photosensitizer administration. The implant response was evaluated at 0, 12, and 24 h after light delivery. The change in ATF3 levels, a transcription factor induced under severe hypoxic conditions, was investigated immediately after treatment. The implant volume increased slowly during the first 4 weeks and then involuted. At 5 weeks after transplantation, plump endothelial cells formed tightly packed sinusoidal channels, and the endothelial cells were positive for CD31 and GLUT1 expression. At 24 h after photosensitizer administration, confocal analysis showed that the photosensitizer was present within CD31-positive cells. The implant volume was significantly decreased in the treated implants compared with the untreated implants (p < 0.0001). At 24 h after light delivery, most cells had collapsed. ATF3 expression increased gradually and then reached a maximum level at 4 h after treatment. Photodynamic therapy was effective in the treatment of infantile hemangioma. Apoptosis, a major mechanism of hemangioma destruction in the early phase, might be caused by ischemic injury as well as direct effects of photodynamic therapy.
- Published
- 2014
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20. [Overview: liver tumors].
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Graziadei I
- Subjects
- Adenoma, Liver Cell diagnosis, Adenoma, Liver Cell pathology, Adenoma, Liver Cell therapy, Bile Duct Neoplasms diagnosis, Bile Duct Neoplasms pathology, Bile Duct Neoplasms therapy, Bile Ducts, Intrahepatic pathology, Carcinoma, Hepatocellular diagnosis, Carcinoma, Hepatocellular pathology, Carcinoma, Hepatocellular therapy, Cholangiocarcinoma diagnosis, Cholangiocarcinoma pathology, Cholangiocarcinoma therapy, Diagnosis, Differential, Diagnostic Imaging, Female, Focal Nodular Hyperplasia diagnosis, Focal Nodular Hyperplasia pathology, Focal Nodular Hyperplasia therapy, Hemangioma diagnosis, Hemangioma pathology, Hemangioma therapy, Humans, Incidental Findings, Liver pathology, Liver Neoplasms pathology, Liver Neoplasms secondary, Male, Minimally Invasive Surgical Procedures, Neoplasm Staging, Prognosis, Liver Neoplasms diagnosis, Liver Neoplasms therapy
- Abstract
Since the introduction of abdominal ultrasound liver lesions have been increasingly detected. Being usually diagnosed by chance these lesions create psychological stress among patients because a potential malignant disease has to be taken into consideration. The increasing use of oral contraceptives with high estrogen doses starting in the 1980s led to a rising incidence of adenomas, whose natural history differed from those described in surgical and autoptic studies. This fact brought about a change towards a modern pathophysiologic and prognostic differentiation. Current histologic and molecular biological techniques are able to distinguish benign adenomas from those with malignant potential.
- Published
- 2013
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21. [Hemangioma. New aspects of pathogenesis, differential diagnosis and therapy].
- Author
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Höger PH
- Subjects
- Child, Child, Preschool, Female, Humans, Infant, Newborn, Male, Vasodilator Agents therapeutic use, Cryotherapy methods, Hemangioma diagnosis, Hemangioma therapy, Propranolol therapeutic use, Skin Neoplasms diagnosis, Skin Neoplasms therapy
- Abstract
With a prevalence of 10–12% infantile hemangiomas (IH) represent the most common skin tumor in infancy. They are characterized by a sequence of growth and, in 90%, spontaneous regression. Special manifestations of IH include hemangiomatosis, congenital hemangioma (RICH/NICH), reticular and segmental hemangiomas (PHACE, PELVIS/SACRAL syndrome). The latter represent a transition between vascular tumor and vascular malformation. Important differential diagnoses of IH include pyogenic granuloma (PG) and hemangioendothelioma (HAE) of which PG is a common, benign vascular tumor with a predilection for the facial region and a proneness to bleed whereas HAE is a slowly growing tumor exhibiting infiltrative growth; unlike IH it is associated with the Kasabach-Merritt syndrome of consumptive coagulopathy. The majority of IHs do not require therapy, however, therapy is absolutely indicated for ulcerating or obstructive IH where propranolol is considered the first-line therapy. Non-obstructive facial IH represents a relative indication for therapy. Cryotherapy is most suitable for IH with diameters below 1 cm and a depth < 4 mm.
- Published
- 2012
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22. Pediatric vascular malformations: pathophysiology, diagnosis, and the role of interventional radiology.
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Cahill AM and Nijs EL
- Subjects
- Angiography, Arteriovenous Fistula diagnosis, Arteriovenous Fistula genetics, Arteriovenous Fistula physiopathology, Arteriovenous Fistula therapy, Arteriovenous Malformations diagnosis, Arteriovenous Malformations genetics, Child, Child, Preschool, Embolization, Therapeutic methods, Female, Fluoroscopy, Hemangioma diagnosis, Hemangioma genetics, Humans, Infant, Infant, Newborn, Lymphangioma diagnosis, Lymphangioma genetics, Magnetic Resonance Imaging, Male, Phlebography, Sclerotherapy methods, Tomography, X-Ray Computed, Ultrasonography, Ultrasonography, Doppler, Color, Veins abnormalities, Arteriovenous Malformations physiopathology, Arteriovenous Malformations therapy, Hemangioma physiopathology, Hemangioma therapy, Lymphangioma physiopathology, Lymphangioma therapy, Radiology, Interventional methods
- Abstract
The Mulliken and Glowacki classification (1982) differentiated vascular anomalies into two groups based on their endothelial characteristics: hemangiomas and vascular malformations. Vascular anomalies are localized defects of the vasculature that affect a limited number of vessels in a restricted area of the body. These defects are secondary to errors in vascular morphogenesis. Depending on the type of vessel involved, the vascular malformation group was subdivided into high-flow (such as arteriovenous malformation and arteriovenous fistula) and low-flow lesions (such as venous and lymphatic malformations). Depending on the type of lesion, the location and degree of involvement and the clinical effect, different types of treatment would be required. For the purpose of this review, we concentrate solely on vascular malformations: the clinical features, genetics, diagnosis, and current treatment options.
- Published
- 2011
- Full Text
- View/download PDF
23. Bleeding scrotal vascular lesions: interventional management with transcatheter embolization.
- Author
-
Jaganathan S, Gamanagatti S, Mukund A, and Dhar A
- Subjects
- Adult, Angiography, Digital Subtraction, Arteriovenous Malformations diagnostic imaging, Child, Preschool, Diagnosis, Differential, Follow-Up Studies, Genital Neoplasms, Male diagnostic imaging, Hemangioma diagnostic imaging, Hemorrhage diagnostic imaging, Humans, Male, Arteriovenous Malformations therapy, Embolization, Therapeutic methods, Genital Neoplasms, Male therapy, Hemangioma therapy, Hemorrhage therapy, Scrotum blood supply
- Abstract
Vascular lesions of the scrotum are uncommon; the most common among them are varicocele lesions. The other vascular lesions that may involve the scrotum are hemangioma, lymphangioma, and arteriovenous malformations, which are exceedingly rare. The imaging modalities useful in the diagnosis and management of scrotal vascular lesions are grayscale sonography, color Doppler sonography, magnetic resonance imaging, magnetic resonance angiography, and digital subtraction angiography. We present two cases of scrotal vascular lesions involving the extratesticular scrotal soft tissues. Patients presented with bleeding and were treated by radiological interventional technique. We emphasize the importance of superselective catheterization and distal embolization.
- Published
- 2011
- Full Text
- View/download PDF
24. PHACES association: a vasculocutaneous syndrome.
- Author
-
Rao RP, Drolet BA, Holland KE, and Frommelt PC
- Subjects
- Face, Female, Hemangioma therapy, Humans, Infant, Infant, Newborn, Male, Skin Neoplasms therapy, Syndrome, Abnormalities, Multiple, Aorta, Thoracic abnormalities, Hemangioma complications, Skin Neoplasms complications, Vascular Malformations complications, Vascular Malformations surgery
- Abstract
PHACES association is a spectrum of anomalies that might occur in infants with large facial hemangiomas. Most infants with PHACES association have segmental hemangiomas of the head or neck. Cardiac and cerebrovascular anomalies might be the most important association, as they carry a significant risk of complications. This article summarizes the dermatologic, cardiac, and cerebral vascular findings in a cohort of infants diagnosed with PHACES association. All had large segmental facial hemangiomas and aortic arch abnormalities. Four of the five were not suspected of having arch obstruction prior to imaging studies because of the aberrant origin of both subclavian arteries, and 4/5 required either interventional or surgical repair for arch obstruction. In contrast to classic aortic coarctation, the aortic anomalies found in the cohort had unusually complex and unpredictable anatomic involvement. Cerebral vascular anomalies were identified in 5/5, and 2/5 had neurologic complications secondary to abnormal cerebral vascular supply. It is important for care providers to recognize this association that presents with a cutaneous stigma, as it is associated with potentially lethal and often unrecognized vascular anomalies. Earlier recognition of the associated vascular pathologies might enable preemptive treatments before potentially devastating and irreversible sequelae.
- Published
- 2008
- Full Text
- View/download PDF
25. Percutaneous pediculoplasty for vertebral hemangioma involving the neural arch: a case report.
- Author
-
Fuwa S, Numaguchi Y, Kobayashi N, and Saida Y
- Subjects
- Adult, Back Pain etiology, Bone Cements therapeutic use, Female, Fractures, Compression diagnosis, Fractures, Compression etiology, Fractures, Compression therapy, Hemangioma diagnosis, Humans, Magnetic Resonance Imaging, Polymethyl Methacrylate therapeutic use, Spinal Fractures diagnosis, Spinal Fractures etiology, Spinal Fractures therapy, Spinal Neoplasms complications, Spinal Neoplasms diagnosis, Tomography, X-Ray Computed, Hemangioma therapy, Spinal Neoplasms therapy, Thoracic Vertebrae diagnostic imaging, Thoracic Vertebrae pathology, Vertebroplasty methods
- Abstract
Vertebral hemangiomas occasionally involve the neural arch and they can be symptomatic. We report a case of symptomatic vertebral hemangioma mainly involving the unilateral neural arch which was successfully treated with percutaneous pediculoplasty using a single-needle technique.
- Published
- 2008
- Full Text
- View/download PDF
26. [Blue-rubber-bleb-nevus syndrome].
- Author
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Tartler U, Stege H, Moritz A, and Reifenberger J
- Subjects
- Gastrointestinal Neoplasms therapy, Hemangioma therapy, Humans, Male, Nevus, Blue therapy, Skin Neoplasms therapy, Syndrome, Arm pathology, Gastrointestinal Neoplasms pathology, Hemangioma pathology, Nevus, Blue pathology, Skin Neoplasms pathology
- Published
- 2005
- Full Text
- View/download PDF
27. [Hemangiomas and vascular malformations in the area of the head and neck].
- Author
-
Ernemann U, Hoffmann J, Grönewäller E, Breuninger H, Rebmann H, Adam C, and Reinert S
- Subjects
- Adolescent, Child, Child, Preschool, Diagnosis, Differential, Head and Neck Neoplasms classification, Head and Neck Neoplasms diagnosis, Head and Neck Neoplasms therapy, Hemangioma classification, Hemangioma diagnosis, Hemangioma therapy, Humans, Infant, Infant, Newborn, Intracranial Arteriovenous Malformations classification, Intracranial Arteriovenous Malformations therapy, Patient Care Team, Prognosis, Diagnostic Imaging, Head and Neck Neoplasms congenital, Hemangioma congenital, Image Enhancement, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Intracranial Arteriovenous Malformations diagnosis
- Abstract
The treatment of paediatric patients with extended vascular anomalies in the head and neck requires a multidisciplinary approach involving paediatricians, maxillofacial surgeons, dermatologists and radiologists. Therapeutic strategies are based on an internationally accepted classification of vascular anomalies, which distinguishes haemangiomas and vascular malformations. Whereas haemangiomas are endothelial proliferations, vascular malformations are considered to be developmental anomalies which are classified into high-flow or low-flow lesions and, according to their vascular channels, into capillary, lymphatic or venous malformations. In this review we present guidelines for the diagnostic assessment of paediatric patients with vascular anomalies in the head and neck region. The indications for treatment are discussed and therapeutic options are outlined.
- Published
- 2003
- Full Text
- View/download PDF
28. Percutaneous technique for sclerotherapy of vertebral hemangioma compressing spinal cord.
- Author
-
Gabal AM
- Subjects
- Adult, Embolization, Therapeutic, Female, Hemangioma complications, Hemangioma diagnostic imaging, Humans, Injections, Intralesional, Lumbar Vertebrae, Male, Middle Aged, Oleic Acids administration & dosage, Sclerosing Solutions administration & dosage, Spinal Cord Compression diagnostic imaging, Spinal Neoplasms complications, Spinal Neoplasms diagnostic imaging, Thoracic Vertebrae, Hemangioma therapy, Radiography, Interventional, Sclerotherapy methods, Spinal Cord Compression etiology, Spinal Neoplasms therapy, Tomography, X-Ray Computed
- Abstract
Purpose: In this study we report a percutaneous technique to achieve sclerosis of vertebral hemangioma and decompression of the spinal cord and nerve roots., Methods: Under CT guidance the affected vertebral body is punctured by a biopsy needle and sclerosant is injected directly into the tumor. In the case of large paravertebral extension, additional injection is given in the paravertebral soft tissue component to induce shrinkage of the whole tumor mass and release of the compressed spinal cord., Results: Using this technique we treated five patients in whom vertebral hemangioma gave rise to neurologic symptoms. In three patients, sclerotherapy was the only treatment given. In the other two patients, sclerotherapy was preceded by transcatheter embolization. Neither decompressive surgery, radiation therapy nor stabilization was required with this technique., Conclusion: Our experience with CT-guided intraosseous sclerotherapy has proved highly satisfactory.
- Published
- 2002
- Full Text
- View/download PDF
29. [Current status of laser therapy of hemangioma in infants. Case reports and review of the literature].
- Author
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Werner S and Raulin C
- Subjects
- Child, Child, Preschool, Equipment Design, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Facial Neoplasms therapy, Hemangioma therapy, Laser Therapy, Skin Neoplasms therapy
- Abstract
Today the management of hemangiomas is still a great challenge for physicians, even for the most experienced of clinicians. With the introduction of lasers, new ways of treating hemangiomas have been found. Four case reports document the importance of early treatment. In addition, the differentiated use of various laser systems and their effects, limitations, and side effects are shown and discussed.
- Published
- 1999
- Full Text
- View/download PDF
30. [Percutaneous therapeutic embolization in therapy refractory, non-traumatic epistaxis].
- Author
-
Kramann B, Roth R, Schneider G, Uder M, Federspil P, and Iro H
- Subjects
- Adult, Aged, Angiography, Epistaxis diagnostic imaging, Epistaxis etiology, Female, Follow-Up Studies, Hemangioma complications, Hemangioma diagnostic imaging, Hemangioma therapy, Humans, Male, Middle Aged, Nose Neoplasms complications, Nose Neoplasms diagnostic imaging, Nose Neoplasms therapy, Retreatment, Telangiectasia, Hereditary Hemorrhagic complications, Telangiectasia, Hereditary Hemorrhagic diagnostic imaging, Telangiectasia, Hereditary Hemorrhagic therapy, Embolization, Therapeutic, Epistaxis therapy
- Abstract
Unlabelled: The records of 24 patients with severe intractable non-traumatic epistaxis were reviewed to evaluate the efficacy of embolism therapy., Material and Method: The histories of 17 patients with idiopathic epistaxis, 6 patients with Osler-Rendu-Weber disease and 1 patient with a high-flow angioma were analyzed. All patients were treated by means of percutaneous embolization of the maxillary artery and its branches., Results: In 5/17 patients with idiopathic epistaxis repeat embolization was necessary in 5 cases, while permanent hemostasis was achieved in 16/17 patients with embolism alone. Five of the 6 patients with Osler-Rendu-Weber disease labelled stage III before treatment were managed successfully with repeated embolizations, while all cases were reduced to stage I disease. The high-flow angioma was successfully ablated after embolization combined with direct injection of thrombosing material and laser resection.
- Published
- 1998
- Full Text
- View/download PDF
31. Development of a testicular haemangioma after interferon therapy for hepatic haemangiomas: a case report.
- Author
-
Yanai S, Tsutsumi H, Hotsubo T, Takahashi A, Miyao N, Satoh M, and Chiba S
- Subjects
- Hemangioma diagnostic imaging, Hemangioma pathology, Humans, Infant, Injections, Subcutaneous, Interferon alpha-2, Interferon-alpha administration & dosage, Liver Neoplasms diagnostic imaging, Liver Neoplasms pathology, Male, Neoplasms, Second Primary diagnostic imaging, Neoplasms, Second Primary pathology, Orchiectomy, Radiography, Recombinant Proteins, Testicular Neoplasms diagnostic imaging, Testicular Neoplasms pathology, Testis pathology, Hemangioma chemically induced, Hemangioma therapy, Interferon-alpha adverse effects, Liver Neoplasms therapy, Neoplasms, Second Primary chemically induced, Testicular Neoplasms chemically induced
- Abstract
Unlabelled: We report a 2-month-old Japanese boy presenting with large multiple haemangiomas invading his liver. He was treated with daily subcutaneous injection of interferon alfa (IFN-alpha)-2a with progressive reduction of the hepatic haemangioma. He developed a scrotal mass 2 months after discontinuation of IFN, and this mass eventually required surgical management. Resected tumour was a juvenile haemangioma. The escape of this haemangioma from IFN therapy may be correlated to the quite low level of injected IFN in testis., Conclusion: IFN therapy may not be curative for testicular haemangioma although it is effective in shrinking haemangiomas of the liver and skin.
- Published
- 1997
- Full Text
- View/download PDF
32. [Differential therapy of cerebral angiomas].
- Author
-
Grzyska U, Neumaier Probst E, Koch C, and Westphal M
- Subjects
- Adult, Brain Neoplasms diagnostic imaging, Brain Neoplasms mortality, Female, Hemangioma diagnostic imaging, Hemangioma mortality, Humans, Intracranial Arteriovenous Malformations diagnostic imaging, Intracranial Arteriovenous Malformations mortality, Male, Patient Care Team, Radiography, Survival Rate, Treatment Outcome, Brain Neoplasms therapy, Embolization, Therapeutic, Hemangioma therapy, Intracranial Arteriovenous Malformations therapy, Microsurgery
- Abstract
Patients with cerebral arteriovenous malformations (cAVMs) are usually young at the time of diagnosis with a mean age of 32 years. These patients are in a crucial phase of their lives, starting a family and establishing a professional position. Facing a relative annual risk of 2 to 3% for a severe hemorrhage which cumulates to a 50% risk of hemorrhage over the next four decades of their lives, these patients have to make the decision about possible treatment of their cAVM. Advice can only be given to the patients on an individual basis because there are almost no two identical lesions. Nevertheless, based on a grading system and within established treatment regimens, risk estimations are possible and particularly with close neuroradiological/neurosurgical cooperation these risks can be defined and minimized. In this context we report a series of 184 patients with cAVMs which were taken care of at the Departments of Neurosurgery and Neuroradiology at the University of Hamburg between February 1988 and July 1996 and who were treated according to a standardized joint protocol with interventional and microsurgical options.
- Published
- 1997
33. Interferon-alpha therapy for multiple hemangiomas associated with coarctation of the aorta.
- Author
-
Hijii T, Fukushige J, Tasaki K, and Ueda K
- Subjects
- Aortic Coarctation diagnosis, Aortic Coarctation surgery, Face, Female, Follow-Up Studies, Hemangioma complications, Hemangioma congenital, Humans, Infant, Neck, Skin Neoplasms complications, Skin Neoplasms congenital, Antineoplastic Agents therapeutic use, Aortic Coarctation complications, Hemangioma therapy, Interferon-alpha therapeutic use, Skin Neoplasms therapy
- Abstract
We report a rare combination of multiple hemangiomas and coarctation of the aorta in a 2-month-old female infant who responded to interferon-alpha (IFN-alpha) therapy. The coarctation was repaired successfully with the use of an artificial graft. In patients with symptomatic hemangiomas that do not respond to steroid therapy, IFN-alpha therapy should be considered.
- Published
- 1996
- Full Text
- View/download PDF
34. Diffuse neonatal haemangiomatosis with intra-uterine haemorrhage and hydrops fetalis: a case report.
- Author
-
Wu TJ and Teng RJ
- Subjects
- Anemia, Neonatal etiology, Fatal Outcome, Fetal Diseases physiopathology, Heart Failure etiology, Hemangioma complications, Hemangioma pathology, Hemangioma therapy, Humans, Infant, Newborn, Male, Neoplasms, Multiple Primary pathology, Hemangioma congenital, Hydrops Fetalis complications, Neoplasms, Multiple Primary congenital
- Abstract
A case of diffuse neonatal haemangiomatosis involving the skin, liver, lungs, adrenals, gums, diaphragm, skull, and testes is reported. Intra-uterine onset of bleeding led to bloody amniotic fluid, severe anaemia, congestive heart failure, and hydrops fetalis. Intractable coagulopathy and renal failure resulted in persistent bleeding, anuria, metabolic acidosis, and hyperkalaemia, leading to a fatal outcome.
- Published
- 1994
- Full Text
- View/download PDF
35. [Subarachnoid hemorrhage caused by spinal arteriovenous angioma. Diagnostic difficulties and therapeutic possibilities].
- Author
-
Herb E, Brückmann H, and Freudenberger T
- Subjects
- Adult, Angiography, Diagnosis, Differential, Embolization, Therapeutic, Hemangioma therapy, Humans, Male, Recurrence, Spinal Cord blood supply, Spinal Cord Neoplasms therapy, Subarachnoid Hemorrhage therapy, Hemangioma diagnosis, Spinal Cord Neoplasms diagnosis, Subarachnoid Hemorrhage diagnosis
- Abstract
In a young patient with spinal angioma, the diagnosis was not established until the fourth episode of bleeding. Exemplified by this case, the clinical symptomatology of spinal subarachnoid hemorrhage is described, and the diagnostic and therapeutic procedures are reviewed. In patients with SAH it is necessary to look for spinal symptoms, especially if cerebral angiography proves negative. In diagnosing a spinal SAH priority should be given to myelography and/or MRT, followed by spinal angiography.
- Published
- 1994
36. [Angiographic occult vascular abnormalities in the area of the pons. Two case reports].
- Author
-
Marák R and Muchová B
- Subjects
- Adult, Brain Neoplasms diagnosis, Brain Neoplasms therapy, Cerebral Angiography, Diagnosis, Differential, Empty Sella Syndrome diagnosis, Empty Sella Syndrome therapy, Female, Hemangioma diagnosis, Hemangioma therapy, Humans, Hypophysectomy, Intracranial Arteriovenous Malformations therapy, Magnetic Resonance Imaging, Neurologic Examination, Postoperative Complications diagnosis, Postoperative Complications therapy, Radiosurgery, Subarachnoid Hemorrhage diagnosis, Subarachnoid Hemorrhage therapy, Intracranial Arteriovenous Malformations diagnosis, Pons blood supply
- Abstract
On the basis of two case reports of occult vascular malformation of the pons that had been followed since the first clinical manifestation, clinical picture, diagnosis using modern imaging methods (especially magnetic resonance imaging--MRI) and therapy of this disease are discussed. In addition to a precise localization diagnosis based on typical scans of varying signal intensity, particularly after bleeding, MRI also allows a preoperative qualitative identification of the lesion and provides important information about the dynamics of the process. Further experience with this uncommon clinical category will improve the early diagnosis and selection of an adequate therapy because the technique of stereotactic radiotherapy (gamma-knife) appears to be most suitable.
- Published
- 1993
37. Selective arterial embolization in the treatment of aneurysmal bone cyst and angioma of bone.
- Author
-
De Cristofaro R, Biagini R, Boriani S, Ricci S, Ruggieri P, Rossi G, Fabbri N, and Roversi R
- Subjects
- Adolescent, Adult, Bone Cysts diagnostic imaging, Bone Neoplasms diagnostic imaging, Female, Femur, Hemangioma diagnostic imaging, Humans, Humerus, Male, Middle Aged, Osteogenesis, Polyvinyl Alcohol therapeutic use, Radiography, Remission Induction, Spinal Diseases therapy, Spinal Neoplasms therapy, Steel, Bone Cysts therapy, Bone Neoplasms therapy, Embolization, Therapeutic, Hemangioma therapy
- Abstract
Nineteen aneurysmal bone cysts and five angiomas of bone were treated by selective arterial embolization. The median follow-up was 22 months. In 17 patients healing occurred with complete relief of symptoms; in 11 of these almost complete ossification of the lesion resulted. In the remaining cases, little or no ossification was apparent but ossification may take 1 year or more to occur. No recurrence was observed in any of these cases. Recurrence occurred only in two cases. In one, growth of the recurrence stopped after a second embolization, and the X-rays showed no change. Selective arterial embolization represents a treatment of choice in aneurysmal bone cyst and angioma of bone especially of the spine, sacrum, or pelvis. In these sites embolization replaces surgery which might be hazardous due to intraoperative bleeding.
- Published
- 1992
- Full Text
- View/download PDF
38. Diffuse infantile haemangiomatosis: clinicopathological features and management problems in five fatal cases.
- Author
-
Byard RW, Burrows PE, Izakawa T, and Silver MM
- Subjects
- Female, Hemangioma, Cavernous pathology, Hemangioma, Cavernous therapy, Humans, Infant, Infant, Newborn, Male, Hemangioma pathology, Hemangioma therapy, Skin Neoplasms pathology, Skin Neoplasms therapy
- Abstract
The clinicopathological features of five fatal cases of diffuse haemangiomatosis presenting in neonatal life or early infancy are presented. The infants all had multiple skin haemangiomas as well as deep-seated lesions in many different tissues that caused protean clinical manifestations and management problems. Because the outlook may be improved by early diagnosis and application of new modes of treatment, any infant with multiple cutaneous haemangiomas should be closely assessed for possible visceral involvement. Development of hepatomegaly, high-output cardiac failure, unexplained anaemia or thrombocytopenia in these infants should immediately suggest disseminated disease. Early recognition with implementation of steroid and/or antiangiogenic therapy, embolization and/or surgery is essential to improve the chances of survival.
- Published
- 1991
- Full Text
- View/download PDF
39. Catheter embolization in the central nervous system and the gastrointestinal tract.
- Author
-
Schumacher FW, Hunold J, and Bayindir S
- Subjects
- Brain Neoplasms blood supply, Gastrointestinal Hemorrhage therapy, Gastrointestinal Neoplasms blood supply, Hemangioma therapy, Humans, Spinal Cord Neoplasms blood supply, Brain Neoplasms therapy, Embolization, Therapeutic methods, Gastrointestinal Neoplasms therapy, Spinal Cord Neoplasms therapy
- Published
- 1983
- Full Text
- View/download PDF
40. [Therapeutic use of lasers in dermatology].
- Author
-
Landthaler M, Haina D, Waidelich W, and Braun Falco O
- Subjects
- Cicatrix surgery, Female, Hemangioma therapy, Humans, Male, Skin Neoplasms surgery, Tattooing, Telangiectasis therapy, Wound Healing, Laser Therapy, Skin Diseases therapy
- Abstract
Lasers are used increasingly in dermatology. The use of different laser types for various indications is discussed. Nevi and benign vessel tumors, tattoos, condylomata acuminata, hypertrophic scars, and keloids are indications for laser therapy. The application of lasers in the treatment of malignant tumors, such as malignant melanoma or malignant vessel tumors, is discussed. Finally, the stimulating effects of laser light with low energy density on wound healing is mentioned.
- Published
- 1981
41. [Congenital arteriovenous fistula with an angioma. Therapeutic possibilities].
- Author
-
Lechner W
- Subjects
- Adult, Arteriovenous Malformations diagnostic imaging, Arteriovenous Malformations therapy, Embolization, Therapeutic, Female, Foot Diseases diagnostic imaging, Foot Diseases therapy, Hemangioma diagnostic imaging, Hemangioma therapy, Humans, Radiography, Arteriovenous Malformations complications, Foot blood supply, Foot Diseases complications, Hemangioma complications
- Abstract
Arteriovenous fistulas associated with an angioma are characterized by a relatively fast growth. Therapy consists in operative removal of the entire angioma. This often means partial amputation of extremities. An embolization of the angioma, as in an observed patient can prevent further progression. A disfiguring operation can be delayed or possibly even avoided.
- Published
- 1982
42. Hemorrhagic renal angiomyolipoma: superselective renal arterial embolization for preservation of renal function.
- Author
-
Sanchez FW, Vujic I, Ayres RI, Curry NS, and Gobien RP
- Subjects
- Adult, Aneurysm complications, Aneurysm diagnostic imaging, Angiography, Female, Hemangioma complications, Hemangioma diagnostic imaging, Hematuria etiology, Humans, Kidney Neoplasms complications, Kidney Neoplasms diagnostic imaging, Lipoma complications, Lipoma diagnostic imaging, Tuberous Sclerosis complications, Embolization, Therapeutic, Hemangioma therapy, Kidney Neoplasms therapy, Lipoma therapy, Renal Artery
- Abstract
A 35-year-old woman with tuberous sclerosis and known bilateral renal angiomyolipomas presented with shock due to massive hematuria arising from the left kidney. The cause of bleeding was diagnosed angiographically as arising from a left upper pole renal artery aneurysm within the tumor. Cessation of bleeding and clinical stabilization occurred without deterioration of renal function after superselective embolization of the dorsal segmental renal artery with a single 5-mm Gianturco coil.
- Published
- 1985
- Full Text
- View/download PDF
43. [Clinical aspects and therapy of hemangioma].
- Author
-
Staindl O
- Subjects
- Capillaries pathology, Hemangioma therapy, Hemangioma, Cavernous pathology, Humans, Magnesium administration & dosage, Muscle, Smooth, Vascular pathology, Skin Neoplasms therapy, Hemangioma pathology, Skin Neoplasms pathology
- Abstract
Vascular malformations of the skin, such as angiomatous naevi (haemangiomas) are discussed in the present paper. Haemangiomas can be differentiated by histology into "capillary" and "cavernous" types. Therapy should be very conservative because about 95% of all haemangiomas in childhood tend to involute spontaneously. Active treatment is necessary for complications, such as bleeding or ulceration, the Kasabach-Merritt syndrome, or tumours at special sites such as the eyelid, lips etc. Conservative treatment includes steroids and embolisation by fibrin. Surgery includes the largely forgotten magnesium seed treatment first described 90 years ago; 99.8% pure magnesium foil and wires 0.5 and 1.0 mm thick were implanted into nine haemangiomas. Fibrosis and tumour regression were observed in seven cases: two further cases are still under treatment.
- Published
- 1988
44. [Nevi, hemangiomas and lymphangiomas in the head and neck area].
- Subjects
- Humans, Head and Neck Neoplasms therapy, Hemangioma therapy, Lymphangioma therapy, Nevus therapy
- Published
- 1984
45. [Treatment of facial hemangiomas].
- Author
-
Hochstein HJ
- Subjects
- Child, Female, Humans, Male, Facial Neoplasms therapy, Hemangioma therapy
- Published
- 1986
46. [Diagnostic and therapeutic results of superselective cerebral angiographies in pathologic lesions in the vascular area of the human external carotid artery (author's transl)].
- Author
-
Voigt K and Djindjian R
- Subjects
- Adolescent, Adult, Arteriovenous Fistula diagnostic imaging, Brain Neoplasms blood supply, Brain Neoplasms diagnostic imaging, Brain Neoplasms therapy, Carotid Artery, External abnormalities, Carotid Artery, External diagnostic imaging, Catheterization methods, Embolization, Therapeutic, Female, Gelatin Sponge, Absorbable therapeutic use, Hemangioma diagnostic imaging, Hemangioma therapy, Humans, Lip Neoplasms blood supply, Lip Neoplasms diagnostic imaging, Male, Meningeal Arteries diagnostic imaging, Meningioma diagnostic imaging, Middle Aged, Skull Neoplasms diagnostic imaging, Temporal Bone, Carotid Artery Diseases diagnostic imaging, Cerebral Angiography methods
- Abstract
Technical performance, radiological findings as well as the diagnostic and therapeutic significance of superselective cerebral angiographies, performed with a telescopic catheter system, and consecutive embolizations are described in pathologic lesions in the vascular area of the human external carotid artery. In 46 patients vascular malformations (angiomas, fistulas) and vascular tumors (angiofibromas) as well as other tumors (glomus tumors, meningeomas) were demonstrated by angiographies of distal external carotid branches; in further 16 patients there were normal angiographic findings. It is shown by examples that superselective cerebral angiographies fulfill microangiographic properties. Pathological findings of vascular malformations and tumors were demonstrated which could not have been shown with other examination techniques. Besides the improved and more detailed diagnostic information these superselective angiographies of external carotid branches enabled successful embolizations of pathologic lesions by gelfoam-injections or selective occlusions of branches feeding angiomas or tumors by silicone polymerization. These embolizations were not done in patients with arterio-venous fistulas (9). The clinical application, limitations and further development of cerebral embolization techniques are discussed.
- Published
- 1976
47. Hepatic artery embolisation; successful treatment of multinodular haemangiomatosis of the liver.
- Author
-
Vomberg PP, Büller HA, Marsman JW, Lam J, van Zaane DJ, and Heymans HS
- Subjects
- Female, Humans, Infant, Neoplasm Regression, Spontaneous, Skin Neoplasms, Embolization, Therapeutic, Hemangioma therapy, Hepatic Artery, Liver Neoplasms therapy
- Abstract
A patient with multinodular haemangiomatosis of the liver, rapidly deteriorating in the first weeks of life due to severe progressive congestive heart failure, was successfully treated by hepatic artery catheter embolisation at the age of 6 weeks.
- Published
- 1986
- Full Text
- View/download PDF
48. [New aspects in the treatment of hemangioma].
- Author
-
Krüger A
- Subjects
- Child, Preschool, Combined Modality Therapy, Cryosurgery, Drug Combinations administration & dosage, Factor XIII administration & dosage, Female, Fibrin Tissue Adhesive, Fibrinogen administration & dosage, Follow-Up Studies, Humans, Lip Neoplasms therapy, Thrombin administration & dosage, Tissue Adhesives administration & dosage, Embolization, Therapeutic methods, Facial Neoplasms therapy, Hemangioma therapy, Hemangioma, Cavernous therapy
- Abstract
This paper describes the successful therapy of cavernous and capillary haemangiomata by inducing thrombosis with Tissucol homologous fibrinogen and thrombin. After angiography, infants and small children were injected with Tissucol directly into the vascular convolution at two weekly intervals, resulting in complete thrombosis with subsequent fibrosis, leading to diminution of the haemangioma until it finally disappeared. Histological examination showed fibrosis and sclerosis, with granular tissue rich in fibrinoblasts as a manifestation of a partially organised thrombosis. There were no traces of inflammation. In a large number of adults, reduction of the haemangioma was successfully achieved by injections of Tissucol, leading to thrombosis, followed by immediate surgical removal of the entire haemangioma. Treatment of small haemangiomata by cryosurgical measures with liquid nitrogen, as recommended by Lexer in 1921, was likewise successfully applied.
- Published
- 1985
49. [Skin neoplasms].
- Author
-
Wintsch K
- Subjects
- Carcinoma, Basal Cell surgery, Carcinoma, Basal Cell therapy, Diagnosis, Differential, Female, Hemangioma surgery, Hemangioma therapy, Humans, Lip Neoplasms, Lymphangioma surgery, Lymphangioma therapy, Male, Melanoma diagnosis, Melanoma surgery, Nevus, Pigmented diagnosis, Nevus, Pigmented surgery, Nose Neoplasms surgery, Skin Neoplasms diagnosis, Skin Neoplasms therapy, Surgery, Plastic, Skin Neoplasms surgery
- Published
- 1974
50. [Treatment of hemangioma & teleangiectatic nevi].
- Author
-
RAUSCH L
- Subjects
- Humans, Hemangioma therapy, Nevus therapy, Nevus, Pigmented, Radiotherapy, Skin Neoplasms, Telangiectasis
- Published
- 1957
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