49 results on '"van Dam, Rob M."'
Search Results
2. An atlas of genetic scores to predict multi-omic traits
- Author
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Xu, Yu, primary, Ritchie, Scott C., additional, Liang, Yujian, additional, Timmers, Paul R. H. J., additional, Pietzner, Maik, additional, Lannelongue, Loïc, additional, Lambert, Samuel A., additional, Tahir, Usman A., additional, May-Wilson, Sebastian, additional, Foguet, Carles, additional, Johansson, Åsa, additional, Surendran, Praveen, additional, Nath, Artika P., additional, Persyn, Elodie, additional, Peters, James E., additional, Oliver-Williams, Clare, additional, Deng, Shuliang, additional, Prins, Bram, additional, Luan, Jian’an, additional, Bomba, Lorenzo, additional, Soranzo, Nicole, additional, Di Angelantonio, Emanuele, additional, Pirastu, Nicola, additional, Tai, E. Shyong, additional, van Dam, Rob M., additional, Parkinson, Helen, additional, Davenport, Emma E., additional, Paul, Dirk S., additional, Yau, Christopher, additional, Gerszten, Robert E., additional, Mälarstig, Anders, additional, Danesh, John, additional, Sim, Xueling, additional, Langenberg, Claudia, additional, Wilson, James F., additional, Butterworth, Adam S., additional, and Inouye, Michael, additional
- Published
- 2023
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3. Measuring social desirability bias in a multi-ethnic cohort sample: its relationship with self-reported physical activity, dietary habits, and factor structure
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Teh, Wen Lin, primary, Abdin, Edimansyah, additional, P.V., Asharani, additional, Siva Kumar, Fiona Devi, additional, Roystonn, Kumarasan, additional, Wang, Peizhi, additional, Shafie, Saleha, additional, Chang, Sherilyn, additional, Jeyagurunathan, Anitha, additional, Vaingankar, Janhavi Ajit, additional, Sum, Chee Fang, additional, Lee, Eng Sing, additional, van Dam, Rob M., additional, and Subramaniam, Mythily, additional
- Published
- 2023
- Full Text
- View/download PDF
4. Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
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Kanoni, Stavroula, primary, Graham, Sarah E., additional, Wang, Yuxuan, additional, Surakka, Ida, additional, Ramdas, Shweta, additional, Zhu, Xiang, additional, Clarke, Shoa L., additional, Bhatti, Konain Fatima, additional, Vedantam, Sailaja, additional, Winkler, Thomas W., additional, Locke, Adam E., additional, Marouli, Eirini, additional, Zajac, Greg J. M., additional, Wu, Kuan-Han H., additional, Ntalla, Ioanna, additional, Hui, Qin, additional, Klarin, Derek, additional, Hilliard, Austin T., additional, Wang, Zeyuan, additional, Xue, Chao, additional, Thorleifsson, Gudmar, additional, Helgadottir, Anna, additional, Gudbjartsson, Daniel F., additional, Holm, Hilma, additional, Olafsson, Isleifur, additional, Hwang, Mi Yeong, additional, Han, Sohee, additional, Akiyama, Masato, additional, Sakaue, Saori, additional, Terao, Chikashi, additional, Kanai, Masahiro, additional, Zhou, Wei, additional, Brumpton, Ben M., additional, Rasheed, Humaira, additional, Havulinna, Aki S., additional, Veturi, Yogasudha, additional, Pacheco, Jennifer Allen, additional, Rosenthal, Elisabeth A., additional, Lingren, Todd, additional, Feng, QiPing, additional, Kullo, Iftikhar J., additional, Narita, Akira, additional, Takayama, Jun, additional, Martin, Hilary C., additional, Hunt, Karen A., additional, Trivedi, Bhavi, additional, Haessler, Jeffrey, additional, Giulianini, Franco, additional, Bradford, Yuki, additional, Miller, Jason E., additional, Campbell, Archie, additional, Lin, Kuang, additional, Millwood, Iona Y., additional, Rasheed, Asif, additional, Hindy, George, additional, Faul, Jessica D., additional, Zhao, Wei, additional, Weir, David R., additional, Turman, Constance, additional, Huang, Hongyan, additional, Graff, Mariaelisa, additional, Choudhury, Ananyo, additional, Sengupta, Dhriti, additional, Mahajan, Anubha, additional, Brown, Michael R., additional, Zhang, Weihua, additional, Yu, Ketian, additional, Schmidt, Ellen M., additional, Pandit, Anita, additional, Gustafsson, Stefan, additional, Yin, Xianyong, additional, Luan, Jian’an, additional, Zhao, Jing-Hua, additional, Matsuda, Fumihiko, additional, Jang, Hye-Mi, additional, Yoon, Kyungheon, additional, Medina-Gomez, Carolina, additional, Pitsillides, Achilleas, additional, Hottenga, Jouke Jan, additional, Wood, Andrew R., additional, Ji, Yingji, additional, Gao, Zishan, additional, Haworth, Simon, additional, Yousri, Noha A., additional, Mitchell, Ruth E., additional, Chai, Jin Fang, additional, Aadahl, Mette, additional, Bjerregaard, Anne A., additional, Yao, Jie, additional, Manichaikul, Ani, additional, Hwu, Chii-Min, additional, Hung, Yi-Jen, additional, Warren, Helen R., additional, Ramirez, Julia, additional, Bork-Jensen, Jette, additional, Kårhus, Line L., additional, Goel, Anuj, additional, Sabater-Lleal, Maria, additional, Noordam, Raymond, additional, Mauro, Pala, additional, Matteo, Floris, additional, McDaid, Aaron F., additional, Marques-Vidal, Pedro, additional, Wielscher, Matthias, additional, Trompet, Stella, additional, Sattar, Naveed, additional, Møllehave, Line T., additional, Munz, Matthias, additional, Zeng, Lingyao, additional, Huang, Jianfeng, additional, Yang, Bin, additional, Poveda, Alaitz, additional, Kurbasic, Azra, additional, Lamina, Claudia, additional, Forer, Lukas, additional, Scholz, Markus, additional, Galesloot, Tessel E., additional, Bradfield, Jonathan P., additional, Ruotsalainen, Sanni E., additional, Daw, EWarwick, additional, Zmuda, Joseph M., additional, Mitchell, Jonathan S., additional, Fuchsberger, Christian, additional, Christensen, Henry, additional, Brody, Jennifer A., additional, Vazquez-Moreno, Miguel, additional, Feitosa, Mary F., additional, Wojczynski, Mary K., additional, Wang, Zhe, additional, Preuss, Michael H., additional, Mangino, Massimo, additional, Christofidou, Paraskevi, additional, Verweij, Niek, additional, Benjamins, Jan W., additional, Engmann, Jorgen, additional, Tsao, Noah L., additional, Verma, Anurag, additional, Slieker, Roderick C., additional, Lo, Ken Sin, additional, Zilhao, Nuno R., additional, Le, Phuong, additional, Kleber, Marcus E., additional, Delgado, Graciela E., additional, Huo, Shaofeng, additional, Ikeda, Daisuke D., additional, Iha, Hiroyuki, additional, Yang, Jian, additional, Liu, Jun, additional, Demirkan, Ayşe, additional, Leonard, Hampton L., additional, Marten, Jonathan, additional, Frank, Mirjam, additional, Schmidt, Börge, additional, Smyth, Laura J., additional, Cañadas-Garre, Marisa, additional, Wang, Chaolong, additional, Nakatochi, Masahiro, additional, Wong, Andrew, additional, Hutri-Kähönen, Nina, additional, Sim, Xueling, additional, Xia, Rui, additional, Huerta-Chagoya, Alicia, additional, Fernandez-Lopez, Juan Carlos, additional, Lyssenko, Valeriya, additional, Nongmaithem, Suraj S., additional, Bayyana, Swati, additional, Stringham, Heather M., additional, Irvin, Marguerite R., additional, Oldmeadow, Christopher, additional, Kim, Han-Na, additional, Ryu, Seungho, additional, Timmers, Paul R. H. J., additional, Arbeeva, Liubov, additional, Dorajoo, Rajkumar, additional, Lange, Leslie A., additional, Prasad, Gauri, additional, Lorés-Motta, Laura, additional, Pauper, Marc, additional, Long, Jirong, additional, Li, Xiaohui, additional, Theusch, Elizabeth, additional, Takeuchi, Fumihiko, additional, Spracklen, Cassandra N., additional, Loukola, Anu, additional, Bollepalli, Sailalitha, additional, Warner, Sophie C., additional, Wang, Ya Xing, additional, Wei, Wen B., additional, Nutile, Teresa, additional, Ruggiero, Daniela, additional, Sung, Yun Ju, additional, Chen, Shufeng, additional, Liu, Fangchao, additional, Yang, Jingyun, additional, Kentistou, Katherine A., additional, Banas, Bernhard, additional, Nardone, Giuseppe Giovanni, additional, Meidtner, Karina, additional, Bielak, Lawrence F., additional, Smith, Jennifer A., additional, Hebbar, Prashantha, additional, Farmaki, Aliki-Eleni, additional, Hofer, Edith, additional, Lin, Maoxuan, additional, Concas, Maria Pina, additional, Vaccargiu, Simona, additional, van der Most, Peter J., additional, Pitkänen, Niina, additional, Cade, Brian E., additional, van der Laan, Sander W., additional, Chitrala, Kumaraswamy Naidu, additional, Weiss, Stefan, additional, Bentley, Amy R., additional, Doumatey, Ayo P., additional, Adeyemo, Adebowale A., additional, Lee, Jong Young, additional, Petersen, Eva R. B., additional, Nielsen, Aneta A., additional, Choi, Hyeok Sun, additional, Nethander, Maria, additional, Freitag-Wolf, Sandra, additional, Southam, Lorraine, additional, Rayner, Nigel W., additional, Wang, Carol A., additional, Lin, Shih-Yi, additional, Wang, Jun-Sing, additional, Couture, Christian, additional, Lyytikäinen, Leo-Pekka, additional, Nikus, Kjell, additional, Cuellar-Partida, Gabriel, additional, Vestergaard, Henrik, additional, Hidalgo, Bertha, additional, Giannakopoulou, Olga, additional, Cai, Qiuyin, additional, Obura, Morgan O., additional, van Setten, Jessica, additional, Li, Xiaoyin, additional, Liang, Jingjing, additional, Tang, Hua, additional, Terzikhan, Natalie, additional, Shin, Jae Hun, additional, Jackson, Rebecca D., additional, Reiner, Alexander P., additional, Martin, Lisa Warsinger, additional, Chen, Zhengming, additional, Li, Liming, additional, Kawaguchi, Takahisa, additional, Thiery, Joachim, additional, Bis, Joshua C., additional, Launer, Lenore J., additional, Li, Huaixing, additional, Nalls, Mike A., additional, Raitakari, Olli T., additional, Ichihara, Sahoko, additional, Wild, Sarah H., additional, Nelson, Christopher P., additional, Campbell, Harry, additional, Jäger, Susanne, additional, Nabika, Toru, additional, Al-Mulla, Fahd, additional, Niinikoski, Harri, additional, Braund, Peter S., additional, Kolcic, Ivana, additional, Kovacs, Peter, additional, Giardoglou, Tota, additional, Katsuya, Tomohiro, additional, de Kleijn, Dominique, additional, de Borst, Gert J., additional, Kim, Eung Kweon, additional, Adams, Hieab H. H., additional, Ikram, M. Arfan, additional, Zhu, Xiaofeng, additional, Asselbergs, Folkert W., additional, Kraaijeveld, Adriaan O., additional, Beulens, Joline W. J., additional, Shu, Xiao-Ou, additional, Rallidis, Loukianos S., additional, Pedersen, Oluf, additional, Hansen, Torben, additional, Mitchell, Paul, additional, Hewitt, Alex W., additional, Kähönen, Mika, additional, Pérusse, Louis, additional, Bouchard, Claude, additional, Tönjes, Anke, additional, Chen, Yii-Der Ida, additional, Pennell, Craig E., additional, Mori, Trevor A., additional, Lieb, Wolfgang, additional, Franke, Andre, additional, Ohlsson, Claes, additional, Mellström, Dan, additional, Cho, Yoon Shin, additional, Lee, Hyejin, additional, Yuan, Jian-Min, additional, Koh, Woon-Puay, additional, Rhee, Sang Youl, additional, Woo, Jeong-Taek, additional, Heid, Iris M., additional, Stark, Klaus J., additional, Zimmermann, Martina E., additional, Völzke, Henry, additional, Homuth, Georg, additional, Evans, Michele K., additional, Zonderman, Alan B., additional, Polasek, Ozren, additional, Pasterkamp, Gerard, additional, Hoefer, Imo E., additional, Redline, Susan, additional, Pahkala, Katja, additional, Oldehinkel, Albertine J., additional, Snieder, Harold, additional, Biino, Ginevra, additional, Schmidt, Reinhold, additional, Schmidt, Helena, additional, Bandinelli, Stefania, additional, Dedoussis, George, additional, Thanaraj, Thangavel Alphonse, additional, Kardia, Sharon L. R., additional, Peyser, Patricia A., additional, Kato, Norihiro, additional, Schulze, Matthias B., additional, Girotto, Giorgia, additional, Böger, Carsten A., additional, Jung, Bettina, additional, Joshi, Peter K., additional, Bennett, David A., additional, De Jager, Philip L., additional, Lu, Xiangfeng, additional, Mamakou, Vasiliki, additional, Brown, Morris, additional, Caulfield, Mark J., additional, Munroe, Patricia B., additional, Guo, Xiuqing, additional, Ciullo, Marina, additional, Jonas, Jost B., additional, Samani, Nilesh J., additional, Kaprio, Jaakko, additional, Pajukanta, Päivi, additional, Tusié-Luna, Teresa, additional, Aguilar-Salinas, Carlos A., additional, Adair, Linda S., additional, Bechayda, Sonny Augustin, additional, de Silva, H. Janaka, additional, Wickremasinghe, Ananda R., additional, Krauss, Ronald M., additional, Wu, Jer-Yuarn, additional, Zheng, Wei, additional, Hollander, Anneke Iden, additional, Bharadwaj, Dwaipayan, additional, Correa, Adolfo, additional, Wilson, James G., additional, Lind, Lars, additional, Heng, Chew-Kiat, additional, Nelson, Amanda E., additional, Golightly, Yvonne M., additional, Wilson, James F., additional, Penninx, Brenda, additional, Kim, Hyung-Lae, additional, Attia, John, additional, Scott, Rodney J., additional, Rao, D. C., additional, Arnett, Donna K., additional, Hunt, Steven C., additional, Walker, Mark, additional, Koistinen, Heikki A., additional, Chandak, Giriraj R., additional, Mercader, Josep M., additional, Costanzo, Maria C., additional, Jang, Dongkeun, additional, Burtt, Noël P., additional, Villalpando, Clicerio Gonzalez, additional, Orozco, Lorena, additional, Fornage, Myriam, additional, Tai, EShyong, additional, van Dam, Rob M., additional, Lehtimäki, Terho, additional, Chaturvedi, Nish, additional, Yokota, Mitsuhiro, additional, Liu, Jianjun, additional, Reilly, Dermot F., additional, McKnight, Amy Jayne, additional, Kee, Frank, additional, Jöckel, Karl-Heinz, additional, McCarthy, Mark I., additional, Palmer, Colin N. A., additional, Vitart, Veronique, additional, Hayward, Caroline, additional, Simonsick, Eleanor, additional, van Duijn, Cornelia M., additional, Jin, Zi-Bing, additional, Qu, Jia, additional, Hishigaki, Haretsugu, additional, Lin, Xu, additional, März, Winfried, additional, Gudnason, Vilmundur, additional, Tardif, Jean-Claude, additional, Lettre, Guillaume, additional, Hart, Leen M.‘t, additional, Elders, Petra J. M., additional, Damrauer, Scott M., additional, Kumari, Meena, additional, Kivimaki, Mika, additional, van der Harst, Pim, additional, Spector, Tim D., additional, Loos, Ruth J. F., additional, Province, Michael A., additional, Parra, Esteban J., additional, Cruz, Miguel, additional, Psaty, Bruce M., additional, Brandslund, Ivan, additional, Pramstaller, Peter P., additional, Rotimi, Charles N., additional, Christensen, Kaare, additional, Ripatti, Samuli, additional, Widén, Elisabeth, additional, Hakonarson, Hakon, additional, Grant, Struan F. A., additional, Kiemeney, Lambertus A. L. M., additional, de Graaf, Jacqueline, additional, Loeffler, Markus, additional, Kronenberg, Florian, additional, Gu, Dongfeng, additional, Erdmann, Jeanette, additional, Schunkert, Heribert, additional, Franks, Paul W., additional, Linneberg, Allan, additional, Jukema, J. Wouter, additional, Khera, Amit V., additional, Männikkö, Minna, additional, Jarvelin, Marjo-Riitta, additional, Kutalik, Zoltan, additional, Francesco, Cucca, additional, Mook-Kanamori, Dennis O., additional, van Dijk, Ko Willems, additional, Watkins, Hugh, additional, Strachan, David P., additional, Grarup, Niels, additional, Sever, Peter, additional, Poulter, Neil, additional, Chuang, Lee-Ming, additional, Rotter, Jerome I., additional, Dantoft, Thomas M., additional, Karpe, Fredrik, additional, Neville, Matt J., additional, Timpson, Nicholas J., additional, Cheng, Ching-Yu, additional, Wong, Tien-Yin, additional, Khor, Chiea Chuen, additional, Li, Hengtong, additional, Sabanayagam, Charumathi, additional, Peters, Annette, additional, Gieger, Christian, additional, Hattersley, Andrew T., additional, Pedersen, Nancy L., additional, Magnusson, Patrik K. E., additional, Boomsma, Dorret I., additional, Willemsen, Allegonda H. M., additional, Cupples, LAdrienne, additional, van Meurs, Joyce B. J., additional, Ghanbari, Mohsen, additional, Gordon-Larsen, Penny, additional, Huang, Wei, additional, Kim, Young Jin, additional, Tabara, Yasuharu, additional, Wareham, Nicholas J., additional, Langenberg, Claudia, additional, Zeggini, Eleftheria, additional, Kuusisto, Johanna, additional, Laakso, Markku, additional, Ingelsson, Erik, additional, Abecasis, Goncalo, additional, Chambers, John C., additional, Kooner, Jaspal S., additional, de Vries, Paul S., additional, Morrison, Alanna C., additional, Hazelhurst, Scott, additional, Ramsay, Michèle, additional, North, Kari E., additional, Daviglus, Martha, additional, Kraft, Peter, additional, Martin, Nicholas G., additional, Whitfield, John B., additional, Abbas, Shahid, additional, Saleheen, Danish, additional, Walters, Robin G., additional, Holmes, Michael V., additional, Black, Corri, additional, Smith, Blair H., additional, Baras, Aris, additional, Justice, Anne E., additional, Buring, Julie E., additional, Ridker, Paul M., additional, Chasman, Daniel I., additional, Kooperberg, Charles, additional, Tamiya, Gen, additional, Yamamoto, Masayuki, additional, van Heel, David A., additional, Trembath, Richard C., additional, Wei, Wei-Qi, additional, Jarvik, Gail P., additional, Namjou, Bahram, additional, Hayes, M. Geoffrey, additional, Ritchie, Marylyn D., additional, Jousilahti, Pekka, additional, Salomaa, Veikko, additional, Hveem, Kristian, additional, Åsvold, Bjørn Olav, additional, Kubo, Michiaki, additional, Kamatani, Yoichiro, additional, Okada, Yukinori, additional, Murakami, Yoshinori, additional, Kim, Bong-Jo, additional, Thorsteinsdottir, Unnur, additional, Stefansson, Kari, additional, Zhang, Jifeng, additional, Chen, YEugene, additional, Ho, Yuk-Lam, additional, Lynch, Julie A., additional, Rader, Daniel J., additional, Tsao, Philip S., additional, Chang, Kyong-Mi, additional, Cho, Kelly, additional, O’Donnell, Christopher J., additional, Gaziano, John M., additional, Wilson, Peter W. F., additional, Frayling, Timothy M., additional, Hirschhorn, Joel N., additional, Kathiresan, Sekar, additional, Mohlke, Karen L., additional, Sun, Yan V., additional, Morris, Andrew P., additional, Boehnke, Michael, additional, Brown, Christopher D., additional, Natarajan, Pradeep, additional, Deloukas, Panos, additional, Willer, Cristen J., additional, Assimes, Themistocles L., additional, and Peloso, Gina M., additional
- Published
- 2022
- Full Text
- View/download PDF
5. Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
- Author
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Wang, Zhe, Emmerich, Andrew, Pillon, Nicolas J., Moore, Tim, Hemerich, Daiane, Cornelis, Marilyn C., Mazzaferro, Eugenia, Broos, Siacia, Ahluwalia, Tarunveer S., Bartz, Traci M., Bentley, Amy R., Bielak, Lawrence F., Chong, Mike, Chu, Audrey Y., Berry, Diane, Dorajoo, Rajkumar, Dueker, Nicole D., Kasbohm, Elisa, Feenstra, Bjarke, Feitosa, Mary F., Gieger, Christian, Graff, Mariaelisa, Hall, Leanne M., Haller, Toomas, Hartwig, Fernando P., Hillis, David A., Huikari, Ville, Heard-Costa, Nancy, Holzapfel, Christina, Jackson, Anne U., Johansson, Åsa, Jørgensen, Anja Moltke, Kaakinen, Marika A., Karlsson, Robert, Kerr, Kathleen F., Kim, Boram, Koolhaas, Chantal M., Kutalik, Zoltan, Lagou, Vasiliki, Lind, Penelope A., Lorentzon, Mattias, Lyytikäinen, Leo-Pekka, Mangino, Massimo, Metzendorf, Christoph, Monroe, Kristine R., Pacolet, Alexander, Pérusse, Louis, Pool, Rene, Richmond, Rebecca C., Rivera, Natalia V., Robiou-du-Pont, Sebastien, Schraut, Katharina E., Schulz, Christina-Alexandra, Stringham, Heather M., Tanaka, Toshiko, Teumer, Alexander, Turman, Constance, van der Most, Peter J., Vanmunster, Mathias, van Rooij, Frank J. A., van Vliet-Ostaptchouk, Jana V., Zhang, Xiaoshuai, Zhao, Jing-Hua, Zhao, Wei, Balkhiyarova, Zhanna, Balslev-Harder, Marie N., Baumeister, Sebastian E., Beilby, John, Blangero, John, Boomsma, Dorret I., Brage, Søren Karl, Braund, Peter S., Brody, Jennifer A., Bruinenberg, Marcel, Ekelund, Ulf, Liu, Ching-Ti, Cole, John W., Collins, Francis S., Cupples, L. Adrienne, Esko, Tõnu, Enroth, Stefan, Faul, Jessica D., Fernandez-Rhodes, Lindsay, Fohner, Alison E., Franco, Oscar H., Galesloot, Tessel E., Gordon, Scott D., Grarup, Niels, Hartman, Catharina A., Heiss, Gerardo, Hui, Jennie, Illig, Thomas, Jago, Russell, James, Alan, Joshi, Peter K., Jung, Taeyeong, Kähönen, Mika, Kilpeläinen, Tuomas O., Koh, Woon-Puay, Kolcic, Ivana, Kraft, Peter P., Kuusisto, Johanna, Launer, Lenore J., Li, Aihua, Linneberg, Allan, Luan, Jian’an, Vidal, Pedro Marques, Medland, Sarah E., Milaneschi, Yuri, Moscati, Arden, Musk, Bill, Nelson, Christopher P., Nolte, Ilja M., Pedersen, Nancy L., Peters, Annette, Peyser, Patricia A., Power, Christine, Raitakari, Olli T., Reedik, Mägi, Reiner, Alex P., Ridker, Paul M., Rudan, Igor, Ryan, Kathy, Sarzynski, Mark A., Scott, Laura J., Scott, Robert A., Sidney, Stephen, Siggeirsdottir, Kristin, Smith, Albert V., Smith, Jennifer A., Sonestedt, Emily, Strøm, Marin, Tai, E. Shyong, Teo, Koon K., Thorand, Barbara, Tönjes, Anke, Tremblay, Angelo, Uitterlinden, Andre G., Vangipurapu, Jagadish, van Schoor, Natasja, Völker, Uwe, Willemsen, Gonneke, Williams, Kayleen, Wong, Quenna, Xu, Huichun, Young, Kristin L., Yuan, Jian Min, Zillikens, M. Carola, Zonderman, Alan B., Ameur, Adam, Bandinelli, Stefania, Bis, Joshua C., Boehnke, Michael, Bouchard, Claude, Chasman, Daniel I., Smith, George Davey, de Geus, Eco J. C., Deldicque, Louise, Dörr, Marcus, Evans, Michele K., Ferrucci, Luigi, Fornage, Myriam, Fox, Caroline, Garland, Theodore, Gudnason, Vilmundur, Gyllensten, Ulf, Hansen, Torben, Hayward, Caroline, Horta, Bernardo L., Hyppönen, Elina, Jarvelin, Marjo-Riitta, Johnson, W. Craig, Kardia, Sharon L. R., Kiemeney, Lambertus A., Laakso, Markku, Langenberg, Claudia, Lehtimäki, Terho, Marchand, Loic Le, Alizadeh, Behrooz Z., Boezen, H. Marike, Franke, Lude, Swertz, Morris, Wijmenga, Tjitske Nienke, van der Harst, Pim, Navis, Gerjan, Rots, Marianne, Wolffenbuttel, Bruce H. R., Magnusson, Patrik K. E., Martin, Nicholas G., Melbye, Mads, Metspalu, Andres, Meyre, David, North, Kari E., Ohlsson, Claes, Oldehinkel, Albertine J., Orho-Melander, Marju, Pare, Guillaume, Park, Taesung, Pedersen, Oluf, Penninx, Brenda W. J. H., Pers, Tune H., Polasek, Ozren, Prokopenko, Inga, Rotimi, Charles N., Samani, Nilesh J., Sim, Xueling, Snieder, Harold, Sørensen, Thorkild I. A., Spector, Tim D., Timpson, Nicholas J., van Dam, Rob M., van der Velde, Nathalie, van Duijn, Cornelia M., Vollenweider, Peter, Völzke, Henry, Voortman, Trudy, Waeber, Gérard, Wareham, Nicholas J., Weir, David R., Wichmann, Heinz-Erich, Wilson, James F., Hevener, Andrea L., Krook, Anna, Zierath, Juleen R., Thomis, Martine A. I., Loos, Ruth J. F., Hoed, Marcel den, Epidemiology, Internal Medicine, Tampere University, Department of Clinical Chemistry, Clinical Medicine, Department of Clinical Physiology and Nuclear Medicine, Wang, Zhe, Emmerich, Andrew, Pillon, Nicolas J, Moore, Tim, Hyppönen, Elina, den Hoed, Marcel, Lifelines Cohort Study, Alizadeh, B.Z., Boezen, H.M., Franke, L., Swertz, M., Wijmenga, C., van der Harst, P., Navis, G., Rots, M., Wolffenbuttel, BHR, Wang, Zhe [0000-0002-8046-4969], Emmerich, Andrew [0000-0002-0908-9924], Pillon, Nicolas J [0000-0003-1107-9490], Moore, Tim [0000-0003-4250-3370], Ameur, Adam [0000-0001-6085-6749], Bis, Joshua C [0000-0002-3409-1110], Boehnke, Michael [0000-0002-6442-7754], Bouchard, Claude [0000-0002-0048-491X], Chasman, Daniel I [0000-0003-3357-0862], Smith, George Davey [0000-0002-1407-8314], de Geus, Eco JC [0000-0001-6022-2666], Dörr, Marcus [0000-0001-7471-475X], Ferrucci, Luigi [0000-0002-6273-1613], Fornage, Myriam [0000-0003-0677-8158], Garland, Theodore [0000-0002-7916-3552], Gyllensten, Ulf [0000-0002-6316-3355], Hansen, Torben [0000-0001-8748-3831], Horta, Bernardo L [0000-0001-9843-412X], Hyppönen, Elina [0000-0003-3670-9399], Johnson, W Craig [0000-0002-3161-3753], Kiemeney, Lambertus A [0000-0002-2368-1326], Laakso, Markku [0000-0002-3394-7749], Langenberg, Claudia [0000-0002-5017-7344], Lehtimäki, Terho [0000-0002-2555-4427], Magnusson, Patrik KE [0000-0002-7315-7899], Martin, Nicholas G [0000-0003-4069-8020], Melbye, Mads [0000-0001-8264-6785], Metspalu, Andres [0000-0002-3718-796X], Meyre, David [0000-0003-4850-7444], North, Kari E [0000-0002-8903-0366], Ohlsson, Claes [0000-0002-9633-2805], Oldehinkel, Albertine J [0000-0003-3925-3913], Orho-Melander, Marju [0000-0002-3578-2503], Pare, Guillaume [0000-0002-6795-4760], Park, Taesung [0000-0002-8294-590X], Pedersen, Oluf [0000-0002-3321-3972], Pers, Tune H [0000-0003-0207-4831], Polasek, Ozren [0000-0002-5765-1862], Prokopenko, Inga [0000-0003-1624-7457], Rotimi, Charles N [0000-0001-5759-053X], Sim, Xueling [0000-0002-1233-7642], Snieder, Harold [0000-0003-1949-2298], Sørensen, Thorkild IA [0000-0003-4821-430X], Spector, Tim D [0000-0002-9795-0365], Timpson, Nicholas J [0000-0002-7141-9189], Voortman, Trudy [0000-0003-2830-6813], Waeber, Gérard [0000-0003-4193-788X], Wareham, Nicholas J [0000-0003-1422-2993], Weir, David R [0000-0002-1661-2402], Wilson, James F [0000-0001-5751-9178], Krook, Anna [0000-0002-0891-0258], Zierath, Juleen R [0000-0001-6891-7497], Thomis, Martine AI [0000-0001-9093-2191], Loos, Ruth JF [0000-0002-8532-5087], Hoed, Marcel den [0000-0001-8081-428X], Apollo - University of Cambridge Repository, Center for Liver, Digestive and Metabolic Diseases (CLDM), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Life Course Epidemiology (LCE), Geriatrics, AMS - Ageing & Vitality, APH - Aging & Later Life, Biological Psychology, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, APH - Mental Health, APH - Methodology, and AMS - Sports
- Subjects
Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] ,631/208/205/2138 ,610 Medicine & health ,heritability ,Actinin/genetics ,Cross-Sectional Studies ,Exercise/physiology ,Genome-Wide Association Study ,Humans ,Leisure Activities ,Sedentary Behavior ,apolipoprotein-e genotype ,Lifelines Cohort Study ,360 Social problems & social services ,692/308/575 ,Genetics ,Actinin ,Exercise ,Medicinsk genetik ,exercise ,APOLIPOPROTEIN-E GENOTYPE ,LD SCORE REGRESSION ,GENE-EXPRESSION ,EXERCISE ,COMPLEX ,PERFORMANCE ,GWAS ,HERITABILITY ,MORTALITY ,FITNESS ,360 Soziale Probleme, Sozialdienste ,692/308/2056 ,article ,gwas ,gene-expression ,mortality ,3142 Public health care science, environmental and occupational health ,fitness ,Urological cancers Radboud Institute for Health Sciences [Radboudumc 15] ,LD score regression ,3111 Biomedicine ,610 Medizin und Gesundheit ,Medical Genetics ,complex ,performance - Abstract
Funder: Kjell och Märta Beijers Stiftelse (Kjell and Marta Beijer Foundation); doi: https://doi.org/10.13039/501100006353, Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention.
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- 2022
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6. Acceptance of healthy lifestyle nudges in the general population of Singapore
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Tan, Yeow Wee Brian, primary, Tan, Edward Ryan, additional, Sin, Koh Yen, additional, AshaRani, P. V., additional, Abdin, Edimansyah, additional, Roystonn, Kumarasan, additional, Wang, Peizhi, additional, Devi, Fiona, additional, Vaingankar, Janhavi, additional, van Dam, Rob M, additional, Sum, Chee Fang, additional, Lee, Eng Sing, additional, Chow, Wai Leng, additional, Chong, Siow Ann, additional, and Subramaniam, Mythily, additional
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- 2022
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7. Caffeine consumption and cardiovascular health
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van Dam, Rob M., primary and Hu, Frank B., additional
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- 2022
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8. Genetic determinants of liking and intake of coffee and other bitter foods and beverages
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Cornelis, Marilyn C., primary and van Dam, Rob M., additional
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- 2021
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9. Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian individuals
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Chen, Yuqing, primary, Kassam, Irfahan, additional, Lau, Suk Hiang, additional, Kooner, Jaspal S., additional, Wilson, Rory, additional, Peters, Annette, additional, Winkelmann, Juliane, additional, Chambers, John C., additional, Chow, Vincent T., additional, Khor, Chiea Chuen, additional, van Dam, Rob M., additional, Teo, Yik-Ying, additional, Loh, Marie, additional, and Sim, Xueling, additional
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- 2021
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10. The Pre-Diabetes Interventions and Continued Tracking to Ease-out Diabetes (Pre-DICTED) program: study protocol for a randomized controlled trial
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Yeung, Kar-Fu, primary, Gandhi, Mihir, additional, Lam, Amanda Yun Rui, additional, Julianty, Selly, additional, Chia, Alvin Yeow Meng, additional, Tan, Gilbert Choon Seng, additional, Goh, Su-Yen, additional, Ho, Emily Tse Lin, additional, Koh, Angela Fang Yung, additional, Tan, Gavin Siew Wei, additional, Shum, Eugene Jin Wen, additional, Finkelstein, Eric A., additional, Jafar, Tazeen H., additional, Teoh, Yee Leong, additional, van Dam, Rob M., additional, Whitton, Clare, additional, Thumboo, Julian, additional, and Bee, Yong Mong, additional
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- 2021
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11. Associations of park access, park use and physical activity in parks with wellbeing in an Asian urban environment: a cross-sectional study
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Petrunoff, Nicholas A., primary, Yi, Ng Xian, additional, Dickens, Borame, additional, Sia, Angelia, additional, Koo, Joel, additional, Cook, Alex R., additional, Lin, Wee Hwee, additional, Ying, Lu, additional, Hsing, Ann W., additional, van Dam, Rob M., additional, and Müller-Riemenschneider, Falk, additional
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- 2021
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12. Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population
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Chang, Xuling, primary, Gurung, Resham L., additional, Wang, Ling, additional, Jin, Aizhen, additional, Li, Zheng, additional, Wang, Renwei, additional, Beckman, Kenneth B., additional, Adams-Haduch, Jennifer, additional, Meah, Wee Yang, additional, Sim, Kar Seng, additional, Lim, Weng Khong, additional, Davila, Sonia, additional, Tan, Patrick, additional, Teo, Jing Xian, additional, Yeo, Khung Keong, additional, M., Yiamunaa, additional, Liu, Sylvia, additional, Lim, Su Chi, additional, Liu, Jianjun, additional, van Dam, Rob M., additional, Friedlander, Yechiel, additional, Koh, Woon-Puay, additional, Yuan, Jian-Min, additional, Khor, Chiea Chuen, additional, Heng, Chew-Kiat, additional, and Dorajoo, Rajkumar, additional
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- 2021
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13. Plasma sphingolipids and risk of cardiovascular diseases: a large-scale lipidomic analysis
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Seah, Jowy Yi Hoong, primary, Chew, Wee Siong, additional, Torta, Federico, additional, Khoo, Chin Meng, additional, Wenk, Markus R., additional, Herr, Deron R., additional, Choi, Hyungwon, additional, Tai, E. Shyong, additional, and van Dam, Rob M., additional
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- 2020
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14. Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood
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Zheng, Yan, primary, Huang, Tao, additional, Wang, Tiange, additional, Mei, Zhendong, additional, Sun, Zhonghan, additional, Zhang, Tao, additional, Ellervik, Christina, additional, Chai, Jin-Fang, additional, Sim, Xueling, additional, van Dam, Rob M., additional, Tai, E-Shyong, additional, Koh, Woon-Puay, additional, Dorajoo, Rajkumar, additional, Saw, Seang-Mei, additional, Sabanayagam, Charumathi, additional, Wong, Tien Yin, additional, Gupta, Preeti, additional, Rossing, Peter, additional, Ahluwalia, Tarunveer S., additional, Vinding, Rebecca K., additional, Bisgaard, Hans, additional, Bønnelykke, Klaus, additional, Wang, Yujie, additional, Graff, Mariaelisa, additional, Voortman, Trudy, additional, van Rooij, Frank J. A., additional, Hofman, Albert, additional, van Heemst, Diana, additional, Noordam, Raymond, additional, Estampador, Angela C., additional, Varga, Tibor V., additional, Enzenbach, Cornelia, additional, Scholz, Markus, additional, Thiery, Joachim, additional, Burkhardt, Ralph, additional, Orho-Melander, Marju, additional, Schulz, Christina-Alexandra, additional, Ericson, Ulrika, additional, Sonestedt, Emily, additional, Kubo, Michiaki, additional, Akiyama, Masato, additional, Zhou, Ang, additional, Kilpeläinen, Tuomas O., additional, Hansen, Torben, additional, Kleber, Marcus E., additional, Delgado, Graciela, additional, McCarthy, Mark, additional, Lemaitre, Rozenn N., additional, Felix, Janine F., additional, Jaddoe, Vincent W. V., additional, Wu, Ying, additional, Mohlke, Karen L., additional, Lehtimäki, Terho, additional, Wang, Carol A., additional, Pennell, Craig E., additional, Schunkert, Heribert, additional, Kessler, Thorsten, additional, Zeng, Lingyao, additional, Willenborg, Christina, additional, Peters, Annette, additional, Lieb, Wolfgang, additional, Grote, Veit, additional, Rzehak, Peter, additional, Koletzko, Berthold, additional, Erdmann, Jeanette, additional, Munz, Matthias, additional, Wu, Tangchun, additional, He, Meian, additional, Yu, Caizheng, additional, Lecoeur, Cécile, additional, Froguel, Philippe, additional, Corella, Dolores, additional, Moreno, Luis A., additional, Lai, Chao-Qiang, additional, Pitkänen, Niina, additional, Boreham, Colin A., additional, Ridker, Paul M., additional, Rosendaal, Frits R., additional, de Mutsert, Renée, additional, Power, Chris, additional, Paternoster, Lavinia, additional, Sørensen, Thorkild I. A., additional, Tjønneland, Anne, additional, Overvad, Kim, additional, Djousse, Luc, additional, Rivadeneira, Fernando, additional, Lee, Nanette R., additional, Raitakari, Olli T., additional, Kähönen, Mika, additional, Viikari, Jorma, additional, Langhendries, Jean-Paul, additional, Escribano, Joaquin, additional, Verduci, Elvira, additional, Dedoussis, George, additional, König, Inke, additional, Balkau, Beverley, additional, Coltell, Oscar, additional, Dallongeville, Jean, additional, Meirhaeghe, Aline, additional, Amouyel, Philippe, additional, Gottrand, Frédéric, additional, Pahkala, Katja, additional, Niinikoski, Harri, additional, Hyppönen, Elina, additional, März, Winfried, additional, Mackey, David A., additional, Gruszfeld, Dariusz, additional, Tucker, Katherine L., additional, Fumeron, Frédéric, additional, Estruch, Ramon, additional, Ordovas, Jose M., additional, Arnett, Donna K., additional, Mook-Kanamori, Dennis O., additional, Mozaffarian, Dariush, additional, Psaty, Bruce M., additional, North, Kari E., additional, Chasman, Daniel I., additional, and Qi, Lu, additional
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- 2020
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15. Identification of type 2 diabetes loci in 433,540 East Asian individuals
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Spracklen, Cassandra N., primary, Horikoshi, Momoko, additional, Kim, Young Jin, additional, Lin, Kuang, additional, Bragg, Fiona, additional, Moon, Sanghoon, additional, Suzuki, Ken, additional, Tam, Claudia H. T., additional, Tabara, Yasuharu, additional, Kwak, Soo-Heon, additional, Takeuchi, Fumihiko, additional, Long, Jirong, additional, Lim, Victor J. Y., additional, Chai, Jin-Fang, additional, Chen, Chien-Hsiun, additional, Nakatochi, Masahiro, additional, Yao, Jie, additional, Choi, Hyeok Sun, additional, Iyengar, Apoorva K., additional, Perrin, Hannah J., additional, Brotman, Sarah M., additional, van de Bunt, Martijn, additional, Gloyn, Anna L., additional, Below, Jennifer E., additional, Boehnke, Michael, additional, Bowden, Donald W., additional, Chambers, John C., additional, Mahajan, Anubha, additional, McCarthy, Mark I., additional, Ng, Maggie C. Y., additional, Petty, Lauren E., additional, Zhang, Weihua, additional, Morris, Andrew P., additional, Adair, Linda S., additional, Akiyama, Masato, additional, Bian, Zheng, additional, Chan, Juliana C. N., additional, Chang, Li-Ching, additional, Chee, Miao-Li, additional, Chen, Yii-Der Ida, additional, Chen, Yuan-Tsong, additional, Chen, Zhengming, additional, Chuang, Lee-Ming, additional, Du, Shufa, additional, Gordon-Larsen, Penny, additional, Gross, Myron, additional, Guo, Xiuqing, additional, Guo, Yu, additional, Han, Sohee, additional, Howard, Annie-Green, additional, Huang, Wei, additional, Hung, Yi-Jen, additional, Hwang, Mi Yeong, additional, Hwu, Chii-Min, additional, Ichihara, Sahoko, additional, Isono, Masato, additional, Jang, Hye-Mi, additional, Jiang, Guozhi, additional, Jonas, Jost B., additional, Kamatani, Yoichiro, additional, Katsuya, Tomohiro, additional, Kawaguchi, Takahisa, additional, Khor, Chiea-Chuen, additional, Kohara, Katsuhiko, additional, Lee, Myung-Shik, additional, Lee, Nanette R., additional, Li, Liming, additional, Liu, Jianjun, additional, Luk, Andrea O., additional, Lv, Jun, additional, Okada, Yukinori, additional, Pereira, Mark A., additional, Sabanayagam, Charumathi, additional, Shi, Jinxiu, additional, Shin, Dong Mun, additional, So, Wing Yee, additional, Takahashi, Atsushi, additional, Tomlinson, Brian, additional, Tsai, Fuu-Jen, additional, van Dam, Rob M., additional, Xiang, Yong-Bing, additional, Yamamoto, Ken, additional, Yamauchi, Toshimasa, additional, Yoon, Kyungheon, additional, Yu, Canqing, additional, Yuan, Jian-Min, additional, Zhang, Liang, additional, Zheng, Wei, additional, Igase, Michiya, additional, Cho, Yoon Shin, additional, Rotter, Jerome I., additional, Wang, Ya-Xing, additional, Sheu, Wayne H. H., additional, Yokota, Mitsuhiro, additional, Wu, Jer-Yuarn, additional, Cheng, Ching-Yu, additional, Wong, Tien-Yin, additional, Shu, Xiao-Ou, additional, Kato, Norihiro, additional, Park, Kyong-Soo, additional, Tai, E-Shyong, additional, Matsuda, Fumihiko, additional, Koh, Woon-Puay, additional, Ma, Ronald C. W., additional, Maeda, Shiro, additional, Millwood, Iona Y., additional, Lee, Juyoung, additional, Kadowaki, Takashi, additional, Walters, Robin G., additional, Kim, Bong-Jo, additional, Mohlke, Karen L., additional, and Sim, Xueling, additional
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- 2020
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16. Associations of autozygosity with a broad range of human phenotypes
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Clark, David W, primary, Okada, Yukinori, additional, Moore, Kristjan H S, additional, Mason, Dan, additional, Pirastu, Nicola, additional, Gandin, Ilaria, additional, Mattsson, Hannele, additional, Barnes, Catriona L K, additional, Lin, Kuang, additional, Zhao, Jing Hua, additional, Deelen, Patrick, additional, Rohde, Rebecca, additional, Schurmann, Claudia, additional, Guo, Xiuqing, additional, Giulianini, Franco, additional, Zhang, Weihua, additional, Medina-Gomez, Carolina, additional, Karlsson, Robert, additional, Bao, Yanchun, additional, Bartz, Traci M, additional, Baumbach, Clemens, additional, Biino, Ginevra, additional, Bixley, Matthew J, additional, Brumat, Marco, additional, Chai, Jin-Fang, additional, Corre, Tanguy, additional, Cousminer, Diana L, additional, Dekker, Annelot M, additional, Eccles, David A, additional, van Eijk, Kristel R, additional, Fuchsberger, Christian, additional, Gao, He, additional, Germain, Marine, additional, Gordon, Scott D, additional, de Haan, Hugoline G, additional, Harris, Sarah E, additional, Hofer, Edith, additional, Huerta-Chagoya, Alicia, additional, Igartua, Catherine, additional, Jansen, Iris E, additional, Jia, Yucheng, additional, Kacprowski, Tim, additional, Karlsson, Torgny, additional, Kleber, Marcus E, additional, Li, Shengchao Alfred, additional, Li-Gao, Ruifang, additional, Mahajan, Anubha, additional, Matsuda, Koichi, additional, Meidtner, Karina, additional, Meng, Weihua, additional, Montasser, May E, additional, van der Most, Peter J, additional, Munz, Matthias, additional, Nutile, Teresa, additional, Palviainen, Teemu, additional, Prasad, Gauri, additional, Prasad, Rashmi B, additional, Priyanka, Tallapragada Divya Sri, additional, Rizzi, Federica, additional, Salvi, Erika, additional, Sapkota, Bishwa R, additional, Shriner, Daniel, additional, Skotte, Line, additional, Smart, Melissa C, additional, Smith, Albert Vernon, additional, van der Spek, Ashley, additional, Spracklen, Cassandra N, additional, Strawbridge, Rona J, additional, Tajuddin, Salman M, additional, Trompet, Stella, additional, Turman, Constance, additional, Verweij, Niek, additional, Viberti, Clara, additional, Wang, Lihua, additional, Warren, Helen R, additional, Wootton, Robyn E, additional, Yanek, Lisa R, additional, Yao, Jie, additional, Yousri, Noha A, additional, Zhao, Wei, additional, Adeyemo, Adebowale A, additional, Afaq, Saima, additional, Aguilar-Salinas, Carlos Alberto, additional, Akiyama, Masato, additional, Albert, Matthew L, additional, Allison, Matthew A, additional, Alver, Maris, additional, Aung, Tin, additional, Azizi, Fereidoun, additional, Bentley, Amy R, additional, Boeing, Heiner, additional, Boerwinkle, Eric, additional, Borja, Judith B, additional, de Borst, Gert J, additional, Bottinger, Erwin P, additional, Broer, Linda, additional, Campbell, Harry, additional, Chanock, Stephen, additional, Chee, Miao-Li, additional, Chen, Guanjie, additional, Chen, Yii-Der I, additional, Chen, Zhengming, additional, Chiu, Yen-Feng, additional, Cocca, Massimiliano, additional, Collins, Francis S, additional, Concas, Maria Pina, additional, Corley, Janie, additional, Cugliari, Giovanni, additional, van Dam, Rob M, additional, Damulina, Anna, additional, Daneshpour, Maryam S, additional, Day, Felix R, additional, Delgado, Graciela E, additional, Dhana, Klodian, additional, Doney, Alexander S F, additional, Dörr, Marcus, additional, Doumatey, Ayo P, additional, Dzimiri, Nduna, additional, Ebenesersdóttir, S Sunna, additional, Elliott, Joshua, additional, Elliott, Paul, additional, Ewert, Ralf, additional, Felix, Janine F, additional, Fischer, Krista, additional, Freedman, Barry I, additional, Girotto, Giorgia, additional, Goel, Anuj, additional, Gögele, Martin, additional, Goodarzi, Mark O, additional, Graff, Mariaelisa, additional, Granot-Hershkovitz, Einat, additional, Grodstein, Francine, additional, Guarrera, Simonetta, additional, Gudbjartsson, Daniel F, additional, Guity, Kamran, additional, Gunnarsson, Bjarni, additional, Guo, Yu, additional, Hagenaars, Saskia P, additional, Haiman, Christopher A, additional, Halevy, Avner, additional, Harris, Tamara B, additional, Hedayati, Mehdi, additional, van Heel, David A, additional, Hirata, Makoto, additional, Höfer, Imo, additional, Hsiung, Chao Agnes, additional, Huang, Jinyan, additional, Hung, Yi-Jen, additional, Ikram, M Arfan, additional, Jagadeesan, Anuradha, additional, Jousilahti, Pekka, additional, Kamatani, Yoichiro, additional, Kanai, Masahiro, additional, Kerrison, Nicola D, additional, Kessler, Thorsten, additional, Khaw, Kay-Tee, additional, Khor, Chiea Chuen, additional, de Kleijn, Dominique P V, additional, Koh, Woon-Puay, additional, Kolcic, Ivana, additional, Kraft, Peter, additional, Krämer, Bernhard K, additional, Kutalik, Zoltán, additional, Kuusisto, Johanna, additional, Langenberg, Claudia, additional, Launer, Lenore J, additional, Lawlor, Deborah A, additional, Lee, I-Te, additional, Lee, Wen-Jane, additional, Lerch, Markus M, additional, Li, Liming, additional, Liu, Jianjun, additional, Loh, Marie, additional, London, Stephanie J, additional, Loomis, Stephanie, additional, Lu, Yingchang, additional, Luan, Jian’an, additional, Mägi, Reedik, additional, Manichaikul, Ani W, additional, Manunta, Paolo, additional, Másson, Gísli, additional, Matoba, Nana, additional, Mei, Xue W, additional, Meisinger, Christa, additional, Meitinger, Thomas, additional, Mezzavilla, Massimo, additional, Milani, Lili, additional, Millwood, Iona Y, additional, Momozawa, Yukihide, additional, Moore, Amy, additional, Morange, Pierre-Emmanuel, additional, Moreno-Macías, Hortensia, additional, Mori, Trevor A, additional, Morrison, Alanna C, additional, Muka, Taulant, additional, Murakami, Yoshinori, additional, Murray, Alison D, additional, de Mutsert, Renée, additional, Mychaleckyj, Josyf C, additional, Nalls, Mike A, additional, Nauck, Matthias, additional, Neville, Matt J, additional, Nolte, Ilja M, additional, Ong, Ken K, additional, Orozco, Lorena, additional, Padmanabhan, Sandosh, additional, Pálsson, Gunnar, additional, Pankow, James S, additional, Pattaro, Cristian, additional, Pattie, Alison, additional, Polasek, Ozren, additional, Poulter, Neil, additional, Pramstaller, Peter P, additional, Quintana-Murci, Lluis, additional, Räikkönen, Katri, additional, Ralhan, Sarju, additional, Rao, Dabeeru C, additional, van Rheenen, Wouter, additional, Rich, Stephen S, additional, Ridker, Paul M, additional, Rietveld, Cornelius A, additional, Robino, Antonietta, additional, van Rooij, Frank J A, additional, Ruggiero, Daniela, additional, Saba, Yasaman, additional, Sabanayagam, Charumathi, additional, Sabater-Lleal, Maria, additional, Sala, Cinzia Felicita, additional, Salomaa, Veikko, additional, Sandow, Kevin, additional, Schmidt, Helena, additional, Scott, Laura J, additional, Scott, William R, additional, Sedaghati-Khayat, Bahareh, additional, Sennblad, Bengt, additional, van Setten, Jessica, additional, Sever, Peter J, additional, Sheu, Wayne H-H, additional, Shi, Yuan, additional, Shrestha, Smeeta, additional, Shukla, Sharvari Rahul, additional, Sigurdsson, Jon K, additional, Sikka, Timo Tonis, additional, Singh, Jai Rup, additional, Smith, Blair H, additional, Stančáková, Alena, additional, Stanton, Alice, additional, Starr, John M, additional, Stefansdottir, Lilja, additional, Straker, Leon, additional, Sulem, Patrick, additional, Sveinbjornsson, Gardar, additional, Swertz, Morris A, additional, Taylor, Adele M, additional, Taylor, Kent D, additional, Terzikhan, Natalie, additional, Tham, Yih-Chung, additional, Thorleifsson, Gudmar, additional, Thorsteinsdottir, Unnur, additional, Tillander, Annika, additional, Tracy, Russell P, additional, Tusié-Luna, Teresa, additional, Tzoulaki, Ioanna, additional, Vaccargiu, Simona, additional, Vangipurapu, Jagadish, additional, Veldink, Jan H, additional, Vitart, Veronique, additional, Völker, Uwe, additional, Vuoksimaa, Eero, additional, Wakil, Salma M, additional, Waldenberger, Melanie, additional, Wander, Gurpreet S, additional, Wang, Ya Xing, additional, Wareham, Nicholas J, additional, Wild, Sarah, additional, Yajnik, Chittaranjan S, additional, Yuan, Jian-Min, additional, Zeng, Lingyao, additional, Zhang, Liang, additional, Zhou, Jie, additional, Amin, Najaf, additional, Asselbergs, Folkert W, additional, Bakker, Stephan J L, additional, Becker, Diane M, additional, Lehne, Benjamin, additional, Bennett, David A, additional, van den Berg, Leonard H, additional, Berndt, Sonja I, additional, Bharadwaj, Dwaipayan, additional, Bielak, Lawrence F, additional, Bochud, Murielle, additional, Boehnke, Mike, additional, Bouchard, Claude, additional, Bradfield, Jonathan P, additional, Brody, Jennifer A, additional, Campbell, Archie, additional, Carmi, Shai, additional, Caulfield, Mark J, additional, Cesarini, David, additional, Chambers, John C, additional, Chandak, Giriraj Ratan, additional, Cheng, Ching-Yu, additional, Ciullo, Marina, additional, Cornelis, Marilyn, additional, Cusi, Daniele, additional, Smith, George Davey, additional, Deary, Ian J, additional, Dorajoo, Rajkumar, additional, van Duijn, Cornelia M, additional, Ellinghaus, David, additional, Erdmann, Jeanette, additional, Eriksson, Johan G, additional, Evangelou, Evangelos, additional, Evans, Michele K, additional, Faul, Jessica D, additional, Feenstra, Bjarke, additional, Feitosa, Mary, additional, Foisy, Sylvain, additional, Franke, Andre, additional, Friedlander, Yechiel, additional, Gasparini, Paolo, additional, Gieger, Christian, additional, Gonzalez, Clicerio, additional, Goyette, Philippe, additional, Grant, Struan F A, additional, Griffiths, Lyn R, additional, Groop, Leif, additional, Gudnason, Vilmundur, additional, Gyllensten, Ulf, additional, Hakonarson, Hakon, additional, Hamsten, Anders, additional, van der Harst, Pim, additional, Heng, Chew-Kiat, additional, Hicks, Andrew A, additional, Hochner, Hagit, additional, Huikuri, Heikki, additional, Hunt, Steven C, additional, Jaddoe, Vincent W V, additional, De Jager, Philip L, additional, Johannesson, Magnus, additional, Johansson, Åsa, additional, Jonas, Jost B, additional, Jukema, J Wouter, additional, Junttila, Juhani, additional, Kaprio, Jaakko, additional, Kardia, Sharon L. R., additional, Karpe, Fredrik, additional, Kumari, Meena, additional, Laakso, Markku, additional, van der Laan, Sander W, additional, Lahti, Jari, additional, Laudes, Matthias, additional, Lea, Rodney A, additional, Lieb, Wolfgang, additional, Lumley, Thomas, additional, Martin, Nicholas G, additional, März, Winfried, additional, Matullo, Giuseppe, additional, McCarthy, Mark I, additional, Medland, Sarah E, additional, Merriman, Tony R, additional, Metspalu, Andres, additional, Meyer, Brian F, additional, Mohlke, Karen L, additional, Montgomery, Grant W, additional, Mook-Kanamori, Dennis, additional, Munroe, Patricia B, additional, North, Kari E, additional, Nyholt, Dale R, additional, O’connell, Jeffery R, additional, Ober, Carole, additional, Oldehinkel, Albertine J, additional, Palmas, Walter, additional, Palmer, Colin, additional, Pasterkamp, Gerard G, additional, Patin, Etienne, additional, Pennell, Craig E, additional, Perusse, Louis, additional, Peyser, Patricia A, additional, Pirastu, Mario, additional, Polderman, Tinca J. C., additional, Porteous, David J, additional, Posthuma, Danielle, additional, Psaty, Bruce M, additional, Rioux, John D, additional, Rivadeneira, Fernando, additional, Rotimi, Charles, additional, Rotter, Jerome I, additional, Rudan, Igor, additional, Den Ruijter, Hester M, additional, Sanghera, Dharambir K, additional, Sattar, Naveed, additional, Schmidt, Reinhold, additional, Schulze, Matthias B, additional, Schunkert, Heribert, additional, Scott, Robert A, additional, Shuldiner, Alan R, additional, Sim, Xueling, additional, Small, Neil, additional, Smith, Jennifer A, additional, Sotoodehnia, Nona, additional, Tai, E-Shyong, additional, Teumer, Alexander, additional, Timpson, Nicholas J, additional, Toniolo, Daniela, additional, Tregouet, David-Alexandre, additional, Tuomi, Tiinamaija, additional, Vollenweider, Peter, additional, Wang, Carol A, additional, Weir, David R, additional, Whitfield, John B, additional, Wijmenga, Cisca, additional, Wong, Tien-Yin, additional, Wright, John, additional, Yang, Jingyun, additional, Yu, Lei, additional, Zemel, Babette S, additional, Zonderman, Alan B, additional, Perola, Markus, additional, Magnusson, Patrik K. E., additional, Uitterlinden, André G, additional, Kooner, Jaspal S, additional, Chasman, Daniel I, additional, Loos, Ruth J. F., additional, Franceschini, Nora, additional, Franke, Lude, additional, Haley, Chris S, additional, Hayward, Caroline, additional, Walters, Robin G, additional, Perry, John R. B., additional, Esko, Tōnu, additional, Helgason, Agnar, additional, Stefansson, Kari, additional, Joshi, Peter K, additional, Kubo, Michiaki, additional, and Wilson, James F, additional
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- 2019
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17. Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies
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Dorajoo, Rajkumar, primary, Chang, Xuling, additional, Gurung, Resham Lal, additional, Li, Zheng, additional, Wang, Ling, additional, Wang, Renwei, additional, Beckman, Kenneth B., additional, Adams-Haduch, Jennifer, additional, M, Yiamunaa, additional, Liu, Sylvia, additional, Meah, Wee Yang, additional, Sim, Kar Seng, additional, Lim, Su Chi, additional, Friedlander, Yechiel, additional, Liu, Jianjun, additional, van Dam, Rob M., additional, Yuan, Jian-Min, additional, Koh, Woon-Puay, additional, Khor, Chiea Chuen, additional, and Heng, Chew-Kiat, additional
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- 2019
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18. Adherence to the Mediterranean diet and risk of stroke and stroke subtypes
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Chen, Guo-Chong, primary, Neelakantan, Nithya, additional, Martín-Calvo, Nerea, additional, Koh, Woon-Puay, additional, Yuan, Jian-Min, additional, Bonaccio, Marialaura, additional, Iacoviello, Licia, additional, Martínez-González, Miguel A., additional, Qin, Li-Qiang, additional, and van Dam, Rob M., additional
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- 2019
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19. Screen viewing behavior and sleep duration among children aged 2 and below
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Chen, Bozhi, primary, van Dam, Rob M., additional, Tan, Chuen Seng, additional, Chua, Hwee Ling, additional, Wong, Pey Gein, additional, Bernard, Jonathan Y., additional, and Müller-Riemenschneider, Falk, additional
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- 2019
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20. Rice intake and risk of type 2 diabetes: the Singapore Chinese Health Study
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Seah, Jowy Y. H., primary, Koh, Woon-Puay, additional, Yuan, Jian-Min, additional, and van Dam, Rob M., additional
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- 2018
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21. Impact of tax and subsidy framed messages on high- and lower-sugar beverages sold in vending machines: a randomized crossover trial
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Seah, Sharna Si Ying, primary, Rebello, Salome A., additional, Tai, Bee Choo, additional, Tay, Zoey, additional, Finkelstein, Eric Andrew, additional, and van Dam, Rob M., additional
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- 2018
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22. Stepping volume and intensity patterns in a multi-ethnic urban Asian population
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Sumner, Jennifer, primary, Uijtdewilligen, Léonie, additional, Chu, Anne HY, additional, Ng, Sheryl HX, additional, Barreira, Tiago V., additional, Sloan, Robert Alan, additional, Van Dam, Rob M., additional, and Müller-Riemenschneider, Falk, additional
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- 2018
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23. Gene-diet interaction effects on BMI levels in the Singapore Chinese population
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Chang, Xuling, primary, Dorajoo, Rajkumar, additional, Sun, Ye, additional, Han, Yi, additional, Wang, Ling, additional, Khor, Chiea-Chuen, additional, Sim, Xueling, additional, Tai, E-Shyong, additional, Liu, Jianjun, additional, Yuan, Jian-Min, additional, Koh, Woon-Puay, additional, van Dam, Rob M., additional, Friedlander, Yechiel, additional, and Heng, Chew-Kiat, additional
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- 2018
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24. Genome-wide association study identifies a missense variant at APOA5 for coronary artery disease in Multi-Ethnic Cohorts from Southeast Asia
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Han, Yi, primary, Dorajoo, Rajkumar, additional, Chang, Xuling, additional, Wang, Ling, additional, Khor, Chiea-Chuen, additional, Sim, Xueling, additional, Cheng, Ching-Yu, additional, Shi, Yuan, additional, Tham, Yih Chung, additional, Zhao, Wanting, additional, Chee, Miao Ling, additional, Sabanayagam, Charumathi, additional, Chee, Miao Li, additional, Tan, Nicholas, additional, Wong, Tien Yin, additional, Tai, E-Shyong, additional, Liu, Jianjun, additional, Goh, Daniel Y. T., additional, Yuan, Jian-Min, additional, Koh, Woon-Puay, additional, van Dam, Rob M., additional, Low, Adrian F., additional, Chan, Mark Yan-Yee, additional, Friedlander, Yechiel, additional, and Heng, Chew-Kiat, additional
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- 2017
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25. Whole milk consumption and risk of cardiovascular disease and mortality: Isfahan Cohort Study
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Talaei, Mohammad, primary, Hosseini, Naeimeh, additional, van Dam, Rob M., additional, Sadeghi, Masoumeh, additional, Oveisgharan, Shahram, additional, Dianatkhah, Minoo, additional, and Sarrafzadegan, Nizal, additional
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- 2017
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26. Determinants of eating at local and western fast-food venues in an urban Asian population: a mixed methods approach
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Naidoo, Nasheen, primary, van Dam, Rob M., additional, Ng, Sheryl, additional, Tan, Chuen Seng, additional, Chen, Shiqi, additional, Lim, Jia Yi, additional, Chan, Mei Fen, additional, Chew, Ling, additional, and Rebello, Salome A., additional
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- 2017
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27. Validation of NoSAS score for screening of sleep-disordered breathing in a multiethnic Asian population
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Tan, Adeline, primary, Hong, Yueheng, additional, Tan, Linda W.L., additional, van Dam, Rob M., additional, Cheung, Yan Yi, additional, and Lee, Chi-Hang, additional
- Published
- 2017
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28. A genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population
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Dorajoo, Rajkumar, primary, Sun, Ye, additional, Han, Yi, additional, Ke, Tingjing, additional, Burger, Ayala, additional, Chang, Xuling, additional, Low, Hui Qi, additional, Guan, Weihua, additional, Lemaitre, Rozenn N., additional, Khor, Chiea-Chuen, additional, Yuan, Jian-Min, additional, Koh, Woon-Puay, additional, Ong, Choon Nam, additional, Tai, E. Shyong, additional, Liu, Jianjun, additional, van Dam, Rob M., additional, Heng, Chew-Kiat, additional, and Friedlander, Yechiel, additional
- Published
- 2015
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29. Correction: Corrigendum: New loci and coding variants confer risk for age-related macular degeneration in East Asians
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Cheng, Ching-Yu, primary, Yamashiro, Kenji, additional, Jia Chen, Li, additional, Ahn, Jeeyun, additional, Huang, Lulin, additional, Huang, Lvzhen, additional, Cheung, Chui Ming G., additional, Miyake, Masahiro, additional, Cackett, Peter D., additional, Yeo, Ian Y., additional, Laude, Augustinus, additional, Mathur, Ranjana, additional, Pang, Junxiong, additional, Sim, Kar Seng, additional, Koh, Adrian H., additional, Chen, Peng, additional, Lee, Shu Yen, additional, Wong, Doric, additional, Chan, Choi Mun, additional, Loh, Boon Kwang, additional, Sun, Yaoyao, additional, Davila, Sonia, additional, Nakata, Isao, additional, Nakanishi, Hideo, additional, Akagi-Kurashige, Yumiko, additional, Gotoh, Norimoto, additional, Tsujikawa, Akitaka, additional, Matsuda, Fumihiko, additional, Mori, Keisuke, additional, Yoneya, Shin, additional, Sakurada, Yoichi, additional, Iijima, Hiroyuki, additional, Iida, Tomohiro, additional, Honda, Shigeru, additional, Lai, Timothy Yuk Yau, additional, Tam, Pancy Oi Sin, additional, Chen, Haoyu, additional, Tang, Shibo, additional, Ding, Xiaoyan, additional, Wen, Feng, additional, Lu, Fang, additional, Zhang, Xiongze, additional, Shi, Yi, additional, Zhao, Peiquan, additional, Zhao, Bowen, additional, Sang, Jinghong, additional, Gong, Bo, additional, Dorajoo, Rajkumar, additional, Yuan, Jian-Min, additional, Koh, Woon-Puay, additional, van Dam, Rob M., additional, Friedlander, Yechiel, additional, Lin, Yin, additional, Hibberd, Martin L., additional, Foo, Jia Nee, additional, Wang, Ningli, additional, Wong, Chang Hua, additional, Tan, Gavin S., additional, Park, Sang Jun, additional, Bhargava, Mayuri, additional, Gopal, Lingam, additional, Naing, Thet, additional, Liao, Jiemin, additional, Ong, Peng Guan, additional, Mitchell, Paul, additional, Zhou, Peng, additional, Xie, Xuefeng, additional, Liang, Jinlong, additional, Mei, Junpu, additional, Jin, Xin, additional, Saw, Seang-Mei, additional, Ozaki, Mineo, additional, Mizoguchi, Takinori, additional, Kurimoto, Yasuo, additional, Woo, Se Joon, additional, Chung, Hum, additional, Yu, Hyeong-Gon, additional, Shin, Joo Young, additional, Park, Dong Ho, additional, Kim, In Taek, additional, Chang, Woohyok, additional, Sagong, Min, additional, Lee, Sang-Joon, additional, Kim, Hyun Woong, additional, Lee, Ji Eun, additional, Li, Yi, additional, Liu, Jianjun, additional, Teo, Yik Ying, additional, Heng, Chew Kiat, additional, Lim, Tock Han, additional, Yang, Suk-Kyun, additional, Song, Kyuyoung, additional, Vithana, Eranga N., additional, Aung, Tin, additional, Bei, Jin Xin, additional, Zeng, Yi Xin, additional, Tai, E. Shyong, additional, Li, Xiao Xin, additional, Yang, Zhenglin, additional, Park, Kyu-Hyung, additional, Pang, Chi Pui, additional, Yoshimura, Nagahisa, additional, Wong, Tien Yin, additional, and Khor, Chiea Chuen, additional
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- 2015
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30. New loci and coding variants confer risk for age-related macular degeneration in East Asians
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Cheng, Ching-Yu, primary, Yamashiro, Kenji, additional, Jia Chen, Li, additional, Ahn, Jeeyun, additional, Huang, Lulin, additional, Huang, Lvzhen, additional, Cheung, Chui Ming G., additional, Miyake, Masahiro, additional, Cackett, Peter D., additional, Yeo, Ian Y., additional, Laude, Augustinus, additional, Mathur, Ranjana, additional, Pang, Junxiong, additional, Sim, Kar Seng, additional, Koh, Adrian H., additional, Chen, Peng, additional, Lee, Shu Yen, additional, Wong, Doric, additional, Chan, Choi Mun, additional, Loh, Boon Kwang, additional, Sun, Yaoyao, additional, Davila, Sonia, additional, Nakata, Isao, additional, Nakanishi, Hideo, additional, Akagi-Kurashige, Yumiko, additional, Gotoh, Norimoto, additional, Tsujikawa, Akitaka, additional, Matsuda, Fumihiko, additional, Mori, Keisuke, additional, Yoneya, Shin, additional, Sakurada, Yoichi, additional, Iijima, Hiroyuki, additional, Iida, Tomohiro, additional, Honda, Shigeru, additional, Lai, Timothy Yuk Yau, additional, Tam, Pancy Oi Sin, additional, Chen, Haoyu, additional, Tang, Shibo, additional, Ding, Xiaoyan, additional, Wen, Feng, additional, Lu, Fang, additional, Zhang, Xiongze, additional, Shi, Yi, additional, Zhao, Peiquan, additional, Zhao, Bowen, additional, Sang, Jinghong, additional, Gong, Bo, additional, Dorajoo, Rajkumar, additional, Yuan, Jian-Min, additional, Koh, Woon-Puay, additional, van Dam, Rob M., additional, Friedlander, Yechiel, additional, Lin, Ying, additional, Hibberd, Martin L., additional, Foo, Jia Nee, additional, Wang, Ningli, additional, Wong, Chang Hua, additional, Tan, Gavin S., additional, Park, Sang Jun, additional, Bhargava, Mayuri, additional, Gopal, Lingam, additional, Naing, Thet, additional, Liao, Jiemin, additional, Guan Ong, Peng, additional, Mitchell, Paul, additional, Zhou, Peng, additional, Xie, Xuefeng, additional, Liang, Jinlong, additional, Mei, Junpu, additional, Jin, Xin, additional, Saw, Seang-Mei, additional, Ozaki, Mineo, additional, Mizoguchi, Takanori, additional, Kurimoto, Yasuo, additional, Woo, Se Joon, additional, Chung, Hum, additional, Yu, Hyeong-Gon, additional, Shin, Joo Young, additional, Park, Dong Ho, additional, Kim, In Taek, additional, Chang, Woohyok, additional, Sagong, Min, additional, Lee, Sang-Joon, additional, Kim, Hyun Woong, additional, Lee, Ji Eun, additional, Li, Yi, additional, Liu, Jianjun, additional, Teo, Yik Ying, additional, Heng, Chew Kiat, additional, Lim, Tock Han, additional, Yang, Suk-Kyun, additional, Song, Kyuyoung, additional, Vithana, Eranga N., additional, Aung, Tin, additional, Bei, Jin Xin, additional, Zeng, Yi Xin, additional, Tai, E. Shyong, additional, Li, Xiao Xin, additional, Yang, Zhenglin, additional, Park, Kyu-Hyung, additional, Pang, Chi Pui, additional, Yoshimura, Nagahisa, additional, Yin Wong, Tien, additional, and Khor, Chiea Chuen, additional
- Published
- 2015
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31. Maternal caffeine intake during pregnancy is associated with risk of low birth weight: a systematic review and dose-response meta-analysis
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Chen, Ling-Wei, primary, Wu, Yi, additional, Neelakantan, Nithya, additional, Chong, Mary Foong-Fong, additional, Pan, An, additional, and van Dam, Rob M, additional
- Published
- 2014
- Full Text
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32. Changes in coffee intake and subsequent risk of type 2 diabetes: three large cohorts of US men and women
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Bhupathiraju, Shilpa N., primary, Pan, An, additional, Manson, JoAnn E., additional, Willett, Walter C., additional, van Dam, Rob M., additional, and Hu, Frank B., additional
- Published
- 2014
- Full Text
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33. Effect of fenugreek (Trigonella foenum-graecumL.) intake on glycemia: a meta-analysis of clinical trials
- Author
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Neelakantan, Nithya, primary, Narayanan, Madanagopal, additional, de Souza, Russell J, additional, and van Dam, Rob M, additional
- Published
- 2014
- Full Text
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34. Coffee Consumption and Cardiovascular Health: Getting to the Heart of the Matter
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Rebello, Salome A., primary and van Dam, Rob M., additional
- Published
- 2013
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35. Television screen time, but not computer use and reading time, is associated with cardio-metabolic biomarkers in a multiethnic Asian population: a cross-sectional study
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Nang, Ei Ei Khaing, primary, Salim, Agus, additional, Wu, Yi, additional, Tai, E Shyong, additional, Lee, Jeannette, additional, and Van Dam, Rob M, additional
- Published
- 2013
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36. The effects of caffeinated and decaffeinated coffee on sex hormone-binding globulin and endogenous sex hormone levels: a randomized controlled trial
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Wedick, Nicole M, primary, Mantzoros, Christos S, additional, Ding, Eric L, additional, Brennan, Aoife M, additional, Rosner, Bernard, additional, Rimm, Eric B, additional, Hu, Frank B, additional, and van Dam, Rob M, additional
- Published
- 2012
- Full Text
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37. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways
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Stolk, Lisette, primary, Perry, John R B, additional, Chasman, Daniel I, additional, He, Chunyan, additional, Mangino, Massimo, additional, Sulem, Patrick, additional, Barbalic, Maja, additional, Broer, Linda, additional, Byrne, Enda M, additional, Ernst, Florian, additional, Esko, Tõnu, additional, Franceschini, Nora, additional, Gudbjartsson, Daniel F, additional, Hottenga, Jouke-Jan, additional, Kraft, Peter, additional, McArdle, Patrick F, additional, Porcu, Eleonora, additional, Shin, So-Youn, additional, Smith, Albert V, additional, van Wingerden, Sophie, additional, Zhai, Guangju, additional, Zhuang, Wei V, additional, Albrecht, Eva, additional, Alizadeh, Behrooz Z, additional, Aspelund, Thor, additional, Bandinelli, Stefania, additional, Lauc, Lovorka Barac, additional, Beckmann, Jacques S, additional, Boban, Mladen, additional, Boerwinkle, Eric, additional, Broekmans, Frank J, additional, Burri, Andrea, additional, Campbell, Harry, additional, Chanock, Stephen J, additional, Chen, Constance, additional, Cornelis, Marilyn C, additional, Corre, Tanguy, additional, Coviello, Andrea D, additional, d'Adamo, Pio, additional, Davies, Gail, additional, de Faire, Ulf, additional, de Geus, Eco J C, additional, Deary, Ian J, additional, Dedoussis, George V Z, additional, Deloukas, Panagiotis, additional, Ebrahim, Shah, additional, Eiriksdottir, Gudny, additional, Emilsson, Valur, additional, Eriksson, Johan G, additional, Fauser, Bart C J M, additional, Ferreli, Liana, additional, Ferrucci, Luigi, additional, Fischer, Krista, additional, Folsom, Aaron R, additional, Garcia, Melissa E, additional, Gasparini, Paolo, additional, Gieger, Christian, additional, Glazer, Nicole, additional, Grobbee, Diederick E, additional, Hall, Per, additional, Haller, Toomas, additional, Hankinson, Susan E, additional, Hass, Merli, additional, Hayward, Caroline, additional, Heath, Andrew C, additional, Hofman, Albert, additional, Ingelsson, Erik, additional, Janssens, A Cecile J W, additional, Johnson, Andrew D, additional, Karasik, David, additional, Kardia, Sharon L R, additional, Keyzer, Jules, additional, Kiel, Douglas P, additional, Kolcic, Ivana, additional, Kutalik, Zoltán, additional, Lahti, Jari, additional, Lai, Sandra, additional, Laisk, Triin, additional, Laven, Joop S E, additional, Lawlor, Debbie A, additional, Liu, Jianjun, additional, Lopez, Lorna M, additional, Louwers, Yvonne V, additional, Magnusson, Patrik K E, additional, Marongiu, Mara, additional, Martin, Nicholas G, additional, Klaric, Irena Martinovic, additional, Masciullo, Corrado, additional, McKnight, Barbara, additional, Medland, Sarah E, additional, Melzer, David, additional, Mooser, Vincent, additional, Navarro, Pau, additional, Newman, Anne B, additional, Nyholt, Dale R, additional, Onland-Moret, N Charlotte, additional, Palotie, Aarno, additional, Paré, Guillaume, additional, Parker, Alex N, additional, Pedersen, Nancy L, additional, Peeters, Petra H M, additional, Pistis, Giorgio, additional, Plump, Andrew S, additional, Polasek, Ozren, additional, Pop, Victor J M, additional, Psaty, Bruce M, additional, Räikkönen, Katri, additional, Rehnberg, Emil, additional, Rotter, Jerome I, additional, Rudan, Igor, additional, Sala, Cinzia, additional, Salumets, Andres, additional, Scuteri, Angelo, additional, Singleton, Andrew, additional, Smith, Jennifer A, additional, Snieder, Harold, additional, Soranzo, Nicole, additional, Stacey, Simon N, additional, Starr, John M, additional, Stathopoulou, Maria G, additional, Stirrups, Kathleen, additional, Stolk, Ronald P, additional, Styrkarsdottir, Unnur, additional, Sun, Yan V, additional, Tenesa, Albert, additional, Thorand, Barbara, additional, Toniolo, Daniela, additional, Tryggvadottir, Laufey, additional, Tsui, Kim, additional, Ulivi, Sheila, additional, van Dam, Rob M, additional, van der Schouw, Yvonne T, additional, van Gils, Carla H, additional, van Nierop, Peter, additional, Vink, Jacqueline M, additional, Visscher, Peter M, additional, Voorhuis, Marlies, additional, Waeber, Gérard, additional, Wallaschofski, Henri, additional, Wichmann, H Erich, additional, Widen, Elisabeth, additional, Wijnands-van Gent, Colette J M, additional, Willemsen, Gonneke, additional, Wilson, James F, additional, Wolffenbuttel, Bruce H R, additional, Wright, Alan F, additional, Yerges-Armstrong, Laura M, additional, Zemunik, Tatijana, additional, Zgaga, Lina, additional, Zillikens, M Carola, additional, Zygmunt, Marek, additional, Study, The LifeLines Cohort, additional, Arnold, Alice M, additional, Boomsma, Dorret I, additional, Buring, Julie E, additional, Crisponi, Laura, additional, Demerath, Ellen W, additional, Gudnason, Vilmundur, additional, Harris, Tamara B, additional, Hu, Frank B, additional, Hunter, David J, additional, Launer, Lenore J, additional, Metspalu, Andres, additional, Montgomery, Grant W, additional, Oostra, Ben A, additional, Ridker, Paul M, additional, Sanna, Serena, additional, Schlessinger, David, additional, Spector, Tim D, additional, Stefansson, Kari, additional, Streeten, Elizabeth A, additional, Thorsteinsdottir, Unnur, additional, Uda, Manuela, additional, Uitterlinden, André G, additional, van Duijn, Cornelia M, additional, Völzke, Henry, additional, Murray, Anna, additional, Murabito, Joanne M, additional, Visser, Jenny A, additional, and Lunetta, Kathryn L, additional
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- 2012
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38. Validity of the international physical activity questionnaire and the Singapore prospective study program physical activity questionnaire in a multiethnic urban Asian population
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Nang, Ei Ei Khaing, primary, Gitau Ngunjiri, Susan Ayuko, additional, Wu, Yi, additional, Salim, Agus, additional, Tai, E Shyong, additional, Lee, Jeannette, additional, and Van Dam, Rob M, additional
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- 2011
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39. Effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: a randomized controlled trial
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Wedick, Nicole M, primary, Brennan, Aoife M, additional, Sun, Qi, additional, Hu, Frank B, additional, Mantzoros, Christos S, additional, and van Dam, Rob M, additional
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- 2011
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40. A prospective cohort study of dietary patterns of non-western migrants in the Netherlands in relation to risk factors for cardiovascular diseases: HELIUS-Dietary Patterns
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Dekker, Louise H, primary, Snijder, Marieke B, additional, Beukers, Marja H, additional, de Vries, Jeanne HM, additional, Brants, Henny AM, additional, de Boer, Evelien J, additional, van Dam, Rob M, additional, Stronks, Karien, additional, and Nicolaou, Mary, additional
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- 2011
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41. Coffee and tea consumption in relation to inflammation and basal glucose metabolism in a multi-ethnic Asian population: a cross-sectional study
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Rebello, Salome A, primary, Chen, Cynthia H, additional, Naidoo, Nasheen, additional, Xu, Wang, additional, Lee, Jeannette, additional, Chia, Kee Seng, additional, Tai, E Shyong, additional, and van Dam, Rob M, additional
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- 2011
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42. Cholesterol-raising diterpenes in types of coffee commonly consumed in Singapore, Indonesia and India and associations with blood lipids: A survey and cross sectional study
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Naidoo, Nasheen, primary, Chen, Cynthia, additional, Rebello, Salome A, additional, Speer, Karl, additional, Tai, E Shyong, additional, Lee, Jeanette, additional, Buchmann, Sandra, additional, Koelling-Speer, Isabelle, additional, and van Dam, Rob M, additional
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- 2011
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43. Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on incretin hormones
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Olthof, Margreet R, primary, van Dijk, Aimée E, additional, Deacon, Carolyn F, additional, Heine, Robert J, additional, and van Dam, Rob M, additional
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- 2011
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44. Patterns of physical activity in different domains and implications for intervention in a multi-ethnic Asian population: a cross-sectional study
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Khaing Nang, Ei Ei, primary, Khoo, Eric YH, additional, Salim, Agus, additional, Tai, E Shyong, additional, Lee, Jeannette, additional, and Van Dam, Rob M, additional
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- 2010
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45. Mechanical Compression Versus Subcutaneous Heparin Therapy in Postoperative and Posttrauma Patients: A Systematic Review and Meta-Analysis
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Eppsteiner, Robert W., primary, Shin, Jennifer J., additional, Johnson, Jonas, additional, and van Dam, Rob M., additional
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- 2009
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46. 25-Hydroxyvitamin D is not Associated with Carotid Intima-Media Thickness in Older Men and Women
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Pilz, Stefan, primary, Henry, Ronald M. A., additional, Snijder, Marieke B., additional, van Dam, Rob M., additional, Nijpels, Giel, additional, Stehouwer, Coen D. A., additional, Tomaschitz, Andreas, additional, Pieber, Thomas R., additional, and Dekker, Jacqueline M., additional
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- 2009
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47. Review: The epidemiology of lifestyle and risk for type 2 diabetes
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van Dam, Rob M., primary
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- 2002
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48. Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
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Kilpeläinen, Tuomas O, Bentley, Amy R, Noordam, Raymond, Sung, Yun Ju, Schwander, Karen, Winkler, Thomas W, Jakupović, Hermina, Chasman, Daniel I, Manning, Alisa, Ntalla, Ioanna, Aschard, Hugues, Brown, Michael R, De Las Fuentes, Lisa, Franceschini, Nora, Guo, Xiuqing, Vojinovic, Dina, Aslibekyan, Stella, Feitosa, Mary F, Kho, Minjung, Musani, Solomon K, Richard, Melissa, Wang, Heming, Wang, Zhe, Bartz, Traci M, Bielak, Lawrence F, Campbell, Archie, Dorajoo, Rajkumar, Fisher, Virginia, Hartwig, Fernando P, Horimoto, Andrea RVR, Li, Changwei, Lohman, Kurt K, Marten, Jonathan, Sim, Xueling, Smith, Albert V, Tajuddin, Salman M, Alver, Maris, Amini, Marzyeh, Boissel, Mathilde, Chai, Jin Fang, Chen, Xu, Divers, Jasmin, Evangelou, Evangelos, Gao, Chuan, Graff, Mariaelisa, Harris, Sarah E, He, Meian, Hsu, Fang-Chi, Jackson, Anne U, Zhao, Jing Hua, Kraja, Aldi T, Kühnel, Brigitte, Laguzzi, Federica, Lyytikäinen, Leo-Pekka, Nolte, Ilja M, Rauramaa, Rainer, Riaz, Muhammad, Robino, Antonietta, Rueedi, Rico, Stringham, Heather M, Takeuchi, Fumihiko, Van Der Most, Peter J, Varga, Tibor V, Verweij, Niek, Ware, Erin B, Wen, Wanqing, Li, Xiaoyin, Yanek, Lisa R, Amin, Najaf, Arnett, Donna K, Boerwinkle, Eric, Brumat, Marco, Cade, Brian, Canouil, Mickaël, Chen, Yii-Der Ida, Concas, Maria Pina, Connell, John, De Mutsert, Renée, De Silva, H Janaka, De Vries, Paul S, Demirkan, Ayşe, Ding, Jingzhong, Eaton, Charles B, Faul, Jessica D, Friedlander, Yechiel, Gabriel, Kelley P, Ghanbari, Mohsen, Giulianini, Franco, Gu, Chi Charles, Gu, Dongfeng, Harris, Tamara B, He, Jiang, Heikkinen, Sami, Heng, Chew-Kiat, Hunt, Steven C, Ikram, M Arfan, Jonas, Jost B, Koh, Woon-Puay, Komulainen, Pirjo, Krieger, Jose E, Kritchevsky, Stephen B, Kutalik, Zoltán, Kuusisto, Johanna, Langefeld, Carl D, Langenberg, Claudia, Launer, Lenore J, Leander, Karin, Lemaitre, Rozenn N, Lewis, Cora E, Liang, Jingjing, Lifelines Cohort Study, Liu, Jianjun, Mägi, Reedik, Manichaikul, Ani, Meitinger, Thomas, Metspalu, Andres, Milaneschi, Yuri, Mohlke, Karen L, Mosley, Thomas H, Murray, Alison D, Nalls, Mike A, Nang, Ei-Ei Khaing, Nelson, Christopher P, Nona, Sotoodehnia, Norris, Jill M, Nwuba, Chiamaka Vivian, O'Connell, Jeff, Palmer, Nicholette D, Papanicolau, George J, Pazoki, Raha, Pedersen, Nancy L, Peters, Annette, Peyser, Patricia A, Polasek, Ozren, Porteous, David J, Poveda, Alaitz, Raitakari, Olli T, Rich, Stephen S, Risch, Neil, Robinson, Jennifer G, Rose, Lynda M, Rudan, Igor, Schreiner, Pamela J, Scott, Robert A, Sidney, Stephen S, Sims, Mario, Smith, Jennifer A, Snieder, Harold, Sofer, Tamar, Starr, John M, Sternfeld, Barbara, Strauch, Konstantin, Tang, Hua, Taylor, Kent D, Tsai, Michael Y, Tuomilehto, Jaakko, Uitterlinden, André G, Van Der Ende, M Yldau, Van Heemst, Diana, Voortman, Trudy, Waldenberger, Melanie, Wennberg, Patrik, Wilson, Gregory, Xiang, Yong-Bing, Yao, Jie, Yu, Caizheng, Yuan, Jian-Min, Zhao, Wei, Zonderman, Alan B, Becker, Diane M, Boehnke, Michael, Bowden, Donald W, De Faire, Ulf, Deary, Ian J, Elliott, Paul, Esko, Tõnu, Freedman, Barry I, Froguel, Philippe, Gasparini, Paolo, Gieger, Christian, Kato, Norihiro, Laakso, Markku, Lakka, Timo A, Lehtimäki, Terho, Magnusson, Patrik KE, Oldehinkel, Albertine J, Penninx, Brenda WJH, Samani, Nilesh J, Shu, Xiao-Ou, Van Der Harst, Pim, Van Vliet-Ostaptchouk, Jana V, Vollenweider, Peter, Wagenknecht, Lynne E, Wang, Ya X, Wareham, Nicholas J, Weir, David R, Wu, Tangchun, Zheng, Wei, Zhu, Xiaofeng, Evans, Michele K, Franks, Paul W, Gudnason, Vilmundur, Hayward, Caroline, Horta, Bernardo L, Kelly, Tanika N, Liu, Yongmei, North, Kari E, Pereira, Alexandre C, Ridker, Paul M, Tai, E Shyong, Van Dam, Rob M, Fox, Ervin R, Kardia, Sharon LR, Liu, Ching-Ti, Mook-Kanamori, Dennis O, Province, Michael A, Redline, Susan, Van Duijn, Cornelia M, Rotter, Jerome I, Kooperberg, Charles B, Gauderman, W James, Psaty, Bruce M, Rice, Kenneth, Munroe, Patricia B, Fornage, Myriam, Cupples, L Adrienne, Rotimi, Charles N, Morrison, Alanna C, Rao, Dabeeru C, and Loos, Ruth JF
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Adult ,Male ,Adolescent ,Genotype ,LIM-Homeodomain Proteins ,Black People ,Muscle Proteins ,Nerve Tissue Proteins ,White People ,Young Adult ,Asian People ,Humans ,Exercise ,Triglycerides ,Aged ,Aged, 80 and over ,Calcium-Binding Proteins ,Cholesterol, HDL ,Membrane Proteins ,Cholesterol, LDL ,Hispanic or Latino ,Middle Aged ,Lipid Metabolism ,Lipids ,3. Good health ,Cholesterol ,Genetic Loci ,lipids (amino acids, peptides, and proteins) ,Female ,Microtubule-Associated Proteins ,Brazil ,Genome-Wide Association Study ,Transcription Factors - Abstract
Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.
49. Associations of autozygosity with a broad range of human phenotypes
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Clark, David W, Okada, Yukinori, Moore, Kristjan HS, Mason, Dan, Pirastu, Nicola, Gandin, Ilaria, Mattsson, Hannele, Barnes, Catriona LK, Lin, Kuang, Zhao, Jing Hua, Deelen, Patrick, Rohde, Rebecca, Schurmann, Claudia, Guo, Xiuqing, Giulianini, Franco, Zhang, Weihua, Medina-Gomez, Carolina, Karlsson, Robert, Bao, Yanchun, Bartz, Traci M, Baumbach, Clemens, Biino, Ginevra, Bixley, Matthew J, Brumat, Marco, Chai, Jin-Fang, Corre, Tanguy, Cousminer, Diana L, Dekker, Annelot M, Eccles, David A, Van Eijk, Kristel R, Fuchsberger, Christian, Gao, He, Germain, Marine, Gordon, Scott D, De Haan, Hugoline G, Harris, Sarah E, Hofer, Edith, Huerta-Chagoya, Alicia, Igartua, Catherine, Jansen, Iris E, Jia, Yucheng, Kacprowski, Tim, Karlsson, Torgny, Kleber, Marcus E, Li, Shengchao Alfred, Li-Gao, Ruifang, Mahajan, Anubha, Matsuda, Koichi, Meidtner, Karina, Meng, Weihua, Montasser, May E, Van Der Most, Peter J, Munz, Matthias, Nutile, Teresa, Palviainen, Teemu, Prasad, Gauri, Prasad, Rashmi B, Priyanka, Tallapragada Divya Sri, Rizzi, Federica, Salvi, Erika, Sapkota, Bishwa R, Shriner, Daniel, Skotte, Line, Smart, Melissa C, Smith, Albert Vernon, Van Der Spek, Ashley, Spracklen, Cassandra N, Strawbridge, Rona J, Tajuddin, Salman M, Trompet, Stella, Turman, Constance, Verweij, Niek, Viberti, Clara, Wang, Lihua, Warren, Helen R, Wootton, Robyn E, Yanek, Lisa R, Yao, Jie, Yousri, Noha A, Zhao, Wei, Adeyemo, Adebowale A, Afaq, Saima, Aguilar-Salinas, Carlos Alberto, Akiyama, Masato, Albert, Matthew L, Allison, Matthew A, Alver, Maris, Aung, Tin, Azizi, Fereidoun, Bentley, Amy R, Boeing, Heiner, Boerwinkle, Eric, Borja, Judith B, De Borst, Gert J, Bottinger, Erwin P, Broer, Linda, Campbell, Harry, Chanock, Stephen, Chee, Miao-Li, Chen, Guanjie, Chen, Yii-Der I, Chen, Zhengming, Chiu, Yen-Feng, Cocca, Massimiliano, Collins, Francis S, Concas, Maria Pina, Corley, Janie, Cugliari, Giovanni, Van Dam, Rob M, Damulina, Anna, Daneshpour, Maryam S, Day, Felix R, Delgado, Graciela E, Dhana, Klodian, Doney, Alexander SF, Dörr, Marcus, Doumatey, Ayo P, Dzimiri, Nduna, Ebenesersdóttir, S Sunna, Elliott, Joshua, Elliott, Paul, Ewert, Ralf, Felix, Janine F, Fischer, Krista, Freedman, Barry I, Girotto, Giorgia, Goel, Anuj, Gögele, Martin, Goodarzi, Mark O, Graff, Mariaelisa, Granot-Hershkovitz, Einat, Grodstein, Francine, Guarrera, Simonetta, Gudbjartsson, Daniel F, Guity, Kamran, Gunnarsson, Bjarni, Guo, Yu, Hagenaars, Saskia P, Haiman, Christopher A, Halevy, Avner, Harris, Tamara B, Hedayati, Mehdi, Van Heel, David A, Hirata, Makoto, Höfer, Imo, Hsiung, Chao Agnes, Huang, Jinyan, Hung, Yi-Jen, Ikram, M Arfan, Jagadeesan, Anuradha, Jousilahti, Pekka, Kamatani, Yoichiro, Kanai, Masahiro, Kerrison, Nicola D, Kessler, Thorsten, Khaw, Kay-Tee, Khor, Chiea Chuen, De Kleijn, Dominique PV, Koh, Woon-Puay, Kolcic, Ivana, Kraft, Peter, Krämer, Bernhard K, Kutalik, Zoltán, Kuusisto, Johanna, Langenberg, Claudia, Launer, Lenore J, Lawlor, Deborah A, Lee, I-Te, Lee, Wen-Jane, Lerch, Markus M, Li, Liming, Liu, Jianjun, Loh, Marie, London, Stephanie J, Loomis, Stephanie, Lu, Yingchang, Luan, Jian'an, Mägi, Reedik, Manichaikul, Ani W, Manunta, Paolo, Másson, Gísli, Matoba, Nana, Mei, Xue W, Meisinger, Christa, Meitinger, Thomas, Mezzavilla, Massimo, Milani, Lili, Millwood, Iona Y, Momozawa, Yukihide, Moore, Amy, Morange, Pierre-Emmanuel, Moreno-Macías, Hortensia, Mori, Trevor A, Morrison, Alanna C, Muka, Taulant, Murakami, Yoshinori, Murray, Alison D, De Mutsert, Renée, Mychaleckyj, Josyf C, Nalls, Mike A, Nauck, Matthias, Neville, Matt J, Nolte, Ilja M, Ong, Ken K, Orozco, Lorena, Padmanabhan, Sandosh, Pálsson, Gunnar, Pankow, James S, Pattaro, Cristian, Pattie, Alison, Polasek, Ozren, Poulter, Neil, Pramstaller, Peter P, Quintana-Murci, Lluis, Räikkönen, Katri, Ralhan, Sarju, Rao, Dabeeru C, Van Rheenen, Wouter, Rich, Stephen S, Ridker, Paul M, Rietveld, Cornelius A, Robino, Antonietta, Van Rooij, Frank JA, Ruggiero, Daniela, Saba, Yasaman, Sabanayagam, Charumathi, Sabater-Lleal, Maria, Sala, Cinzia Felicita, Salomaa, Veikko, Sandow, Kevin, Schmidt, Helena, Scott, Laura J, Scott, William R, Sedaghati-Khayat, Bahareh, Sennblad, Bengt, Van Setten, Jessica, Sever, Peter J, Sheu, Wayne H-H, Shi, Yuan, Shrestha, Smeeta, Shukla, Sharvari Rahul, Sigurdsson, Jon K, Sikka, Timo Tonis, Singh, Jai Rup, Smith, Blair H, Stančáková, Alena, Stanton, Alice, Starr, John M, Stefansdottir, Lilja, Straker, Leon, Sulem, Patrick, Sveinbjornsson, Gardar, Swertz, Morris A, Taylor, Adele M, Taylor, Kent D, Terzikhan, Natalie, Tham, Yih-Chung, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tillander, Annika, Tracy, Russell P, Tusié-Luna, Teresa, Tzoulaki, Ioanna, Vaccargiu, Simona, Vangipurapu, Jagadish, Veldink, Jan H, Vitart, Veronique, Völker, Uwe, Vuoksimaa, Eero, Wakil, Salma M, Waldenberger, Melanie, Wander, Gurpreet S, Wang, Ya Xing, Wareham, Nicholas J, Wild, Sarah, Yajnik, Chittaranjan S, Yuan, Jian-Min, Zeng, Lingyao, Zhang, Liang, Zhou, Jie, Amin, Najaf, Asselbergs, Folkert W, Bakker, Stephan JL, Becker, Diane M, Lehne, Benjamin, Bennett, David A, Van Den Berg, Leonard H, Berndt, Sonja I, Bharadwaj, Dwaipayan, Bielak, Lawrence F, Bochud, Murielle, Boehnke, Mike, Bouchard, Claude, Bradfield, Jonathan P, Brody, Jennifer A, Campbell, Archie, Carmi, Shai, Caulfield, Mark J, Cesarini, David, Chambers, John C, Chandak, Giriraj Ratan, Cheng, Ching-Yu, Ciullo, Marina, Cornelis, Marilyn, Cusi, Daniele, Smith, George Davey, Deary, Ian J, Dorajoo, Rajkumar, Van Duijn, Cornelia M, Ellinghaus, David, Erdmann, Jeanette, Eriksson, Johan G, Evangelou, Evangelos, Evans, Michele K, Faul, Jessica D, Feenstra, Bjarke, Feitosa, Mary, Foisy, Sylvain, Franke, Andre, Friedlander, Yechiel, Gasparini, Paolo, Gieger, Christian, Gonzalez, Clicerio, Goyette, Philippe, Grant, Struan FA, Griffiths, Lyn R, Groop, Leif, Gudnason, Vilmundur, Gyllensten, Ulf, Hakonarson, Hakon, Hamsten, Anders, Van Der Harst, Pim, Heng, Chew-Kiat, Hicks, Andrew A, Hochner, Hagit, Huikuri, Heikki, Hunt, Steven C, Jaddoe, Vincent WV, De Jager, Philip L, Johannesson, Magnus, Johansson, Åsa, Jonas, Jost B, Jukema, J Wouter, Junttila, Juhani, Kaprio, Jaakko, Kardia, Sharon LR, Karpe, Fredrik, Kumari, Meena, Laakso, Markku, Van Der Laan, Sander W, Lahti, Jari, Laudes, Matthias, Lea, Rodney A, Lieb, Wolfgang, Lumley, Thomas, Martin, Nicholas G, März, Winfried, Matullo, Giuseppe, McCarthy, Mark I, Medland, Sarah E, Merriman, Tony R, Metspalu, Andres, Meyer, Brian F, Mohlke, Karen L, Montgomery, Grant W, Mook-Kanamori, Dennis, Munroe, Patricia B, North, Kari E, Nyholt, Dale R, O'connell, Jeffery R, Ober, Carole, Oldehinkel, Albertine J, Palmas, Walter, Palmer, Colin, Pasterkamp, Gerard G, Patin, Etienne, Pennell, Craig E, Perusse, Louis, Peyser, Patricia A, Pirastu, Mario, Polderman, Tinca JC, Porteous, David J, Posthuma, Danielle, Psaty, Bruce M, Rioux, John D, Rivadeneira, Fernando, Rotimi, Charles, Rotter, Jerome I, Rudan, Igor, Den Ruijter, Hester M, Sanghera, Dharambir K, Sattar, Naveed, Schmidt, Reinhold, Schulze, Matthias B, Schunkert, Heribert, Scott, Robert A, Shuldiner, Alan R, Sim, Xueling, Small, Neil, Smith, Jennifer A, Sotoodehnia, Nona, Tai, E-Shyong, Teumer, Alexander, Timpson, Nicholas J, Toniolo, Daniela, Tregouet, David-Alexandre, Tuomi, Tiinamaija, Vollenweider, Peter, Wang, Carol A, Weir, David R, Whitfield, John B, Wijmenga, Cisca, Wong, Tien-Yin, Wright, John, Yang, Jingyun, Yu, Lei, Zemel, Babette S, Zonderman, Alan B, Perola, Markus, Magnusson, Patrik KE, Uitterlinden, André G, Kooner, Jaspal S, Chasman, Daniel I, Loos, Ruth JF, Franceschini, Nora, Franke, Lude, Haley, Chris S, Hayward, Caroline, Walters, Robin G, Perry, John RB, Esko, Tōnu, Helgason, Agnar, Stefansson, Kari, Joshi, Peter K, Kubo, Michiaki, and Wilson, James F
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Consanguinity ,Cognition ,Fertility ,Inbreeding Depression ,Risk-Taking ,Haplotypes ,Health Status ,Homozygote ,Body Size ,Humans ,Alleles ,3. Good health - Abstract
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44-66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.
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