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Start Over Topic breast cancer Topic prognosis Publisher springer us
306 results

6. Analysis of pattern, time and risk factors influencing recurrence in triple-negative breast cancer patients

Author

Katarzyna Pogoda, Anna Niwińska, Tadeusz Pienkowski, Magdalena Murawska, and Epidemiology

Subjects
Oncology, Adult, Cancer Research, medicine.medical_specialty, Multivariate analysis, medicine.medical_treatment, Breast Neoplasms, Receptors, Cell Surface, Kaplan-Meier Estimate, Recurrence pattern, Disease-Free Survival, Young Adult, Breast cancer, SDG 3 - Good Health and Well-being, Triple-negative breast cancer, Risk Factors, Internal medicine, Pattern time, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, In patient, Young adult, Mastectomy, Aged, Neoplasm Staging, Aged, 80 and over, Original Paper, Prognostic factor, Hematology, Radiotherapy, business.industry, Brain metastases, General Medicine, Tumor size, Middle Aged, medicine.disease, Metastatic breast cancer, Prognosis, Combined Modality Therapy, Radiation therapy, Female, Neoplasm Recurrence, Local, business
Abstract

e11553 Background: The aim of the study was to assess the rate, pattern and time of recurrence in patients with triple-negative breast cancer (TNBC) treated in one institution. The second goal was to evaluate factors influencing recurrence and overall survival in this group of patients. Methods: 2534 consecutive breast cancer patients were diagnosed at the Cancer Center and Institute of Oncology in Warsaw, Poland, between January 2005 and December 2006. Out of 2534 patients, 228 (9%) were TNBC (ER/PR/HER2-negative). The clinicopathological characteristics were determined using descriptive statistics. The overall survival (OS) and disease-free survival (DFS) were calculated using the Kaplan-Meier method. The univariate and multivariate analyses were developed to identify factors influencing recurrence and survival in TNBC patients. Results: Most of the patients were diagnosed with stage II or III breast cancer (47% and 34%, respectively), the median age at diagnosis was 54.5 years. The most common histological type was ductal cancer (81%). 31% of patients were treated with neoadjuvant chemotherapy and 49% with adjuvant chemotherapy – almost all consisted of anthracyclines. 6 years of observation revealed that the metastatic disease occurred in 35% of all TNBC patients: 15% in the brain, 14% in the lungs, 11% in the bones, 8% in the liver and 14% had locoregional relapse. The highest risk of recurrence was during the first 3 years after primary treatment and then during the next two years of observation it did not change. Median DFS and OS were not reached at the time of analysis, 6-year DFS and OS were 68% and 62%, respectively.Factors influencing recurrence were: tumor size and systemic adjuvant chemotherapy while factors influencing overall survival were: tumor size, nodal status, adjuvant/neoadjuvant treatment and metastases in the brain, liver and bones. Conclusions: Characteristic pattern of recurrence in time was revealed. The tumor size was responsible for recurrence despite lack of involvement of lymph nodes. Aggressive adjuvant/neoadjuvant treatment ordered in all clinical stages of TNBC (including N0) was factor responsible for avoiding local and distant relapse and prolonging overall survival.

Published
2013

26. Prognostic impact of adjuvant endocrine therapy for estrogen receptor-positive and HER2-negative T1a/bN0M0 breast cancer

Author

Sasada, Shinsuke, Kondo, Naoto, Hashimoto, Hiroya, Takahashi, Yuko, Terata, Kaori, Kida, Kumiko, Sagara, Yasuaki, Ueno, Takayuki, Anan, Keisei, Suto, Akihiko, Kanbayashi, Chizuko, Takahashi, Mina, Nakamura, Rikiya, Ishiba, Toshiyuki, Tsuneizumi, Michiko, Nishimura, Seiichiro, Naito, Yoichi, Hara, Fumikata, Shien, Tadahiko, and Iwata, Hiroji

Published
2023
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