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Background The incidence of classic radiation-induced liver disease (cRILD) has been significantly reduced. However, non-classic radiation-induced liver disease (ncRILD) remains a major concern following radiotherapy in patients with hepatocellular carcinoma (HCC). This study evaluated the incidence of ncRILD following intensity-modulated radiotherapy (IMRT) for Child–Pugh grade B (CP-B) patients with locally advanced HCC and established a nomogram for predicting ncRILD probability. Methods Seventy-five CP-B patients with locally advanced HCC treated with IMRT between September 2014 and July 2021 were included. The max tumor size was 8.39 cm ± 5.06, and the median prescribed dose was 53.24 Gy ± 7.26. Treatment-related hepatotoxicity was evaluated within three months of completing IMRT. A nomogram model was formulated to predict the probability of ncRILD, using univariate and multivariate analysis. Results Among CP-B patients with locally advanced HCC, ncRILD occurred in 17 (22.7%) patients. Two patients (2.7%) exhibited a transaminase elevation of ≥ G3, fourteen (18.7%) exhibited a Child–Pugh score increase of ≥ 2, and one (1.3%) demonstrated both a transaminase elevation of ≥ G3 and a Child–Pugh score increase of ≥ 2. No cRILD cases were observed. A mean dose to the normal liver of ≥ 15.1 Gy was used as the cutoff for ncRILD. Multivariate analysis revealed that the prothrombin time before IMRT, tumour number, and mean dose to the normal liver were independent risk factors for ncRILD. The nomogram established on the basis of these risk factors displayed exceptional predictive performance (AUC = 0.800, 95% CI 0.674–0.926). Conclusions The incidence of ncRILD following IMRT for CP-B patients with locally advanced HCC was acceptable. A nomogram based on prothrombin time before IMRT, tumour number, and mean dose to the normal liver accurately predicted the probability of ncRILD in these patients.

The service life of the purging plug is one of the fundamental factors that determine the downtime and usage efficiency of the whole ladle. The creep behaviour of the purging plug was thus investigated to identify the possible failure mechanism. At first, the creep parameters of the Norton–Bailey strain hardening rule were inversely identified via the results of the creep test. Then, the thermal-solid coupling model approach was employed to predict the creep behaviour of the purging plug, in which the Norton–Bailey strain hardening rule was applied. The numerical results show that the temperature of the purging plug presents a cyclic trend after the first service period since the preheating temperature is lower than the temperature of molten steel. Furthermore, the distribution of the creep strain intensity in a layered form could also contribute to a gradual spalling of the purging plug end in service. Besides, the creep strain concentration around the slit can be responsible for the clogging of the purging plug.

Background For patients with unresectable hepatocellular carcinoma (uHCC), intensity-modulated radiotherapy (IMRT) has become one of the options for clinical local treatment. Immune parameters, including platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR) and systemic immune inflammatory (SII), predict survival in various cancers. This study aimed to determine whether peripheral immune parameters can predict survival in patients with uHCC undergoing IMRT and establish a clinically useful prognostic nomogram for survival prediction. Methods The clinical data of 309 HCC patients were retrospectively analyzed and randomly divided into training (n = 216) and validation (n = 93) cohorts. PLR, NLR and SII were collected before and after IMRT. Univariate and multivariate Cox analyses were performed to identify independent prognostic factors affecting survival, which were used to generate a nomogram. Results The median survival was 16.3 months, and significant increases in PLR, NLR, and SII were observed after IMRT (P P Conclusions High levels of immune parameters are associated with poor prognosis in uHCC patients receiving IMRT. Our nomogram accurately predicts the survival of patients with uHCC receiving IMRT.

Glass-forming ability is a long-standing concern in the field of metallic glasses (MGs), which greatly limits their maximum casting size and extensive applications. In this work, we report an ultrasonic-assisted rapid cold welding of bulk MGs without using any additives. MGs with various compositions are welded together under a 20,000-Hz high-frequency ultrasonic vibration without losing their amorphous nature. The ultrasonic technology offers the advantages of rapid bonding (< 1 s) at low temperature (near room temperature) and low stress (< 1 MPa). According to the phenomenon observed in the experiment, the activated fresh atoms diffuse through the broken channel port under continuous rupture of the oxide layer, and the ultrasonic vibration accelerates the atomic-diffusion process. Finally, stable bonding of the MG interface is realized. This universal ultrasonic-assisted welding process can realize the composition design of dissimilar MGs as well as tuning of new materials with new performance.

So far, many investigations have reported that Zr-based bulk metallic glasses (BMGs) could be precisely and flexibly shaped by electrical discharge machining (EDM). However, EDM induced crystallization and roughness is still a bottleneck. In this research, bench-mode electrochemical surface smoothing (ESS) in the NaCl-ethylene glycol (EG) electrolyte has been proposed to post-process the spark erosion treated Zr-based BMGs in order to solve the abovementioned problems. The utilization of the NaCl-EG electrolyte overcomes the difference in electrochemical dissolution mechanisms of multiple components contained in Zr-based BMGs. Taking a sort of Zr-based BMGs, Vit1 (Zr41.2Ti13.8Cu12.5Ni10.0Be22.5), as an example, voltammetry and chronoamperometry methods have been performed on the BMG surface before and after wire-EDM, respectively, in the NaCl-EG electrolyte to reveal the steady and transient electrochemical behaviors. In order to achieve high-efficiency and high-quality ESS of Zr-based BMGs, a 3D printed setup with lateral flushing has been developed, combined with the micron sized inter-electrode gap (IEG) and the pulse current. The surface morphologies after ESS have been compared to evaluate the effects of the initial surface morphologies, dwell time, and pulse parameters. The surface material properties and mechanical performance before and after ESS have also been investigated by EDS, XRD, XPS, and nanoindentation. The results suggests that the proposed ESS method is capable of quickly eliminating the crystalline layer induced by the thermal shock and reducing roughness caused by the discharge craters, which has been finally validated by fast ESS of two Zr-based BMG molds with ruled surfaces in the NaCl-EG solution.

The microstructure evolution and the pitting corrosion resistance of a supermartensitic stainless steel after deep cryogenic treatment process were clarified through X-ray diffraction, field emission scanning electron microscopy, transmission electron microscopy (TEM) and electrochemical methods. The results showed that the microstructure of supermartensitic stainless steel mainly consisted of reversed austenite, tempered martensite, and M23C6 carbides after tempering. The deep cryogenic treatment promoted the refinement of the martensite laths and the precipitation of the carbides in comparison with the traditional process. TEM analysis indicated that the segregation of Si atoms at the boundary was found at the interface between carbide and martensite. The pitting corrosion potential of the specimens subjected to deep cryogenic treatment decreased with the elevated tempering temperature, and the lowest pitting corrosion potential was found at the tempering temperature of 650 °C. The sensitivity of the pitting corrosion potential was attributed to the precipitation of M23C6 carbides and Si atoms segregation. Si atoms segregation engendered the formation of Cr-depleted zone near M23C6 and impeded the recovery of Cr-depleted zone.

Electrical discharge machining (EDM) has been widely used in the machining of mechanical parts. However, the parts obtained by EDM have recast layers and micro-cracks on their surface, which seriously affect their mechanical properties. In order to remove the recast layers and micro-cracks resulted from EDM, this paper proposed to combine micro-EDM with negative polarity micro-EDM. First, the mechanical part was machined using conventional EDM, after which the surface of the part had a distinct recast layer and micro-cracks. As the conventional EDM was nearing completion, the power supply was replaced by a micro-EDM power supply and then the part was processed by micro-EDM to reduce the thickness of the recast layer. After micro-EDM, the part was processed by negative polarity micro-EDM, which can remove the recast layer and the micro-cracks on the surface of the part. Conventional EDM was performed on 304 stainless steel using a copper electrode with voltage of 250 V, pulse width of 7 ms, and pulse interval of 5 ms. The experimental results showed that the recast layer and micro-cracks on the surface of the part were obvious and the surface quality of the part was poor. After that, the same part was sequentially subjected to micro-EDM and negative polarity micro-EDM with voltage of 110 V, pulse width of 0.5 μs, and pulse interval of 15 μs. The experimental results showed that the recast layer and micro-cracks on the surface of the part were almost invisible and the surface quality of the part was greatly improved.

Three-dimensional (3D) microelectrodes can be fabricated by laminating multilayer copper microelectrodes. When the 3D microelectrode is used for micro electrical discharge machining (micro-EDM), the 3D microstructure can be obtained with an up-and-down reciprocating motion. The process is simple and the machining efficiency is high. In micro-EDM process, the 3D microelectrode has wear, which affects the shape accuracy and dimensional accuracy of the microstructure. To obtain the wear characteristics and predict the wear of the 3D microelectrode, the paper discretized 3D microelectrode into several microelectrodes with square cross-sections. The discretized 3D microelectrodes comprised a number of α-type electrodes, β-type electrodes, and γ-type electrodes. The wear of these microelectrodes was studied by numerous experiments, and the wear characteristics of individual microelectrodes were integrated to obtain the wear characteristics of the 3D microelectrode. The study found that the wear of these three types of electrodes was linearly related to the machining depth. The fit slope of the α-type electrode was equal to − 0.24071, and it had the most wear. The fit slope of the β-type electrode was equal to − 0.21524, and it had the second-highest wear. The fit slope of the γ-type electrode was equal to − 0.19767, and its wear was the lowest. Finally, a 3D microelectrode with semi-cylindrical features was used for micro-EDM to verify the correctness of the wear characteristics. The experimental results were compared with the theoretical calculation, and the theoretical calculation of the 3D microelectrode wear was basically consistent with the experimental results. The maximum error between the theoretical calculation and the experimental results was 21.85 μm, and the minimum error was 3.16 μm.

Understanding the impact of rock bareness on the transpiration in karst plants is essential to karst rocky desertification control and sustainable management of plantation in karst area. This study focused on the variations in sap flow of Zenia insignis caused by different rock bareness rate, and the impact of climate factors, soil water content (SWC) and leaf area index (LAI) on transpiration in karst plants, by continuously measuring sap flux densities (Fd) of 12 sample trees using thermal dissipation probes and monitoring micrometeorology and SWC on a typical karst hill in north Guangdong of China during the year of 2016. Results show that: (1) the maximum hourly sap flux density occurred at 11:00–14:00 and the peak daily sap flux density occurred in September. (2) Sap flow density of Zenia insignis increased with rock bareness rate at all hourly, daily and monthly scales, with the sequence of extremely severe > severe > moderate > mild rock bareness. (3) The transpiration of Zenia insignis is controlled by different factors at different temporal scales. At hourly scale, transpiration was highly (n=144, R2>0.72) correlated to Solar radiation (Rs), Air temperature (Ta), relative humidity (RH), and water vapor pressure deficit (VPD). At daily scale, transpiration was greatly (77=366, R2>0.31) affected by Solar radiation (Rs), Air temperature (Ta), and water vapor pressure deficit (VPD). While at monthly scale, transpiration was mainly (n=12, R2=0.8s) controlled by LAI. Our study proved that Zenia insignis has a good physiecological adaption to fragile karst environment, and Zenia insignis plantation has long-term sustainability even in extremely rocky landscapes. The results may provide scientific basis for plantation management and ecological restoration in karst area.

Based on a planned process design path, a foil queue microelectrode (FQ-microelectrode) is applied sequentially in micro-electrical discharge machining (micro-EDM) in which the micro-EDM results can superimpose to produce the 3D micro-structure. However, in this process, each foil microelectrode (F-microelectrode) inevitably experiences wear, and the wear has an unfavorable effect on the machining accuracy of 3D micro-structure. In this study, the wear of F-microelectrodes for different technological parameters is studied in detail. The experimental results show that the first three pieces of the F-microelectrodes exhibit serious wear, and the wear values are all over 7 μm. As the processing proceeds, the wear of the microelectrode gradually decreases to 2 μm, as a result of an improvement in the processing environment. To ensure the machining accuracy of 3D micro-structure, this paper compensates the wear of the first three pieces of the F-microelectrode through rough and finish machining. Finally, based on the experimental results, a 3D micro-structure with good form accuracy can be fabricated in cemented carbide with pulse width Ton = 80 ns, pulse interval Toff = 160 ns, and machining voltage V = 100 V.

In this study, the combination of dimensional analysis (DA) and analysis of variance (ANOVA) was used to predict the volumetric mass transfer coefficient (k(L)a) values under different operating conditions for orbitally shaken bioreactors (OSRs) with different filling volumes. It was found that Reynolds number and the interaction between Froude number and geometric number have the largest impact on k(L)a with impact indexes of 7.41 and 7.50, respectively. Moreover, the volume number has the largest negative impact on k(L)a, with an impact index of − 5.34. Thus, an effective way to increase the oxygen supply is by increasing the shaking speed and shaking diameter or decreasing the vessel diameter. However, cell cultivation with a higher filling volume will have an increased risk of oxygen scarcity. Therefore, with the help of the k(L)a prediction model, a suitable operating condition can be determined effectively and easily.

This study aimed to evaluate whether the addition of oxaliplatin to a neoadjuvant chemoradiotherapy (CRT) regimen could improve survival benefit in locally advanced rectal cancer (LARC) patients. We retrospectively analysed 73 LARC patients (cT2-4 and/or cN1-2) who received preoperative CRT with capecitabine followed by surgery (arm A, 43 patients) or capecitabine plus oxaliplatin followed by surgery (arm B, 30 patients). The main endpoints of the study were pathologic complete response (pCR) rate, overall survival (OS) and disease-free survival (DFS). The secondary endpoints included the sphincter preservation rate and safety. The pCR for arms A and B were 28% and 17% (P = 0.267). In arms A and B, the mean OS was 84.287 months (95% CI 68.413–100.160) and 106.333 months (95% CI 99.281–113.386) (P = 0.185); the mean DFS was 72.812 months (95% CI 56.271–89.353) and 95.073 months (95% CI 83.392–106.754) (P = 0.310); and the sphincter preservation rates were 72% and 67%, respectively (P = 0.619). The incidence of grade 3 toxicity was much higher in arm B than in arm A (57% vs. 21%, P = 0.002). Adding oxaliplatin to a preoperative CRT regimen for LARC did not improve the survival benefits of patients or increase toxicity.

We successfully fabricate high-entropy alloys and amorphous alloy composites by adopting the proposed ultrasonic vibration method. The low-stress, low-temperature method enables us to create composites that combine both amorphous and crystalline properties. Microscopic observations and computed tomography measurements indicate good bonding quality without pores or cracks in the composites. Due to the unique structure which mixes soft and rigid phases, the composite exhibits improved mechanical performance compared to that obtained from a pure single phase. Our results are promising for the manual design and fabrication of smart materials containing multiple phases and compositions.

The applicability of micro-electrical discharge machining (micro-EDM) using laminated 3D microelectrodes to eliminate defects such as numerous micro-stripes that are prone to appear on the sidewalls of microstructures manufactured via micro-electrochemical machining (micro-ECM) was examined. The study proposes the fabrication of 3D microstructures with laminated 3D microelectrodes through micro-EDM with deionized water containing B4C powder having a particle size of 1 μm. First, the effect of different machining voltages, B4C concentrations, and microelectrode back-off distances on the unilateral gap was investigated. The results indicated that a machining voltage of 100 V, a B4C concentration of 3 g/L, and a microelectrode back-off distance of 200 μm resulted in a 69 μm unilateral gap of the 3D microstructures. Given the effect of micro-EDM and that B4C is a semiconductor, the plasma discharge channels were enlarged, and the material removal was uniform. This significantly improved the machining efficiency. Furthermore, the polishing of B4C on electrode surfaces and workpiece surfaces smoothly removed the processing attachments with dielectric and ensured efficient and stable machining. Based on the optimized process parameters and after 1.5 h, 3D microstructures with a depth of 800 μm with a square-shaped blind hole and with semicircular and rectangular islands were obtained, and the corresponding roughness (Ra) of the bottom surface was 0.389, 0.388, and 0.392 μm. However, the corresponding microelectrodes wear was low and approximately corresponded to 20, 15, and 15 μm.

To investigate the effects of femtosecond laser ablation on the surface morphology and microstructure of ultrafine-grained copper, point, single-line scanning, and area scanning ablation of ultrafine-grained and coarse-grained copper were performed at room temperature. The ablation threshold gradually increased and materials processing became more difficult with decreasing grain size. In addition, the ablation depth and width of the channels formed by single-line scanning ablation gradually increased with increasing grain size for the same laser pulse energy. The microhardness of the ablated specimens was also evaluated as a function of laser pulse energy using area scanning ablation. The microhardness difference before and after ablation increased with decreasing grain size for the same laser pulse energy. In addition, the microhardness after ablation gradually decreased with increasing laser pulse energy for the ultrafine-grained specimens. However, for the coarse-grained copper specimens, no clear changes of the microhardness were observed after ablation with varying laser pulse energies. The grain sizes of the ultrafine-grained specimens were also surveyed as a function of laser pulse energy using electron backscattered diffraction (EBSD). The heat generated by laser ablation caused recrystallization and grain growth of the ultrafine-grained copper; moreover, the grain size gradually increased with increasing pulse energy. In contrast, no obvious changes in grain size were observed for the coarse-grained copper specimens with increasing pulse energy.

The effect of solution pH, Cl− concentration and temperature on the electrochemical corrosion behavior of PH13-8Mo steel in acidic solution was investigated by using the electrochemical tests, scanning electron microscopy and X-ray photoelectron spectroscopy. The PH13-8Mo martensitic precipitation hardened stainless steel is in the passivity state when the pH value is above 3.0, below which the anodic polarization curves of the steel are actively dissolved. The corrosion current density gradually decreases with increasing the solution pH and decreasing Cl− concentration and solution temperature. Pits are initiated on the sample surface in the presence of the Cl− and gradually developed into uniform corrosion with increasing the Cl− concentrations. Moreover, the corrosion is more serious with an increase in solution temperature.

The deformation of thin-wall stacked structures with low stiffness has been a common problem in the aircraft assembly process, making it difficult to achieve tight tolerance of the countersink depth in one-shot stack drilling. This difficulty is attributed to the complex tool position relative to the workpiece during the machining process. In this paper, an approach to countersink depth control composed of real measurement of the workpiece deformation and compensation of the tool position is presented. The deformation of the workpiece is divided into the following two categories: the rotation angle perpendicular to the feed direction and the deformation along the feed direction. These types of deformation are analysed regarding their influence on the countersink depth error. Effective measures are taken to ensure the countersink depth accuracy; such measures include the adjustment of the normal vector of the drilling position after the clamping process, the error monitoring of the normal vector during machining, and the multi-level compensation during machining. Theoretical analysis and validation of the proposed solution via comparative experiments showed a clear understanding of the coupled interaction of the thrust force with the workpiece deformation and corresponding reduction in the countersink depth error. The compensation solution requires simple computation and is straightforward to implement in industrial automatic drilling applications.