3 results on '"Xuejun Qian"'
Search Results
2. A combined ultrasonic B-mode and color Doppler system for the classification of breast masses using neural network
- Author
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Jie Ma, Bo Zhang, Qisen Xiao, Xuejun Qian, Xiang Chen, Yuzheng Yang, Qifa Zhou, Zeyu Chen, Lifang Liu, K. Kirk Shung, Yi Wei, Xiaoqiong Chen, Jingyuan Liu, Shaoqiang Liu, and Yueai Wang
- Subjects
Adult ,Convex hull ,medicine.medical_specialty ,Breast Neoplasms ,Sensitivity and Specificity ,030218 nuclear medicine & medical imaging ,Set (abstract data type) ,03 medical and health sciences ,0302 clinical medicine ,Radiologists ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Ultrasonography, Doppler, Color ,Aged ,Retrospective Studies ,Neuroradiology ,Artificial neural network ,Receiver operating characteristic ,business.industry ,Ultrasound ,Pattern recognition ,General Medicine ,Middle Aged ,Confidence interval ,ROC Curve ,Area Under Curve ,030220 oncology & carcinogenesis ,Test set ,Female ,Neural Networks, Computer ,Ultrasonography, Mammary ,Artificial intelligence ,Radiology ,business - Abstract
To develop a dual-modal neural network model to characterize ultrasound (US) images of breast masses. A combined US B-mode and color Doppler neural network model was developed to classify US images of the breast. Three datasets with breast masses were originally detected and interpreted by 20 experienced radiologists according to Breast Imaging-Reporting and Data System (BI-RADS) lexicon ((1) training set, 103212 masses from 45,433 + 12,519 patients. (2) held-out validation set, 2748 masses from 1197 + 395 patients. (3) test set, 605 masses from 337 + 78 patients). The neural network was first trained on training set. Then, the trained model was tested on a held-out validation set to evaluate agreement on BI-RADS category between the model and the radiologists. In addition, the model and a reader study of 10 radiologists were applied to the test set with biopsy-proven results. To evaluate the performance of the model in benign or malignant classifications, the receiver operating characteristic curve, sensitivities, and specificities were compared. The trained dual-modal model showed favorable agreement with the assessment performed by the radiologists (κ = 0.73; 95% confidence interval, 0.71–0.75) in classifying breast masses into four BI-RADS categories in the validation set. For the binary categorization of benign or malignant breast masses in the test set, the dual-modal model achieved the area under the ROC curve (AUC) of 0.982, while the readers scored an AUC of 0.948 in terms of the ROC convex hull. The dual-modal model can be used to assess breast masses at a level comparable to that of an experienced radiologist. • A neural network model based on ultrasonic imaging can classify breast masses into different Breast Imaging-Reporting and Data System categories according to the probability of malignancy. • A combined ultrasonic B-mode and color Doppler neural network model achieved a high level of agreement with the readings of an experienced radiologist and has the potential to automate the routine characterization of breast masses.
- Published
- 2020
3. Multi-functional Ultrasonic Micro-elastography Imaging System
- Author
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Qifa Zhou, Xuejun Qian, Xiaoyang Chen, Teng Ma, Mingyue Yu, and K. Kirk Shung
- Subjects
medicine.medical_specialty ,Materials science ,Science ,Field of view ,01 natural sciences ,Article ,010309 optics ,Chicken Liver ,0103 physical sciences ,medicine ,Fine resolution ,Animals ,Medical physics ,010301 acoustics ,Microscale chemistry ,Ultrasonography ,Acoustic radiation force impulse imaging ,Multidisciplinary ,medicine.diagnostic_test ,Optical Imaging ,Transducer ,Liver ,Elasticity Imaging Techniques ,Medicine ,Ultrasonic sensor ,Elastography ,Chickens ,Biomedical engineering - Abstract
In clinical decision making, in addition to anatomical information, biomechanical properties of soft tissues may provide additional clues for disease diagnosis. Given the fact that most of diseases are originated from micron sized structures, an elastography imaging system of fine resolution (~100 µm) and deep penetration depth capable of providing both qualitative and quantitative measurements of biomechanical properties is desired. Here, we report a newly developed multi-functional ultrasonic micro-elastography imaging system in which acoustic radiation force impulse imaging (ARFI) and shear wave elasticity imaging (SWEI) are implemented. To accomplish this, the 4.5 MHz/40 MHz transducer were used as the excitation/detection source, respectively. The imaging system was tested with tissue-mimicking phantoms and an ex vivo chicken liver through 2D/3D imaging. The measured lateral/axial elastography resolution and field of view are 223.7 ± 20.1/109.8 ± 6.9 µm and 1.5 mm for ARFI, 543.6 ± 39.3/117.6 ± 8.7 µm and 2 mm for SWEI, respectively. These results demonstrate that the promising capability of this high resolution elastography imaging system for characterizing tissue biomechanical properties at microscale level and its translational potential into clinical practice.
- Published
- 2017
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