1. Actual long-term survival in HCC patients with portal vein tumor thrombus after liver resection: a nationwide study
- Author
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Minshan Chen, Jian-Hua Lin, Tian-Fu Wen, Yangqing Huang, Jing Li, Xiu-Ping Zhang, Zhen-Hua Chen, Shu-Qun Cheng, Yu Zhang, Yufu Tang, Yu-Gang Lu, Cheng-Qian Zhong, Fan Zhang, Dong Zhou, Xiao-Jing Wu, Jie Shi, Wei-Xing Guo, Ding-Hua Yang, Yi-Jun Xia, Rui-Fang Fan, Yi-Ren Hu, L.-Q. Li, Wei-Dong Jia, Zuo-Jun Zhen, and Joseph Lau
- Subjects
Male ,China ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Cirrhosis ,medicine.medical_treatment ,Long Term Adverse Effects ,Resection ,Cancer Survivors ,Internal medicine ,medicine ,Hepatectomy ,Humans ,Survival rate ,Neoplasm Staging ,Retrospective Studies ,Hepatology ,Portal Vein ,business.industry ,Liver Neoplasms ,Thrombosis ,Perioperative ,Middle Aged ,Neoplastic Cells, Circulating ,medicine.disease ,Colorectal surgery ,Surgery ,Survival Rate ,Hepatocellular carcinoma ,Female ,Neoplasm Recurrence, Local ,business - Abstract
Liver resection for hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT) offers a chance of cure, although survival is often limited. The actual 3-year survival and its associated prognostic factors have not been reported. A nationwide database of HCC patients with PVTT who underwent liver resection with ‘curative’ intent was analyzed. The clinicopathologic characteristics, the perioperative, and survival outcomes for the actual long-term survivors were compared with the non-long-term survivors (patients who died within 3 years of surgery). Univariable and multivariable regression analyses were performed to identify predictive factors associated with long-term survival outcomes. The study included 1590 patients with an actuarial 3-year survival of 16.6%, while the actual 3-year survival rate was 11.7%. There were 171 patients who survived for at least 3 years after surgery and 1290 who died within 3 years of surgery. Multivariable regression analysis revealed that total bilirubin > 17.1 μmol/l, AFP > 400 ng/ml, types of hepatectomy, extent of PVTT, intraoperative blood loss > 400 ml, tumor diameter > 5 cm, tumor encapsulation, R0 resection, liver cirrhosis, adjuvant TACE, postoperative early recurrence (
- Published
- 2020