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Actual fluids have different flow regimes due to viscosity. The regimes include laminar flow and turbulent flow. The regimes, viscosity, and pipe wall surface have influence on flow resistance, which leads to head loss for fluids flow. In this chapter, we will firstly introduce types of head loss (friction loss and minor head loss) and two regimes of fluids flow. Then we will study characteristics of laminar flow and turbulent flow in circular pipe. Furthermore, we will present the definition of friction factor and discuss ways to determine value of friction factor in order to calculate friction loss. Finally, we will give determination of minor head loss.