1. Defective DNA Repair in Humans: Clinical and Molecular Studies of Xeroderma Pigmentosum
- Author
-
Kenneth H. Kraemer, Saraswathy Seetharam, Michael M. Seidman, Anders Bredberg, Douglas Brash, Haywood L. Waters, Miroslava Protić-Sablijć, Gary Peck, John DiGiovanna, Alan Moshell, Robert E. Tarone, Gary Jones, Ram Parshad, and Katherine Sanford
- Subjects
Genetics ,Xeroderma pigmentosum ,integumentary system ,DNA repair ,Cancer ,Pyrimidine dimer ,Biology ,medicine.disease ,Host-Cell Reactivation ,Molecular biology ,medicine ,Cytotoxic T cell ,Skin cancer ,skin and connective tissue diseases ,Nucleotide excision repair - Abstract
Xeroderma pigmentosum (XP), is a rare autosomal recessive disorder with increased sun sensitivity, multiple pigmentary abnormalities and a more than 1000-fold increased frequency of cancer of the sun exposed portions of the skin and eyes. Cultured cells from XP patients are hypersensitive to the cytotoxic and mutagenic effects of UV radiation and have defective DNA repair (reviewed in Robbins et al, 1974; Kraemer and Slor, 1985; Kraemer, 1987; Cleaver and Kraemer, 1989).
- Published
- 1990
- Full Text
- View/download PDF