1. Analysis of Glial Scarring in the Mammalian CNS with a GFAP cDNA Probe
- Author
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Alain Privat, Philippe Vernier, and Pierre Rataboul
- Subjects
Pathology ,medicine.medical_specialty ,Glial fibrillary acidic protein ,biology ,Hyperplasia ,medicine.disease ,Glial scar ,Muscle hypertrophy ,chemistry.chemical_compound ,medicine.anatomical_structure ,chemistry ,Complementary DNA ,medicine ,biology.protein ,Intracellular ,Ibotenic acid ,Astrocyte - Abstract
Reactive gliosis, leading to the formation of glial scar, is the response of astrocytes to CNS injury. It is an ubiquitous reaction observed in a large number of pathological conditions, such as mechanical and chemical lesions, as well as degenerative processes (Fulcrand and Privat, 1977; Eng and De Armond, 1982). This reaction is twofold, being characterized by an astrocyte multiplication (hyperplasia) as well as an hypertrophy of the perikarya and processes (Hain et al., 1960; Nathaniel and Nathaniel, 1981). The main intracellular event is an increase of the number of gliafilaments, paralleled by a raise in GFAP immunoreactivity.
- Published
- 1990
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