1. Electroacupuncture alters the expression of genes associated with lipid metabolism and immune reaction in liver of hypercholesterolemia mice
- Author
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Min Li, Jinmei Kang, Wenqi Yan, Yizheng Zhang, Yaoxia Kang, and Xingjie Li
- Subjects
medicine.medical_specialty ,Transcription, Genetic ,Electroacupuncture ,medicine.medical_treatment ,Hypercholesterolemia ,Down-Regulation ,Bioengineering ,Inflammation ,Biology ,Applied Microbiology and Biotechnology ,Mice ,chemistry.chemical_compound ,Internal medicine ,Gene expression ,medicine ,Animals ,Electrophoresis, Agar Gel ,Cholesterol ,Gene Expression Profiling ,Nucleic Acid Hybridization ,Lipid metabolism ,General Medicine ,Metabolism ,Lipid Metabolism ,Up-Regulation ,Metabolism disorder ,Endocrinology ,Gene Expression Regulation ,Liver ,chemistry ,Suppression subtractive hybridization ,Receptors, Adiponectin ,medicine.symptom ,Biotechnology - Abstract
Acupuncture or electroacupuncture (EA) is effective in treating various metabolism disorders. Previously we found that EA at the acupoint, Fenglong (ST40), had the cholesterol-lowering effect and regulated genes expression in liver of hypercholesterolemia mice (M Li and YZ Zhang, Int J Mol Med 2007, 19: 617-629). To explain gene expression associated with EA, suppression subtractive hybridization (SSH), combined with targeted display (TD), was used and 26 up-regulated and 24 down-regulated genes with known functions were identified in hypercholesterolemia mice liver, some of which are involved in key reactions of lipid metabolism and immune reaction. Promoting lipid metabolism and suppressing inflammation via modulating mRNA expression may be the mechanism of EA inducing modulation of cholesterol concentrations.
- Published
- 2007
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