1. Anti-inflammatory Effect of Bumblebee Alcohol Extracts in CFA-Induced Rat Edema
- Author
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Yun Eun Young, Mi Young Ahn, Jea Woong Han, Jae Sam Hwang, and Hyung Joo Yoon
- Subjects
medicine.medical_specialty ,biology ,Bumblebee alcohol extract ,business.industry ,medicine.drug_class ,Health, Toxicology and Mutagenesis ,Rat model ,Pharmacology toxicology ,Alcohol ,Articles ,Pharmacology ,Toxicology ,biology.organism_classification ,Anti-inflammatory ,Surgery ,chemistry.chemical_compound ,chemistry ,Edema ,medicine ,medicine.symptom ,No production ,business ,Bumblebee ,Paw edema - Abstract
In this study, we prepared alcohol extracts of the larva, pupa, queen, and cocoon (clony) of B. ignitus, B. terrestris, and B. h. sapporoensis, and tested the anti-inflammatory activity of the extracts by using a rat model of adjuvant-induced edema. The extracts derived from the queen of B. ignitus, the queen of B. terrestris, and the cocoon of B. ignitus decreased hind paw edema after 1 day of i.p. administration. These extracts also induced vasorelaxation and NO production in calf pulmonary artery endothelial cells. These results suggest that bumblebee alcohol extracts has anti-inflammatory and vasorelaxant properties.
- Published
- 2012
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