13 results on '"Xinyu, Tang"'
Search Results
2. Selenium Deficiency Induces Inflammatory Response and Decreased Antimicrobial Peptide Expression in Chicken Jejunum Through Oxidative Stress
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Yujiao, He, Lin, Peng, Xiaochun, Zhao, Xue, Fan, Xinyu, Tang, Guangliang, Shi, and Shu, Li
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Inorganic Chemistry ,Endocrinology, Diabetes and Metabolism ,Biochemistry (medical) ,Clinical Biochemistry ,General Medicine ,Biochemistry - Abstract
Selenium deficiency can affect the level of selenoprotein in organs and tissues and cause inflammation. However, the mechanism of selenium deficiency on jejunal injury in chickens remains unclear. In this study, we established a selenium deficiency model in chickens by feeding a low selenium diet and observed ultrastructural and pathological changes in the jejunum. The expression levels of 25 selenoproteins, the levels of oxidative stress, tight junction (TJ) proteins, and antimicrobial peptides (AMP), as well as the expression levels of factors related to inflammatory signaling pathways, were examined in the intestine and analyzed using principal component analysis (PCA). The results of PCA and quantitative real-time PCR (qRT-PCR) showed that selenium deficiency mainly affected the expression of antioxidant selenoproteins in chicken jejunum, especially glutathione peroxidases, thioredoxin reductase, and iodothyronine deiodinase, thus weakening the antioxidant function in the intestine and inducing oxidative stress. We also found disruption of intestinal TJ structures, a significant reduction in TJ protein expression, and downregulation of antimicrobial peptide levels, suggesting that selenium deficiency led to damage of the intestinal barrier. In addition, a significant increase in inflammatory cell infiltration and expression of inflammatory factors was observed in the jejunum, indicating that selenium deficiency induces inflammatory injury. In conclusion, selenium deficiency downregulates antioxidant selenoproteins levels, induces oxidative stress, decreases intestinal AMP levels, and leads to inflammatory injury and disruption of the intestinal barrier in the jejunum. These results shed new light on the molecular mechanisms of intestinal damage caused by selenium deficiency.
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- 2022
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3. Flame-retardant, heat-insulating and char formation properties of densified Pinus sylvestris treated with different compression pressures
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Zhisheng Xu, Wenjun Zhao, Yuwei Feng, Xinyu Tang, and Long Yan
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General Materials Science ,Forestry - Published
- 2022
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4. Improved closed-loop tracking interferometer measurement for a five-axis machine tool with a bi-rotary milling head
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XinYu Tang, Kun Xu, QingZhen Bi, ZhiYong Song, YuLei Ji, and DeHou Qian
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General Engineering ,General Materials Science - Published
- 2022
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5. Rhodopsin-mediated nutrient uptake by cultivated photoheterotrophic Verrucomicrobiota
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Rinat Bar-Shalom, Andrey Rozenberg, Matan Lahyani, Babak Hassanzadeh, Gobardhan Sahoo, Markus Haber, Ilia Burgsdorf, Xinyu Tang, Valeria Squatrito, Laura Gomez-Consarnau, Oded Béjà, and Laura Steindler
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Microbiology ,Ecology, Evolution, Behavior and Systematics - Abstract
Rhodopsin photosystems convert light energy into electrochemical gradients used by the cell to produce ATP, or for other energy-demanding processes. While these photosystems are widespread in the ocean and have been identified in diverse microbial taxonomic groups, their physiological role in vivo has only been studied in few marine bacterial strains. Recent metagenomic studies revealed the presence of rhodopsin genes in the understudied Verrucomicrobiota phylum, yet their distribution within different Verrucomicrobiota lineages, their diversity, and function remain unknown. In this study, we show that more than 7% of Verrucomicrobiota genomes (n = 2916) harbor rhodopsins of different types. Furthermore, we describe the first two cultivated rhodopsin-containing strains, one harboring a proteorhodopsin gene and the other a xanthorhodopsin gene, allowing us to characterize their physiology under laboratory-controlled conditions. The strains were isolated in a previous study from the Eastern Mediterranean Sea and read mapping of 16S rRNA gene amplicons showed the highest abundances of these strains at the deep chlorophyll maximum (source of their inoculum) in winter and spring, with a substantial decrease in summer. Genomic analysis of the isolates suggests that motility and degradation of organic material, both energy demanding functions, may be supported by rhodopsin phototrophy in Verrucomicrobiota. Under culture conditions, we show that rhodopsin phototrophy occurs under carbon starvation, with light-mediated energy generation supporting sugar transport into the cells. Overall, this study suggests that photoheterotrophic Verrucomicrobiota may occupy an ecological niche where energy harvested from light enables bacterial motility toward organic matter and supports nutrient uptake.
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- 2023
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6. Functions and regulatory mechanisms of resting hematopoietic stem cells: a promising targeted therapeutic strategy
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Xinyu Tang, Zhenzhen Wang, Jingyi Wang, Siyuan Cui, Ruirong Xu, and Yan Wang
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Molecular Medicine ,Medicine (miscellaneous) ,Cell Biology ,Biochemistry, Genetics and Molecular Biology (miscellaneous) - Abstract
Hematopoietic stem cells (HSCs) are the common and essential precursors of all blood cells, including immune cells, and they are responsible for the lifelong maintenance and damage repair of blood tissue homeostasis. The vast majority (> 95%) of HSCs are in a resting state under physiological conditions and are only activated to play a functional role under stress conditions. This resting state affects their long-term survival and is also closely related to the lifelong maintenance of hematopoietic function; however, abnormal changes may also be an important factor leading to the decline of immune function in the body and the occurrence of diseases in various systems. While the importance of resting HSCs has attracted increasing research attention, our current understanding of this topic remains insufficient, and the direction of clinical targeted treatments is unclear. Here, we describe the functions of HSCs, analyze the regulatory mechanisms that affect their resting state, and discuss the relationship between resting HSCs and different diseases, with a view to providing guidance for the future clinical implementation of related targeted treatments.
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- 2023
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7. Selenium deficiency increased duodenal permeability and decreased expression of antimicrobial peptides by activating ROS/NF-κB signal pathway in chickens
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Yujiao, He, primary, Xinyu, Tang, additional, Xue, Fan, additional, Zhe, Li, additional, Lin, Peng, additional, Guangliang, Shi, additional, and Shu, Li, additional
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- 2022
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8. Chromosomal Abnormalities Affect the Surgical Outcome in Infants with Hypoplastic Left Heart Syndrome: A Large Cohort Analysis
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Parthak Prodhan, Rupal T. Bhakta, Nahed O. ElHassan, Dala Zakaria, and Xinyu Tang
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Male ,Pediatrics ,medicine.medical_specialty ,Databases, Factual ,medicine.medical_treatment ,Population ,Chromosome Disorders ,030204 cardiovascular system & hematology ,Norwood Procedures ,Hypoplastic left heart syndrome ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Hypoplastic Left Heart Syndrome ,medicine ,Humans ,Hospital Mortality ,030212 general & internal medicine ,Cardiopulmonary resuscitation ,education ,Retrospective Studies ,Genetic testing ,Chromosome Aberrations ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,Infant, Newborn ,Infant ,Gestational age ,Length of Stay ,Vascular surgery ,medicine.disease ,Survival Analysis ,Cardiac surgery ,Hospitalization ,Treatment Outcome ,Pediatrics, Perinatology and Child Health ,Necrotizing enterocolitis ,Heart Transplantation ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Patients with hypoplastic left heart syndrome (HLHS) can have associated genetic abnormalities. This study evaluated the incidence of genetic abnormalities among infants with HLHS and the short-term outcomes of this population during the first hospitalization. This is a retrospective analysis of the multi-center Pediatric Heath Information System database of infants with HLHS who underwent Stage I Norwood, Hybrid, or heart transplant during their first hospitalization from 2004 through 2013. We compared clinical data between infants with and without genetic abnormality, among the three most common chromosomal abnormalities, and between survivors and non-survivors. Multivariable analysis was completed to evaluate predictors of mortality among patients with genetic abnormalities. A total of 5721 infants with HLHS were identified; 282 (5%) had associated genetic abnormalities. The three most common chromosomal abnormalities were Turner (25%), DiGeorge (22%), and Downs (12.7%) syndromes. Over the study period, the number of patients with genetic abnormalities undergoing cardiac operations increased without any significant increases in mortality. Infants with genetic abnormalities compared to those without abnormalities had longer hospital length of stay and higher morbidity and mortality. Variables associated with mortality were lower gestational age, longer duration of vasopressor therapy, need for dialysis, and cardiopulmonary resuscitation; and complicated clinical course as suggested by necrotizing enterocolitis, septicemia. Presence of any genetic abnormality in infants with HLHS undergoing cardiac surgery is associated with increased mortality and morbidity. Timely genetic testing, appropriate family counseling, and thorough preoperative case selection are suggested for these patients for any operative intervention.
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- 2017
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9. Efficient method to verify the integrity of data with supporting dynamic data in cloud computing
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Cheng Guo, Bin Feng, Yingmo Jie, and Xinyu Tang
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020203 distributed computing ,021110 strategic, defence & security studies ,General Computer Science ,Computer science ,business.industry ,Distributed computing ,Dynamic data ,0211 other engineering and technologies ,0202 electrical engineering, electronic engineering, information engineering ,Cloud computing ,02 engineering and technology ,business - Published
- 2018
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10. PDGFRA gene, maternal binge drinking and obstructive heart defects
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Charlotte A. Hobbs, Mario A. Cleves, Xinyu Tang, Johann K. Eberhart, Stewart L. MacLeod, Wendy N. Nembhard, Jingyun Li, and Ming Li
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Adult ,Heart Defects, Congenital ,0301 basic medicine ,Receptor, Platelet-Derived Growth Factor alpha ,lcsh:Medicine ,Physiology ,Binge drinking ,PDGFRA ,Polymorphism, Single Nucleotide ,Article ,Binge Drinking ,03 medical and health sciences ,Pregnancy ,Genotype ,Humans ,Medicine ,Genetic Predisposition to Disease ,Allele ,lcsh:Science ,Multidisciplinary ,business.industry ,lcsh:R ,Confounding ,Maternal effect ,medicine.disease ,3. Good health ,030104 developmental biology ,Prenatal Exposure Delayed Effects ,lcsh:Q ,Female ,Animal studies ,business - Abstract
Obstructive heart defects (OHDs) are a major health concern worldwide. The platelet-derived growth factor (PDGF) genes are known to have regulatory functions that are essential for proper heart development. In a zebrafish model, Pdgfra was further demonstrated to interact with ethanol during craniofacial development. In this article, we investigated interactions between variants in PDGF genes and periconceptional alcohol exposure on the risk of OHDs by applying log-linear models to 806 OHD case and 995 control families enrolled in the National Birth Defects Prevention Study. The interactions between four variants in PDGFA and maternal binge drinking reached a nominal significance level. The maternal T allele of rs869978 was estimated to increase OHD risk among women who binge drink, while infant genotypes of rs2291591, rs2228230, rs1547904, and rs869978 may reduce the risk. Although none of these associations remain statistically significant after multiple testing adjustment and the estimated maternal effect may be influenced by unknown confounding factors, such as maternal smoking, these findings are consistent with previous animal studies supporting potential interactions between the PDGFRA gene and maternal alcohol exposure. Replication studies with larger sample sizes are needed to further elucidate this potential interplay and its influence on OHD risks.
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- 2018
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11. Pattern-Mixture-Type Estimation and Testing of Neuroblastoma Treatment Regimes
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Xinyu Tang and Abdus S. Wahed
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Statistics and Probability ,Clinical trial ,Dynamic treatment regime ,Maintenance therapy ,Proportional hazards model ,Statistics ,Parametric model ,Estimator ,Missing data ,Article ,Survival analysis ,Mathematics - Abstract
Sequentially randomized designs are commonly used in biomedical research, particularly in clinical trials, to assess and compare the effects of different treatment regimes. In such designs, eligible patients are first randomized to one of the initial therapies, then patients with some intermediate response (e.g. without progressive diseases) are randomized to one of the maintenance therapies. The goal is to evaluate dynamic treatment regimes consisting of an initial therapy, the intermediate response, and a maintenance therapy. In this article, we demonstrate the use of pattern-mixture model (commonly used for analyzing missing data) for estimating the effects of treatment regimes based on familiar survival analysis techniques such as Nelson-Aalen and parametric models. Moreover, we demonstrate how to use estimates from pattern-mixture models to test for the differences across treatment regimes in a weighted log-rank setting. We investigate the properties of the proposed estimators and test in a Monte Carlo simulation study. Finally we demonstrate the methods using the long-term survival data from the high risk neuroblastoma study.
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- 2014
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12. Cumulative Hazard Ratio Estimation for Treatment Regimes in Sequentially Randomized Clinical Trials
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Abdus S. Wahed and Xinyu Tang
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Statistics and Probability ,Randomization ,Proportional hazards model ,business.industry ,Hazard ratio ,Estimator ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,Article ,law.invention ,Randomized controlled trial ,law ,Statistics ,Covariate ,Econometrics ,Medicine ,business ,Statistic ,Survival analysis - Abstract
The proportional hazards model is widely used in survival analysis to allow adjustment for baseline covariates. The proportional hazard assumption may not be valid for treatment regimes that depend on intermediate responses to prior treatments received, and it is not clear how such a model can be adapted to clinical trials employing more than one randomization. Besides, since treatment is modified post-baseline, the hazards are unlikely to be proportional across treatment regimes. Although Lokhnygina and Helterbrand (Biometrics 63: 422–428, 2007) introduced the Cox regression method for two-stage randomization designs, their method can only be applied to test the equality of two treatment regimes that share the same maintenance therapy. Moreover, their method does not allow auxiliary variables to be included in the model nor does it account for treatment effects that are not constant over time. In this article, we propose a model that assumes proportionality across covariates within each treatment regime but not across treatment regimes. Comparisons among treatment regimes are performed by testing the log ratio of the estimated cumulative hazards. The ratio of the cumulative hazard across treatment regimes is estimated using a weighted Breslow-type statistic. A simulation study was conducted to evaluate the performance of the estimators and proposed tests.
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- 2013
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13. Clinical analysis of HCPT plus FOLFOX4 regimen as salvage therapy for patients with advanced gastric cancer
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Xiao-Qiang Fan, Xiangyong Li, Dejian Pan, Xinyu Tang, Xijian Zhou, and Rengui Zhou
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medicine.medical_specialty ,business.industry ,Therapeutic effect ,Salvage therapy ,medicine.disease ,Gastroenterology ,Surgery ,Oxaliplatin ,Metastasis ,Regimen ,Bolus (medicine) ,Oncology ,Bone marrow suppression ,Internal medicine ,medicine ,Vomiting ,medicine.symptom ,business ,medicine.drug - Abstract
To evaluate the therapeutic as well as side effects of hydroxycamptothecin (HCPT) plus FOLFOX4 regimen as salvage therapy for patients with advanced gastric cancer. A total of 19 patients with advanced gastric cancer received HCPT plus FOLFOX4 as salvage therapy, in detail, Oxaliplatin 85 mg/m2 was given intravenously on day 1, CF 200 mg/m2, 5-Fu 400 mg/m2 given in bolus immediately after CF, days 1–2; 5-Fu 600 mg/m2 given continuously after bolus for 22 h on day 1, day 2, HCPT given intravenously at dosage of 10 mg/m2 on days 1–2. Therapeutic effects were evaluated at least after two cycles of treatment. 17 cases among the 19 patients were valid for response evaluation, with CR 1, PR 6, SD 4, PD 6. The response rate was 41.2%. For the 12 patients with liver metastasis, response rate of the liver foci was 50%. The main toxicities were bone marrow suppression, nausea and vomiting, and peripheral neuropathy; there were no chemotherapy-related deaths. The combination regimen with HCPT plus FOFLOX4 regimen was effective as salvage therapy for patients with advanced gastric cancer, with particularly high response rate for liver metastasis, and the side effects were tolerable and manageable.
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- 2008
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