27 results on '"Ying-Ying Wang"'
Search Results
2. Structural and electronic properties of neutral boron clusters doped with two potassium atoms
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Guo Li Chen, Yu Quan Yuan, Chun Ping Wang, Ying Ying Wang, Ting Liu, Teng Xin Huang, Wei Lin, and Jing Yang
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General Physics and Astronomy - Published
- 2023
3. Dynamic Analysis of A Subsea Suspended Manifold Going Through Splash Zone During Installation
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Ying-ying Wang, Chao Yang, Zhong-shan Yang, Xiao-yu Zhao, Jian-xi Yin, and Yang-dong Hu
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Renewable Energy, Sustainability and the Environment ,Mechanical Engineering ,Ocean Engineering ,Oceanography - Abstract
The subsea suspended manifold designed to replace the traditional foundation structure with the buoys is a new generation subsea production system that can be suspended at a certain height from the seafloor and rapidly recycled by its own buoyancy. Due to complex environmental conditions, its hydrodynamic performance in the splash zone is extremely important for the safety of the whole installation process. In this paper, the mathematical model for the dynamic analysis of the seawater ingress process of the single-layer pre-set horizontal cabin is proposed based on the different center of gravity positions of the buoy. Meanwhile, the theoretical analysis of fiber cable is divided into infinite differential units by the discretization method, and the formulae of the horizontal displacement of the subsea suspended manifold are presented. In addition, the simulations are carried out to verify the rules of the dynamic responses on the subsea suspended manifold system with the consideration of the environmental conditions in the South China Sea. Comparing with the calculated value of the mathematical model of the cabin water ingress, the error of the simulation result by use of FLUENT is about 5.47%. Furthermore, the wave height is greater than the current impact on the lowering manifold system and the azimuth angle of the installation vessel is aligned with the direction of the environmental load.
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- 2022
4. Distributed feedback fiber laser-based broadband air acoustic sensor using PI film and PEEK shell structure
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Ying-Ying Wang, Chang Wang, Shi-Wei Zhao, Fa-Xiang Zhang, Shu-Juan Li, and Xiao-Mei Ma
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Atomic and Molecular Physics, and Optics - Published
- 2022
5. Ethyl ferulate protects against lipopolysaccharide-induced acute lung injury by activating AMPK/Nrf2 signaling pathway
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Jun Zhu, Dan Chen, Wei Mingxia, Bin-bin Wan, Qing-feng Pang, Feng Qian, Ying-ying Wang, Yong-quan Chen, Gang Liu, Zhi-Qi Gao, Ya-Xian Wu, Feng-juan Jiang, and Jing Zuo
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Lipopolysaccharides ,Male ,ARDS ,Lipopolysaccharide ,NF-E2-Related Factor 2 ,Neutrophils ,Acute Lung Injury ,Anti-Inflammatory Agents ,Nitric Oxide Synthase Type II ,Inflammation ,AMP-Activated Protein Kinases ,Pharmacology ,Lung injury ,Nitric Oxide ,Article ,Proinflammatory cytokine ,Gene Knockout Techniques ,Mice ,chemistry.chemical_compound ,Caffeic Acids ,Gene expression ,medicine ,Animals ,Pharmacology (medical) ,Lung ,Mice, Knockout ,AMPK ,General Medicine ,respiratory system ,medicine.disease ,Mice, Inbred C57BL ,RAW 264.7 Cells ,Neutrophil Infiltration ,chemistry ,Mutation ,Knockout mouse ,Cytokines ,medicine.symptom ,Signal Transduction - Abstract
Ethyl ferulate (EF) is abundant in Rhizoma Chuanxiong and grains (e.g., rice and maize) and possesses antioxidative, antiapoptotic, antirheumatic, and anti-inflammatory properties. However, its effect on lipopolysaccharide (LPS)-induced acute lung injury (ALI) is still unknown. In the present study, we found that EF significantly alleviated LPS-induced pathological damage and neutrophil infiltration and inhibited the gene expression of proinflammatory cytokines (TNF-α, IL-1β, and IL-6) in murine lung tissues. Moreover, EF reduced the gene expression of TNF-α, IL-1β, IL-6, and iNOS and decreased the production of NO in LPS-stimulated RAW264.7 cells and BMDMs. Mechanistic experiments revealed that EF prominently activated the AMPK/Nrf2 pathway and promoted Nrf2 nuclear translocation. AMPK inhibition (Compound C) and Nrf2 inhibition (ML385) abolished the beneficial effect of EF on the inflammatory response. Furthermore, the protective effect of EF on LPS-induced ALI was not observed in Nrf2 knockout mice. Taken together, the results of our study suggest that EF ameliorates LPS-induced ALI in an AMPK/Nrf2-dependent manner. These findings provide a foundation for developing EF as a new anti-inflammatory agent for LPS-induced ALI/ARDS therapy. [Image: see text]
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- 2021
6. Comparison of intracorporeal and extracorporeal anastomosis and resection in right colectomy: a systematic review and meta-analysis
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Wei Chen, Jian-Chun Zheng, Ying-Ying Wang, Jian-Xiang Wu, Yu Tang, and Shuai Zhao
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Laparoscopic surgery ,medicine.medical_specialty ,Ileus ,medicine.medical_treatment ,Operative Time ,Anastomosis ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Colectomy ,Retrospective Studies ,business.industry ,Anastomosis, Surgical ,Length of Stay ,Vascular surgery ,medicine.disease ,Surgery ,Treatment Outcome ,Cardiothoracic surgery ,030220 oncology & carcinogenesis ,Colonic Neoplasms ,Right Colectomy ,Laparoscopy ,030211 gastroenterology & hepatology ,business ,Abdominal surgery - Abstract
Laparoscopic surgery is the standard surgical approach for colon cancer. However, there is no standard surgery for right colectomy. Selection between total laparoscopic right colectomy (TLRC) and laparoscopic-assisted right colectomy (LARC) is a topic of interest. In this systematic review, we compared the short-term outcomes of TLRC and LARC in the treatment of right colon cancer.We identified studies (PubMed, Web of Science, Cochrane Library, Embase) comparing TLRC and LARC up to February 2021. Surgical duration; volume of intraoperative blood loss; number of harvested lymph nodes; incision length; hospitalization duration; time to first flatus; time to first defecation; and anastomotic leakage, ileus, and wound infection were compared.Thirty studies (TLRC, 1948 patients; LARC, 2369 patients) were evaluated. All studies were retrospective, except seven prospective studies, three RCTs, and three case-control studies. TLRC demonstrated lesser intraoperative blood loss volume (P 0.01), less frequent intraoperative conversion to laparotomy (P = 0.02), shorter hospitalization duration (P 0.01), smaller incision length (P 0.01), shorter time to first flatus (P 0.01) and first defecation (P 0.01), and lesser frequent wound infection (P 0.01) compared with LARC. The surgical duration, number of harvested lymph nodes, anastomotic leakage, and ileus were similar between TLRC and LARC (P 0.05).TLRC is associated with significantly earlier bowel recovery, lesser blood loss, smaller incision length, lower rate of conversion, shorter hospitalization duration, and lesser frequent wound infection compared with LARC.
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- 2021
7. Childhood trauma mediates repetitive transcranial magnetic stimulation efficacy in major depressive disorder
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Sara Tremblay, Xi Wen Hu, Yu Ting Hu, Georg Northoff, Jin Fang Han, Jianfeng Zhang, Ying Ying Wang, Zhong Lin Tan, and Annemarie Wolff
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business.industry ,medicine.medical_treatment ,CTQ tree ,Beck Depression Inventory ,General Medicine ,medicine.disease ,behavioral disciplines and activities ,030227 psychiatry ,Transcranial magnetic stimulation ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,Pharmacotherapy ,mental disorders ,Beck Hopelessness Scale ,Hamd ,medicine ,Major depressive disorder ,Pharmacology (medical) ,business ,030217 neurology & neurosurgery ,Biological Psychiatry ,Anxiety scale ,Clinical psychology - Abstract
Childhood trauma is one of the most prominent risk factors in developing major depressive disorder (MDD) and may lead to unfavorable outcomes of pharmacotherapy and psychotherapy in MDD. While how it modulates the treatment outcome of the repetitive transcranial magnetic stimulation (rTMS) and how sex difference may play a role in mediating this relationship remain unknown. To evaluate this question, 51 (37 women) MDD patients were treated with 10 Hz rTMS to the left dorsolateral prefrontal cortex (lDLPFC). The experience of childhood trauma was quantified by the Childhood Traumatic Questionnaire (CTQ). The depressive severity was assessed by Hamilton Depression Scale (HAMD) and Beck Depression Inventory (BDI) as the primary and secondary assessments. Beck Hopelessness Scale (BHS) and Hamilton Anxiety Scale (HAMA) were also assessed for further confirmation. Thirty-six (70.6%) participants showed a response including 17 (33.3%) achieving remission to the rTMS treatment. The alleviation of depressive symptoms was negatively correlated with the CTQ scores, specifically in women but not men, in subjective BDI and BHS, but not objective HAMD or HAMA. We demonstrate that childhood trauma negatively affects the subjective perception of rTMS-lDLPFC treatment outcomes in female MDD patients. This highlights the importance of measuring childhood trauma-related symptoms in routine clinical rTMS treatment, as they may impact perceived efficacy.
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- 2021
8. TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target
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Rui-Yang Li, Qi Qin, Han-Chen Yang, Ying-Ying Wang, Ying-Xin Mi, Yun-Si Yin, Meng Wang, Chao-Ji Yu, and Yi Tang
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Central Nervous System ,Cellular and Molecular Neuroscience ,Membrane Glycoproteins ,Alzheimer Disease ,Brain ,Humans ,Microglia ,Neurology (clinical) ,Receptors, Immunologic ,Lipid Metabolism ,Molecular Biology - Abstract
Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane immune receptor that is mainly expressed on microglia in the brain and macrophages in the periphery. Recent studies have identified TREM2 as a risk factor for Alzheimer’s disease (AD). Increasing evidence has shown that TREM2 can affect lipid metabolism both in the central nervous system (CNS) and in the periphery. In the CNS, TREM2 affects the metabolism of cholesterol, myelin, and phospholipids and promotes the transition of microglia into a disease-associated phenotype. In the periphery, TREM2 influences lipid metabolism by regulating the onset and progression of obesity and its complications, such as hypercholesterolemia, atherosclerosis, and nonalcoholic fatty liver disease. All these altered lipid metabolism processes could influence the pathogenesis of AD through several means, including affecting inflammation, insulin resistance, and AD pathologies. Herein, we will discuss a potential pathway that TREM2 mediates lipid metabolism to influence the pathogenesis of AD in both the CNS and periphery. Moreover, we discuss the possibility that TREM2 may be a key factor that links central and peripheral lipid metabolism under disease conditions, including AD. This link may be due to impacts on the integrity of the blood–brain barrier, and we introduce potential pathways by which TREM2 affects the blood–brain barrier. Moreover, we discuss the role of lipids in TREM2-associated treatments for AD. We propose some potential therapies targeting TREM2 and discuss the prospect and limitations of these therapies.
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- 2022
9. Spontaneous positive exchange bias effect in SrFeO3−x/SrCoO3−x epitaxial bilayer
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Ying-Ying Wang, Xiaohong Xu, Zhi-Yong Quan, Xiao-Jiao Wang, Wei Zhang, Jun Zhang, Tian-Cong Su, Guo-Wei Zhou, and Hui-Hui Ji
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Materials science ,Spintronics ,Condensed matter physics ,020502 materials ,Bilayer ,Metals and Alloys ,02 engineering and technology ,Condensed Matter Physics ,Magnetic field ,Exchange bias ,0205 materials engineering ,Ferromagnetism ,Materials Chemistry ,Antiferromagnetism ,Physical and Theoretical Chemistry ,Spin (physics) ,Magnetic dipole - Abstract
A novel phenomenon of spontaneous positive exchange bias (PEB) is reported in SrFeO3−x/SrCoO3−x epitaxial bilayer without undergoing any magnetic field treatment. When inserting a thick SrTiO3 (STO) nonmagnetic spacer (about 6 nm) into the bilayer interface, this phenomenon still exists. Based on a series of testing means, the spontaneous PEB effect is supposed to be mainly related to short-range ferromagnetic (FM) exchange coupling at the interface when there is no STO spacer. As the STO interlayer reaches up to a certain thickness, short-range coupling interaction basically disappears. At this time, the long-range dipole field may be responsible for the coupling of the FM and antiferromagnetic (AFM) layer across the nonmagnetic STO and then leads to the same bias effect. Our discoveries provide a new way to realize and manipulate spontaneous exchange bias-based spintronics devices, such as magnetic recording heads and spin valves.
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- 2020
10. Nano-SnO2 Decorated Carbon Cloth as Flexible, Self-supporting and Additive-Free Anode for Sodium/Lithium-Ion Batteries
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Bao-Hua Hou, Haosen Fan, Xing-Long Wu, Xu Yang, Guang Wang, Xin-Xin Zhao, Ying-Ying Wang, and Hao-Jie Liang
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010302 applied physics ,Materials science ,Annealing (metallurgy) ,Sodium ,Metals and Alloys ,chemistry.chemical_element ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Electrochemistry ,01 natural sciences ,Industrial and Manufacturing Engineering ,Anode ,Ion ,chemistry ,Chemical engineering ,0103 physical sciences ,Nano ,Electrode ,0210 nano-technology ,Current density - Abstract
In this study, nano-sized SnO2 decorated on carbon cloth (SnO2/CC) is prepared through a simple and facile solid method. The nano-sized SnO2 is uniformly distributed on the surface of carbon fibers in carbon cloth, providing sufficient free space to relieve volume expansion and reduce electrode pulverization during cycling. The as-prepared SnO2/CC as a flexible, self-supporting and additive-free anode electrode for sodium-ion/lithium-ion batteries (SIBs/LIBs) can demonstrate outstanding electrochemical performance. SnO2/CC after annealing at 350 °C (SC-350) as an anode for SIBs can deliver a reversible capacity of 0.587 mA h cm−2 at the current density of 0.3 mA cm−2 after 100 cycles. In addition, when cycling at 1.5 mA cm−2, SC-350 can maintain 1.69 mA h cm−2 after 500 cycles when used as LIB anode. These results illustrate that the as-prepared SnO2/CC can be a promising flexible anode material for flexible SIBs/LIBs and provide a simple and practical method for designing new flexible electrode materials.
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- 2020
11. Bioassay-Guided Isolation of Cytotoxic Steroids from Neosartorya fischeri
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Shu-Ning Zheng, Ting Tian, Zhen-Zhen Zheng, Zha-Jun Zhan, Wei-Guang Shan, You-Min Ying, Lie-Feng Ma, and Ying-Ying Wang
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Chemistry ,Cytotoxic T cell ,Bioassay ,Plant Science ,General Chemistry ,Isolation (microbiology) ,Neosartorya fischeri ,General Biochemistry, Genetics and Molecular Biology ,Microbiology - Published
- 2020
12. Protein acetylation regulates xylose metabolism during adaptation of Saccharomyces cerevisiae
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Zhen Zhu, Zhi-Hua Liu, Yong-Shui Tan, Qi-En He, Li Wang, Ying-Ying Wang, Ying-Jin Yuan, Bing-Zhi Li, and Kai Song
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biology ,Xylose consumption memory ,Chemistry ,Renewable Energy, Sustainability and the Environment ,Research ,Saccharomyces cerevisiae ,Protein acetylation ,Management, Monitoring, Policy and Law ,biology.organism_classification ,Fuel ,Applied Microbiology and Biotechnology ,H4K5Ac ,General Energy ,Xylose metabolism ,Biochemistry ,TP315-360 ,Protein Acetylation ,Adaptation ,TP248.13-248.65 ,Synthetic biology ,Biotechnology - Abstract
Background Lignocellulosic biomass upgrading has become a promising alternative route to produce transportation fuels in response to energy security and environmental concerns. As the second most abundant polysaccharide in nature, hemicellulose mainly containing xylose is an important carbon source that can be used for the bioconversion to fuels and chemicals. However, the adaptation phenomena could appear and influence the bioconversion performance of xylose when Saccharomyces cerevisiae strain was transferred from the glucose to the xylose environment. Therefore, it is crucial to elucidate the mechanism of this adaptation phenomena, which can guide the strategy exploration to improve the efficiency of xylose utilization. Results In this study, xylose-utilizing strains had been constructed to effectively consume xylose. It is found that the second incubation of yYST218 strain in synthetic complete-xylose medium resulted in a 1.24-fold increase in xylose consumption ability as compared with the first incubation in synthetic complete-xylose medium. The results clearly showed that growing S. cerevisiae again in synthetic complete-xylose medium can significantly reduce the stagnation time and thus achieved a faster growth rate, by comparing the growth status of the strain in synthetic complete-xylose medium for the first and second time at the single-cell level through Microfluidic technology. Although these xylose-utilizing strains possessed different xylose metabolism pathways, they exhibited the “transient memory” phenomenon of xylose metabolism after changing the culture environment to synthetic complete-xylose medium, which named ‘xylose consumption memory (XCM)’ of S. cerevisiae in this study. According to the identification of protein acetylation, partial least squares analysis and the confirmatory test had verified that H4K5Ac affected the state of “XCM” in S. cerevisiae. Knockout of the acetylase-encoding genes GCN5 and HPA2 enhanced the “XCM” of the strain. Protein acetylation analysis suggested that xylose induced perturbation in S. cerevisiae stimulated the rapid adaptation of strains to xylose environment by regulating the level of acetylation. Conclusions All these results indicated protein acetylation modification is an important aspect that protein acetylation regulated the state of “XCM” in S. cerevisiae and thus determine the environmental adaptation of S. cerevisiae. Systematically exploiting the regulation approach of protein acetylation in S. cerevisiae could provide valuable insights into the adaptation phenomena of microorganisms in complex industrial environments.
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- 2021
13. An asymmetric supercapacitor based on NiCo2O4 nanosheets as anode and partially reduced graphene oxides/carbon nanotubes as cathode
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Yong-Ping Gao, Ning-Ning Liu, Ying-Ying Wang, Ke Yan, Juan Wu, Zhi-Qiang Hou, and Ji-Tao Li
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Supercapacitor ,Materials science ,Graphene ,General Chemical Engineering ,Oxide ,02 engineering and technology ,General Chemistry ,Carbon nanotube ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Electrochemistry ,01 natural sciences ,Biochemistry ,Capacitance ,Industrial and Manufacturing Engineering ,Cathode ,0104 chemical sciences ,law.invention ,Anode ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,law ,Materials Chemistry ,0210 nano-technology - Abstract
Nickel–cobalt oxide has been given more attention to being used as the supercapacitor's electrode materials due to its two-dimensional layered structure, good electron conductivity, and excellent stability. In this work, NiCo2O4 nanosheets were successfully prepared by the simple solvothermal reaction and the thermal treatment process. Under the three-electrode system, it exhibits a maximum specific capacitance of 978 F/g at 1.5 A/g and good cycle stability. Meanwhile, a freestanding of partially reduced graphene oxides/carbon nanotubes (PRGO/CNTs) film was obtained by the vacuum filter and solvothermal methods, which can provide a wide potential window of − 1 ~ 0 V and a maximum specific capacitance of 236 F/g at 0.5 A/g. Finally, an asymmetric supercapacitor of PRGO/CNTs//NiCo2O4 was assembled, which exhibits good electrochemical performance, such as specific capacitance of 82 F/g at 0.5 A/g, energy density of 18.8 Wh/kg at 0.32 kW/kg, and 99.5% of capacitance retention after 5000 cycles at 5 A/g. This test results reveal that PRGO/CNTs//NiCo2O4 ASC has great potential for practical application in energy storage systems.
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- 2019
14. Microglial EED is required for synapse engulfment
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Ying-Ying Wang, Yu-Sen Deng, Shang-Kun Dai, Ting-Wei Mi, Rui-Yang Li, Pei-Pei Liu, Cong Liu, Bao-Dong He, Xuan-Cheng He, Hong-Zhen Du, Han-Chen Yang, Yi Tang, Chang-Mei Liu, and Zhao-Qian Teng
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Cellular and Molecular Neuroscience ,Psychiatry and Mental health ,Molecular Biology - Published
- 2022
15. Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a
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Wei Xie, Peng Jin, Bing Bai, Zhenping Chen, Yuxin Li, Ying Cheng, Zhi-Meng Wang, Yunhee Kang, Xiaona Wang, Zuo-Lun Chen, Chang-Mei Liu, Zhi-Jie Dai, Ting-Wei Mi, Ying-Ying Wang, Weiqi Tan, Cong Liu, Shuting Xia, An Liu, Xusheng Wang, Shuang-Feng Zhang, Zhao-Qian Teng, Qinmiao Sun, Yujing Li, Hong Wang, Nina Xie, Zikai Zhou, Dahua Chen, Junmin Peng, Hai-Liang Yan, Li Lin, and Gang-Bin Tang
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0301 basic medicine ,Nervous system ,medicine.medical_specialty ,Biology ,Article ,Germline ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Papaverine ,Internal medicine ,medicine ,Animals ,Learning ,Social Behavior ,Mice, Knockout ,Gene knockdown ,Neuronal Plasticity ,Behavior, Animal ,Phosphoric Diester Hydrolases ,General Neuroscience ,Neurogenesis ,medicine.disease ,MicroRNAs ,030104 developmental biology ,Endocrinology ,medicine.anatomical_structure ,Schizophrenia ,Knockout mouse ,Synaptic plasticity ,PDE10A ,Stereotyped Behavior ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Genetic analyses have linked microRNA-137 (MIR137) to neuropsychiatric disorders, including schizophrenia and autism spectrum disorder. miR-137 plays important roles in neurogenesis and neuronal maturation, but the impact of miR-137 loss-of-function in vivo remains unclear. Here we show the complete loss of miR-137 in the mouse germline knockout or nervous system knockout (cKO) leads to postnatal lethality, while heterozygous germline knockout and cKO mice remain viable. Partial loss of miR-137 in heterozygous cKO mice results in dysregulated synaptic plasticity, repetitive behavior, and impaired learning and social behavior. Transcriptomic and proteomic analyses revealed that the miR-137 mRNA target, phosphodiesterase 10a (Pde10a), is elevated in heterozygous knockout mice. Treatment with the Pde10a inhibitor papaverine or knockdown of Pde10a ameliorates the deficits observed in the heterozygous cKO mice. Collectively, our results suggest that MIR137 plays essential roles in postnatal neurodevelopment and that dysregulation of miR-137 potentially contributes to neuropsychiatric disorders in humans.
- Published
- 2018
16. Spatial patterns of interprovincial mountain geographical names in China and implications for regional governance
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Dai-chao Li, Shengrui Zhang, Lei Fang, Yingjie Wang, Ying-ying Wang, Hongrun Ju, and Tongyan Zhang
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Global and Planetary Change ,education.field_of_study ,Government ,Poverty ,business.industry ,Corporate governance ,05 social sciences ,Geography, Planning and Development ,Population ,0211 other engineering and technologies ,0507 social and economic geography ,Elevation ,Distribution (economics) ,021107 urban & regional planning ,Geology ,02 engineering and technology ,Geography ,Regional science ,Spatial ecology ,China ,business ,education ,050703 geography ,Nature and Landscape Conservation ,Earth-Surface Processes - Abstract
Suffering from fragile environment, poor accessibility and infrastructure, as well as social, political and economic marginality, the interprovincial mountain geographical entities are difficult areas for the regional governance in China. By analyzing the spatial patterns and the influencing factors of the interprovincial mountain geographical names (IMGNs), the goal of this research is to clarify the geographical features of IMGNs and offer alternatives for the management of interprovincial mountain regions in China. The spatial visualization, the analysis of spatial agglomeration and the influencing factors of IMGNs were all implemented under a geographical information system. Results showed that there were 6869 IMGNs in China according to the database of “China’s Second National Survey of Geographical Names (2014–2018)”, including 4209 mountain geographical names, 1684 mountain peak geographical names and 976 the other mountain geographical names. Hunan Province had the largest number of names while Shanghai had the smallest number of names. In addition, the spatial variance of the mountain peak names and the mountain names were larger than that of the other mountain geographical names, and the IMGNs showed a significant clustering phenomenon in the southern part of China. The relative elevation and the population had an impact on the distribution of the IMGNs. The largest number of the names occurred where the relative elevation was between 1000–2000 m and where the population was between 40–50 million. Density of unnamed interprovincial mountain geographical entities declined from west to east in China. The analysis of generic names of different types of IMGNs implied that the naming of IMGNs is inconsistent. Based on these analyses, it is suggested that the government should take the IMGNs as management units, strengthen the naming of unnamed interprovincial mountain geographical entities, standardize the generic names of IMGNs and identify areas of poverty based on the survey of IMGNs.
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- 2018
17. Relationship between renal tissues phospholipase A2 receptor and its serum antibody and clinical condition and prognosis of idiopathic membranous nephropathy: a meta-analysis
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Lu Zhang, Li Song, Ting-ting Fan, Ying-ying Wang, Dan Dong, and Li Zhang
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Nephrology ,medicine.medical_specialty ,PLA2R ,Anti-PLA2R antibody ,030232 urology & nephrology ,Serum albumin ,Renal function ,Urine ,030204 cardiovascular system & hematology ,lcsh:RC870-923 ,Glomerulonephritis, Membranous ,Gastroenterology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Autoantibodies ,Idiopathic membranous nephropathy ,Creatinine ,biology ,business.industry ,Receptors, Phospholipase A2 ,Antibody titer ,lcsh:Diseases of the genitourinary system. Urology ,Prognosis ,Meta-analysis ,Titer ,chemistry ,Disease Progression ,biology.protein ,Antibody ,business ,Research Article - Abstract
Objective To investigate the correlation of M-type phospholipase A2 receptor (PLA2R) expression and serum anti-PLA2R antibody with the clinical parameters and prognosis of patients with idiopathic membranous nephropathy (IMN). Methods A literature search for relevant original articles published between January 2009 and October 2019 was conducted on domestic and foreign databases. RevMan 5.3 software was used for meta-analysis. Results Eighteen studies were included in this meta-analysis. There were 1235 anti-PLA2R antibody-positive and PLA2R-positive patients, and 407 serum anti-PLA2R antibody-negative and PLA2R-negative patients. Compared with negative group, patients in the serum PLA2R antibody -positive group had lower serum albumin [SMD = -1.11, 95% CI (− 1.82, − 0.40), P P P P P = 0.002]. No significant difference was observed between anti-PLA2R antibody -positive and -negative groups with respect to adverse events. Serum anti-PLA2R antibody titer did not affect the adverse event rate. Conclusion As compared to PLA2R, serum anti-PLA2R antibody is more closely related with IMN disease progression.
- Published
- 2019
18. CRISPR/Cas9 genome editing technology significantly accelerated herpes simplex virus research
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Shi-Bao Song, Ying-Ying Wang, Xian-Wang Wang, Xiao-Chun Peng, Yan-Ning Lyu, Hong-Wu Xin, Lin Chen, Cheng-Bin Li, Ying Xiang, Zhaowu Ma, Jiafu Ji, Victoria W. Xin, and Dong Wang
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Gene Editing ,0301 basic medicine ,Cancer Research ,Cas9 ,Genetic enhancement ,Genome, Viral ,Computational biology ,Biology ,medicine.disease_cause ,Genome ,Virus ,03 medical and health sciences ,030104 developmental biology ,Herpes simplex virus ,Genome editing ,medicine ,Animals ,Humans ,Simplexvirus ,Molecular Medicine ,CRISPR ,CRISPR-Cas Systems ,Molecular Biology ,Genome size - Abstract
Herpes simplex viruses (HSVs) are important pathogens and ideal for gene therapy due to its large genome size. Previous researches on HSVs were hampered because the technology to construct recombinant HSVs were based on DNA homology-dependent repair (HDR) and plaque assay, which are inefficient, laborious, and time-consuming. Fortunately, clustered regularly interspaced short palindromic repeat/CRISPR-associated protein 9 (CRISPR/Cas9) recently provided the possibility to precisely, efficiently, and rapidly edit genomes and indeed is successfully being used in HSVs. Importantly, CRISPR/Cas9 technology increased HSV HDR efficiency exponentially by a 10,000-1,000,000 times when making recombinant HSVs, and its combination with flow cytometric technology made HSV recombination practically automatic. These may have a significant impact on virus and gene therapy researches. This review will summarize the latest development and molecular mechanisms of CRISPR/Cas9 genome editing technology and its recent application in HSVs.
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- 2018
19. Correction to: Childhood trauma mediates repetitive transcranial magnetic stimulation efficacy in major depressive disorder
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Yu Ting Hu, Georg Northoff, Zhong Lin Tan, Annemarie Wolff, Jin Fang Han, Jianfeng Zhang, Sara Tremblay, Ying Ying Wang, and Xi Wen Hu
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,MEDLINE ,General Medicine ,medicine.disease ,Transcranial magnetic stimulation ,Psychiatry and Mental health ,Physical medicine and rehabilitation ,Medicine ,Major depressive disorder ,Pharmacology (medical) ,business ,Biological Psychiatry - Published
- 2021
20. Correction to: The old CEACAMs find their new role in tumor immunotherapy
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Zhaowu Ma, Zi-Wen Han, Xiao-Chun Peng, Wen-Qi Cai, Ying Zhang, Bin Cui, Ying-Ying Wang, Jun-Ting Cheng, Xian-Wang Wang, Mo Yang, Ying Xiang, Hong-Wu Xin, Zhi-Wu Lyv, Yang Zhou, and Shuzhong Cui
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Pharmacology ,Oncology ,medicine.medical_specialty ,business.industry ,Internal medicine ,medicine.medical_treatment ,Pharmacology toxicology ,medicine ,MEDLINE ,Pharmacology (medical) ,Immunotherapy ,business - Published
- 2020
21. Molecular genetic analysis of grain protein content and flour whiteness degree using RILs in common wheat
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Ying-ying Wang, Sishen Li, Zhao-Guo Qian, Ying Guo, Xian-yin Sun, Yan Zhao, Fanmei Kong, and Ke Wu
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0106 biological sciences ,0301 basic medicine ,Genotype ,Genetic Linkage ,Flour ,Quantitative Trait Loci ,Color ,Quantitative trait locus ,Biology ,01 natural sciences ,Chromosomes, Plant ,Protein content ,03 medical and health sciences ,Genetic linkage ,Genetics ,Plant breeding ,Allele ,Common wheat ,Gene–environment interaction ,Alleles ,Crosses, Genetic ,Genetic Association Studies ,Triticum ,Plant Proteins ,Chromosome Mapping ,food and beverages ,Plant Breeding ,Phenotype ,030104 developmental biology ,Gene-Environment Interaction ,Edible Grain ,010606 plant biology & botany - Abstract
Grain protein content (GPC) and flour whiteness degree (FWD) are important qualitative traits in common wheat. Quantitative trait locus (QTL) mapping for GPC and FWD was conducted using a set of 131 recombinant-inbred lines derived from the cross 'Chuan 35050 × Shannong 483' in six environmental conditions. A total of 22 putative QTLs (nine GPC and 13 FWD) were identified on 12 chromosomes with individual QTL explaining 4.5-34.0% phenotypic variation. Nine QTLs (40.9%) were detected in two or more environments. The colocated QTLs were on chromosomes 1B and 4B. Among the QTLs identified for GPC, QGpc.sdau-4A from the parent Shannong 483 represented some important favourable QTL alleles. QGpc.sdau-2A.1 and QFwd.sdau-2A.1 had a significant association with both GPC and FWD. The markers detected on top of QTL regions could be potential targets for marker-assisted selection.
- Published
- 2016
22. Application of Minimum Reward Risk Model in Reservoir Generation Scheduling
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Ying-Ying Wang, Fei Yang, Wu Jingxiu, Fan Ziwu, and Zhang Ming
- Subjects
Mathematical optimization ,business.industry ,Stochastic process ,0208 environmental biotechnology ,Scheduling (production processes) ,02 engineering and technology ,Stochastic programming ,020801 environmental engineering ,Risk model ,Electricity generation ,Discrete time and continuous time ,Economics ,Markov decision process ,business ,Hydropower ,Water Science and Technology ,Civil and Structural Engineering - Abstract
Discrete time Markov decision process is studied and the minimum reward risk model is established for the reservoir long-term generation optimization. Different form the commonly used optimization criterion of best expected reward in reservoir scheduling, the probability that the expected generation of the whole period not exceeding the predete reward target to be smallest is chosen as the optimizing target for this random process. For the hydropower tends to operate as peak-clipping mode in Market-based model to gain more profits, the function of electricity price and output can be founded by analyzing on the typical day load course of the electricity system. Compared with the generally used criteria of the largest expectation power generation model, this model is fitted for the decision-making in which the risk is needed to be limited to reflect the risk preference of the policy makers. Stochastic dynamic programming method is adopted to solve the model and the model is tested on the Three Gorges Hydropower Station.
- Published
- 2016
23. Author Correction: Genetically encoded tags for direct synthesis of EM-visible gold nanoparticles in cells
- Author
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Xiao-Man Liu, Xiaobin Sun, Yanyong Hu, Gaihong Cai, Yuhua Li, Ying Liu, Yaqi Tang, Li-Lin Du, Ying-Ying Wang, Xiumei Jin, Zhaodi Jiang, Pei Zhao, She Chen, Sitong Liu, Wanzhong He, Yan Liu, Xinbin Cai, Xiangbing Qi, and Ming Li
- Subjects
Chemistry ,Colloidal gold ,Published Erratum ,Nanotechnology ,Cell Biology ,Molecular Biology ,Biochemistry ,Biotechnology - Published
- 2020
24. Potassium (K) effects and QTL mapping for K efficiency traits at seedling and adult stages in wheat
- Author
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Yan Zhao, Sishen Li, Ying Guo, Fanmei Kong, Xue Liang, Chun-Hong Wu, and Ying-ying Wang
- Subjects
biology ,fungi ,food and beverages ,Soil Science ,Plant physiology ,Plant Science ,Quantitative trait locus ,biology.organism_classification ,Nutrient ,Agronomy ,Dry weight ,Inbred strain ,Seedling ,Shoot ,Common wheat - Abstract
Potassium (K) is one of the most important mineral nutrients limiting plant growth in agricultural systems. This study investigated the effects of low-K treatments and detected quantitative trait loci (QTLs) for K efficiency traits at the seedling and adult stages of wheat. Eleven seedling traits under a hydroponic culture trial with five K treatments and nine adult traits in a pot trial and a field trial with three K treatments were investigated using a set of wheat recombinant inbred lines (RILs). Values of most of the seedling and adult traits decreased with decreasing K supply, but the K-use efficiency and ratio of dry weight between seedling roots and shoots (RSDW) increased. A total of 87 QTLs for seedling traits in the hydroponic culture trial and 51 and 29 QTLs for adult traits in the pot and field trials, respectively, were detected. We also identified 15 relatively high-frequency QTLs (RHF-QTLs) which can be detected in over half of the treatments and 21 QTL clusters which is defined as the co-location of QTLs for more than two traits. K efficiency traits and the related QTLs of wheat were greatly affected by K treatments. Several relatively stable QTLs and important QTL clusters may be potential targets for marker-assisted selection for wheat nutrient efficiency.
- Published
- 2013
25. Biodegradable mucus-penetrating nanoparticles composed of diblock copolymers of polyethylene glycol and poly(lactic-co-glycolic acid)
- Author
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Ying Ying Wang, Jie Fu, Sarah Pulicare, Justin Hanes, Olcay Mert, Tao Yu, Craig S. Schneider, Weixi Zhong, Ming Yang, Woo Jin Choi, and Samuel K. Lai
- Subjects
technology, industry, and agriculture ,Pharmaceutical Science ,Nanoparticle ,Nanotechnology ,macromolecular substances ,Polyethylene glycol ,Mucus ,Article ,Solvent ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,Drug delivery ,Drug carrier ,Ethylene glycol ,Glycolic acid - Abstract
Mucus secretions coating entry points to the human body that are not covered by skin efficiently trap and clear conventional drug carriers, limiting controlled drug delivery at mucosal surfaces. To overcome this challenge, we recently engineered nanoparticles that readily penetrate a variety of human mucus secretions, which we termed mucus-penetrating particles (MPP). Here, we report a new biodegradable MPP formulation based on diblock copolymers of poly(lactic-co-glycolic acid) and poly(ethylene glycol) (PLGA-PEG). PLGA-PEG nanoparticles prepared by a solvent diffusion method rapidly diffused through fresh, undiluted human cervicovaginal mucus (CVM) with an average speed only eightfold lower than their theoretical speed in water. In contrast, PLGA nanoparticles were slowed more than 12,000-fold in the same CVM secretions. Based on the measured diffusivities, as much as 75% of the PLGA-PEG nanoparticles are expected to penetrate a 10-μm-thick mucus layer within 30 min, whereas virtually no PLGA nanoparticles are expected to do so over the same duration. These results encourage further development of PLGA-PEG nanoparticles as mucus-penetrating drug carriers for improved drug and gene delivery to mucosal surfaces.
- Published
- 2011
26. Study on the expression and significance of TGF-β1, p-ERK1/2and K-ras in colorectal cancer using tissue microarray technique
- Author
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Shouli Wang, Lingling Guo, Yuting Kuang, Ying-ying Wang, Xin Hu, Yu-juan Zhang, and Mao-ming Sun
- Subjects
Tissue microarray ,ERK1/2 ,business.industry ,Kinase ,Colorectal cancer ,Normal colon ,colorectal cancer ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,lcsh:RC254-282 ,tissue microarray technique ,TGF-β1 ,Immunology ,Cancer research ,Extracellular ,General Earth and Planetary Sciences ,Medicine ,Immunohistochemistry ,Stage (cooking) ,K-ras ,business ,General Environmental Science ,Transforming growth factor - Abstract
OBJECTIVE This study aimed to explore the expression and significance of transforming growth factor β1(TGF-β1), extracellular signal-regulated kinases 1/2 (ERK1/2), and K-ras in colorectal cancer (CRC) using tissue microarray technology.METHODS The expressions of TGF-β1, ERK1/2, and K-ras in colon cancer cells taken from the specimens of 92 CRC patients (stage I: 16 cases, stage II: 28 cases, stage III: 24 cases, and stage IV: 24 cases) were analyzed using tissue microarray technology and immunohistochemistry, and compared with those of 20 normal colon tissue samples.RESULTS High immunoreactive scores (IRS) of TGF-β1, p-ERK1/2, and K-ras protein in CRC were obtained, which were 66.3% (61/92), 59.8% (55/92), and 48.9% (45/92), respectively, and those in normal epithelial cells of colon were 10% (2/20), 20% (4/20), and 30% (6/20), respectively (P0.05).CONCLUSION High level expressions of TGF-β1 and ERK1/2 are closely related to the clinical stages of colon cancer and crosstalk may exist between the 2 signal pathways.
- Published
- 2011
27. Gradient analysis of landscape spatial and temporal pattern changes in Beijing metropolitan area
- Author
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Qiming Zhou, Ying Ying Wang, Ye Tao Yang, and Jian Ya Gong
- Subjects
Gradient analysis ,Geography ,Beijing ,Urbanization ,General Engineering ,Urban sprawl ,General Materials Science ,Moving window ,Physical geography ,Transect ,Spatial extent ,Metropolitan area - Abstract
The gradient based landscape metrics analysis is now widely used to study the landscape pattern changes in respond to the urbanization. In order to discover the trend of spatio-temporal changes in Beijing metropolitan area during the past 15 years, several landscape metrics are computed using a moving window along a 96 km long transect across Beijing metropolitan area from west to east. Specially, the spatial extent of sub-landscape, which is determined by the moving window’s size, is profoundly examined. The results show that the metrics varies smoothly and regularly along the selected transect when the window size is greater than 6 km×6 km, and irregularly fluctuated for the smaller window size, that the spatial and temporal landscape characteristics of Beijing city match the hypothetical framework of spatio-temporal urban sprawl in the form of alternating processes of diffusion and coalescence well, and that some new trends of the urban sprawl style in Beijing metropolitan area, such as leap-frog manner, are also detected by the gradient landscape analysis.
- Published
- 2010
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