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1. The Significance of Serum and Urinary Guanidinoacetic Acid Level for the Restoration of Renal Metabolic Function in Patients with Kidney Transplantation

Author

Kazuo Isoda, Hidehiko Honda, Ryo Tanaka, Tetsuya Mitarai, Kenichi Sugimoto, Ryoji Nagasawa, Takeo Yokoyama, Hidehiko Kashiwabara, Satoru Hirose, and Noritsugu Imamura

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Kidney, business.industry, Urinary system, nutritional and metabolic diseases, Urine, medicine.disease, Creatine, Excretion, chemistry.chemical_compound, Endocrinology, medicine.anatomical_structure, chemistry, Excretory system, Internal medicine, medicine, In patient, business, Kidney transplantation
Abstract

It is well known that guanidinoacetic acid (GAA), precursor of creatine, is mainly producted by the kidney and the concentration of GAA in serum and urine and decreased in patients with chronic renal failure (CRF). However, the mechanism for the excretion of this substance by the kidney still remains to be clarified. Therefore, this study is aimed to assess the restoration of the metabolic function of the transplanted kidney and the excretory manoeuvre by means of measurements of serum and urinary guanidino compounds, especially the GAA levels using fluorometric HPLC.

Published
1989
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