1. injury in rats
- Author
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Ozden, A, Tetik, C, Bilgihan, A, Calli, N, Bostanci, B, Yis, O, and Duzcan, E
- Subjects
malondialdehyde ,myeloperoxidase ,antithrombin IIE ,reperfusion injury ,intestinal ischemia - Abstract
We investigated the effect of antithrombin III on 60 min warm intestinal ischemia-reperfusion (IR) injury in rats. Sprague-Dawley rats, weighing 220-250 g, were divided into three groups: group 1 sham-operated group (no IR injury, n=8), group 2 ischemic control group (control, Ringer's lactate infused, n=8), group 3 Antithrombin III treated group (2.50 U/kg before ischemia, n=8). Intestinal ischemia was induced in rats by occluding the superior mesenteric artery for 60 min. Malondialdehyde (MDA) levels, myeloperoxidase activity (MPO) and mucosal damage were investigated after 120 min reperfusion. Elevated MDA levels and MPO activity and severe histopathological damage were observed in the control group compared with the sham group (P
- Published
- 1999