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315 results on '"Huang, Tian"'

9. Small molecule QF84139 ameliorates cardiac hypertrophy via activating the AMPK signaling pathway

Author

Youyi Zhang, Yong-Xian Cheng, Shenyan Liu, Yan-Jun Zheng, Peng Zhang, Xuxia Li, Jing-Jing Wang, Yong-Ming Yan, Jiliang Tan, Huang-Tian Yang, and Yang Yang

Subjects
0301 basic medicine, Male, Cell Survival, p38 mitogen-activated protein kinases, Cardiomegaly, Pharmacology, AMP-Activated Protein Kinases, Article, Muscle hypertrophy, Rats, Sprague-Dawley, 03 medical and health sciences, Mice, Phenylephrine, 0302 clinical medicine, medicine, Animals, Pharmacology (medical), Myocytes, Cardiac, RNA, Small Interfering, Protein kinase B, Aorta, Gene knockdown, Dose-Response Relationship, Drug, Chemistry, Kinase, AMPK, General Medicine, Organ Size, medicine.disease, Rats, Mice, Inbred C57BL, 030104 developmental biology, Animals, Newborn, 030220 oncology & carcinogenesis, Heart failure, Phosphorylation, Signal Transduction
Abstract

Cardiac hypertrophy is a common adaptive response to a variety of stimuli, but prolonged hypertrophy leads to heart failure. Hence, discovery of agents treating cardiac hypertrophy is urgently needed. In the present study, we investigated the effects of QF84139, a newly synthesized pyrazine derivative, on cardiac hypertrophy and the underlying mechanisms. In neonatal rat cardiomyocytes (NRCMs), pretreatment with QF84139 (1–10 μM) concentration-dependently inhibited phenylephrine-induced hypertrophic responses characterized by fetal genes reactivation, increased ANP protein level and enlarged cardiomyocytes. In adult male mice, administration of QF84139 (5–90 mg·kg(−1)·d(−1), i.p., for 2 weeks) dose-dependently reversed transverse aortic constriction (TAC)-induced cardiac hypertrophy displayed by cardiomyocyte size, left ventricular mass, heart weights, and reactivation of fetal genes. We further revealed that QF84139 selectively activated the AMPK signaling pathway without affecting the phosphorylation of CaMKIIδ, ERK1/2, AKT, PKCε, and P38 kinases in phenylephrine-treated NRCMs and in the hearts of TAC-treated mice. In NRCMs, QF84139 did not show additive effects with metformin on the AMPK activation, whereas the anti-hypertrophic effect of QF84139 was abolished by an AMPK inhibitor Compound C or knockdown of AMPKα2. In AMPKα2-deficient mice, the anti-hypertrophic effect of QF84139 was also vanished. These results demonstrate that QF84139 attenuates the PE- and TAC-induced cardiac hypertrophy via activating the AMPK signaling. This structurally novel compound would be a promising lead compound for developing effective agents for the treatment of cardiac hypertrophy.

Published
2021

10. A Novel Approach for Identifying Electromagnetic Space–Time Coupling Load of Wind Turbine

Author

Mao, Wengui, Li, Jianhua, Hu, Chaoliang, Pei, Shixiong, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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11. A Nonlinear Lateral-Torsional Coupling Dynamic Model of Planetary Transmission and Verification with Experiment

Author

Yunkun, Xie, Hui, Liu, Zhaobin, Zhan, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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12. Development of Intelligent Post-processing Algorithm for Three Degrees of Rotation Freedom CNC Machine Tools

Author

Zhao, Pengrui, Liu, Zhifeng, Li, Zhixiong, Cao, Zirui, Su, Lihang, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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13. Design of a Hybrid-Drive Upper Limb Powered Exoskeleton Robot

Author

Yuan, Xiaoqing, Zhang, Jiakun, Fang, Fujun, Wang, Wendong, Su, Huimin, Xu, Yaqing, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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14. A Novel Piecewise Modification of Cycloidal Gear and Tooth Contact Analysis

Author

Li, Guolong, Wu, Chenfa, Pang, Yuan, Cao, Bing, Ran, Quanfu, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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15. PSO-Based Material Stiffness Optimization for Dynamic Problems

Author

Zhou, Yicong, Lin, Qiyin, Wang, Chen, Wei, Fangyan, Hong, Jun, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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16. Analysis of Ship Shaft Bending Vibration Characteristics Based on Bearing Oil Film Stiffness

Author

Liu, Shuqing, Huo, Rui, Li, Yuanbo, Li, Chuangye, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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17. Knowledge-Driven Adaptive Sequential Modeling and Prediction of Aerodynamic Characteristics

Author

Pu, Xuening, Hao, Jia, Zhang, Fulin, He, Shipei, Long, Yongsong, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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18. Development of Parametric Design System of Double Circular Arc Spiral Bevel Gear Nutation Drive Based on SolidWorks

Author

Xie, Zetong, Yao, Ligang, Ding, Jiaxin, Ren, Kanghong, Jia, Bingbing, Liu, Jinglin, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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19. Finite Element Simulation and Analysis of Machining Characteristics of Aluminum Alloys During High-Speed Machining

Author

Chen, Dexiong, Chen, Delong, She, Qingqing, Li, Zhe, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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22. Study on Anti-backlash Mechanism Used in Precise Transmission: A Review

Author

Luo, Wei, Liu, Geng, Wang, Haiwei, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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23. Motioning Planning and Vibration Suppression of Rigid-Flexible Coupled Joint SCARA Robot

Author

Lin, Junxiang, Yang, Zhijun, Huang, Guanxin, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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24. Research on Multi-objective Optimization of Processing Parameters of Non-metallic Laser Cutting Machine for Low Energy Consumption

Author

Bao, Hong, Zhang, Junguo, Yang, Jing, Liu, Tianci, Zhang, Lei, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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25. Simulation of Horizontal Double Head Screw Conveyor Based on EDEM

Author

Mei, Lei, Cheng, Chuang, Tan, Xin, Fan, Ziqiang, Liang, Xiaolei, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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26. Design of AGV Structure and Control System for Hospital Drug Delivery

Author

Guo, Jidong, Liang, Jiaxin, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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30. Simulation and Analysis of Dynamic Characteristics of Loader Seats Under Different Pavements

Author

Wang, Lu, Yang, Hexu, Gao, Yu, Wang, Xuejun, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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31. Workspace Analysis of Planar Suspended Two-Cable-Driven Parallel Robots

Author

Peng, Yijia, Bu, Wanghui, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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32. The FEM Analysis of Contact Deformation of Conical Interface Considering Temperature Rise

Author

Jin, Lan, Yin, Haoxun, Li, Weibing, Yi, Tinghua, Rui, Zhiyuan, Lu, Shiqi, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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33. Analysis of Load Sharing Characteristics of Power Split Planetary Gear Transmission

Author

Liu, Lan, Ma, Qiangyi, Ren, Pengkai, Wu, Fukang, Gong, Jingyi, Liu, Geng, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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34. Three-Sensor Fusion Localization Method of Security Robot Based on Particle Filtering Algorithm

Author

Rong, Peizhi, Wan, Yi, Ju, Kunting, Liang, Xichang, Hou, Jiarui, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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35. Numerical Simulation and Experimental Research of Oil-Free Single Screw Air Compressor for Hydrogen Fuel Cell

Author

Sun, Jian, Peng, Bin, Zhu, BingGuo, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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36. Research on Electric Induced Vibration Fatigue of Piezoelectric Smart Plates

Author

Fang, Mengxiang, Liu, Wenguang, Wu, Xingyi, Feng, Yiting, Chen, Hongxia, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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37. A Novel Multi-DOF Shipbuilding Crane Manipulator: Type Synthesis and Structure Analysis

Author

Deng, Zhining, Pan, Yuchen, Yue, Minghang, Meng, Zhanbin, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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38. Diodicity Optimization of Tesla-Type Check Valve Based on Surrogate Modeling Techniques

Author

Li, Kunpeng, Wang, Shuo, Zong, Chaoyong, Liu, Yin, Song, Xueguan, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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39. Three-Dimensional Reconstruction Technique Assisted in the Precise Positioning of Bronchoscopy in Children

Author

Bao, Yudong, Li, Xu, Wei, Wen, Qu, Shengqian, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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40. Optimal Design and Analysis of Separable Suspension System of Wheel-Legged Compound Unmanned Ground Vehicle

Author

Ren, Xiaolei, Liu, Hui, Yang, Haiyang, Liu, Baoshuai, Han, Lijin, Ziyong, Han, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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41. Synthesis and Error Characteristics Analysis of 3T Parallel Mechanism Based on Single-Opened-Chain—Position Orientation Characteristics

Author

Wang, Yage, Gao, Moyao, Wang, De, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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42. Design and Study of Symmetrical Two-Fingered In-Hand Dexterous Manipulation

Author

Xie, XiongDun, James, ZhiQing Wen, Li, Wei, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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43. Multi-branch Cable Harness Layout Optimization Based on Pattern Search Improved Particle Swarm Optimization Algorithm

Author

Zhang, Dan, Cai, Chaoli, Zhou, Chen, Chen, Wenqiang, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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44. Effect of Dam Number of Straight Bar Plate on the Pulp Flow in the Low Consistency Disc Refiner

Author

Duan, Chuanwu, Dong, Jixian, Liu, Huan, Tian, Yangyuan, Qi, Kai, Yang, Ruifan, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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45. Considering Pedestrian Perceived Risk and Living Area in Studying the Effect of eHMI in Automated Vehicle and Pedestrian Interaction

Author

She, Jinjuan, Islam, Marufa, Fanok, Megan, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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46. Novel Design of a Modular Multi-stage Crusher with Adaptive Clearance by TRIZ Method

Author

Wang, Jie, Zhu, Zhifang, Zeng, Junhao, Yang, Shengtian, Guan, Yisheng, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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49. Design and Contact Analysis of Mover Locking Device

Author

Wu, Xingguang, Lu, Lu, Xiong, Youxing, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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50. A State-of-the-Art Review for Product Engineering Design for Sustainability Focusing on Aims and Methodologies

Author

Li, Zhong-kai, Wang, Shuai, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Tan, Jianrong, editor

Published
2022
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