1. Detraining Effects on Musculoskeletal Parameters in Early Postmenopausal Osteopenic Women: 3-Month Follow-Up of the Randomized Controlled ACTLIFE Study
- Author
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Mikko Julin, Michael Hettchen, Matthias Kohl, Simon von Stengel, Marie H. Murphy, Tapani Risto, Laura Bragonzoni, Wolfgang Kemmler, Kemmler W., Hettchen M., Kohl M., Murphy M., Bragonzoni L., Julin M., Risto T., and von Stengel S.
- Subjects
High-intensity exercise ,Adult ,medicine.medical_specialty ,Bone density ,Coronavirus disease 2019 (COVID-19) ,Endocrinology, Diabetes and Metabolism ,Detraining ,030209 endocrinology & metabolism ,lean body mass ,Follow-Up Studie ,Early Termination of Clinical Trial ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Bone Density ,strength and power ,Bone mineral density ,Clinical endpoint ,Humans ,Medicine ,Orthopedics and Sports Medicine ,ddc:610 ,high-intensity exercise ,Exercise ,Musculoskeletal System ,Osteoporosis, Postmenopausal ,detraining ,Original Research ,Bone mineral ,business.industry ,030229 sport sciences ,Middle Aged ,Postmenopause ,Lean body ma ,Strength and power ,Lean body mass ,Early Termination of Clinical Trials ,Orthopedic surgery ,Physical therapy ,Female ,Lumbar spine ,bone mineral density ,business ,original research ,Human ,Follow-Up Studies ,Month follow up - Abstract
Periods of absence from supervised group exercise while maintaining physical activity might be a frequent pattern in adults' exercise habits. The aim of the present study was to determine detraining effects on musculoskeletal outcomes after a 3-month detraining period in early post-menopausal, osteopenic women. Due to the COVID-19 pandemic, we terminated the 18-month randomized controlled ACTLIFE exercise intervention immediately after the 13-month follow-up assessment. This put an abrupt stop to the high-intensity aerobic and resistance group exercise sessions undertaken three times per week by the exercise group (EG: n = 27) and the gentle exercise program performed once per week for the attention control group (CG: n = 27); but both groups were permitted to conduct individual outdoor activity for the 3-month lock-down period. Study endpoints were lean body mass (LBM), bone mineral density (BMD) at the lumbar spine (LS), maximum hip-/leg extension strength and power. Detraining-induced reductions of LBM, hip/leg strength and power (but not BMD-LS) were significantly greater (p p = 0.044) compared with the CG. Significant exercise effects, i.e. differences between EG and CG, present after 13 months of exercise, were lost after 3 months of detraining for LBM (p = 0.157) and BMD-LS (p = 0.065), but not for strength (p p Trial registration number: ClinicalTrials.gov: NCT04420806, 06.05.2020.
- Published
- 2021
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