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Start Over Author "Zhang, Dongyun" Publisher springer science and business media llc
21 results on '"Zhang, Dongyun"'

5. Amplified intracellular Ca2+ for synergistic anti-tumor therapy of microwave ablation and chemotherapy

Author

Xianwei Meng, Qiong Wu, Jianping Dou, Ping Liang, Changhui Fu, Zhang Dongyun, and Jie Yu

Subjects
Programmed cell death, lcsh:Medical technology, lcsh:Biotechnology, medicine.medical_treatment, Biomedical Engineering, Mice, Nude, Pharmaceutical Science, Medicine (miscellaneous), Bioengineering, Ablation, Applied Microbiology and Biotechnology, Polylactic Acid-Polyglycolic Acid Copolymer, In vivo, Neoplasms, lcsh:TP248.13-248.65, Synergistic therapy, medicine, Animals, Humans, Chemotherapy, Microwaves, Inner mitochondrial membrane, Antibiotics, Antineoplastic, Chemistry, Research, Microwave ablation, Hep G2 Cells, Hyperthermia, Induced, lcsh:R855-855.5, Doxorubicin, Apoptosis, Intracellular Ca2+, Cancer research, Nanoparticles, Molecular Medicine, Doxorubicin Hydrochloride, Calcium, Female, Intracellular
Abstract

Background Developing new strategies to reduce the output power of microwave (MW) ablation while keeping anti-tumor effect are highly desirable for the simultaneous achievement of effective tumor killing and avoidance of complications. We find that mild MW irradiation can significantly increase intracellular Ca2+ concentration in the presence of doxorubicin hydrochloride (DOX) and thus induce massive tumor cell apoptosis. Herein, we designed a synergistic nanoplatform that not only amplifies the intracellular Ca2+ concentration and induce cell death under mild MW irradiation but also avoids the side effect of thermal ablation and chemotherapy. Results The as-made NaCl–DOX@PLGA nanoplatform selectively elevates the temperature of tumor tissue distributed with nanoparticles under low-output MW, which further prompts the release of DOX from the PLGA nanoparticles and tumor cellular uptake of DOX. More importantly, its synergistic effect not only combines thermal ablation and chemotherapy, but also obviously increases the intracellular Ca2+ concentration. Changes of Ca2+ broke the homeostasis of tumor cells, decreased the mitochondrial inner membrane potential and finally induced the cascade of apoptosis under nonlethal temperature. As such, the NaCl–DOX@PLGA efficiently suppressed the tumor cell progression in vivo and in vitro under mild MW irradiation for the triple synergic effect. Conclusions This work provides a biocompatible and biodegradable nanoplatform with triple functions to realize the effective tumor killing in unlethal temperature. Those findings provide reliable solution to solve the bottleneck problem bothering clinics about the balance of thermal efficiency and normal tissue protection.

Published
2019

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