1. Dystonic reactions following neuroleptics: time course and proposed mechanisms.
- Author
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Garver DL, Davis DM, Dekirmenjian H, Ericksen S, Gosenfeld L, and Haraszti J
- Subjects
- Acetylcholine metabolism, Antipsychotic Agents blood, Dopamine metabolism, Humans, Kinetics, Phenothiazines adverse effects, Time Factors, Antipsychotic Agents adverse effects, Muscle Tonus drug effects, Muscular Diseases chemically induced
- Abstract
The occurrence of acute dystonic reactions was studied relative to drug pharmacokinetic parameters following a single dose of the phenothiazine, butaperazine. Dystonias occurred more than one half-life from peak butaperazine levels, 23 to 56 h after drug administration. The authors postulate that the appearance of dystonias on falling plasma concentrations may be due to disruption of dopaminergic-cholinergic balance caused by differential antidopaminergic and anticholinergic potencies of the drug.
- Published
- 1976
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