1. Antibiotic Treatment in an Animal Model of Inflammatory Lung Disease
- Author
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Diana Canals Hernaez, Melina Messing, Alissa Cait, Jessica Cait, and Kelly M. McNagny
- Subjects
0301 basic medicine ,Inflammatory lung disease ,Allergy ,business.industry ,medicine.drug_class ,Antibiotics ,Disease ,medicine.disease ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Animal model ,Immunology ,Medicine ,Vancomycin ,Microbiome ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Allergic disease is on the rise and yet the underlying cause and risk factors are not fully understood. While lifesaving in many circumstances, the use of antibiotics and the subsequent disruption of the microbiome are positively correlated with the development of allergies. Here, we describe the use of the antibiotic vancomycin in combination with the papain-induced mouse model of allergic disease that allows for the assessment of microbiome perturbations and the impact on allergy development.
- Published
- 2020
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