10 results on '"Yumi Oshiro"'
Search Results
2. Synchronous gallbladder metastasis originating from residual gastric cancer: a case report and the review of literature
- Author
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Ami Kawamoto, Koichi Kimura, Kosuke Hirose, Takuma Izumi, Daisuke Taniguchi, Hiroko Yano, Yuichiro Kajiwara, Ryosuke Minagawa, Kazuhito Minami, Yumi Oshiro, and Takashi Nishizaki
- Abstract
Background Gastric cancer rarely metastasizes to the gallbladder. Furthermore, there has never been a case report of simultaneous gallbladder metastasis from residual gastric cancer. Here, we report a case of synchronous gallbladder metastasis originating from a residual gastric cancer. Case presentation A 67-year-old man underwent a follow-up upper endoscopy 18 months after a partial gastrectomy for gastric cancer; an ulcerative lesion was found in the remnant stomach at the gastrojejunal anastomosis. A biopsy revealed gastric signet-ring cell carcinoma (SRCC). A full-body examination revealed no abnormalities other than gallstones in the gallbladder. With a diagnosis of residual gastric cancer (cT2N0M0 cStage I), the patient underwent open total gastrectomy and cholecystectomy. Macroscopic findings of the resected specimen revealed thickening of the gallbladder wall; however, no obvious neoplastic lesions were found on the mucosal surface of the gallbladder. The pathological findings showed that the SRCC had invaded the submucosa of the gastrojejunostomy site with a high degree of lymphatic invasion and lymph node metastases. SRCCs were also found in the lymphatic vessels of the gallbladder wall. These findings suggested the possibility of gallbladder metastasis through lymphatic vessels. The patient and his family members refused postoperative chemotherapy. Ten months after the operation, the patient experienced respiratory failure due to lymphangitis carcinomatosa and died. Conclusions At present, it is difficult to determine whether resection of the gallbladder contributes to an improved prognosis of gastric cancer patients. However, reports in such cases demonstrate that gallbladder metastasis could be a poor predictor of prognosis for gastric cancer.
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- 2022
3. Recurrent intraductal papillary neoplasm of the bile duct due to intraductal dissemination: a case report and literature review
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Yumi Oshiro, Ryosuke Minagawa, Takashi Nishizaki, Kosuke Hirose, Mizuki Ninomiya, Daisuke Taniguchi, Yuki Nakayama, Yuichiro Kajiwara, Takahiro Tomino, Kazuhito Minami, and Takuma Izumi
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medicine.medical_specialty ,RD1-811 ,Common bile duct ,business.industry ,Bile duct ,medicine.medical_treatment ,Intraductal papillary neoplasm of the bile duct ,Intrahepatic bile ducts ,Case Report ,Pancreaticoduodenectomy ,Abdominal mass ,Biliary tumor ,medicine.anatomical_structure ,Recurrence ,medicine ,Resection margin ,Surgery ,Radiology ,medicine.symptom ,business ,Duct (anatomy) ,Left Hepatic Duct - Abstract
Background Intraductal papillary neoplasm of the bile duct (IPNB) is a subtype of biliary tumor. The 5-year survival rate of patients with IPNB who underwent curative resection is 81%. However, IPNB is known to often recur in other parts of the bile duct. Nevertheless, its mechanism remains poorly understood. Herein, we report the case of a patient with recurrent IPNB, which was considered to be attributed to intraductal dissemination in the common bile duct at 12 months after curative resection. We also made a review of the existing literature. Case presentation A 69-year-old man was referred to our hospital for the evaluation and dilation of an intrahepatic bile duct (IHBD) mass. Computed tomography (CT) findings confirmed a mass in the left hepatic duct. Left trisectionectomy, extrahepatic bile duct resection with biliary reconstruction, and regional lymph node dissection were performed. Intraoperative examination of the resection margin at the common bile duct and posterior segmental branch of the hepatic duct was negative for the presence of malignant cells. Histologically, the tumor showed intraductal papillary growth of the mucinous epithelium and was diagnosed as non-invasive IPNB. It had a papillary structure with atypical epithelial cells lined up along the neoplastic fibrovascular stalks. Immunohistochemically, this was as a gastric-type lesion. At 12 postoperative months, CT revealed a 1.5-cm mass in the lower remnant common bile duct. We performed subtotal stomach-preserving pancreaticoduodenectomy. The tumor exhibited papillary growth and was microscopically and immunohistochemically similar to the first tumor. At approximately 16 months after the patient’s second discharge, CT showed an abdominal mass at the superior mesenteric plexus, which was diagnosed as recurrent IPNB. Chemotherapy is ongoing, and the patient is still alive. In this case, as described in many previous reports, IPNB recurred below the primary lesion in the bile duct. Conclusion Based on our review of previous reports on IPNB recurrence, intraductal dissemination was considered one of the mechanisms underlying recurrence after multicentric development. Considering the high frequency and oncological conversion of recurrence in IPNB, regular follow-up examination is essential to achieve better prognosis in patients with recurrent IPNB.
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- 2021
4. Pancreatic enzymatic mediastinitis followed by total gastrectomy with splenectomy: report of two cases
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Takuma Izumi, Daisuke Taniguchi, Yumi Oshiro, Yoko Zaitsu, Kazuhito Minami, Yuichiro Kajiwara, and Takashi Nishizaki
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medicine.medical_specialty ,RD1-811 ,Pancreatic enzymatic mediastinitis ,business.industry ,medicine.medical_treatment ,Splenectomy ,Mediastinum ,Case Report ,medicine.disease ,Pancreatic necrosis ,Mediastinitis ,Curvatures of the stomach ,Surgery ,medicine.anatomical_structure ,Total gastrectomy ,Pancreatic fistula ,medicine ,Gastrectomy ,Pneumomediastinum ,business ,Abdominal surgery - Abstract
Background Acute mediastinitis is a rare disease that rapidly progresses with a high mortality rate. Its most common cause is direct injury of the mediastinum, including iatrogenic causes such as cardiac surgery or upper endoscopy. Enzymatic mediastinitis is a rare complication of a pancreatic fistula caused by the inflammatory digestion of the parietal peritoneum spreading to the mediastinum. Here, we present two cases of enzymatic mediastinitis caused by total gastrectomy with splenectomy. One of them was successfully treated and cured after early diagnosis and transabdominal drainage. Case presentation Case 1 was that of a 60-year-old man (body mass index [BMI] 27) with a medical history of diabetes and hypertension who was diagnosed with advanced gastric cancer in the upper body of the stomach. A total gastrectomy with splenectomy was performed. The patient experienced acute respiratory failure 24 h after surgery. Pulmonary embolism was suspected, so a computed tomography (CT) scan was performed; however, no relevant causes were found. Although he was immediately intubated and treated with catecholamine, he died in the intensive care unit (ICU) 40 h after surgery. Post-mortem findings revealed retroperitonitis caused by a pancreatic fistula spreading towards the mediastinum, causing severe mediastinitis; a review of the CT scan revealed pneumomediastinum. We concluded that the cause of death was enzymatic mediastinitis due to post-gastrectomy pancreatic fistula. Case 2 involved a 61-year-old man (BMI 25) with a medical history of appendicitis who was diagnosed with advanced gastric cancer at the gastric angle between the lesser curvature and the pylorus, spreading to the upper body of the stomach. A total gastrectomy with splenectomy was also performed. The patient had a high fever 3 days after the surgery, and a CT scan revealed pneumomediastinum, indicating mediastinitis. As the inflammation was below the bronchial bifurcation, we chose a transabdominal approach for drainage. The patient was successfully treated and discharged. Conclusion Acute mediastinitis caused by gastrectomy is rare. The acknowledgment of abdominal surgery as a cause of mediastinitis is important. In treating mediastinitis caused by abdominal surgery, transabdominal drainage may be a minimally invasive yet effective method if the inflammation is mainly located below the bifurcation of the trachea.
- Published
- 2021
5. Clinicopathological findings of systemic Epstein-Barr virus-positive T-lymphoproliferative diseases in younger and older adults
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Yasushi Takamatsu, Ken Takase, Ziyao Wang, Hiromi Iwasaki, Tsutomu Daa, Seiya Momosaki, Shoichi Kimura, Morishige Takeshita, Masao Ogata, Kosuke Makihara, Yumi Oshiro, and Ayako Gamachi
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Male ,Epstein-Barr Virus Infections ,Herpesvirus 4, Human ,Pathology ,Hemophagocytic lymphohistiocytosis ,CD8-Positive T-Lymphocytes ,medicine.disease_cause ,0302 clinical medicine ,Chronic active EBV infection ,RB1-214 ,Etoposide ,Aged, 80 and over ,Remission Induction ,General Medicine ,Middle Aged ,Treatment Outcome ,medicine.anatomical_structure ,Systemic EBV+ T-cell lymphoma of childhood ,Child, Preschool ,030220 oncology & carcinogenesis ,Host-Pathogen Interactions ,Female ,medicine.drug ,Adult ,medicine.medical_specialty ,Histology ,Antineoplastic Agents ,Lymphoma, T-Cell ,Lymphohistiocytosis, Hemophagocytic ,Pathology and Forensic Medicine ,Young Adult ,03 medical and health sciences ,Biomarkers, Tumor ,medicine ,Humans ,Epstein-Barr virus ,CD8+ T-cell lymphoma ,Aged ,Cell Proliferation ,Retrospective Studies ,business.industry ,Research ,Cell Transformation, Viral ,medicine.disease ,Epstein–Barr virus ,Lymphoma ,Transplantation ,Bone marrow ,business ,CD8 ,Stem Cell Transplantation ,030215 immunology - Abstract
Background Systemic Epstein-Barr virus+ T-cell lymphoma (sEBV+ TCL) occurs in childhood and young adults, and is exceptionally rare in older adults. Methods We investigated clinicopathological features in 16 patients of various ages with systemic EBV+ CD8+ T-lymphoproliferative diseases. Results Eight younger patients and four of eight older adults had sEBV+ CD8+ TCL, with invasion by medium-sized to/or large atypical lymphocytes primarily in bone marrow and lymph nodes, hemophagocytic lymphohistiocytosis (HLH), and progressive clinicopathological course. A further two patients demonstrated EBV+ node-based CD8+ large TCL without HLH, while the remaining two had the systemic form of chronic active EBV infection (sCAEBV) with CD8+ small lymphocytes. Past history of sCAEBV-like lesions was observed in one sEBV+ TCL patient (8.3%). Immunohistologically, in 12 sEBV+ TCL patients, atypical lymphocytes were positive for phosphate signal transducer and activator of transcription 3 (66.7%), CMYC (83.3%), and p53 (75%). Strong reactions of programmed cell death-ligand (PD-L)1+ tumor or non-neoplastic cells were detected in nine sEBV+ TCL patients (75%). Clonal peaks of the T-cell receptor (TCR) γ gene were detected in eight sEBV+ TCL patients by polymerase chain reaction. Four younger patients in sEBV+ TCL (33.3%) are in remission with chemotherapies including etoposide, and three of the four underwent allogeneic stem cell transplantation (SCT). Conclusion sEBV+ CD8+ TCL was observed in younger and older adults with less history of sCAEBV. HLH, tumor cell atypia, immunohistological findings, and progressive clinical course were characteristic of sEBV+ CD8+ TCL. Prompt chemotherapy and SCT induced tumor regression in sEBV+ CD8+ TCL patients.
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- 2021
6. Clinicopathological review of solitary fibrous tumors: dedifferentiation is a major cause of patient death
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Mikiko Hashisako, Kenji Tsuchihashi, Hidetaka Yamamoto, Sadafumi Tamiya, Yui Nozaki, Yoshihiro Itou, Yasuharu Nakashima, Masato Yoshimoto, Yumi Honda, Takeshi Inoue, Satoshi O. Suzuki, Yuichi Yamada, Izumi Kinoshita, Yoshifumi Matsushita, Kenichi Kohashi, Toru Iwaki, Yutaka Koga, Yoshinao Oda, Yumi Oshiro, Masutaka Furue, Shin Ishihara, Daichi Kitahara, Daisuke Kiyozawa, Munenori Mukai, Yu Toda, Fumiyoshi Fushimi, Takeshi Iwasaki, Gouji Toyokawa, and Kenichi Taguchi
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Adult ,Male ,0301 basic medicine ,Pathology ,medicine.medical_specialty ,Solitary fibrous tumor ,Adolescent ,Central nervous system ,Hypoglycemia ,Pathology and Forensic Medicine ,Metastasis ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Statistical significance ,medicine ,Humans ,Neoplasm ,Clinical significance ,Child ,Molecular Biology ,Aged ,Hemangiopericytoma ,business.industry ,Cell Biology ,General Medicine ,Cell Dedifferentiation ,Middle Aged ,medicine.disease ,030104 developmental biology ,medicine.anatomical_structure ,Child, Preschool ,Solitary Fibrous Tumors ,030220 oncology & carcinogenesis ,Female ,business - Abstract
Solitary fibrous tumor (SFT) is a soft-tissue neoplasm of intermediate malignant potential, presenting a wide histopathological spectrum. Poorer prognosis of hemangiopericytoma of the central nervous system (CNS), hypoglycemic SFT, and dedifferentiation are well-known characters of SFT, but their clinical significance were not demonstrated enough by large-sized study. Here, the clinicopathological features of SFTs are reviewed and the relationship between genetics and clinicopathological features is examined using 145 SFT cases. All cases were STAT6 IHC-positive and/or NAB2-STAT6 fusion gene-positive. Tumor location was classified into three categories: 30 pleuropulmonary, 96 non-pleuropulmonary/non-central nervous system (CNS), and 18 CNS tumors. The tumor developed recurrence in 21 of 93 available cases (22.5%), metastasis in 11 of 93 (11.8%), and tumor death in 9 of 93 (9.6%). Hypoglycemia occurred in 2 primary tumors and 1 metastatic tumor among 63 reviewable cases, and dedifferentiation occurred in 10 cases (6.8%) including 6 primary tumors, 2 recurrent tumors, and 2 metastatic tumors. Recurrence was positively associated with CNS location (p = 0.0109) and hypoglycemia (p = 0.001); metastasis was positively associated with CNS location (p = 0.0231), hypoglycemia (p
- Published
- 2019
7. Visual assessment of Ki67 at a glance is an easy method to exclude many luminal-type breast cancers from counting 1000 cells
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Takuya Moriya, Yumi Oshiro, Hiromichi Inoue, Hidetoshi Kawaguchi, Natsumi Yamashita, and Akira I. Hida
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Adult ,Oncology ,medicine.medical_specialty ,Receptor, ErbB-2 ,Labeling index ,Breast Neoplasms ,Breast pathology ,Breast cancer ,Surgical oncology ,Internal medicine ,Visual assessment ,medicine ,Humans ,Pharmacology (medical) ,Radiology, Nuclear Medicine and imaging ,Luminal type ,Estrogen Metabolism ,Aged ,Aged, 80 and over ,business.industry ,Carcinoma, Ductal, Breast ,General Medicine ,Luminal a ,Middle Aged ,medicine.disease ,Immunohistochemistry ,Ki-67 Antigen ,Receptors, Estrogen ,Female ,Receptors, Progesterone ,business - Abstract
The Ki67 labeling index (LI) reflects the proliferative activity of breast cancers and defines luminal A and B tumors; however, no detailed method to measure Ki67 has been standardized. Here, we propose a fast and easy way to evaluate Ki67.Immunohistochemical staining of estrogen receptor (ER), progesterone receptor (PgR), HER2 and Ki67 (MIB-1) was performed on 235 primary invasive ductal carcinomas. For each sample, a hot spot with many Ki67+ cells was identified using a low-power field (40×, 4× objective). Three independent areas in high-power field (400×) were selected at the hot spot, and all cancer cells in the 3 areas were manually counted to calculate LI (% Ki67+ cells). Alternatively, micrographs taken at 100× and 200× fields including the hot spot were shown to 2 pathologists, who visually assessed percentages of Ki67+ cells in 10 % intervals at a glance (Eye-10).Eye-10 and LI were strongly correlated (r = 0.9412, P 0.0001). All cases of Eye-10 ≥ 30 % had LI 14 %; most of those10 % had LI 14 %. Of 170 ER+/HER2- tumors, Eye-10-based subtypes matched 87 % of LI-driven subtypes, and interobserver agreement was good (κ = 0.705).Eye-10 is far easier than counting many cancer cells and useful for classifying breast cancers. Eye-10 can exclude obviously high and low Ki67 cases, leaving a "gray zone" around a cutoff point. Combining Eye-10 and manual counting is a good candidate for a standard method to evaluate Ki67.
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- 2013
8. Etiological factors in primary hepatic B-cell lymphoma
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Kanta Kikuma, Satoshi Toyoshima, Tatsuo Shimogama, Yumi Oshiro, Tetsuro Soda, Yumi Honda, Naokuni Uike, Tadaaki Yokota, Seiya Momosaki, Koichi Higaki, Seiichi Okamura, Morishige Takeshita, and Jiro Watanabe
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Male ,Pathology ,medicine.medical_specialty ,Lymphoma, B-Cell ,Hepacivirus ,Autoimmune hepatitis ,Pathology and Forensic Medicine ,Primary biliary cirrhosis ,immune system diseases ,hemic and lymphatic diseases ,Autoimmune disease ,Humans ,Medicine ,Hepatitis B e Antigens ,B-cell lymphoma ,Molecular Biology ,Aged ,Hepatitis ,B-Lymphocytes ,business.industry ,Malignant lymphoma ,Liver Neoplasms ,MALT lymphoma ,Cell Biology ,General Medicine ,Hepatitis C ,Hepatitis C Antibodies ,Middle Aged ,medicine.disease ,BCL6 ,Survival Analysis ,Lymphoma ,Liver ,HCV ,Original Article ,Female ,Lymphoma, Large B-Cell, Diffuse ,business - Abstract
Sixty-four cases of malignant lymphoma involving the liver were examined. Of these, 20 cases were histologically confirmed to be primary hepatic B-cell lymphoma. Twelve of these 20 cases were diffuse large B-cell lymphoma (DLBCL) and eight cases were mucosa-associated lymphoid tissue (MALT) lymphoma. Of the 12 cases of DLBCL, six were immunohistologically positive for CD10 and/or Bcl6 (indicating a germinal center phenotype), six were positive for Bcl2, and five were positive for CD25. Eight of the 12 DLBCL cases (66.7%) and two of the eight MALT lymphoma cases (25%) had serum anti-hepatitis C virus (HCV) antibodies and HCV RNA. The incidence of HCV infection was significantly higher in the hepatic DLBCL cases than in systemic intravascular large B-cell cases with liver involvement (one of 11 cases, 9.1%) and T/NK-cell lymphoma cases (one of 19 cases, 5.3%) (p
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- 2012
9. Coexistence of mucinous cystic neoplasm occurring in the head of the pancreas with annular pancreas: Report of a case
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Hideki Ijichi, Takeshi Shiraishi, Yumi Oshiro, Ikuo Takahashi, Takashi Nishizaki, Takahiro Terashi, Shigetoshi Murata, Kouji Joko, Shinji Yoshioka, and Hiroya Wada
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Pancreatic duct ,medicine.medical_specialty ,Endoscopic retrograde cholangiopancreatography ,Pancreatic disease ,medicine.diagnostic_test ,business.industry ,General Medicine ,Annular pancreas ,Middle Aged ,Cystadenocarcinoma, Mucinous ,medicine.disease ,Cystic Neoplasm ,Pancreatic Neoplasms ,medicine.anatomical_structure ,Surgical oncology ,medicine ,Humans ,Female ,Surgery ,Radiology ,Cystadenocarcinoma ,business ,Pancreas - Abstract
Mucinous cystic neoplasms (MCN) of the pancreas are rare tumors that are almost exclusively located in the body or the tail of the pancreas. A 60-year-old woman with no history of pancreatic disease was referred to our hospital with a chief complaint of dull pain in the upper abdomen. Abdominal computed tomography showed a multilocular cystic mass of 7.0 cm in the head of the pancreas, and endoscopic retrograde cholangiopancreatography showed no communication between the cystic mass and the main pancreatic duct. A pancreatoduodenectomy was performed for the complete resection of the tumor, and an annular pancreas was discovered by accident. The pathological examination of the tumor led to a definitive diagnosis of MCN with ovarian-type stroma. To our knowledge this is the first documented case of MCN occurring in the head of the pancreas and associated with annular pancreas.
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- 2009
10. Mutations of the p53 gene in malignant rhabdoid tumors of soft tissue and the kidney: immunohistochemical and DNA direct sequencing analysis
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Sadafumi Tamiya, Sachiyo Suita, Yoichi Hachitanda, Yumi Oshiro, Yoshinao Oda, Hideki Shiratsuchi, Masazumi Tsuneyoshi, and Yoshiaki Kinoshita
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Adult ,Male ,Cancer Research ,Pathology ,medicine.medical_specialty ,Tumor suppressor gene ,DNA Mutational Analysis ,Soft Tissue Neoplasms ,Biology ,medicine.disease_cause ,Polymerase Chain Reaction ,Antibodies ,Gene product ,Biomarkers, Tumor ,Carcinoma ,medicine ,Humans ,Child ,Rhabdoid Tumor ,Soft tissue sarcoma ,Infant ,Soft tissue ,DNA, Neoplasm ,General Medicine ,Genes, p53 ,medicine.disease ,Immunohistochemistry ,Kidney Neoplasms ,Oncology ,Child, Preschool ,Mutation ,Cancer research ,Female ,Tumor Suppressor Protein p53 ,Carcinogenesis ,Kidney disease - Abstract
Malignant rhabdoid tumor (MRT) is characterized by the presence of intracytoplasmic eosinophilic inclusions composed of whorls of intermediate filaments. This tumor was originally described as an entity of the abortive type of Wilms' tumor in childhood. Recently, it has been proved that these rhabdoid cells can be observed in various types of malignant tumors, including soft tissue sarcoma or carcinoma. To investigate the oncogenesis of this tumor, we examined the p53 gene alteration by means of immunohistochemical analysis and DNA direct sequencing in three cases of malignant rhabdoid tumor (MRT) of the soft tissue and three cases of MRT of the kidney. All the cases of MRT of the soft tissue and two of the cases of MRT of the kidney showed immunopositivity for p53 protein. Among them, one of the cases of MRT of the soft tissue and two of the cases of MRT of the kidney showed missense mutations of the p53 gene. These results strongly suggest that p53 gene alterations may have an important role to play in the aggressive biological behavior and poor prognosis of this tumor.
- Published
- 2001
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