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Your search keyword '"Prausnitz, Mark R."' showing total 32 results
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32 results on '"Prausnitz, Mark R."'

12. Role of drug delivery technologies in the success of COVID-19 vaccines: a perspective

Author

Massachusetts Institute of Technology. Department of Chemical Engineering, Labouta, Hagar I., Langer, Robert, Cullis, Pieter R., Merkel, Olivia M., Prausnitz, Mark R., Gomaa, Yasmine, Nogueira, Sara S., Kumeria, Tushar, Massachusetts Institute of Technology. Department of Chemical Engineering, Labouta, Hagar I., Langer, Robert, Cullis, Pieter R., Merkel, Olivia M., Prausnitz, Mark R., Gomaa, Yasmine, Nogueira, Sara S., and Kumeria, Tushar

Abstract

The triumphant success of mRNA vaccines is a testimony to the important role drug delivery technologies have played in protecting billions of people against SARS-CoV-2 (or the Corona Virus Disease 2019; COVID-19). Several lipid nanoparticle (LNP) mRNA vaccines were developed and have been instrumental in preventing the disease by boosting the immune system against the pathogen, SARS-CoV-2. These vaccines have been built on decades of scientific research in drug delivery of mRNA, vaccines, and other biologicals. In this manuscript, several leading and emerging scientists in the field of drug delivery share their perspective on the role of drug delivery technologies in developing safe and efficacious vaccines, in a roundtable discussion. The authors also discussed their viewpoint on the current challenges, and the key research questions that should drive this important area of research.

Published
2022

32. Polymer particle-based micromolding to fabricate novel microstructures.

Author

Park JH, Choi SO, Kamath R, Yoon YK, Allen MG, and Prausnitz MR

Subjects
Materials Testing, Microspheres, Particle Size, Surface Properties, Biocompatible Materials chemical synthesis, Polymers chemistry
Abstract

Conventional micromolding provides rapid and low-cost methods to fabricate polymer microstructures, but has limitations when producing sophisticated designs. To provide more versatile micromolding techniques, we developed methods based on filling micromolds with polymer microparticles, as opposed to polymer melts, to produce microstructures composed of multiple materials, having complex geometries, and made using mild processing conditions. Polymer microparticles of 1 to 30 microm in size were made from PLA, PGA and PLGA using established spray drying and emulsion techniques either with or without encapsulating model drug compounds. These polymer microparticles were filled into PDMS micromolds at room temperature and melted or bonded together to form microstructures according to different protocols. Porous microstructures were fabricated by ultrasonically welding microparticles together in the mold while maintaining the voids inherent in their packing structure. Multi-layered microstructures were fabricated to have different compositions of polymers and encapsulated compounds located in different regions of the microstructures. More complex arrowhead microstructures were fabricated in a two-step process using a single mold. To assess possible applications, microstructures were designed as microneedles for minimally invasive drug delivery. Multi-layer microneedles were shown to insert into cadaver tissue and, according to design, detach from their base substrate and remain embedded in the tissue for controlled release drug delivery over time. We conclude that polymer particle-based micromolding can encapsulate compounds within microstructures composed of multiple materials, having complex geometries, and made using mild processing conditions.

Published
2007
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