1. The role of lipoprotein(a) in coronavirus disease 2019 (COVID-19) with relation to development of severe acute kidney injury
- Author
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Giuseppe Lippi, Maria Helena Santos de Oliveira, Ivan Szergyuk, Brandon Michael Henry, Justin L. Benoit, Stefanie W. Benoit, and Emmanuel J. Favaloro
- Subjects
medicine.medical_specialty ,Fibrinogen ,Gastroenterology ,Article ,Acute kidney injury, Coagulopathy, Coronavirus disease 2019, Lipoprotein(a), Thrombosis ,Pathogenesis ,chemistry.chemical_compound ,Coagulopathy ,Internal medicine ,medicine ,Humans ,Creatinine ,biology ,Coronavirus disease 2019 ,business.industry ,SARS-CoV-2 ,Acute kidney injury ,Interleukin ,COVID-19 ,Thrombosis ,Hematology ,Lipoprotein(a) ,Acute Kidney Injury ,medicine.disease ,chemistry ,biology.protein ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers ,Lipoprotein ,medicine.drug - Abstract
Lipoprotein(a) (Lp(a)) is a prothrombotic and anti-fibrinolytic lipoprotein, whose role has not been clearly defined in the pathogenesis of coronavirus disease 2019 (COVID-19). In this prospective observational study, serum Lp(a) as well as outcomes were measured in 50 COVID-19 patients and 30 matched sick controls. Lp(a) was also assessed for correlation with a wide panel of biomarkers. Serum Lp(a) did not significantly differ between COVID-19 patients and sick controls, though its concentration was found to be significantly associated with severity of COVID-19 illness, including acute kidney failure stage (r = 0.380, p = 0.007), admission disease severity (r = 0.355, p = 0.013), and peak severity (r = 0.314; p = 0.03). Lp(a) was also positively correlated with interleukin (IL)-8 (r = 0.308; p = 0.037), fibrinogen (r = 0.344; p = 0.032) and creatinine (r = 0.327; p = 0.027), and negatively correlated with ADAMTS13 activity/VWF:Ag (r = − 0.335; p = 0.021); but not with IL-6 (r = 0.241; p = 0.106). These results would hence suggest that adverse outcomes in patients with COVID-19 may be aggravated by a genetically determined hyper-Lp(a) state rather than any inflammation induced elevations. Supplementary Information The online version contains supplementary material available at 10.1007/s11239-021-02597-y.
- Published
- 2021