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15 results on '"Cognitive behavioral therapy (CBT)"'

13. Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults

Author

Anna Andreasson, Mike K. Kemani, Gunnar L. Olsson, Mats Lekander, Julie Lasselin, Marie Kanstrup, Rikard K. Wicksell, and John Axelsson

Subjects
Adult, Male, medicine.medical_specialty, Medizin, Inflammation, Chronic pain, Pilot Projects, Article, 03 medical and health sciences, Basal (phylogenetics), 0302 clinical medicine, Quality of life, 030202 anesthesiology, Behavior Therapy, Internal medicine, medicine, Humans, Pain Management, Psychology(all), General Psychology, Cognitive behavioral therapy (CBT), Interleukin-6, Tumor Necrosis Factor-alpha, Treatment responders, Behavioral treatment, Interleukin, Middle Aged, medicine.disease, Chronic low-grade inflammation, Health psychology, Psychiatry and Mental health, Treatment Outcome, Physical therapy, Quality of Life, Cytokines, Tumor necrosis factor alpha, Female, medicine.symptom, Psychological inflexibility, Psychology, 030217 neurology & neurosurgery
Abstract

The purpose of the present pilot study was to explore the moderating role of basal inflammation on the effects of behavioral pain treatment in 41 patients with long-standing pain. Baseline pro-inflammatory status moderated behavioral treatment outcomes: higher pre-treatment levels of Tumor Necrosis Factor (TNF)-α and Interleukin (IL)-6 were related to less improvement in pain intensity, psychological inflexibility and in mental health-related quality of life. The treatment outcomes improved in the subgroup that had low levels of pro-inflammatory cytokines at baseline, while the subjects with higher pro-inflammatory status did not. Altogether, results indicate that low-grade inflammation may influence the behavioral treatment outcomes and provide a possible explanation of the heterogeneity in treatment response. OA hybrid - CA extern

Published
2016

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